|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Stress proteins induced by arsenic 显示文摘 | Del Razo L M QuintaniUa - Vega B Brambila - Colom- bres E | 2001 | Toxicology and Applied Pharmacology2001，177，2： | 1 |
| 3 | Setup ad- justment of multiple lots using a sequential monte carlo meth- od显示文摘 | LIAN Z COLSIMO B M DEL CASTILLO E | 2006 | Technometries2006，48，3： | 1 |
| 4 | Activa- tion of Racl by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression 显示文摘 | TZIMA E DEL POZO M A KIOSSES W B | 2002 | EMBO J2002，21，24： | 1 |
| 5 | Bayesian modelingand optimization of functional responses affected by noise factors显示文摘 | Del Castillo E Colosimo B M Alshraideh H | 2012 | Journal of Quality Technology2012，44，2： | 1 |
| 6 | Successful tocilizumab treatment in a child with refractory Takayasu arteritis显示文摘 | Bravo Mancheno B Perm F Guez Vazquez Del Rey Mdel M | 2012 | Pediatrics2012，130，： | 1 |
| 7 | Antioxidant activity of different fractions of Spirulina platensis protein extract显示文摘 | Estrada P Bescos B P Villar del Fresno A M | 2001 | Farmaco2001，56，： | 1 |
| 8 | Between subjects variability in haemoglobin and dose are not associated with the erythropoiesis-stimulating agent used to treat anaemia in dialysis: a meta-analysis显示文摘 | Pérez-Ruixo J J Cucala-Ramos M Garcia-Gonzalo E Del Val Romero B Valveny N | 2013 | Br J Clin Pharmacol2013，75，： | 1 |
| 9 | Value of indirect hem agglutination and coagglutiation test for serotyping Haemophilus parasuis显示文摘 | Del Rio M L Gut ierrez B C Rodriguez Ferri E F | 2003 | Clin Microbio 12003，41，2： | 1 |
| 10 | Arabidopsis E2Fc functions in cell division and is degraded by the ubiquitin-SCF(At SKP2) pathway in response to light显示文摘 | DEL POZO J C BONIOTTI M B GUTIERREZ C | 2002 | Plant Cell2002，14，： | 1 |
| 11 | Adhesion, autoaggregation and hydrophobicity of 13 strains of Bifidobacterium longum 显示文摘 | DEL Re B SGORBATI B MIGLIOLI M | 2000 | Lett Appl Microbiol2000，31，： | 1 |
| 12 | Insulin Resistance, the Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease显示文摘 | F Angelico M Del Ben R Conti S Francioso K Feole S Fiorello M G. Cavallo B Zalunardo F Lirussi C Alessandri F Violi | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，3： | 1 |
| 13 | Small sample comparison of some process adjustment methods显示文摘 | DEL CASTILLO E PAN R COLOSIMO B M | 2003 | Communications in Statistics Simulation and Computation2003，32，3： | 1 |
| 14 | Gas chromatographic-mass spectrometric method for the determination of bisphenol A and its chlorinated derivatives in urban wastewater 显示文摘 | Zafra A del Olmo M Suarez B Hontoria E Navalon A O Vilchez J L | 2003 | Water Research2003，37，： | 1 |
| 15 | aroA gene PCR-RFLP diversity patterns in Haemophilus parasuis and Actinobacillus species显示文摘 | del Rio M L Martin C B Navas J | 2006 | Research in Veterinary Science2006，80，： | 1 |
| 16 | Acute tissue damage after injection of thrombin and plasmin into rat striatum显示文摘 | Xue M Del B | 2001 | Stroke2001，32，： | 1 |
| 17 | A modified elitist genetic algorithm applied to the design optimization of complex steel structures显示文摘 | GERO M B P GARCIA A B DEL COZ DIAZ J J | 2005 | Journal of Constructional Steel Research2005，61，2： | 1 |
| 18 | Hydrogen peroxide produced during gamna-glutamyltranspeptidase activity is involved in prevention of apop-tosis and maintainance of proliferation in U937 cells 显示文摘 | Paolicchi A Comporti M | 1999 | FASEB-J1999，13，1： | 1 |
| 19 | Color change of fresh- cut apples coated with whey protein concentrate-based edible coatings 显示文摘 | PEREZ-GAGO M B SERRA M del RIO M A | 2006 | Postharvest Biology and Technology2006，39，1： | 1 |
| 20 | Value of fndirect hemagglutination and coagglutination tests for serotyping Haemophilus parasuis显示文摘 | Del Rio M L Gutierrez C B Rodriguez Ferri E F | 2003 | J Clin Microbiol2003，41，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员