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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Public participation in integrated water resources management:the case of Tanzania显示文摘 | ESTHER W D NDALAHWA F M | 2003 | Physics and Chemistry of the Earth Parts A/B/C2003，28，2027： | 1 |
| 4 | Romantie Relationship Aggression and Attitudesin Highschool tudents: The Role of Gender, Grade, and Attachment and Emotional Styles 显示文摘 | ESTHER D AMY HE ETAL | 2002 | Journal of Youth and Adolesence2002，31，5： | 1 |
| 5 | Public participation in integrated water resources management: the case of Tanzania 显示文摘 | Esther W Dungumaro Ndalahwa F Madulu | 2003 | Physics and Chemistry of the Earth2003，28，： | 1 |
| 6 | Quantitative detection of Neospora caninum in bovine aborted fetuses and experimentally infection mice by Real-Time PCR 显示文摘 | Esther C F Luis M Ortega-Mora | 2002 | Clin Microbio2002，40，4： | 1 |
| 7 | An update on in vitro test methods in human hepaticdrug biotransformation research: pros and cons 显示文摘 | Esther F | 2003 | ToxicolApll Pharmacol2003，，189： | 1 |
| 8 | Uterine smooth-muscle tumors with unusual growth patterns: imaging with pathologic correlation 显示文摘 | Daniel T Esther OL Peter F | 2007 | Am J Roentgenol2007，188，1： | 1 |
| 9 | Gene profiling in atherosclerosis reveals a key role for small inducible cytokines validation using a novel monocyte chemoattractant protein monoclonal antibody显示文摘 | Esther L Birgit F Kitty S | 2005 | Circulation2005，111，25： | 1 |
| 10 | Microbleed Burden and Hematoma Expansion in Acute Intracerebral Hemorrhage显示文摘 | Martí-fàbregas Joan Delgado-mederos Raquel Granell Esther Morenas Rodríguez Estrella Marín Lahoz Juan Dinia Lavinia Carrera David Pérez De La Ossa Natalia Sanahuja Jordi Sobrino Tomás De Arce Ana María Alonso De Leci?ana María | 2013 | European Neurology . 2013 (3-4)2013，，3： | 1 |
| 11 | Phenol extraction of proteins for portcomic studies of recalcitrant plant tissues 显示文摘 | Mireille F Esther P Jamila C | 2007 | Methods in Molecular Biology2007，355，： | 1 |
| 12 | Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities显示文摘 | Anna Hernández-Aguilera Anna Rull Esther Rodríguez-Gallego Marta Riera-Borrull Fedra Luciano-Mateo Jordi Camps Javier A. Menéndez Jorge Joven Fábio Santos Lira | 2013 | Mediators of Inflammation2013，，： | 1 |
| 13 | Lactobacillus casei strains isolated from cheese reduce biogenic amine accumulation in an experimental model显示文摘 | ANA H F NOELIA M ESTHER S L | 2012 | International Journal of Food Microbiology2012，157，2： | 1 |
| 14 | Kinetics of disassembly of a DNA-bound porphyrin supra-molecular array显示文摘 | Robert F Pasternack Esther J Gibbs Derek Bruzewicz etal | 2002 | J Am Chem Soc2002，124，： | 1 |
| 15 | Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation,endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy显示文摘 | Tsh~pe C Walther T Esther F | 2005 | FASEBJ2005，19，14： | 1 |
| 16 | Phenol extraction of proteins for proteomic studies of recalcitrant plant tissues显示文摘 | Mireille F Esther P Jamila C | 2008 | proteomics handbook2008，，： | 1 |
| 17 | Vibrational Spectroscopic Observation of Ice De Wetting on MgO(001)显示文摘 | Esther C Andreas A Janaina F G | 2013 | Chemical Communications2013，49，： | 1 |
| 18 | On the availability of r out of N repairable systems显示文摘 | F Esther L Benny | 2002 | Naval Research Logistics2002，49，5： | 1 |
| 19 | On the availability of R out of N repairable systems显示文摘 | Esther F Benny L | 2002 | Naval Research Logistics2002，，49： | 1 |
| 20 | Diplopia was not pre- dictable and not associated with buckle position after seleral buckling surgery for retinal detachment 显示文摘 | Goezinne F Tos TJM Esther WM | 2012 | Retina2012，32，8： | 1 |
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