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| 1 | Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction显示文摘AIM To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of selfexpandable metal stent(SEMS).METHODS This was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography(ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis(PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were classified.RESULTS Among the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients,pancreatic cancer in 79, and non-pancreatic or nonbiliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients(3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy(cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP complications.CONCLUSION Limited ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding. | Hyeong Seok Nam Dae Hwan Kang Hyung Wook Kim Cheol Woong Choi Su Bum Park Su Jin Kim Dae Gon Ryu | 2017 | World Journal of Gastroenterology2017，23，9： | 7 |
| 2 | Preoperative CA 125 is significant indicator of curative resection in gastric cancer patients显示文摘AIM: To investigate the correlation among tumor markers, curative resection, and recurrence in gastric cancer.METHODS: The patients with preoperative tumormakers [Carcinoembryonic antigen, Carbohydrate antigen(CA) 19-9, and CA 125] and elective gastrectomy between January 2000 and December 2009 at Chungbuk National University Hospital were enrolled in this study. We analyzed the relationship among the tumor makers, curative resection and recurrence, retrospectively.RESULTS: Among the 679 patients with gastric cancer, curative resection was 93.6%(n = 636) and noncurative resection was 6.4%(n = 43). The independent risk factors for the non-curative resection were tumor location and the positivity of preoperative serum CA 19-9 and CA 125 levels. After curative resection, the independent prognostic risk factors for recurrence in curative resection were gender, stage, and preoperative increased serum CA 125 level(HR = 2.431, P =0.020), in a multivariate analysis. CONCLUSION: Preoperative CA 125 is a useful predictive biomarker for curative resection and prognostic biomarker for recurrence in gastric cancer patients. | Dae Hoon Kim Hyo Yung Yun Dong Hee Ryu Hye-Suk Han Joung-Ho Han Soon Man Yoon Sei Jin Youn | 2015 | World Journal of Gastroenterology2015，21，4： | 6 |
| 3 | Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans显示文摘AIM:To investigate whether nonalcoholic fatty liver disease(NAFLD)affects coronary artery disease(CAD)and identify candidate mediators.METHODS:Patients who underwent coronary angiography were consecutively recruited.The patients were classified into four groups by coronary artery stenosis:A,insignificant;B,one-vessel disease;C,two-vessel disease;and D,three-vessel disease.Abdominal ultrasonography was performed to determine the presence of a fatty liver and categorize by grade:0,no evidence;1,mild;2,moderate;and 3,severe.We measured not only known CAD risk factors,but also serum insulin,HOMA-index,adiponectin,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein levels.RESULTS:Of the 134 patients who met the inclusion criteria,82(61.2%)had ultrasonographically diagnosed NAFLD.Among the 46 patients with CAD,37(80.4%)had evidence of a fatty liver.The two groups(A vs B-D)were significantly different in terms of age,total cholesterol,triglycerides,low-density lipoprotein levels and fatty liver.Coronary artery stenosis was strongly associated with fatty liver in a grade-dependent manner(P=0.025).In binary logistic regression,NAFLD was a significant independent predictor of CAD(P=0.03,OR=1.685;95%CI:1.051-2.702).Among the candidate mediators,the serum adiponectin level showed a trend toward lowering based on CAD progression(P=0.071).CONCLUSION:NAFLD is an independent risk factor for CAD in a grade-dependent manner.Moreover,adiponectin might be related to the pathogenesis of NAFLD. | Dae Hee Choi Sung Joon Lee Chang Don Kang Myoung Ok Park Dong Wook Choi Tae Suk Kim Wonho Lee Byung Ryul Cho Yong Hoon Kim Bong-ki Lee Dong Ryeol Ryu Ji Won Lee | 2013 | World Journal of Gastroenterology2013，19，38： | 5 |
| 4 | Multicenter Prospective Comparative Study of Robotic Versus Laparoscopic Gastrectomy for Gastric Adenocarcinoma显示文摘 | Hyoung-Il Kim Sang-Uk Han Han-Kwang Yang Young-Woo Kim Hyuk-Joon Lee Keun Won Ryu Joong-Min Park Ji Yeong An Min-Chan Kim Sungsoo Park Kyo Young Song Sung Jin Oh Seong-Ho Kong Byoung Jo Suh Dae Hyun Yang Tae Kyung Ha Youn Nam Kim Woo Jin Hyung | 2016 | Annals of Surgery2016，，1： | 4 |
| 5 | Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma显示文摘AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). METHODS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage Ⅲ and Ⅳ-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m ≥ 20% than in those with TRR1m < 20% (P < 0.001). CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%. | Yeon Seok Seo Jin Nam Kim Bora Keum Sanghoon Park Yong Dae Kwon Yong Sik Kim Yoon Tae Jeen Hoon Jai Chun Chul Yong Kim Chang Duck Kim Ho Sang Ryu Soon Ho Um | 2008 | World Journal of Gastroenterology2008，14，15： | 4 |
| 6 | Assessment of disease activity by fecal immunochemical test in ulcerative colitis显示文摘AIM To evaluate the efficacy of quantitative fecal immunochemical test(FIT) as biomarker of disease activity in ulcerative colitis(UC).METHODS Between February 2013 and November 2014, a total of 82 FIT results, obtained in conjunction with colonoscopies, were retrospectivelyevaluated for 63 patients with UC. The efficacy of FIT for evaluation of disease activity was compared to colonoscopic findings. Quantitative fecal blood with automated equipment examined from collected feces. Endoscopic disease severity were assessed using the Mayo endoscopic subscore(MES) classification. The extent of disease were classified by proctitis(E1), left sided colitis(E2), and extensive colitis(E3). Clinical activity were subgrouped by remission or active.RESULTS All of 21 patients with MES 0 had negative FIT(< 7 ng/mL), but 22 patients with MES 2 or 3 had a mean FIT of > 134.89 ng/m L. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of negative FIT about mucosal healing were 73.33%, 81.82%, 91.49%, 51.43% and 73.17%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of predictive value of positive FIT(cutoff value > 100 ng/mL) about active disease status were 45.45%, 93.33%, 71.43%, 82.35%and 26.83%, respectively. Among patients with clinical remission, FIT was negative in 31(81.6%) of 38 cases, with a mean fecal hemoglobin concentration of 6.12 ng/mL(range, negative to 80.9 ng/mL) for this group of patients. Among patients with clinical active disease, FIT was negative in 16(36.4%) out of 44 cases, with a mean fecal hemoglobin concentration > 167.4 ng/mL for this group of patients. FIT was positively correlated with endoscopic activity(r = 0.626, P < 0.01) and clinical activity(r = 0.496, P < 0.01). But, FIT did not correlate with the extent of disease(r =-0.047, P = 0.676)CONCLUSION Quantitative FIT can be a non-invasive and effective biomarker for evaluation of clinical and endoscopic activity in UC, but not predict the extent of disease. | Dae Gon Ryu Hyung Wook Kim Su Bum Park Dae Hwan Kang Cheol Woong Choi Su Jin Kim Hyeong Seok Nam | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 7 | Predictors for difficult cecal insertion in colonoscopy: The impact of obesity indices显示文摘AIM To identify the factors influencing cecal insertion time(CIT) and to evaluate the effect of obesity indices on CIT. METHODS We retrospectively reviewed the data for participants who received both colonoscopy and abdominal computed tomography(CT) from February 2008 to May 2008 as part of a comprehensive health screening program. Age, gender, obesity indices [body mass index(BMI), waist-to-hip circumference ratio(WHR), waist circumference(WC), visceral adipose tissue(VAT)volume and subcutaneous adipose tissue(SAT) volume on abdominal CT], history of prior abdominal surgery, constipation, experience of the colonoscopist, quality of bowel preparation, diverticulosis and time required to reach the cecum were analyzed. CIT was categorized as longer than 10 min(prolonged CIT) and shorter than or equal to 10 min, and then the factors that required a CIT longer than 10 min were examined.RESULTS A total of 1678 participants were enrolled. The mean age was 50.42 ± 9.931 years and 60.3% were men. The mean BMI, WHR, WC, VAT volume and SAT volume were 23.92 ± 2.964 kg/m2, 0.90 ± 0.076, 86.95 ± 8.030 cm, 905.29 ± 475.220 cm3 and 1707.72 ± 576.550 cm3, respectively. The number of patients who underwent abdominal surgery was 268(16.0%). Colonoscopy was performed by an attending physician alone in 61.9% of cases and with the involvement of a fellow in 38.1% of cases. The median CIT was 7 min(range 2-56 min, IQR 5-10 min), and mean CIT was 8.58 ± 5.291 min. Being female, BMI, VAT volume and involvement of fellow were significantly associated with a prolonged CIT in univariable analysis. In multivariable analysis, being female(OR = 1.29, P = 0.047), lower BMI(< 23 kg/m2)(OR = 1.62, P = 0.004) or higher BMI(≥ 25 kg/m2)(OR = 1.80, P < 0.001), low VAT volume(< 500 cm3)(OR = 1.50, P = 0.013) and fellow involvement(OR = 1.73, P < 0.001) were significant predictors of prolonged CIT. In subgroup analyses for gender, lower BMI or higher BMI and fellow involvement were predictors for prolonged CIT in both genders. However, low VAT volume was associated with prolonged CIT in only women(OR = 1.54, P = 0.034).CONCLUSION Being female, having a lower or higher BMI than the normal range, a low VAT volume, and fellow involvement were predictors of a longer CIT. | Soo Yun Moon Byung Chang Kim Dae Kyung Sohn Kyung Su Han Bun Kim Chang Won Hong Bum Joon Park Kum Hei Ryu Ji Hyung Nam | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 8 | Stress and sleep quality in doctors working on-call shifts are associated with functional gastrointestinal disorders显示文摘AIM To investigate the role of sleep quality and psychosocial problems as predictors of functional gastrointestinal disorders(FGIDs) in doctors that work 24 hour-on-call shifts.METHODS In this cross-sectional observation study, using the Rome Ⅲ Questionnaire and Pittsburgh Sleep Quality Index(PSQI), we analyzed 170 doctors with 24 houron-call shifts. RESULTS Among the participants that had experienced a 24 hour-on-call shift within the last 6 mo, 48(28.2%) had FGIDs. Overall prevalence of irritable bowel syndrome(IBS) and functional dyspepsia(FD) were 16.5% and 17.1%, respectively, with 5.3% exhibiting both. Sleep scores(PSQI)(8.79 ± 2.71 vs 7.30 ± 3.43, P = 0.008), the presence of serious psychosocial alarm(83.3%vs 56.6%, P = 0.004), and the proportion of doctors who experienced over two months of recent on-call work(81.2% vs 68.9%, P = 0.044) were significantly different between individuals with or without FGIDs. Multivariate analysis revealed that presenting serious psychosocial alarm was an independent risk factor for prevalence of FD(OR = 5.47, 95%CI: 1.06-28.15, P = 0.042) and poor sleep quality(PSQI ≥ 6) was a predictor of IBS(OR = 4.17, 95%CI: 1.92-19.02, P = 0.016). CONCLUSION Physicians should recognize the role of sleep impairment and psychological stress in the development of FGIDs and a comprehensive approach should be considered to manage patients with FGIDs. | Soo-Kyung Lim Seung Jin Yoo Dae Lim Koo Chae A Park Han Jun Ryu Yong Jin Jung Ji Bong Jeong Byeong Gwan Kim Kook Lae Lee Seong-Joon Koh | 2017 | World Journal of Gastroenterology2017，23，18： | 2 |
| 9 | Validation of Circulating miRNA Biomarkers for Predicting Lymph Node Metastasis in Gastric Cancer显示文摘 | Shine Young Kim Tae Yong Jeon Chang In Choi Dae Hwan Kim Dong Heon Kim Gwang Ha Kim Dong Yup Ryu Bong Eun Lee Hyung Hoi Kim | 2013 | The Journal of Molecular Diagnostics2013，，： | 2 |
| 10 | Phase 3 Trial of Postoperative Chemotherapy Alone Versus Chemoradiation Therapy in Stage III-IV Gastric Cancer Treated With R0 Gastrectomy and D2 Lymph Node Dissection显示文摘 | Tae Hyun Kim Sook Ryun Park Keun Won Ryu Young-Woo Kim Jae-Moon Bae Jun Ho Lee Il Ju Choi Yeon-Joo Kim Dae Yong Kim | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 2 |
| 11 | Association of colorectal adenoma with components of metabolic syndrome显示文摘 | Byung Kim Aesun Shin Chang Hong Dae Sohn Kyung Han Kum Ryu Bum Park Ji Nam Ji Park Hee Chang Hyo Choi Jeongseon Kim Jae Oh | 2012 | Cancer Causes & Control2012，，5： | 2 |
| 12 | Preoperative serum carbohydrate antigen 19-9 levels predict early recurrence after the resection of early-stage pancreatic ductal adenocarcinoma显示文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a serious disease with a poor prognosis.Only a minority of patients undergo surgery due to the advanced stage of the disease,and patients with early-stage disease,who are expected to have a better prognosis,often experience recurrence.Thus,it is important to identify the risk factors for early recurrence and to develop an adequate treatment plan.AIM To evaluate the predictive factors associated with the early recurrence of earlystage PDAC.METHODS This study enrolled 407 patients with stage I PDAC undergoing upfront surgical resection between January 2000 and April 2016.Early recurrence was defined as a diagnosis of recurrence within 6 mo of surgery.The optimal cutoff values were determined by receiver operating characteristic(ROC)analyses.Univariate and multivariate analyses were performed to identify the risk factors for early recurrence.RESULTS Of the 407 patients,98 patients(24.1%)experienced early disease recurrence:26(26.5%)local and 72(73.5%)distant sites.In total,253(62.2%)patients received adjuvant chemotherapy.On ROC curve analysis,the optimal cutoff values for early recurrence were 70 U/mL and 2.85 cm for carbohydrate antigen 19-9(CA 19-9)levels and tumor size,respectively.Of the 181 patients with CA 19-9 level>70 U/mL,59(32.6%)had early recurrence,compared to 39(17.4%)of 226 patients with CA 19-9 level≤70 U/mL(P<0.001).Multivariate analysis revealed that CA 19-9 level>70 U/mL(P=0.006),tumor size>2.85 cm(P=0.004),poor differentiation(P=0.008),and non-adjuvant chemotherapy(P=0.025)were significant risk factors for early recurrence in early-stage PDAC.CONCLUSION Elevated CA 19-9 level(cutoff value>70 U/mL)can be a reliable predictive factor for early recurrence in early-stage PDAC.As adjuvant chemotherapy can prevent early recurrence,it should be recommended for patients susceptible to early recurrence. | Sarang Hong Ki Byung Song Dae Wook Hwang Jae Hoon Lee Woohyung Lee Eunsung Jun Jaewoo Kwon Yejong Park Seo Young Park Naru Kim Dakyum Shin Hyeyeon Kim Minkyu Sung Yunbeom Ryu Song Cheol Kim | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 13 | Absence of p15 INK4B and p16 INK4A Gene Alterations in Primary Cervical Carcinoma Tissues and Cell Lines with Human Papillomavirus Infection显示文摘 | Jin Woo Kim Sung Eun Namkoong Soon Won Ryu Ho Shik Kim Jin Woong Shin Joon Mo Lee Dae Hoon Kim In Kyung Kim | 1998 | Gynecologic Oncology1998，，1： | 1 |
| 14 | A neuralnetwork model to predict low cycle fatigue life of nitrogen-alloyed 316L stainless steel显示文摘 | Mathew M D Kim Dae Whan Ryu Woo-Seog | 2008 | Materials Science andEngineering A2008，，474： | 1 |
| 15 | Use of 3′-deoxy-3′-[18F]fluorothymidine PET to monitor early responses to radiation therapy in murine SCCVII tumors显示文摘 | You-Jung Yang Jin-Sook Ryu Seog-Young Kim Seung Jun Oh Ki Chun Im Heuiran Lee Sang-wook Lee Kyung Ja Cho Gi-Jeong Cheon Dae Hyuk Moon | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，4： | 1 |
| 16 | Phase 3 Trial of Postoperative Chemotherapy Alone Versus Chemoradiation Therapy in Stage III-IV Gastric Cancer Treated With R0 Gastrectomy and D2 Lymph Node Dissection显示文摘 | Tae Hyun Kim Sook Ryun Park Keun Won Ryu Young-Woo Kim Jae-Moon Bae Jun Ho Lee Il Ju Choi Yeon-Joo Kim Dae Yong Kim | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，5： | 1 |
| 17 | Fully automated synthesis of [ 18 F]fluoromisonidazole using a conventional [ 18 F]FDG module显示文摘 | Seung Jun Oh Dae Yoon Chi Christoph Mosdzianowski Jung Young Kim Hee Seop Gil Se Hun Kang Jin Sook Ryu Dae Hyuk Moon | 2005 | Nuclear Medicine and Biology2005，，8： | 1 |
| 18 | Evaluation of the creep–fatigue damage mechanism of Type 316L and Type 316LN stainless steel显示文摘 | Dae Whan Kim Jong-Hwa Chang Woo-Seog Ryu | 2007 | International Journal of Pressure Vessels and Piping2007，，6： | 1 |
| 19 | Fluid collec- tion in the right lateral portion of the superior aortic recess mimicking a right mediastinal mass: assessment with chest posterior anterior and MDCT 显示文摘 | Dong Rock Shin MD Dae Shick Ryu | 2012 | Korean Radiol2012，13，5： | 1 |
| 20 | Protein tyrosine phosphatase 1B inhibitors from Morus root bark显示文摘 | Long Cui MinKyun Na Hyuncheol Oh Eun Young Bae Dae Gwin Jeong Seong Eon Ryu Sohee Kim Bo Yeon Kim Won Keun Oh Jong Seog Ahn | 2005 | Bioorganic & Medicinal Chemistry Letters2005，，5： | 1 |
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