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| 1 | Diet and microbiota in inflammatory bowel disease: The gut in disharmony显示文摘Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colitis, reinforcing the hypothesis of dysbiosis as a relevant mechanism underlying inflammatory bowel disease(IBD) pathogenesis. Humans and microbes have coexisted and co-evolved for a long time in a mutually beneficial symbiotic association essential for maintaining homeostasis. However, the microbiome is dynamic, changing with age and in response to environmental modifications. Among such environmental factors, food and alimentary habits, progressively altered in modern societies, appear to be critical modulators of the microbiota, contributing to or co-participating in dysbiosis. In addition, food constituents such as micronutrients are important regulators of mucosal immunity, with direct or indirect effects on the gut microbiota. Moreover, food constituents have recently been shown to modulate epigenetic mechanisms, which can result in increased risk for the development and progression of IBD. Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects. | Davy CM Rapozo Claudio Bernardazzi Heitor Siffert Pereira de Souza | 2017 | World Journal of Gastroenterology2017，23，12： | 24 |
| 2 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 3 | CT筛查降低肺癌死亡率的随机试验显示文摘目前在曾经和现在吸烟的男性中,基于容积的低剂量计算机断层扫描(CT)筛查能否降低肺癌死亡率的随机试验证据有限。2020年初新英格兰医学杂志报道了一项来自欧洲的CT筛查对降低肺癌死亡率的临床试验结果。该研究招募了50~74岁的13195名男性(主要分析)和2594名女性(亚组分析),并将其随机分配至不筛查对照组和干预组,后者分别在基线、第1年、第3年和第5.5年进行CT筛查。通过荷兰和比利时国家登记处获得癌症诊断、死亡日期和死因。 | 王红(译) 唐威(译) 石菊芳(译) De Koning HJ Van der Aalst CM De Jong PA | 2020 | 中华预防医学杂志2020，54，7： | 5 |
| 4 | 右心室超声心动图指标预测患新生儿持续性肺动脉高压婴儿的不良预后显示文摘患新生儿持续性肺动脉高压(persistent pulmonary hypertension of the newborn,PPHN)的婴儿肺血管阻力增高可导致右心衰竭和死亡。临床医师必须准确判断常规治疗可能无效的、需要进行体外膜肺氧合(extra corporeal membrane oxygenation,ECMO)治疗的婴儿, | Malowitz JR Forsha DE Smith PB Cotten CM Barker PC Tatum GH 刘莉 叶鹏 | 2015 | 中华高血压杂志2015，23，4： | 3 |
| 5 | Adjuvant dendritic cell-based tumour vaccination for children with malignant brain tumours显示文摘 | Ardon H De Vleeschouwer S Van Calenbergh F Claes L Kramm CM Rutkowski S Wolff JE Van Gool SW. | 2010 | 中国神经肿瘤杂志2010，8，1： | 3 |
| 6 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 7 | Analysis of the sealing ability of different obturation techniques in oval-shaped canals:a study using a bacterial leakage model显示文摘 | De Deus G Murad CF Reis CM | 2006 | Braz Oral Res2006，20，1： | 1 |
| 8 | Impact on daily performances related to wearing orthodontic appliances 显示文摘 | Bemabe E Sheiham A de Oliveira CM | 2008 | Angle Orthod2008，78，3： | 1 |
| 9 | Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans显示文摘 | Bamberger CM Bamberger AM de Castro M | 1995 | J Clin Invest1995，95，： | 1 |
| 10 | Development of a selective culture medium for primary isolation of the main Brucella species 显示文摘 | De Miguel MJ Marin CM Munoz PM | 2011 | J Clin Microbio12011，49，： | 1 |
| 11 | The coagulopathy of massive transfusion显示文摘 | Hardy JF de Moerloose P Samama CM | 2005 | Vox Sang2005，89，3： | 1 |
| 12 | Early maternal age at first birth is associated with chronic diseases and poor physical performance in older age:cross-sectional analysis from the International Mobility in Aging Study显示文摘 | Pirkle CM de Albuquerque Sousa AC Alvarado B | 2014 | BMC Public Health2014，，14： | 1 |
| 13 | Continuous subcutaneous insulin infusion (CSII) versus conventional injection therapy in newly diagnosed diabetic children : Two - year follow - up of a randomized, prospective trial显示文摘 | De Beaufort CE Houtzagers CM Bruining GJ | 1989 | Diabet Med1989，6，9： | 1 |
| 14 | Neutralizing anti- bodies to enterovirus 71 in Belem, Brazil 显示文摘 | Gomes ML de Castro CM OliVeira MJ | 2002 | Mem lnst Oswaldo Cruz2002，97，1： | 1 |
| 15 | Impact on daily performances attributed to malocclusions using the condition-specific feature of the oral impacts on Daily Performances Index 显示文摘 | Bemabe E Tsakos G de Oliveira CM | 2008 | Angle Orthod2008，78，2： | 1 |
| 16 | Effect of biofeed-back accompanying occupational therapy and functional electrical stimulation in hemiplegic patients显示文摘 | Lourencao MI Battistella LR de Brito CM | 2008 | Int J Rehabil Res2008，31，1： | 1 |
| 17 | In vitro evaluation of the effectiveness of ProTaper universal rotar~ retreatment system for gutta-percha removal with or withoul asolvent 显示文摘 | Takahashi CM Cunha RS de Martin AS | 2009 | J Endod2009，35，11： | 1 |
| 18 | Triplane tissue Doppler imaging:a novel three-dimensional imaging modality that predicts reverse left ventricular remodelling after cardiac resynchronisation therapy显示文摘 | Van de Veire NR Yu CM Ajmone-Marsan N | 2008 | Heart2008，94，3： | 1 |
| 19 | Pediatric obesity epidemiology 显示文摘 | Orsi CM Hale DE Lynch ]L | 2011 | Current Opinion in Endocrinology Diabetes &Obesity2011，18，： | 1 |
| 20 | Assessment of the histopathological key features in autoimmune hepatitis显示文摘 | De Boer YS1 van Nieuwkerk CM Witte BI | 2015 | Histopatholo- gy2015，66，3： | 1 |
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