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| 1 | Rubber band ligation for 750 cases of symptomatic hemorrhoids out of 2200 cases显示文摘AIM: To study the results for the treatment of symptomatic hemorrhoids using rubber band ligation (RBL) method. METHODS: A retrospective study for 750 patients who came to the colorectal unit from June, 1998 to September, 2006, data was retrieved from archived fi les. RBL was performed using the Mc Gown applicator on an outpatient basis. The patients were asked to return to out-patient clinic for follow up at 2 wk, 1 mo, 6 mo and through telephone call every 6 mo for 2 years). RESULTS: After RBL, 696 patients (92.8%) were cured with no difference in outcome for second or third degree hemorrhoids (P = 0.31). Symptomatic recurrence was detected in 11.04% after 2 years. A total of 52 patients (6.93%) had 77 complications from RBL which required no hospitalization. Complications were pain, rectal bleeding and vaso-vagal symptoms(4.13%, 4.13% and 1.33% of patients, respectively). At 1 mo there were a significant improvement in mean SF-36 scores over baseline in five items, while after 2 years there were improvement in all items over baseline, but not significant. No significant manometeric changes after band ligation. CONCLUSION: RBL is a simple, safe and effective method for treating symptomatic second and third degree hemorrhoids as an out patient procedure with signifi cant improvement in quality of life. RBL doesn't alter ano-rectal functions. | Ayman M El Nakeeb Amir A Fikry Waleed H Omar Elyamani M Fouda Tito A El Metwally Hosam E Ghazy Sabry A Badr Mohmed Y Abu Elkhar Salih M Elawady Hisham H Abd Elmoniam Waiel W Khafagy Mosaad M Morshed Ramadan E El Lithy Mohamed E Farid | 2008 | World Journal of Gastroenterology2008，14，42： | 24 |
| 2 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 3 | In vitro and in vivo effects of ferulic acid on gastrointestinal motility:Inhibition of cisplatin-induced delay in gastric emptying in rats显示文摘AIM: To study the effects of ferulic acid on gastrointe-stinal motility both in vitro and in vivo.METHODS: Ferulic acid induced concentration-dependent stimulation of the basal tone of isolated guinea pig ileum (2-20 μmol/L) and isolated rat fundus (0.05-0.4 mmol/L). RESULTS: Ferulic acid significantly accelerated the gastrointestinal transit and gastric emptying in rats in a dose-dependent manner (50-200 mg/kg, po). Cisplatin (2.5-20 mg/kg, ip) induced a dose-dependent delay in gastric emptying in rats. Pretreatment with ferulic acid dose-dependently, significantly reversed the cisplatin-induced delay in gastric emptying. CONCLUSION: The endogenous prostaglandins (PGs) are involved in mediating the stimulant effects of ferulic acid. This effect of dietary ferulic acid may help improve other accompanying gastrointestinal symptoms such as abdominal discomfort and also may protect against emesis induced by cytotoxic drugs. | Osama A Badary Azza S Awad Mohey A Sherief Farid MA Hamada | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 4 | Exposing digital forgeries by detecting traces of resampling 显示文摘 | Popescu A C Farid H | 2005 | IEEE Transactions on Signal Proces- sing2005，53，2： | 1 |
| 5 | Using the computational fluid dynamics to analyze the thermal sterilization of solid-liquid foodmixture in cans显示文摘 | Ghani A Farid MM | 2006 | Innovative Food Science and Emerging Technologies2006，7，12： | 1 |
| 6 | Group Decision Making Process for Supplier Selection with VIKOR UnderFuzzy Environment显示文摘 | Sanayei A Farid M S Yazdankhah A | 2013 | Expert Systems with Applications2013，37，1： | 1 |
| 7 | Genetic analysis of ten sheep breeds using microsatellite markers显示文摘 | Farid A O'Reilly E Dollard C | 2000 | Canadian Journal of Animal Science2000，80，： | 1 |
| 8 | Controlling factors affecting the stability and rate of electroless copper plating显示文摘 | Hamid Z Abdel Aal A Abdel | 2003 | Materials Letters2003，58，： | 1 |
| 9 | A new two-step gradient method for large-scale unconstrained optimization显示文摘 | Farid M Leong W J Hassan M A | 2010 | Computers and Mathematics with Applications2010，22，9： | 1 |
| 10 | 水貂DNA指纹的研究Ⅰ.不同遗传群体DNA指纹图谱特征分析显示文摘从水貂闭锁繁育的近交群体和开放性混杂群体中采集鲜肝样品,分离基因组DNA,制成DNA指纹图谱。分别计算各群体中全同胞家系、半同胞家系和不相关个体的DNA指纹图谱特征指数,建立不同近交程度下带纹相似系数与亲缘系数的回归关系。结果表明:不论群体近交程度高低,带纹相似系数随亲缘系数增加而上升,且呈直线回归关系,相关系数分别为0.66(p<0.01)和0.77(p<0.01)。但近交程度较高的群体斜率较小,多态性带纹较少,带纹整齐度较高。 | 刘荣宗 Farid,A | 1995 | 湖南农学院学报1995，21，1： | 1 |
| 11 | Thermal sterilization of canned food in a 3-D pouch using computational fluid dynamics显示文摘 | ABDUL GHANI A G FARID M M CHEN X D | 2001 | Journal of Food Engineering2001，48，2： | 1 |
| 12 | Aleutian mink disease virus in furbearing mammals in Nova Scotia, Canada显示文摘 | Farid A H | 2013 | Acta Veterinaria Scandinavica2013，55，1： | 1 |
| 13 | A review on phase change energy storage:materials and applications显示文摘 | Farid M M Khudhair A M Razaek S A K | 2004 | Energy Conversion & management2004，45，： | 1 |
| 14 | A review on phase change energy storage:Materials and Applications显示文摘 | KHUDHAIR A M SIDDIQUE A K | 2004 | Energy Conversion and Management2004，45，： | 1 |
| 15 | 显示文摘 | Farid M M Khudhair A M Razack S A | 2004 | Energy Conversion and Management2004，45，： | 1 |
| 16 | Co-gasification of Colombian coal and biomass in fluidized bed:An experimental study显示文摘 | JHON F V FARID C CARLOS F V EDER J E CARLOS A L | 2009 | Fuel2009，88，2： | 1 |
| 17 | Using the computational fluid dynamics to analyze the thermal sterilization of-solid-liquid food mixture in cans显示文摘 | ABDUL GHANI A G FARID M M | 2006 | Innovative Food Science & Emerging Technologies2006，7，12： | 1 |
| 18 | Efficiency of plant growth-promoting rhizobacteria(PGPR) for the en- hancement of rice growth显示文摘 | Ashrafuzzaman M Farid A H Razi Ismail M | 2009 | African Journal of Biotechnology2009，8，7： | 1 |
| 19 | Performance of direct contact la- tent heat storage units with two hydrated salts 显示文摘 | FARID M M KHALAF A N | 1994 | Solar Ener- gy1994，52，2： | 1 |
| 20 | Pathogenicity of Rigidoporus microporus and Phellinus noxius against four major plantation tree species in Peninsular Malaysia显示文摘 | A Mohd Farid SS Lee Z Maziah | 2009 | Journal of Tropical Forest Science2009，21，4： | 1 |
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