|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oct 4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells显示文摘Neuroblastoma (NB ) 联系了 endothelial microvessels (他们) 可以被导出肿瘤的 endothelial 房间(侦探) 衬里,那是遗传上不稳定的并且 chemoresistant。这里,我们由集中于 Octamer 有约束力的抄写因素 4 在 NB 探讨了侦探祖先的鉴定(Oct-4 ) 作为一个通常认为的标记。Oct-4 + 房间在主要 NB 样品被检测(n = 23 ) ,变形骨头髓把发成送气音(n = 10 ) , NB 房间线(n = 4 ) ,并且 orthotopic 肿瘤(n = 10 ) 在 immunodeficient 老鼠由 HTLA-230 NB 房间线形成了。大多数 Oct-4 + 房间显示出 perivascular 分布,与他们中的 5% 个一起在 perinecrotic 区域的 homing。自从他们与恶意的房间分享了 MYCN oncogene 的扩大,所有 Oct-4 + 房间是导出肿瘤的。表示的 Perivascular Oct-4 + 细胞起源房间相关的、神经祖先相关、 NB 相关的标记包括表面 Tenascin C (TNC ) ,那不在 perinecrotic Oct-4 + 细胞和体积肿瘤细胞。在 vitro 区分进在包含脉管的 endothelial 生长因素(VEGF ) 的媒介在文化之上表示 vascular-endothelial-cadherin,前列腺特定的膜抗原和 CD31 的象 endothelial 一样房间的 TNC + 然而并非 TNC − HTLA-230 房间。TNC + 然而并非 TNC − HTLA-230 房间形成了 neurospheres 什么时候在没有浆液的媒介有教养。房间部分是 tumorigenic,但是仅仅肿瘤由包含的他们由侦探衬里的 TNC + 房间形成了。在结论,我们在 NB 肿瘤识别了包含 Oct-4 + 肿瘤房间的二个通常认为的壁龛。Oct-4 +/TNC+ perivascular NB 房间显示了粘性的高度并且用作侦探的祖先。Oct4 +/TNC+ 祖先的治疗学的指向可以抵抗导出 NB 的 EC 的贡献到肿瘤恶化和 chemoresistance。 | Annalisa Pezzolo Federica Parodi Danilo MarimPietri Lizzia Raffaghello Claudia Cocco Angela Pistorio Manuela Mosconi Claudio Gambini Michele Cilli Silvia Deaglio Fabio Malavasi Vito Pistoia | 2011 | Cell Research2011，21，10： | 2 |
| 2 | Arsenic trioxide and breast cancer: analysis of the apoptotic ,differentiative and imrnunomodulatory effects 显示文摘 | Baj G Amulfo A Deaglio S | 2002 | Breast Cancer Res Treat2002，73，1： | 1 |
| 3 | In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lym-phocytic leukemia 显示文摘 | Deaglio S Vaisitti T Aydin S | 2006 | Blood2006，108，4： | 1 |
| 4 | Arsenic trioxide and breast cancer:analysis of the apoptotic,differentiative and immunomodulatory effect显示文摘 | BAI G ARNULFO A DEAGLIO S | 2002 | Breast Cancer Res Treat2002，73，1： | 1 |
| 5 | A highly immunogenic re- combinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine显示文摘 | Sandini S La Valle R Deaglio S | 2011 | Immunol Med Microbio12011，62，2： | 1 |
| 6 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression 显示文摘 | Deaglio S Dwyer KM Gao W | 2007 | J Exp Med2007，204，6： | 1 |
| 7 | CD38 and CDI00 lead a network of surface receptors relaying positive signals for B-CLL growth and survival显示文摘 | Deaglio S Vaisitti T Bergui L | 2005 | Blood2005，105，8： | 1 |
| 8 | Evidence of an immunologic mechanism behind the therapeutical effects of arsenic trioxide (As2O3) on myeloma cells显示文摘 | Deaglio S Canella D Baj G | 2001 | Leuk Res2001，25，3： | 1 |
| 9 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression 显示文摘 | Deaglio S Dwyer KM Gao W | 2007 | J Exp Med2007，204，6： | 1 |
| 10 | TFR2localizes in lip-id raft domains and is released in exosomes to activate signal transduction along the MAPK pathway显示文摘 | Calzolari A Raggi C Deaglio S | 2006 | J Cell Sci2006，119，： | 1 |
| 11 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression 显示文摘 | Deaglio S Dwyer KM Gao W | 2007 | J Exp Med2007，204，： | 1 |
| 12 | Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effect 显示文摘 | Baj G Arnulfo A Deaglio S | 2002 | Breast Cancer Res Treat2002，73，1： | 1 |
| 13 | Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effeets 显示文摘 | Baj G Arnulfo A Deaglio S Mallone R Vigone A De Cesaris M G | 2002 | Breast Cancer Res Treat2002，73，： | 1 |
| 14 | Transferrin receptor 2 is frequently expressed in human cancer cell lines显示文摘 | Calzolari A Oliviero I Deaglio S | 2007 | Blood Cells Mol Dis2007，39，1： | 1 |
| 15 | Transferrin receptor 2 is frequently expressed in human cancer cell lines显示文摘 | Calzolari A Oliviero I Deaglio S | 2007 | Blood Cells Mol Dis2007，39，1： | 1 |
| 16 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression 显示文摘 | Deaglio S Dwyer KM Gao W | 2007 | J Exp Med2007，204，： | 1 |
| 17 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression 显示文摘 | Deaglio S Dwyer KM Gao W | 2007 | J Exp Med2007，204，6： | 1 |
| 18 | Adenosine generation catalyze by CD39 and CD73 expressed on regulatory T cells mediates immune suppression显示文摘 | Deaglio S Dwyer KM Gao W | 2007 | J Exp Med2007，204，6： | 1 |
| 19 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression 显示文摘 | Deaglio S Dwyer KM Gao W | 2007 | J Exp Med2007，204，6： | 1 |
| 20 | Transferrin recept- or 2 is frequently expressed in human cancer cell lines显示文摘 | Alessia Calzolari Isabella Oliviero Silvia Deaglio | 2007 | Blood Cells Molecules and Diseases2007，39，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员