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| 1 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 2 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 3 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 4 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 5 | Synergy between Zwittermicin A and Bacillus thuringiensis subsp, leurstaki against gypsy moth (Lepidoptera : Lymantriidae)显示文摘 | Broderick N A Goodman R M Raffa K F el al | 2000 | Environmental Entomology2000，29，： | 1 |
| 6 | Backward stochastic differential equation sand applications to optimal control显示文摘 | El Karoui N Peng S Quenez M C | 1997 | Mathematical Finance1997，7，： | 1 |
| 7 | Effects of water and gas compositions on the internal corrosion of gas pipelines - modeling and experimental studies 显示文摘 | Sridhar N Dunn D S Anderko A M el at | 2001 | Corrosion2001，57，： | 1 |
| 8 | Structural requirements of penetratin absorption enhancement efficiency for in- sulin delivery显示文摘 | KHAFAGY S EL MORISHITA M N NISHIO R | 2010 | J Controlled Release2010，143，3： | 1 |
| 9 | The association between mental health, physical function and hemdeialysis mortality显示文摘 | Knight EL Ofsthun N Teng M | 2003 | Kidney Int2003，，63： | 1 |
| 10 | Dynamic modelling of spur gear pair and application of empirical mode decomposition-based statistical analysis for early detection of localized tooth defect显示文摘 | Parey A Badaoui M El Guillet F Tandon N | 2006 | Journal of Sound and Vibration2006，294，3： | 1 |
| 11 | The Notch target genes Hey l and Hey2 are required for embryonic vascular development 显示文摘 | Fischer A Schumacher N Maier M el al | 2004 | Genes Dev2004，18，8： | 1 |
| 12 | Endoscopic submucosat dissection using Flexknife显示文摘 | KODASHIMA S FUJISHIRO M YAHAGI N el al | 2006 | J Clin Gasroenterol2006，5，： | 1 |
| 13 | Significance of the iso-lation of Candida species from respiratory samples in critically ill, non-neutropenic patients:an immediate postmortem histologic study显示文摘 | el Ebiary M Tones A Fabregas N | 1997 | Am J Respir Crit Care Med1997，156，2： | 1 |
| 14 | Pelvic arteriove- nous malformation: gadolinium-enhanced three-dimensional MR angiography findings显示文摘 | Diaz Candamio M J Lee V S Rofsky N M el al | 2000 | Eur Radiol2000，10，12： | 1 |
| 15 | Selective ex- pression in carotid body lype l ceils of a single sphce variant of the large conductance calcium- and voltage-activated pates-sium channel confers regulation by AMP-activaled protein ki- nase显示文摘 | ROSS F A RAFFEBTY J N DALLAS M L et el | 2011 | J Biol Chem2011，286，11： | 1 |
| 16 | Protein kinase C mediates basie fibroblast growth factor pm- lection of endothelial cells against radiation - induced apoptosis 显示文摘 | HAIMOVlTZ FRIEDMAN A BALABAN N MCI OUGHI IN M el al | 1994 | Cancer Res1994，54，10： | 1 |
| 17 | Strength and fracture toughness of aluminum/alumina composites with interpenetrating networks显示文摘 | PRIELIPP H KNECHTEL M CLAUSSEN N el al | 1995 | Materials Science and Engineering: A1995，197，1： | 1 |
| 18 | A secoiridoid glycosides from Osmanthus asiaticus 显示文摘 | SUGIYAMA M MACHIDA K MATSUDE N el al | 1993 | Phytochemistry1993，34，4： | 1 |
| 19 | Liehenoid Dnag Eruption with Palmoplantar Hyperkeralosis due to Imatinib Mesylate: A Case Report and a Review of the Literatture显示文摘 | Kuraishi N Nagai Y Hasegawa M el al | 2010 | Acta Derm Venereol2010，90，1： | 1 |
| 20 | The association between mental health, physical function, and hemodialysis mortality 显示文摘 | Knight EL Ofsthun N Teng M | 2003 | Kidney Int2003，63，5： | 1 |
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