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| 1 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 2 | Experimental and clinical study of influence of high-frequency electric surgical knives on healing of abdominal incision显示文摘瞄准:在腹壁切口愈合上学习高周波的电的外科的刀的影响。方法:240 只白鼠被划分成 10 (0 ) , 10 (2 ) , 10 (5 ) ,并且 10 (8 ) 组和腹部手术的老鼠模型被分别地使用电的外科的刀和普通口针劝诱。然后,他们分别地被给生理盐水和 0.2 mL 的皮下注射在 10 的集中(2 ) 的埃希氏杆菌属关口 i,葡萄球菌 aureus 和绿脓假单胞菌的量的混合, 10 (5 ) 并且 10 (8 ) 。根据动物实验,经历腹部手术(上面的类型 II ) 的 220 个病人随机被分配进跟随三个组之一:电热刀(EK, 93 个盒子) ,电凝法(EC, 55 个盒子) 并且控制(72 个盒子) 。高周波的电的外科的刀习惯于为在 EK 的血壅滞的腹的纸巾和电凝法组织的 dissect。普通口针和电凝法在 EC 组被使用。普通口针和系住的丝缝线在控制被使用。结果:在除了组 10 的所有组(0 ) ,电的外科的刀做的 incisional 创伤的感染率与普通口针比那显著地高。而且,在组有有效差量 10 (2 ) , 10 (5 ) ,并且 10 (8 )(P<0.05 ) ,然而并非(0 )(P>0.05 ) 在组, 10 在 EK 和 EC 之间组织。临床的研究显示出在控制组在 EK,在 EC 的 11 个盒子(16.36%) 和 2 个盒子(2.86%) 在 16 种情况(17.20%) 中愈合的一处推迟的创伤。在 EK 和控制之间的有效差量组织(chi2 = 8.57, P<0.01 ) ,并且在 EC 和控制组之间(chi2 = 5.66, P<0.05 ) 被观察,然而并非在 EK 和 EC 之间(chi2 = 0.017, P>0.05 ) 。结论:高周波的电的刀可以显著地推迟腹壁切口愈合。它的申请应该被最小化以便减少手术后的复杂并发症的可能性。 | Guang-Wei Ji Yuan-Zhi Wu Xu Wang Hua-Xiong Pan Ping Li Wan-Ying Du Zhi Qi An Huang Li-Wei Zhang Li Zhang Wen Chen Guang-Hua Liu Hui Xu Quan Li Ai-Hua Yuan Xiao-Ping He Guo-Hua Mei | 2006 | World Journal of Gastroenterology2006，12，25： | 23 |
| 3 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 4 | Chemokine SR-PSOX/CXCL16 expression in peripheral blood of patients with acute coronary syndrome显示文摘背景:绑 phosphatidylserine 和氧化 lipoprotein/CXC chemokine ligand 的清道工人受体(SR-PSOX/CXCL16 ) 16 通过肿瘤坏死因素(TNF ) 支持泡沫房间形成 -alpha 调停了机制。因为 chemokine CXCL16 能在动脉粥样硬化患者损害和 induce 平滑肌房间(SMC ) 增长被表示,我们想在病人的外部血的单核白血球 SR-PSOX/CXCL16 察觉将为动脉粥样硬化的早诊断和预后是重要的(作为) 。方法:在这注册了学习是有急性冠的症候群(交流) 的 40 个病人,包括有尖锐心肌的梗塞(AMI ) 的 20 个病人和有不稳定的心绞痛(UAP ) 的 20 个病人,并且 20 正常控制。在外部血的单核白血球被孤立,并且 CXCL16/SR-PSOX mRNA 的表示的变化用反向的抄写聚合酶链反应(RT-PCR ) 被比较,与象内部控制的贝它肌动朊。我们在 ACS 亚群比较了 CXCL16/SR-PSOX 的表示,用对分析蛋白质表示层次西方污点。组织节由象正常控制一样与易传染的心内膜炎,肝肝硬化,和肺癌症从病人拿的活体检视标本制造了。并且 CXCL16/SR-PSOX 的表示与一台共焦的显微镜被分析。结果:在外部血的单核白血球的 CXCL16/SR-PSOX mRNA 和蛋白质的表示比在正常控制在交流病人是显著地更高的(P <
0.05 ) ;然而,在在 UAP 组和 AMI 组之间的 CXCL16/SR-PSOX 表示没有有效差量(P >
0.05 ) 。Immunofluorescence 证明有在正常脉管的 endothelial 的 SR-PSOX 的低表示并且在感染的容器的每层提高了表示,当从 endothelial 传播到包围感染变得更坏的纸巾时。共焦的显微镜学证明 SR-PSOX 的表示在肝肝硬化在渗入的淋巴细胞被提高,并且表示铺平,这对在门 hepatis 和叶的发炎的度相称。结论:在外部血的单核白血球的 CXCL16/SR-PSOX 的表达式比在控制在交流病人是显著地更高的。CXCL16/SR-PSOX-mediated 发炎可以贡献交流的致病,并且 CXCL16 可以在致病和发展起一个重要作用是在人。 | YANG Hui-ling XU Yang-yan DU Li-fen LIU Chang-hui ZHAO Qiang WEI Wu-jie YOU Yong QUAN Zhi-hua | 2008 | Chinese Medical Journal2008，，2： | 17 |
| 5 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 6 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 7 | Optimization of Short Stroke Control Preset for Automatic Width Control of Hot Rolling Mill显示文摘Automatic width control is a key issue in hot strip rolling process. The edge rolling has been widely used in the roughing stand of hot strip mill to control the width of the slab. However, the edge rolling and consequent horizontal rolling will cause a significant width change in the head part and tail part of the slab, which have to be trimmed before the finishing stands. Based on the width reduction deformation curve of the head and tail along the longitudinal direction of slab, the short stroke control (SSC) technology has been developed to overcome this problem. The finite element method has been used to simulate the unsteady edge rolling process. Three short stroke control curves have been compared in order to obtain the best width control result. The optimized short stroke control curve has been applied to the automatic width control system of industrial hot rolling mill,and good performance is obtained. | DU Xiao-zhong YANG Quan LU Cheng WANG Ai-li Tieu A Kiet | 2010 | Journal of Iron and Steel Research(International)2010，17，6： | 12 |
| 8 | Formation control and collision avoidance for multi-UAV systems based on Voronoi partition显示文摘This paper deals with the formation control problem of multiple unmanned aerial vehicles(UAVs) with collision avoidance. A distributed formation control and collision avoidance method is proposed based on Voronoi partition and conventional artificial potential field. The collision avoidance is achieved by partitioning the whole space into non-overlapping regions based on Voronoi partition theory, which is taken as the task region to confine the movement of each UAV. The general motion control law is designed based on the conventional artificial potential field. As this often leads to local optimum when two UAVs are going to collide with each other and they may stay still where the repulsive force is adversely equivalent to the attractive force. To address this problem,the destination switch scheme is further proposed to let UAVs switch destinations when they reach the local equilibrium. Finally,the effectiveness of proposed formation control algorithm is validated by simulations and experiments. | HU JinWen WANG Man ZHAO ChunHui PAN Quan DU Chang | 2020 | Science China(Technological Sciences)2020，63，1： | 12 |
| 9 | Effects of total dissolved gas supersaturated water on lethality and catalase activity of Chinese sucker(Myxocyprinus asiaticus Bleeker)显示文摘Total dissolved gas(TDG) supersaturation caused by dam sluicing can result in gas bubble trauma(GBT) in fish and threaten their survival.In the present study,Chinese suckers(Myxocyprinus asiaticus Bleeker) were exposed to TDG supersaturated water at levels ranging from 120% to 145% for 48 h.The median lethal concentration(LC 50) and the median lethal time(LT 50) were determined to evaluate acute lethal effects on Chinese suckers.The results showed that the LC 50 values of 4,6,8,and 10 h were 142%,137%,135%,and 130%,respectively.The LT 50 values were 3.2,4.7,7.8,9.2,and 43.4 h,respectively,when TDG supersaturated levels were 145%,140%,135%,130%,and 125%.Furthermore,the biological responses in Chinese suckers were studied by assaying the catalase(CAT) activities in gills and muscles at the supersaturation level of 140% within LT 50.The CAT activities in the gills and muscle tissues exhibited a regularity of a decrease after an increase.CAT activities in the muscles were increased significantly at 3/5LT 50(P<0.05) and then came back to the normal level.However,there were no significant differences between the treatment group(TDG level of 140%) and the control group(TDG level of 100%) on CAT activities in the gills before 3/5LT 50(P>0.05),but the activities were significantly lower than the normal level at 4/5LT 50 and LT 50(P<0.05). | Shi-chao CHEN Xiao-qing LIU Wen JIANG Ke-feng LI Jun DU Dan-zhou SHEN Quan GONG | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，10： | 11 |
| 10 | Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis显示文摘印射的背景量的 T2 是为病理学的软骨性质的评估的一个广泛地使用的方法,并且在兔子的骨关节炎的组织学的评价系统被出版了学习的 recently.The 目的是调查为前面的十字形的系带横断( ACLT )的一个兔子模型的关节的软骨损害印射评估的量的 T2 的有效性 osteoarthritis.Methods 二十只新西兰怀特( NZW )兔子被划分成 ACLT 外科的 | WEI Zheng-mao DU Xiang-ke HUO Tian-long LI Xu-bin QUAN Guang-nan LI Tian-ran CHENG Jin ZHANG Wei-tao | 2012 | Chinese Medical Journal2012，，5： | 11 |
| 11 | Laparoscopic distal pancreatectomy with or without splenectomy: spleen-preservation does not increase morbidity显示文摘BACKGROUND: The indications for laparoscopic spleen-preserving distal pancreatectomy (LSPDP) and its morbidity compared with laparoscopic distal pancreatectomy with splenectomy (LDPS) are ill-defined. This study aimed to share the indications for spleen-preservation and investigate the safety and outcome of LSPDP at our institution. METHODS: A retrospective review of patients who were scheduled to receive laparoscopic surgery for distal pancreatic lesions was conducted. The indications, surgical procedures, intra-operative data, and outcomes of the two procedures were collected and compared by statistical analysis. RESULTS: LDPS and LSPDP were successfully performed in 16 and 21 patients respectively, whereas they were converted to open surgery in 9 patients. There were no significant differences in age, gender, operation time, blood loss, and conversion rate between the LDPS and LSPDP groups. The mean tumor size showed an inter-group difference (5.05 vs 2.53 cm, P<0.001). There were no significant differences in complication and morbidity rates between the two groups. All patients remained alive without recurrence during a follow-up of 9 to 67 months (median 35).CONCLUSION: LSPDP has a morbidity and outcome comparable to LDPS. | Yu-Pei Zhao, Xiao Du, Meng-Hua Dai, Tai-Ping Zhang, Quan Liao, Jun-Chao Guo, Lin Cong ,Ge Chen Department of General Surgery, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 8 |
| 12 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 13 | AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs显示文摘AFF1 and AFF4 belong to the AFF(AF4/FMR2) family of proteins, which function as scaffolding proteins linking two different transcription elongation factors, positive elongation factor b(P-TEFb) and ELL1/2, in super elongation complexes(SECs). Both AFF1 and AFF4 regulate gene transcription through elongation and chromatin remodeling. However, their function in the osteogenic differentiation of mesenchymal stem cells(MSCs) is unknown. In this study, we show that small interfering RNA(si RNA)-mediated depletion of AFF1 in human MSCs leads to increased alkaline phosphatase(ALP) activity, enhanced mineralization and upregulated expression of osteogenic-related genes. On the contrary, depletion of AFF4 significantly inhibits the osteogenic potential of MSCs. In addition, we confirm that overexpression of AFF1 and AFF4 differentially affects osteogenic differentiation in vitro and MSC-mediated bone formation in vivo.Mechanistically, we find that AFF1 regulates the expression of DKK1 via binding to its promoter region.Depletion of DKK1 in HA-AFF1-overexpressing MSCs abrogates the impairment of osteogenic differentiation. Moreover, we detect that AFF4 is enriched in the promoter region of ID1. AFF4 knockdown blunts the BRE luciferase activity, SP7 expression and ALP activity induced by BMP2 treatment. In conclusion, our data indicate that AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs. | Chen-chen Zhou Qiu-chan Xiong Xin-xing Zhu Wen Du Peng Deng Xiao-bing Li Yi-zhou Jiang Shu-juan Zou Cun-yu Wang Quan Yuan | 2017 | Bone Research2017，5，3： | 6 |
| 14 | Simple β-lactones are potent irreversible antagonists for strigolactone receptors显示文摘 | Haibo Xian Ruifeng Yao Tianfei Quan Fei Wang Li Chen Xiaoxi DU Wenhao Zhang Haiteng Deng Daoxin Xie Tuoping Luo | 2017 | Cell Research2017，27，12： | 5 |
| 15 | Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs显示文摘 | Guan-hua RAO Hong-min LIU Bao-wei LI Jia-jie HAO Yan-lei YANG Ming-rong WANG Xiao-hui WANG Jun WANG Hai-jing JIN Lei DU Quan CHEN | 2013 | Acta Pharmacologica Sinica2013，34，6： | 5 |
| 16 | Enhanced Reversible Zinc Ion Intercalation in Deficient Ammonium Vanadate for High-Performance Aqueous Zinc-Ion Battery显示文摘Ammonium vanadate with bronze structure(NH_(4)V_(4)O_(10))is a promising cathode material for zinc-ion batteries due to its high specific capacity and low cost.However,the extraction of NH^(+)_(4) at a high voltage during charge/discharge processes leads to irreversible reaction and structure degradation.In this work,partial NH^(+)_(4) ions were pre-removed from NH_(4)V_(4)O_(10) through heat treatment;NH_(4)V_(4)O_(10) nanosheets were directly grown on carbon cloth through hydrothermal method.Defi-cient NH_(4)V_(4)O_(10)(denoted as NVO),with enlarged interlayer spacing,facilitated fast zinc ions transport and high storage capacity and ensured the highly reversible electrochemical reaction and the good stability of layered structure.The NVO nanosheets delivered a high specific capac-ity of 457 mAh g^(−1) at a current density of 100 mA g^(−1) and a capacity retention of 81%over 1000 cycles at 2 A g^(−1).The initial Coulombic efficiency of NVO could reach up to 97%compared to 85%of NH_(4)V_(4)O_(10) and maintain almost 100%during cycling,indicating the high reaction reversibility in NVO electrode. | Quan Zong Wei Du Chaofeng Liu Hui Yang Qilong Zhang Zheng Zhou Muhammad Atif Mohamad Alsalhi Guozhong Cao | 2021 | Nano-Micro Letters2021，13，8： | 4 |
| 17 | Genomic characterizations of H4 subtype avian influenza viruses from live poultry markets in Sichuan province of China, 2014–2015显示文摘Dear Editor,Avian influenza viruses (AIVs) have posed a serious threat to poultry production and public health. To date, more than fourteen AIV subtypes that are able to infect human beings have been documented. Also, it is suggested that new subtypes may be reported in the future, owing to the migration of wild birds and live poultry transportation (Gao, 2018).Poultry may act as a potential incubator for novel subtypes of avian influenza virus (Bi et al., 2016a; Bi et al., 2016b; Liu et al., 2014a; Su et al., 2017). Up to date, the H7N9 AIV emerged in February 2013 has caused 1,567 human cases,with a fatality rate of 39.2%(http://gffzz36b398b81f8a4a4ch6cbxoc09qv9b6uxp.ffgz.tsg.suse.edu.cn/influenza/ | Chuansong Quan Ting Huang Xiuwei Chen Jie Zhang Qianli Wang Cheng Zhang Tiyan Zhang Lijun Zhou Liumei Shu Chunrong Long Lei Yang Xunbo Du Yingze Zhao Peipei Liu Hao Song Weifeng Shi Yuhai Bi Qiang Lv William J.Liu George F.Gao | 2018 | Science China(Life Sciences)2018，61，9： | 4 |
| 18 | Body Mass Index Increases Risk for Colorectal Adenomas Based on Meta-analysis显示文摘 | Qiwen Ben Wei An Ying Jiang Xianbao Zhan Yiqi Du Quan Cai Cai Jie Gao Zhaoshen Li | 2012 | Gastroenterology2012，，4： | 3 |
| 19 | Synthesis of 2,2'-(Substituted Arylmethylene)bis(1,6,6-trimethyl- 6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) Derivatives显示文摘The reactions of tanshinone IIA with aromatic aldehydes have been investigated and several 2, 2’-(substituted arylmethylene) bis (1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]- furan-10, 11-dione) derivatives were obtained. | Jiang Ke QIN Xian Zhang BU Yu Fang WANG Zhi Yun DU Xing Yuan WANG Zhi Shu HUANG Lin MA Lin Kun AN Lian Quan GU | 2005 | Chinese Chemical Letters2005，16，11： | 3 |
| 20 | Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold显示文摘Critical oral-maxillofacial bone defects,damaged by trauma and tumors,not only affect the physiological functions and mental health of patients but are also highly challenging to reconstruct.Personalized biomaterials customized by 3D printing technology have the potential to match oralmaxillofacial bone repair and regeneration requirements.Laponite(LAP)nanosilicates have been added to biomaterials to achieve biofunctional modification owing to their excellent biocompatibility and bioactivity.Herein,porous nanosilicate-functionalized polycaprolactone(PCL/LAP)was fabricated by 3D printing technology,and its bioactivities in bone regeneration were investigated in vitro and in vivo.In vitro experiments demonstrated that PCL/LAP exhibited good cytocompatibility and enhanced the viability of bone marrow mesenchymal stem cells(BMSCs).PCL/LAP functioned to stimulate osteogenic differentiation of BMSCs at the mRNA and protein levels and elevated angiogenic gene expression and cytokine secretion.Moreover,BMSCs cultured on PCL/LAP promoted the angiogenesis potential of endothelial cells by angiogenic cytokine secretion.Then,PCL/LAP scaffolds were implanted into the calvarial defect model.Toxicological safety of PCL/LAP was confirmed,and significant enhancement of vascularized bone formation was observed.Taken together,3D-printed PCL/LAP scaffolds with brilliant osteogenesis to enhance bone regeneration could be envisaged as an outstanding bone substitute for a promising change in oral-maxillofacial bone defect reconstruction. | Xiongcheng Xu Long Xiao Yanmei Xu Jin Zhuo Xue Yang Li Li Nianqi Xiao Jing Tao Quan Zhong Yanfen Li Yuling Chen Zhibin Du Kai Luo | 2021 | Regenerative Biomaterials2021，8，6： | 3 |
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