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760篇 您的检索式：作者名="Edwards L A"

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	题名	作者	年代	出处	被引量
1	Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.	Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao	2017	Bone Research2017，5，1：	9
2	生活方式和饮食因素:预防致死性前列腺癌显示文摘预防致死性前列腺癌是一个重要的公共卫生难题。解决该难题可以改善人们的健康状况,减少罹患该疾病的痛苦。本综述围绕某些与致命性前列腺癌预防有关的生活方式和饮食因素研究进行讨论。我们还对以下行为风险因素的研究进行总结:肥胖和体重变化、体育活动、吸烟状况、抗氧化剂摄入量、维生素D和钙、以及咖啡摄入量。	Kathryn M Wilson Edward L Giovannucci Lorelei A Mucci	2012	Asian Journal of Andrology2012，14，3：	3
3	Piezochromism:Pressure-Induced Rearrangements of Thermochromic and Related Cu(II)Complexes Containing Asymmetrically Substituted Ethylenediamine显示文摘	Kevin L Bray Harry G Drickamer Edward A Schmitt	1989	J Am Chem Soc1989，111，：	2
4	Looped schedules for dataflow descriptions of multirate signal processing algorithms显示文摘	Shuvra S B Edward A L	1994	IEEE Trans on Signal Processing1994，5，3：	1
5	Analysis of stained objects in histological sections by spectral imaging and differential absorption显示文摘	Woemer B M Edwards D A	1999	Journal of Histochemistry & Cytochemistry1999，47，10：	1
6	Measurement ofinterfacial dilational viscosity at high rates of interface expansion using the maximum bubble pressure method 1:Gas-liquid interface显示文摘	Edwards D A Wasan D T	1992	Journal of Colloid and Interface Science1992，148，1：	1
7	Laboratory-scale Purification of Microcystins Using Flash Chromatography and Reversed Phase High Performance Liquid Chromatography显示文摘	Edwards C Lawton L A	1996	J Chromatogr A1996，734，1：	1
8	Influence of sorption on the biological utilization of two simple carbon substrates显示文摘	JONES D L EDWARDS A C	1998	Soil Biology & Biochemistry1998，30，：	1
9	The half-lives of uranium-234 and thorium-230显示文摘	Cheng H Edwards R L Hoff J A	2000	Chem Geol2000，169，：	1
10	Diabetic neuropathies显示文摘	LITTLE A A EDWARDS J L FELDMAN E L	2007	Pract Neurol2007，，7：	1
11	Measurement ofinterfacial dilational viscosity at high rates of interface expansion using the maximum bubble pressure method1:Liquid-liquid interface显示文摘	Edwards D A Wasan D T	1993	Journal of Colloid and Interface Science1993，155，：	1
12	A three-component deformation model for image-guided surgery显示文摘	Edwards P J Hill D L G Little J A	1998	Medical Image Analysis1998，2，4：	1
13	Self-administered topical 5% imiquimod cream for external anogenital warts显示文摘	Edwards L Ferenczy A Eron L	1998	Arch Dermatol1998，134，1：	1
14	Phylogenetic analysis: models and estimation prodedures 显示文摘	CAVALLI-SFORZA L L EDWARDS A W F	1967	AmerJ HumGenet1967，19，：	1
15	Ameloblastic carci- noma: a clinicopathologic study and assessment of eight cases显示文摘	Corio R L Goldblatt L I Edwards P A	1987	Oral Surg Oral Med Oral Pathol1987，64，5：	1
16	Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD显示文摘	Lonas D A Silverman E K Edwards L D	2009	Eur Respir J2009，34，1：	1
17	The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘	Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams	2013	The Lancet Infectious Diseases2013，，2：	1
18	OMEGA EP high-energy petawatt laser: progress and prospects显示文摘	D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien	2008	Journal of Physics: Conference Series2008，，3：	1
19	Annual growth banding in a cave stalagmite显示文摘	Baker A Smart P L Edwards R L Richards D A	1993	Nature1993，364，：	1
20	Gamma titanium aluminides as prospective structural materials显示文摘	EDWARD A L	2000	Intermetallics2000，8，：	1

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