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| 1 | Recently duplicated sesterterpene(C25) gene clusters in Arabidopsis thaliana modulate root microbiota显示文摘Land plants co-speciate with a diversity of continually expanding plant specialized metabolites(PSMs) and root microbial communities(microbiota).Homeostatic interactions between plants and root microbiota are essential for plant survival in natural environments.A growing appreciation of microbiota for plant health is fuelling rapid advances in genetic mechanisms of controlling microbiota by host plants.PSMs have long been proposed to mediate plant and single microbe interactions.However,the effects of PSMs,especially those evolutionarily new PSMs,on root microbiota at community level remain to be elucidated.Here,we discovered sesterterpenes in Arabidopsis thaliana,produced by recently duplicated prenyltransferase-terpene synthase(PT-TPS) gene clusters,with neo-functionalization.A single-residue substitution played a critical role in the acquisition of sesterterpene synthase(sesterTPS) activity in Brassicaceae plants.Moreover,we found that the absence of two root-specific sesterterpenoids,with similar chemical structure,significantly affected root microbiota assembly in similar patterns.Our results not only demonstrate the sensitivity of plant microbiota to PSMs but also establish a complete framework of host plants to control root microbiota composition through evolutionarily dynamic PSMs. | Qingwen Chen Ting Jiang Yong-Xin Liu Haili Liu Tao Zhao Zhixi Liu Xiangchao Gan Asis Hallab Xuemei Wang Juan He Yihua Ma Fengxia Zhang Tao Jin M. Eric Schranz Yong Wang Yang Bai Guodong Wang | 2019 | Science China(Life Sciences)2019，62，7： | 11 |
| 2 | 中草药对良性前列腺增生的疗效及安个性:随机对照试验的系统回顾显示文摘中草药经常被用于治疗良性前列腺增生,但其疗效及安全性仍有待证实。为了比较单用中草药和中药与西药联合治疗良性前列腺增生的疗效及副作用,两位独立的评审员在主要的电子数据库中检索了单用中草药或中草药与西药联用与安慰剂或单用西药之间比较的随机对照试验,于动检索了相关期刊和灰色文献。评估的结果包括泌尿系统症状、尿动力学检测、小草药的效果优于西药。中草药的副作用发生需要有大型的质量更高的随机对照试验。 | Chun Ho Ma Wai Ling Lin Sing Leung Lui Xun-Yuan Cai Vivian Taam Wong Kun-Yuan Cai Eric Zie Zhang-Jin Zhang | 2013 | Asian Journal of Andrology2013，15，4： | 6 |
| 3 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Ontology Dynamics in a Data Life Cycle: Challenges and Recommendations from a Geoscience Perspective显示文摘Ontologies are increasingly deployed as a computer-accessible representation of key semantics in various parts of a data life cycle and, thus, ontology dynamics may pose challenges to data management and re-use. By using examples in the field of geosciences, we analyze challenges raised by ontology dynamics, such as heavy reworking of data, semantic heterogeneity among data providers and users, and error propagation in cross-discipline data discovery and re-use. We also make recommendations to address these challenges:(1) communities of practice on ontologies to reduce inconsistency and duplicated efforts;(2) use ontologies in the procedure of data collection and make them accessible to data users; and(3) seek methods to speed up the reworking of data in a Semantic Web context. | Xiaogang Ma Peter Fox Eric Rozell Patrick West Stephan Zednik | 2014 | Journal of Earth Science2014，25，2： | 3 |
| 6 | Generation and characterization of a human nanobody against VEGFR-2显示文摘瞄准:Nanobody 是由一个单个 monomeric 变量抗体领域组成的抗体碎片,它能被用于许多 biotechnological 和治疗学的目的。这个工作的目的是从噬菌体显示器 library.Methods 对 VEGFR-2 domain3 (VEGFR D3 ) 孤立并且描绘人的信号域抗体:与与 VEGFR2 D3 的高亲密关系生产抗原特定的 recombinant nanobodies,液体阶段 panning 策略被用于 panning 的 all rounds。为 nanobody 表示和纯化,四 VEGFR2 堵住 D3 克隆是进 pETduet-biotin-MBP 表示向量的 subcloned。recombinant 蛋白质带了一个 MBP 标签由亲密关系层析便于纯化。Recombinant NTV (1-4 ) 在另外的胶化过滤层析步以后被获得。在 VEGFR2 D3 和 NTV (1-4 ) 之间的相互作用与基于光的 AlphaScreen 试金和 SPR 试金被估计。Anti-angiogenesis 效果在人的脐的静脉 endothelial 房间(HUVEC ) 被检验 .Results:在 AlphaScreen 试金, NTV1 (100 和 200 nmol/L ) 与 VEGFR2 D3 得到了最高有约束力的信号;NTV2 与 VEGFR2 D3 显示出中等相互作用;NTV3 和 NTV4 展出了有 VEGFR2 D3 的很少或没有相互作用。在 SPR 试金, NTV1 与一个平衡分离常数为 VEGFR2 D3 显示了一种高亲密关系(K 49 ± 的 D ) ; 1.8 nmol/L。NTV1 (1-1000 nmol/L ) dose-dependently 由 HUVECs.Conclusion 禁止了 HUVEC 和 endothelial 试管形成的增长:nanobody NTV1 是堵住 VEGFR2 的一个潜在的治疗学的候选人。这研究为指向 VEGFR2 的基于 nanobody 的癌症治疗学的开发提供新奇、有希望的策略。 | Lin MA Kai GU Cheng-hai ZHANG Xue-tao CHEN Yi JIANG Karsten MELCHER Juan ZHANG Min WANG H Eric XU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 2 |
| 7 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 8 | Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis显示文摘 | Qixia Wang Carlo Selmi Xinmin Zhou Dekai Qiu Zenshan Li Qi Miao Xiaoyu Chen Jianhong Wang Edward L. Krawitt M. Eric Gershwin Ying Han Xiong Ma | 2012 | Journal of Autoimmunity2012，，： | 2 |
| 9 | Evidence of Dichogamy in Santalum album L.显示文摘开花,水果集合,胚胎学的发展,和授粉审判我们在 Santalum 相册 L 的 reinvestigated。每个卵巢可以有三~四颗小卵。在一样的花的 Microsporogenesis andmegasporogenesis 在花开发的更早的阶段被同步。在开花期,当花粉是成熟的时,然而,大孢子仅仅发展了到 aone- 的阶段到二原子核的胚囊。当八原子核的胚囊发展了,一些妈甜瓜房间开始经历规划房间死亡,变成洞八原子核的胚囊延续到哪个,变得“ N ”或“ S ”塑造。到成熟 eight-nucleusembryo 囊的从二原子核的胚囊的发展持续了直到 10 d。从自由传粉的水果集合是不到 2% 。内乳在 zygotic 胚胎和一~三个胚胎和内乳的分割以前发展在一样的水果被形成。一粒成熟种子通常发芽生产一棵幼苗;然而,从一粒种子的二和三棵幼苗也被观察,在低频率的虽然。当开花期被一只袋子盖住时,授粉试用证明没有种子设定;然而,人工授粉能改进水果集合。我们的授粉试用和胚胎学的研究证明 S.album 的花是 dichogamous,水果集合有高杂合现象…… | Guo-Hua Ma Eric Bunn Jing-Feng Zhang Guo-Jiang Wu | 2006 | Journal of Integrative Plant Biology2006，48，3： | 2 |
| 10 | Factors associated with 5-year survival of combined hepatocellular and cholangiocarcinoma显示文摘BACKGROUND Combined hepatocellular and cholangiocarcinoma(HCC/CC)is a rare primary hepatic malignancy which carries a poor prognosis due to its aggressive nature.Few centers have enough cases to draw definitive conclusions and there is limited understanding of prognosis.Given the rarity of HCC/CC,an analysis of large national cancer database was needed to obtain larger number of HCC/CC cases.AIM To identify associated factors for 5-year survival of HCC/CC.METHODS We conducted a retrospective study of The Surveillance,Epidemiology,and End Results(SEER)database obtained from SEER*Stat 8.3.6 software.Previously defined histology code 8180 for the International Classification of Disease for Oncology,3rd edition was used to identify HCC/CC cases from 2004 to 2015.We collected demographics,American Joint Committee on Cancer(AJCC)stage,treatment,tumor size,and survival data.These data were converted to categorical variables.The Shapiro-Wilk normality test was used to assess normal distribution.Mann-Whitney U test was used to compare continuous variables without normal distribution,and t-test was used to compare continuous variables with a normal distribution.The Kaplan-Meier survival curve analyzed 5-year survival.Univariate and multivariate logistic regression model was used to analyze factors associated with 5-year survival.Multivariate Cox proportional hazard regression was done on 5-year survival.We defined P<0.05 was statistically significant.RESULTS We identified 497 patients with the following characteristics:Mean age 62.4 years(SD:11.3),149(30.0%)were female,racial distribution was:276(55.5%)white,53(10.7%)black,84(16.9%)Asian and Pacific Islander(API),77(15.5%)Hispanic,and 7(1.4%)others or unknown.Stage I/II disease occurred in 41.5%and tumor size<50 mm was seen in 35.6%of patients.Twenty-four(4.8%)received locoregional therapy(LRT),119(23.9%)underwent resection,and 50(10.1%)underwent liver transplantation.The overall median survival was 6 mo[Interquartile range(IQR):1-22].After multivariate logistic regression,tumor size<50 mm[Odds ratios(OR):2.415,P=0.05],resection(OR:12.849,P<0.01),and transplant(OR:27.129,P<0.01)showed significance for 5-year survival.Age>60,sex,race,AJCC stages,metastasis,and LRT were not significant.However,API vs white showed significant OR of 2.793(CI:1.120-6.967).Cox proportional hazard regression showed AJCC stages,tumor size<50 mm,LRT,resection,and transplant showed significant hazard ratio.CONCLUSION HCC/CC patients with tumor size<50 mm,resection,and transplant were associated with an increase in 5-year survival.API showed advantageous OR and hazard ratios over white,black. | Tomoki Sempokuya Eric A Wien Robert J Pattison Jihyun Ma Linda L Wong | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 11 | An intelligent system approach tO higher-dimensional classification of volume data 显示文摘 | TZENG F Y ERIC B L MA K L | 2005 | IEEE Transactions on Visualization and Computer Graphics2005，11，3： | 1 |
| 12 | Esophageal varices on computed tomography and subsequent variceal hemorrhage显示文摘 | Ma Somsouk Katherine To’o Mujtaba Ali Eric Vittinghoff Benjamin M. Yeh Judy Yee Alex Monto John M. Inadomi Rizwan Aslam | 2014 | Abdominal Imaging2014，，2： | 1 |
| 13 | Deposition mechanisms of thermal barrier coatings in the solution precursou plas ma spray process显示文摘 | Xie L D Ma X Q Eric H | 2004 | Surface and Coatings Technology2004，，： | 1 |
| 14 | Local Identity and Nationalism: Surveys on Hong Kong Cultural Identification 1996 -2006 显示文摘 | Eric Ma Anthony Fung | 2007 | The Chinese Jour- nal of Communication and Society2007，，3： | 1 |
| 15 | An Automatic On-line Signature Verification System Based on Three Modals显示文摘 | Ma Mingming Sardha Wijesoma W Eric Sung | 2000 | IEEE Transactions on Industrial Electronics2000，4，5： | 1 |
| 16 | Studies on the structure–activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents显示文摘 | Ben Li Eric Dale Jones Enkun Zhou Li Chen Dean Cameron Baylis Shanghai Yu Miao Wang Xing He Jonathan Alan Victor Coates David Ian Rhodes Gang Pei John Joseph Deadman Xin Xie Dawei Ma | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，17： | 1 |
| 17 | A pre- senilin dimer at the core of the gamma-secretase en- zyme:insights from parallel analysis of Notch 1 and APP proteolysis显示文摘 | ERIC H S MA XENIA G I ANNE L B | 2003 | Proc Natl Acad Sci USA2003，100，13： | 1 |
| 18 | FOXL2 is a female sex-determining gene in the goat显示文摘 | Laurent Boulanger Ma?lle Pannetier Laurence Gall Aurélie Allais-Bonnet Ma?va Elzaiat Daniel LeBourhis Nathalie Daniel Christophe Richard Corinne Cotinot Norbert B. Ghyselinck Eric Pailhoux | 2013 | Current Biology2013，，： | 1 |
| 19 | Heterostructure engineering in electrode materials for sodium-ion batteries:Recent progress and perspectives显示文摘Sodium-ion batteries(SIBs)have stepped into the spotlight as a promising alternative to lithium-ion batteries for large-scale energy storage systems.However,SIB electrode materials,in general,have inferior performance than their lithium counterparts because Nat is larger and heavier than Lit.Heterostructure engineering is a promising strategy to overcome this intrinsic limitation and achieve practical SIBs.We provide a brief review of recent progress in heterostructure engineering of electrode materials and research on how the phase interface influences Nat storage and transport properties.Efficient strategies for the design and fabrication of heterostructures(in situ methods)are discussed,with a focus on the heterostructure formation mechanism.The heterostructure's influence on Nat storage and transport properties arises primarily from local distortions of the structure and chemomechanical coupling at the phase interface,which may accelerate ion/electron diffusion,create additional active sites,and bolster structural stability.Finally,we offer our perspectives on the existing challenges,knowledge gaps,and opportunities for the advancement of heterostructure engineering as a means to develop practical,highperformance sodium-ion batteries. | Eric Gabriel Chunrong Ma Kincaid Graff Angel Conrado Dewen Hou Hui Xiong | 2023 | eScience2023，3，5： | 1 |
| 20 | Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance显示文摘 | Klaus S Gutfreund Mark Williams Rajan George Vincent G Bain Mang M Ma Eric M Yoshida Jean-Pierre Villeneuve Karl P Fischer David L.J Tyrrell | 2000 | Journal of Hepatology2000，，3： | 1 |
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