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| 1 | Susceptibility variations of multiple origins of loess from the Ily Basin(NW China)显示文摘The magnetic susceptibility of loess from the Ily Basin,northwestern China shows maximum values in S0 paleosols but minimum values in other paleosols,the mechanism of which has been well debated.In this work,systematic magnetic measurements were made on a representative section from Neleke county.The results show that the loess horizons(L1,L2 and L3) have multi-domain magnetite grains of aeolian origin,S0 is characterized by production of pedogenetic ultrafine-grained ferrimagnetic minerals,and the other paleosols(S1,S2,and S3) are characterized by the formation of nonferrimagnetic minerals associated with waterlogging.The correlation between the low concentration of ferrimagnets,high paramagnetic content,high magnetic coercivity remanence,fine ferrimagnetic grain size and intensified pedogenesis suggest two competing processes of pedogenetic enhancement and pedogenetic depletion in the lower paleosols.Pedogenetic depletion dominates and is responsible for the low susceptibility.Changes in magnetic grain size distribution occur during pedogenetic depletion.The susceptibility variations are of multiple origins in the loess of the Ily Basin.Pedogenetic enhancement,pedogenetic depletion,and allochthonous input of magnetic minerals should all be taken into account to explain the variations of magnetic parameters. | CHEN Qu LIU XiuMing HELLER F HIRT Ann M LU Bin GUO XueLian MAO XueGang ZHAO GuoYong FENG Hua GUO Hui | 2012 | Chinese Science Bulletin2012，57，15： | 9 |
| 2 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 3 | The feasibility of integrating ME-TVC+MEE with azzour south power plant:Economic evaluation显示文摘 | F N Alasfour A O Bin Amer | 2006 | Desalination2006，，197： | 1 |
| 4 | CNC rake grinding for a taper ball end mill with torus shaped grinding wheel显示文摘 | Xiong F Bin H Z | 2003 | The International Journal of Advanced Manufacturing Technology2003，21，8： | 1 |
| 5 | The cause of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F Lam bin TurnerB L Helmut J | 2001 | Global Environmental Change2001，11，： | 1 |
| 6 | Drying of pear d' Anjou with and without osmotic dehydration 显示文摘 | PARK K J BIN A BROD F P R | 2002 | Journal of Food Engineering2002，56，1： | 1 |
| 7 | Adaptive robust motion control of single-rod hydraulic actuators: theory and experiments显示文摘 | Bin Y Bu F P Reedy J | 2000 | IEEE/ASME Transactions on Mechatronics2000，5，1： | 1 |
| 8 | Sensor fault estimation and com- pensation for microsatellite attitude control systems显示文摘 | Gao Z F Bin J Shi P | 2010 | International Journal of Control Automation and Systems2010，8，2： | 1 |
| 9 | Surface studies by scanning tunneling microscope 显示文摘 | Binning G Quate C F Gerber Cb | 1982 | Phys Rev Lett1982，49，1： | 1 |
| 10 | Atomic force microscope显示文摘 | BINNING G QUATE C F GERBER C | 1986 | Phys Rev Lett1986，56，9： | 1 |
| 11 | Irreducible representations of the generalized Jacobson-Witt algebra 显示文摘 | Bin S Yao Y F | 2012 | Algebra Colloq2012，19，1： | 1 |
| 12 | La'_xKxC003 and LaCo'_yFey03 perovskite oxides : Preparation , characterization, and catalytic performance in the simul?taneous removal of NOx and diesel soot显示文摘 | Bin F Song C L Ltl G | 2011 | Industrial and Engneering Chemistry Research2011，50，： | 1 |
| 13 | Atomic force microscopy显示文摘 | Quate C F Gerber C | 1986 | Phys Rev Lett1986，56，9： | 1 |
| 14 | Atomic Force Microscope 显示文摘 | Binning G Quate C F Gerber C | 1986 | Physical Review Letters1986，56，9： | 1 |
| 15 | Atomie force mieroseope 显示文摘 | Binning G Quate C F Gerber C | 1986 | Physical Review Letters1986，56，9： | 1 |
| 16 | Geologic, geochemical and geophysical consequences of plume involvement in the Emeishan flood-basalt province 显示文摘 | Xu Yi-gang He Bin Chung Sun-lin Menzies M A Frey F A | 2004 | Geology2004，32，10： | 1 |
| 17 | Serum immunoreactivity of SMP30 and its tissues expression in hepatocellular carcinoma显示文摘 | Zhou S F Mo F R Bin Y H | 2011 | Clinical Biochemistry2011，44，4： | 1 |
| 18 | Aanlysis of a long-lasting haze episode in Nanjing, China 显示文摘 | HAN Q K BIN Z JI F S | 2013 | Atmospheric Research2013，120，： | 1 |
| 19 | Selective catalytic reduction of nitric oxide with ammonia over zirconium-doped copper/ ZSM-5 catalysts 显示文摘 | Bin F Song C Lv G | 2014 | Applied Catalysis B: Environmental2014，，： | 1 |
| 20 | Expression of T -iiel3er17 cells and signal transducers in patients with psoriasisvulgaris of blood-heat syndrome and blood-stasis syndrome显示文摘 | Bin F a n Xin L i K a n Z e | 2014 | Chin J Integr M e d2014，25，4： | 1 |
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