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| 1 | Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation显示文摘Chemotherapy-induced diarrhea(CID)is a common and often severe side effect experienced by colorectal cancer(CRC)patients during their treatment.As chemotherapy regimens evolve to include more efficacious agents,CID is increasingly becoming a major cause of dose limiting toxicity and merits further investigation.Inflammation is a key factor behind gastrointestinal(GI)toxicity of chemotherapy.Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic mucosa.Here we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of CRC.Insights into the inflammatory response activated during this process gained from various models of GI toxicity are discussed.The inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity,thus conferring added benefit against tumor recurrence and improving patient survival.We review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal cancer.Finally,the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed. | Chun Seng Lee Elizabeth J Ryan Glen A Doherty | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 2 | 蛋白酶和木聚糖酶对育肥猪的生长性能、营养消化率以及粪便气味的影响显示文摘菜籽粕(RSM)和小麦干酒糟及其可溶物(DDGS)作为副产物可应用到猪的日粮中。然而,与小麦和豆粕型日粮相比,RSM和DDGS中含有较高的非淀粉多糖(NSP),其可限制猪对日粮的有效利用。采用2×2因素试验设计研究生长育肥猪饲粮中添加木聚糖酶(0和200mg·kg-1)和蛋白酶(0和200mg·kg-1)对其生长性能、胴体品质、表观回肠消化率、全消化道养分消化率及粪便气体排放的影响及两种酶之间的相互作用。试验1,对猪的生长性能进行评估。将体重为34.2±2.1kg的育肥猪128头随机分配到4个处理组:以DDGS(300g·kg-1)和RSM(210g·kg-1)的基础日粮;基础日粮中添加蛋白酶200mg·kg-1;基础日粮中添加木聚糖酶200mg·kg-1;基础日粮中添加蛋白酶200mg·kg-1和木聚糖酶200mg·k-1。试验1中,在生长育肥-出栏期间(0~出栏),日粮中添加蛋白酶的试验猪较不添加蛋白酶的试验猪相比具有较低的平均日增重(ADG)(P〈0.001)。生长阶段(0—28d),蛋白酶和木聚糖酶对猪的日均采食量(ADFI,P〈0.01)和体重(BW,P〈0.01)的影响存在相互作用。在育肥阶段(28d~出栏),日粮中添加蛋白酶和木聚糖酶的试验猪与仅添加一种没酶的试验猪相比具有较低的ADFI和BW。然而,蛋白酶和木聚糖酶的相互作用在生长期间(0~28d)内并不显著。试验2,选择体重78±2.3kg公猪24只,将其置于代谢笼中进行代谢试验,试验期间按照试验l中的日粮进行饲喂。木聚糖酶和蛋白酶对总能(GE)中的AID存在相互作用(P〈0.05)。与对照组相比,饲粮中添加蛋白酶可以增加GE中的AID,但饲粮中添加两种酶时可降低GE中的AID。饲粮中添加木聚糖酶交不添加木聚糖组相比,猪粪便的臭气排放量降低(598和1306OuE/m3;P〈0.05)。研究表明,蛋白酶可提高GE的AID;木聚糖酶可以减少粪便异味的排放,然而当生长猪育肥以RSM和DDGS为基础饲粮时,两种酶均不能提高其生长性能。 | O'Shea C J Mc Alpine P O Solan P Curran T Varley P F Walsh A M Doherty J V O | 2014 | 饲料博览2014，0，10： | 4 |
| 3 | Peptide lipid interactions of the betahairpin antimicrobial peptide tachyplesin and its linear derivatives from solid state NMR显示文摘 | Doherty T Waring A J Hong M | 2006 | Bioehim Biophys Aeta2006，1758，9： | 1 |
| 4 | JNKI physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1- mediated apoptosis 显示文摘 | Chang N S Doherty J Ensign A | 2003 | J Biol Chem2003，278，11： | 1 |
| 5 | Neural Evidence for Inequality - averse Social Preferences 显示文摘 | Tricomi E Rangel A Camerer C F Doherty J P | 2010 | Na- ture2010，463，： | 1 |
| 6 | High performance LiFePO4 electrode materials: Influence of colloidal particle morphology and porosity on lithium-ion battery power capability 显示文摘 | DOHERTY C M CARUSO R A DRUMMOND C J | 2010 | Energy Environ Sci2010，3，： | 1 |
| 7 | Microchannel wall coatings for protein separations by capillary and chip electrophoresis显示文摘 | Meagher R J Albarghouthi M N | 2003 | Electrophoresis2003，24，： | 1 |
| 8 | Better understanding of plant and pilot plant operations using on-line mass spectrometry 显示文摘 | DESJARDIN M A DOHERTY S J GILBERT J R | 1995 | Process Control Qual1995，6，： | 1 |
| 9 | Current issues in recrystallization:a review显示文摘 | DOHERTY R D HUGHES D A HUMPHREYS F J JONAS J J JENSEN D J KASSNER M E KING W E MCNELLEY T R MCQUEEN H J ROLLETT A D | 1997 | Materials Science and Engineering A1997，238，1： | 1 |
| 10 | Automatic and intentional brain responses during evaluation of trustworthiness of faces显示文摘 | WINSTON J S STRANGE B A O DOHERTY J | 2002 | Nat Neuroscience2002，，5： | 1 |
| 11 | Curreent issues in reerystallization: a review显示文摘 | Doherty R D Hughes D A Humphreys F J | 1997 | Materials Science and Engineering A1997，238，： | 1 |
| 12 | Immune responses to the Mycobacterium tuberculosis-specific antigen ES-AT6 signal subclinical infection among contacts tuberculosis patients显示文摘 | DOHERTY T M DDEMISSIE A OLOBO J | 2002 | J Clin Microbiol2002，40，2： | 1 |
| 13 | Neuronal calcium sensors and synaptic plasticity 显示文摘 | Amici M Doherty A Jo J | 2009 | Biochem Soc Trans2009，37，6： | 1 |
| 14 | Immune responses to the ycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts tuberculosis patients显示文摘 | Doherty TM Demissie A Olobo J Wolday D Britton S Eguale T Ravn P.Andersen P | | 0，，： | 1 |
| 15 | Staging laparoscopy with laparoscopic ultrasonography: optimizing resectability in hepatobiliary and pancreatic malignancy显示文摘 | Mark P Callery Steven M Strasberg Gerard M Doherty Nathaniel J Soper Jeffrey A Norton | 1997 | Journal of the American College of Surgeons1997，，1： | 1 |
| 16 | Preoperative exercise capacity in adult inflammatory bowel disease sufferers,determined by cardiopulmonary exercise testing显示文摘 | Otto J M O'Doherty A F Hennis P J | 2012 | Int J Colorectal Dis2012，27，11： | 1 |
| 17 | JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1- mediated apoptosis 显示文摘 | Chang N S Doherty J Ensign A | 2003 | J Biol Chem2003，278，11： | 1 |
| 18 | Use of the CT component of PET-CT to improve PET-MRregistration: demonstration in soft-tissue sarcoma显示文摘 | Somer E J Benatar N A O'Doherty M J et aI | 2007 | Phys Med Biol2007，52，： | 1 |
| 19 | EULAR evidence based recommendations for the management of hip osteoarthritis,report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)显示文摘 | Zhang W Doherty M Arden N Bannwarth B Bijlsma J Gunther KP Hauselmann H J Herrero-Beaumont G Jordan K Kaklamanis P Leeb B Lequesne M Lohmander S Mazieres B Martin-Mola E Pavelka K Pendleton A Punzi L Swoboda B Varatojo R Verbruggen G Zimmermann-Gorska Ⅰ D | | 0，，05： | 1 |
| 20 | Beef HACCP: intervention and non- intervention systems 显示文摘 | Bolton D J Doherty A M Sheridan J J | 2001 | International Journal of Food Microbiology2001，66，： | 1 |
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