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| 1 | 由“到 laparoscopic 外科的桥 stenting ”的设法的尖锐 colorectal 阻塞: 我们的经验显示文摘 AIM: To verify the clinical results of the endoscopic stenting procedure for colorectal obstructions followed by laparoscopic colorectal resection with 'one stage anastomosis'. METHODS: From March 2003 to March 2009 in our surgical department, 48 patients underwent endoscopic stenting for colorectal occlusive lesion: 30 males (62.5%) and 18 females (37.5%) with an age range from 40 years to 92 years (median age 69.5). All patients enrolled in our study were diagnosed with an intestinal obstruction originating from the colorectal tract without bowel perforation signs. Obstruction was primitive colorectal cancer in 45 cases (93.7%) and benign anastomotic stricture in 3 cases (6.3%). RESULTS: Surgical resection was totally laparoscopic in 69% of cases (24 patients) while 17% (6 patients) of cases were video-assisted due to the local extension of cancer with infiltrations of surrounding structures (urinary bladder in 2 cases, ileus and iliac vessels in the others). In 14% of cases (5 patients), resection was performed by open surgery due to the high American Society of Anesthesiologists score and the elderly age of patients (median age of 89 years). We performed a terminal stomy in only 7 patients out of 35, 6 colostomies and one ileostomy (in a total colectomy). In the other 28 cases (80%), we performed bowel anastomosis at the same time as resection, employing a temporary ileostomy only in 5 cases. CONCLUSION: Colorectal stenting transforms an emergency operation in to an elective operation performable in a totally laparoscopic manner, limiting the confection of colostomy with its correlated complications. | Pierfrancesco Bonfante Luigi D’Ambra Stefano Berti Emilio Falco Massimo Vittorio Cristoni Romolo Briglia | 2012 | World Journal of Gastrointestinal Surgery2012，4，12： | 11 |
| 2 | Percutaneous ablation of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in cases of nonresectable pancreatic cancer. In cases of pancreatic neoplasm that is locally advanced, non-resectable, but non-metastatic, it is possible to apply percutaneous treatments that are able to induce tumor cytoreduction. The aim of this article will be to describe the multiple currently available treatment techniques(radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation), their results, and their possible complications, with the aid of a literature review. | Mirko D'Onofrio Valentina Ciaravino Riccardo De Robertis Emilio Barbi Roberto Salvia Roberto Girelli Salvatore Paiella Camilla Gasparini Nicolò Cardobi Claudio Bassi | 2016 | World Journal of Gastroenterology2016，22，44： | 7 |
| 3 | Radiofrequency ablation of locally advanced pancreatic adenocarcinoma:An overview显示文摘Radiofrequency ablation(RFA)of pancreatic neoplasms is restricted to locally advanced,non-resectable but nonmetastatic tumors.RFA of pancreatic tumors is nowadays an ultrasound-guided procedure performed during laparotomy in open surgery.Intraoperative ultrasound covers the mandatory role of staging,evaluation of feasibility,guidance and monitoring of the procedure.Different types of needle can be used.The first aim in the evaluation of RFA as a treatment for locally advanced pancreatic ductal adenocarcinoma,in order of evaluation but not of importance,is to determine the feasibility of the procedure.The second aim is to establish the effect of RFA on tumoral mass in terms of necrosis andcytoreduction.The most important aim,third in order of evaluation,is the potential improvement of quality of life and survival rate.Nowadays,only a few studies assess the feasibility of the procedure.The present paper is an overview of RFA for pancreatic adenocarcinoma. | Mirko D’Onofrio Emilio Barbi Roberto Girelli Enrico Martone Anna Gallotti Roberto Salvia Paolo Tinazzi Martini Claudio Bassi Paolo Pederzoli Roberto Pozzi Mucelli | 2010 | World Journal of Gastroenterology2010，16，28： | 6 |
| 4 | IBD5 polymorphisms in inflammatory bowel disease: Association with response to infliximab显示文摘AIM: Inflammatory bowel diseases (IBD) are multifactorial pathologies of unknown etiology. One susceptibility locus,IBD5, has been mapped to chromosome 5q31. We analyzed our Spanish cohorts of Crohn's disease (CD)and ulcerative colitis (UC) patients to determine whether this locus is associated with IBD, and to ascertain the main clinical phenotype influenced by this risk factor. The kind of interaction, either genetic heterogeneity or epistasis, between this IBD5 susceptibility region and the NOD2/CARD15 gene mutations was studied as well.Finally, ve assessed whether this locus can predict response to infliximab therapy.METHODS: A case control study was performed with 274CD and 211 UC patients recruited from a single center and 511 healthy ethnically matched controls. Two polymorphisms were genotyped in the IBD5 locus and three in the CARD15/NOD2 gene.RESULTS: Our results evidence association only with CD especially with the fistulizing phenotype and in the absence of NOD2/CARD15 variants (mutant allele frequency in patients vscontrols: OR = 2.03, 95% CI = 1.35-3.06,P<0.01). The frequency of the IBD5 homozygous mutant genotype significantly increased in CD patients lacking response to infliximab (RR = 3.88, 95% CI = 1.18-12.0,P<0.05). UC patients overall do not show association with 5q31 polymorphisms, although a similar trend to the one observed in CD is found within the worse prognosis group.CONCLUSION: The IBD5 variants may enhance an individual carrier's risk for CD, mainly in the absence of the NOD2/CARD15 mutations and in fistulizing patients.The data presented suggest the potential role of the 5q31polymorphisms as markers of response to infiiximab. | Elena Urcelay Juan Luis Mendoza Alfonso Martínez Laura Fernández Carlos Taxonera Manuel Díaz-Rubio Emilio G.de la Concha | 2005 | World Journal of Gastroenterology2005，11，8： | 4 |
| 5 | Pioneering drugs for overactive bladder and detrusor overactivity: Ongoing research and future directions显示文摘The ongoing research on pioneering drug candidates for the overactive bladder(OAB) aimed to overcome the limitations of currently licensed pharmacotherapies, such as antimuscarinics, β3-adrenergic agents, and botulinum neurotoxin, has been reviewed performing a systematic literature review and web search. The review covers the exploratory agents alternative to available medications for OAB and that may ultimately prove to be therapeutically useful in the future management of OAB patients based on preclinical and early clinical data. It emerges that many alternative pharmacological strategies have been discovered or are under investigation in disease-oriented studies. Several potential therapeutics are known for years but still find obstacles to pass the clinical stages of development, while other completely novel compounds, targeting new pharmacological targets, have been recently discovered and show potential to translate into clinical therapeutic agents for idiopathic and neurogenic OAB syndrome. The global scenario of investigational drugs for OAB gives promise for the development of innovative therapeutics that may ultimately prove effective as first, combined or second-line treatments within a realistic timescale of ten years. | Emilio Sacco Salvatore Recupero Riccardo Bientinesi Giuseppe Palermo Daniele D'Agostino Diego Currò Pierfrancesco Bassi | 2015 | World Journal of Obstetrics and Gynecology2015，4，2： | 3 |
| 6 | Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence显示文摘 | Emilio Quaia Mirko D'Onofrio Alessandro Palumbo Stefania Rossi Stefano Bruni Maria Cova | 2006 | European Radiology2006，，7： | 2 |
| 7 | Full Robotic Gastrectomy with Extended (D2) Lymphadenectomy for Gastric Cancer: Surgical Technique and Preliminary Results显示文摘 | Annibale D’Annibale Vito Pende Graziano Pernazza Igor Monsellato Paolo Mazzocchi Giorgio Lucandri Emilio Morpurgo Tania Contardo Gianna Sovernigo | 2011 | Journal of Surgical Research2011，，2： | 2 |
| 8 | Type I Gastric Carcinoids: A Prospective Study on Endoscopic Management and Recurrence Rate显示文摘 | Merola Elettra Sbrozzi-vanni Andrea Panzuto Francesco D’ambra Giancarlo Di Giulio Emilio Pilozzi Emanuela Capurso Gabriele Lahner Edith Bordi Cesare Annibale Bruno Delle Fave Gianfranco | 2012 | Neuroendocrinology2012，，3： | 2 |
| 9 | Learning curve for robotic-assisted laparoscopic rectal cancer surgery显示文摘 | Rosa M. Jiménez-Rodríguez José Manuel Díaz-Pavón Fernando Portilla de Juan Emilio Prendes-Sillero Hisnard Cadet Dussort Javier Padillo | 2013 | International Journal of Colorectal Disease2013，，6： | 2 |
| 10 | Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study显示文摘AIM To investigate the adhesion and anti-inflammatory effects of Lactobacil us rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.METHODS For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and extraction of DNA and RNA for quantification by real-time (RT)-PCR occurred after the incubation. A dose-response study was performed by incubating biopsies at 'regular', double and 5 times higher doses of LGG. For the in vivo experiment, a total of 42 patients (20 UC patients and 22 normal controls) were included. Biopsies were taken from the colons of normal subjects who consumed a commercial formulation of LGG for 7 d prior to the colonoscopy,and the adhesion of the bacteria to the colonic mucosa was evaluated by RT-PCR and compared with that of control biopsies from patients who did not consume the formulation. LGG adhesion and TNFα and IL-17 expression were compared between UC patients who consumed a regular or double dose of LGG supplementation prior to colonoscopy.RESULTS In the ex vivo experiment, LGG showed consistent adhesion to the distal and proximal colon in normal subjects and UC patients, with a trend towards higher concentrations in the distal colon, and in UC patients, adhesion was similar in biopsies with active and quiescent inflammation. In addition, bioptic samples from UC patients incubated with LGG conditioned media (CM) showed reduced expression of TNFα and IL-17 compared with the corresponding expression in controls (P < 0.05). Incubation with a double dose of LGG increased mucosal adhesion and the anti-inflammatory effects (P < 0.05). In the in vivo experiment, LGG was detectable only in the colon of patients who consumed the LGG formulation, and bowel cleansing did not affect LGG adhesion. UC patients who consumed the double LGG dose had increased mucosal concentrations of the bacteria and reduced TNFα and IL-17 expression compared with patients who consumed the regular dose (48% and 40% reduction, respectively, P < 0.05).CONCLUSION In an ex vivo organ culture model, LGG showed consistent adhesion and anti-inflammatory effects. Colonization by LGG after consumption for a week was demonstrated in vivo in the human colon. Increasing the administered dose increased the adhesion and effectiveness of the bacteria. For the first time, we demonstrated that LGG effectively adheres to the colonic mucosa and exerts antiinflammatory effects, both ex vivo and in vivo. | Cristiano Pagnini Vito Domenico Corleto Michela Martorelli Claudio Lanini Giancarlo D'Ambra Emilio Di Giulio Gianfranco Delle Fave | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 11 | Satellite remote sensing analysis to monitor desertification proeesses in the crop-rangeland boundary of Argentina 显示文摘 | ALRFEDO D C EMILIO C | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 12 | Bird communities as hioindicators: The focal species concept in agricultural land- scape 显示文摘 | Emilio P D Marco B Renato M | 2006 | Ecological Indicators2006，，6： | 1 |
| 13 | International inequality in energy intensity levels and the role of production composition and energy efficiency: an analysis of OECD countries 显示文摘 | Juan A D Vicent A Emilio P | 2010 | Ecological Economics2010，69，12： | 1 |
| 14 | Graph Visualization Techniques for Web Clustering Engines 显示文摘 | Emilio D G Walter D Luca G | 2007 | IEEE Transactions on Visualization and Computer Graphics2007，13，2： | 1 |
| 15 | Robotic Right Colon Resection: Evaluation of First 50 Consecutive Cases for Malignant Disease显示文摘 | Annibale D’Annibale MD Graziano Pernazza MD Emilio Morpurgo MD Igor Monsellato MD Vito Pende MD Giorgio Lucandri MD Barbara Termini MD Camillo Orsini MD Gianna Sovernigo MD | 2010 | Annals of Surgical Oncology2010，，11： | 1 |
| 16 | Satellite remote sensing analysis to monitor desertifieation processes in the crop-rangeland boundary of Argentina显示文摘 | Alfredo D C Emilio C Ana C | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 17 | Effect of daily HemodiaLy- sis on monocytes apoptosis 显示文摘 | Emilio A Emanuela B Vincenzo D | 2005 | Blood Purif2005，23，1： | 1 |
| 18 | Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots显示文摘 | Sara Baldelli Dario Cattaneo Luciana Giodini Lorena Baietto Giovanni Di Perri Antonio D’Avolio Emilio Clementi | 2015 | Clinical Chemistry and Laboratory Medicine (CCLM)2015，，3： | 1 |
| 19 | Influence of pH and salt concentration on the cross-flow microfiltration of BSA through a ceramic membrane显示文摘 | Emilio J Casa D Guadix A etal | 2007 | Biochem Eng J2007，33，： | 1 |
| 20 | Satellite remote sensing analysis to monitor desertification processes in the crop-rangeland boundary of Argentina显示文摘 | COLLADO ALFREDO D EMILIO CHUVIECO ANA CAMARASA | 2002 | Journal of Arid Environments2002，52，： | 1 |
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