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| 1 | Hydrogen peroxide-induced changes in intracellular pH of guard cells precede stomatal closure显示文摘Epidermal bioassay demonstrated that benzylamine, a membrane-permeable weak base, can mimick hydrogen peroxide (H2O2) to induce stomatal closure, and butyric acid, a membrane-permeable weak acid, can partly abolish the H2O2-induced stomatal closure. Confocal pH mapping with the probe 5-(and-6)- carboxy seminaphthorhodafluor- 1 - acetoxymethylester (SNARF-1-AM) revealed that H2O2 leads to rapid changes in cytoplasmic and vacuolar pH in guard cells of Viola faba L, i. e. alkalinization of cytoplasmic areas occur red in parallel with a decrease of the vacuolar pH, and that butyric acid pretreatment can abolish alkalinization of cytoplasmic areas and acidification of vacuolar areas of guard cells challenged with H2O2. These results imply that the alkalinization of cytoplasm via efflux of cytosol protons into the vacuole in guard cells challenged with H2O2 is important at an early stage in the signal cascade leading to stomatal closure. | ZHANG XIAO, FA CAI DONG, JUN FENG GAO, CHUN PENG SONG (Department of Biology, Henan University, Kaifeng 475001, China) (College of Life Sciences, Northwest Sci-Tech University of Agriculture and Forestry, Yangling 712100, China) | 2001 | Cell Research2001，11，1： | 24 |
| 2 | Report on Childhood Obesity in China (9): Sugar-sweetened Beverages Consumption and Obesity显示文摘Objective To explore the associations between sugar-sweetened beverage (SSB) consumption and obesity as well as obesity-related cardiometabolic disorders among children in China. Methods A total of 6974 (boys 3558, girls 3412) children aged 6-13 years participated in the study. Each participant's height, weight, waist circumference, fasting glucose, triglycerides, total cholesterol, high- density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured. The type of beverage consumption was determined using a self-administered questionnaire. Results SSBs were consumed regularly by 46.1% of the children. The prevalence [adjusted odds ratio (95% confidence internal (CI)] of obesity was 7.6% [as the reference group (ref.)], 10.1% [1.36(1.07, 1.74)], and 11.6% [1.46(1.21, 1.75)], among children who regularly drank milk, other beverages and SSBs, respectively. Regularly drinking SSBs elevated the likelihood of abdominal obesity [adjusted odds ratio (95% CI): 1.36 (1.17, 1.59)]. The prevalence [adjusted odds ratio (95% CI)] of obesity among children who regularly drank sports/caloric beverages, carbonated beverages, sweet tea, and plant protein beverages was 16.8% [2.00(1.31, 3.07)], 12.7% [1.52(1.23, 1.88)], 11.5% [1.52(1.18, 1.95)], and 10.4% [1.41(1.03, 1.94)], respectively, which was higher than that of regular milk drinkers [7.6 % (ref.)]. The prevalence [adjusted odds ratio (95% CI)] of abdominal obesity among children who regularly drank sweet tea, fruit/vegetable juices, and carbonated beverages was 17.7% [1.55(1.26, 1.90)], 16.2% [1.36(1.09, 1.70)], and 15.3% [1.24(1.03, 1.50)], respectively, which was much higher than that of regular milk drinkers [12.8% (ref.)]. Conclusions Regular SSB consumption was positively related to obesity and abdominal obesity. This relationship should be investigated further using a longitudinal study design. | SHANG Xian Wen LIU Ai Ling ZHANG Qian HU Xiao Qi DU Song Ming MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin LI Ting Yu MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 23 |
| 3 | Report on Childhood Obesity in China (10): Association of Sleep Duration with Obesity显示文摘Objectives To explore the association of sleep duration with obesity among children in urban areas of China.Methods A total of 6 576 children(3 293 boys and 3 283 girls) aged 7-11 years were randomly selected from 36 primary schools in 6 metropolitan cities in China.A 7-day Physical Activity Recall was used to assess the sleep duration and physical activity level.The height,weight,waist circumference(WC) and percentage of body fat(%BF,as determined by bioelectrical impedance analysis technique) were measured by following the standardized operation procedures.The information on demography,lifestyle and eating habits was collected with a self-administered questionnaire from participants and their parents.Results The average sleep duration per night in the children was 9.7 h with the decreasing trends along with the increase of age(P<0.05).The sleep duration was negatively associated with body mass index(BMI) and WC in both boys and girls after adjustment for confounders(β value-0.23 and-0.82 for boys,-0.24 and-0.91 for girls,respectively,P<0.01).However,no significant association of sleep duration with %BF was found.Children who slept less than 9.0 h per night had a higher risk for overweight and obesity(OR=1.29,95% CI:1.01,1.64) and abdominal obesity(OR=1.38,95% CI:1.04,1.83) as compared with those who slept for 10.0-10.9 h.Conclusions Short sleep duration is associated with obesity.It is important to ensure adequate sleep duration of children and foster their healthy lifestyle at an early stage of life. | MENG Li Ping LIUAi Ling HU Xiao Qi ZHANG Qian DU Song Ming FANG Hong Yun MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 16 |
| 4 | Epidemiological Analysis on Reported Hepatitis C Cases in China from 2012 to 2016显示文摘Viralhepatitisisanimportantchallengeto publichealthworldwide.AshepatitisBiswell controlledduetovaccination,thediseaseburden causedbythespreadofhepatitisChasbecome increasinglyprominent.HepatitisCisaninfectious diseasethatismainlyblood-borne.Therateof chronicity ranges from 55%to 85%after people are infected with the hepatitis C virus (HCV)[1-2]. Twenty yearsafterinfectioninthegeneralpopulation,the incidence of cirrhosis ranges from 5%to 15%[3]. | HEI Fa Xin YE Shao Dong DING Guo Wei PANG Lin WANG Xiao Chun LIU Zhong Fu | 2018 | Biomedical and Environmental Sciences2018，31，10： | 10 |
| 5 | Polyoxypregnanes from the stems of Marsdenia tenacissima显示文摘From the stems of Marsdenia tenacissima two new polyoxypregnanes were isolated, their structures were elucidated by 1D, 2D- NMR as 11a,12b-di-O-tigloyl-tenacigenin B (1) and tenacigenoside E(2). | Qi Fa Li Xiao Ling Wang Li Sheng Ding Chang Zhang | 2007 | Chinese Chemical Letters2007，18，7： | 8 |
| 6 | Determination of aniline in environmental water samples by alternating-current oscillopolarographic titration显示文摘A new method for the determination of aniline in environmental water based on oscillopolarographic titration was presented in this paper. Several factors including the kind, concentration, and volume of acid, the dosage of potassium bromide, the temperature and concentration of concomitant substances were investigated in detail. The experimental results indicated that this method was simple, rapid, and sensitive. The linear range was 8.367×10-4 to 2.789×10-2 mol L-1, the relative standard deviation (R.S.D.) was lower than 0.96%, and the spiked recoveries of aniline in environmental water samples were in the range of 99.4-106.9% under the optimal conditions. The results indicated that the present method could be used as an alternative method for aniline determination in realworld water samples. | Jun Ping Xiao Qing Xiang Zhou Xiao Ke Tian Hua Hua Bai Xian Fa Su | 2007 | Chinese Chemical Letters2007，18，6： | 6 |
| 7 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 8 | VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis显示文摘脉管的 endothelial 细胞生长禁止者(VEGI ) 是肿瘤坏死因素总科的一个成员并且在脉管的动态平衡起一个重要作用。在这研究,调查 anticancer 这基因的治疗学的潜力, VEGI (VEGI-251 ) 的分泌 isoform 与 E1B 55 kDa 基因删除(ZD55 ) 被插入到有选择地复制的侵入人体气管粘膜的病菌构造 ZD55-VEGI-251。我们这里报导 potently 从 ZD55-VEGI-251-infected 癌症房间生产的分泌 VEGI-251 禁止 endothelial 房间增长,在在 vivo 的小鸡 chorioallantoic 膜的 vitro 和 angiogenesis 的试管形成。另外, ZD55-VEGI-251 感染在几根人的癌症房间线上比控制病毒导致更严重的 cytopathic 效果,包括颈的癌症房间线 HeLa, hepatoma 房间线 SMMC-7721 和 colorectal 癌症房间线 SW620。进一步的学习表明增加的 cytotoxicity 是 caspase-9 激活,提高的 caspase-3 激活和 PARP 劈开伴随的 VEGI-251 autocrine 依赖的、调停线粒体的 apoptosis 的结果。而且,显著地忍受颈的人和 colorectal 肿瘤异种皮移植的 athymic 裸体人老鼠的 ZD55-VEGI-251-treatment 压制了肿瘤生长。我们的调查结果显示 antiangiogenesis 和 apoptosis 感应的活动的联合效果为癌症使 VEGI-251-armed oncolytic 侵入人体气管粘膜的病菌成为一个有希望的治疗学的代理人。 | Tian Xiao Jun Kai Fan Hong Ling Huang Jin Fa Gu Lu-Yuan Li Xin Yuan Liu | 2010 | Cell Research2010，20，3： | 5 |
| 9 | Effect and mechanism of acute graft versus host disease on early diffuse murine lung injury following allogeneic stem cell transplantation显示文摘To explore the effect and pathogenssis of acute graft-versus-host disease (aGVHD) on early diffuse lung injury in allogeneic hematopoietic stem cell transplantation (allo-HSCT), we established an aGVHD model of C57BL/6→BALB/c mice. Chest computed tomography (CT) scans, histopathology and the levels of cytokines including tumor necrosis factor α (TNFα) and Interferon (IFNγ) in lungs were dynamically detected in recipient mice after transplantation. The incidence of aGVHD was respectively 0%, 0% and 100% in simple irradiation group (A), syngeneic transplant group(B) and allogeneic transplant group (C). Chest CT scans of recipient mice were normal in 3 groups on days +3 and +7 after transplantation. CT showed that two of ten mice had bilateral lung diffuse infiltrate on day +12 (on the brink of death) in group A and 6 of 10 mice had bilateral lung diffuse infiltrate on day +14 (3 d after aGVHD occurring) in group C, and were normal on days +12 and +14 in group B after transplantation. Histopathology of lungs in the 3 groups was similar, consisting of minor interstitial pneumonitis on day +3. Group A showed edema, hyperplasia of epithelial cells and widened alveolar interval on day +7, and epithelial cell necrosis, lymphocyte infiltration, hemorrhage, protein leakage, and local consolidation on day +12. The histopathology of group B showed slight edema of epithelial cells on +7 day, which were slighter than that on day +3, and virtually normal on day +14. The histopathology in group C was characterized by the significant expansion and congestion of capillaries, and lymphocyte infiltration on day +7, the acute pneumonitis was present involving tissue edema, lymphocyte and macrophage infiltration, protein leakage and perivascular inflammation on day +14. In group A, the levels of TNFα were lower on day +7 than on day +3. In group B, the levels of TNFα attained a peak on day +3, which decreased on days +7 and +14. In group C, the levels of TNFα were highest on day +7 and there was a significant difference between those on days +7 and +14 (P=0.816). In group A, the levels of IFNγ on day +7 were higher than on day +3. In group B, the levels of IFNγ increased progressively, but the comparison of IFNγ levels in different times had no statistical significance (P=0.521, 0.118, 0.340). In group C, the levels of IFNγ attained a peak by day +7 and decreased on day +14. aGVHD is the main cause of early non-infectious lung injury. T lymphocytes and TNFα are possibly implicated in the pathogenesis of acute GVHD-induced lung injury. The decreased levels of IFNγ in lung tissues following transplantation might be associated with pulmonary fibrosis in late non-infectious pulmonary complications. | NING Juan, LIU Qi Fa, LUO Xiao Dan, FAN Zhi Ping & Zhang Yu Department of Hematology, Southern Hospital, Southern Medical University, Guang Zhou 510515, China | 2009 | Science China(Life Sciences)2009，52，11： | 4 |
| 10 | Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)显示文摘Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different populations incorporating the efficacy and safety of TUPKP in the treatment of normal volume (< 80 ml) and large-volume (≥ 80 ml) BPH compared with transurethral urethral resection prostate, transurethral plasmakinetic enucleation of prostate and open prostatectomy;the efficacy and safety of TUPKP in high-risk populations and among people taking anticoagulant (antithrombotic) drugs. Questions relevant to the postoperative period incorporated the time and speed of flushing, the time indwelling catheters are needed, principles of postoperative therapeutic use of antibiotics, follow-up time and follow-up content. Questions related to complications incorporated types of complications and their incidence, postoperative leukocyturia, the treatment measures for the perforation and extravasation of the capsule, transurethral resection syndrome, postoperative bleeding, urinary catheter blockage, bladder spasm, overactive bladder, urinary incontinence, urethral stricture, rectal injury during surgery, postoperative erectile dysfunction and retrograde ejaculation. Final questions were related to surgeons’ skills when performing TUPKP for the treatment of BPH. We hope these recommendations can help support healthcare workers caring for patients having TUPKP for the treatment of BPH. | Xian-Tao Zeng Ying-Hui Jin Tong-Zu Liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing Huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li Pei-Jun Li Chao-Zhao Liang Xiu-Heng Liu Zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu Guang-Heng Luo Yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng Wang Feng Wang Yin-Huai Wang Yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang Wei Min-Hui Xiao Wan-Hai Xu Fa-Xian Yi Chao-Yang Zhu Qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-Lin He Xing-Huan Wang 无 | 2022 | Military Medical Research2022，9，5： | 4 |
| 11 | Simultaneous Determination of Bisphenols and Alkylphenols in Water by Solid Phase Extraction and Ultra Performance Liquid Chromatography-tandem Mass Spectrometry显示文摘To establish an analytical method for determination of four bisphenols(BPA,BPB,BPF,and BPS)and two alkylphenols(4-n-OP,4-n-NP)in water by ultra performance liquid chromatographytandem mass spectrometry(UPLC/MS/MS).The water samples were extracted and condensed with solid-phase extraction(SPE)using C18 cartridges and eluted by acetonitrile.Separation was carried out with Acquity BEH C8 column and detection were performed by UPLC/MS/MS.Quantification | SHAN Xiao Mei SHEN Deng Hui WANG Bing Shuang LU Bei Bei HUANG Fa Yuan | 2014 | Biomedical and Environmental Sciences2014，27，6： | 4 |
| 12 | Origin of pit chains in the floor of lunar Copernican craters显示文摘There are small pit chains in the floor of lunar Copernican craters. They are usually so small in scale that there are few lunar spacecrafts to detect their detailed morphology. Combining camera data from Lunar Orbiter, Lunar Reconnaissance Orbiter (LRO), Kaguya and Chang’e-1 missions, 5 representative large Copernican craters on various terrains of the lunar surface are chosen to study the origin of the pit chains in the crater floor. The morphology and distribution characteristic of the pit chains are referred by the high resolution images in this research. It is suggested that it is the magma activities from the subsurface magma layer combining with the existence of fractures and faults under the crater floor that leaded the formation of the pit chains. The model is further verified and discussed using the regolith thickness data in the crater floor. Our model suggests that the pit chains are still developing in the floor of the Copernican craters and the Moon may not be totally cold. Finally, the model limitation and potential future work are discussed based on available data. | XIAO ZhiYong 1* , ZENG ZuoXun 1,2 , XIAO Long 1,2 , FA WenZhe 3 & HUANG Qian 3,4 1 Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 2 Research Center for Space Science and Technology, China University of Geosciences, Wuhan 430074, China 3 Institut de Physique du Globe de Paris, 4 Avenue de Neptune, Saint Maur des Fosse’s, 94100, France 4 Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 4 |
| 13 | Noncoding RNAs in doxorubicin-induced cardiotoxicity and their potential as biomarkers and therapeutic targets显示文摘Anthracyclines,such as doxorubicin(DOX),are well known for their high efficacy in treating multiple cancers,but their clinical usage is limited due to their potential to induce fatal cardiotoxicity.Such detrimental effects significantly impact the overall physical condition or even induce the morbidity and mortality of cancer survivors.Therefore,it is extremely important to understand the mechanisms of DOX-induced cardiotoxicity to develop methods for the early detection of cytotoxicity and therapeutic applications.Studies have shown that many molecular events are involved in DOX-induced cardiotoxicity.However,the precise mechanisms are still not completely understood.Recently,noncoding RNAs(ncRNAs)have been extensively studied in a diverse range of regulatory roles in cellular physiological and pathological processes.With respect to their roles in DOX-induced cardiotoxicity,microRNAs(miRNAs)are the most widely studied,and studies have focused on the regulatory roles of long noncoding RNAs(lncRNAs)and circular RNAs(circRNAs),which have been shown to have significant functions in the cardiovascular system.Recent discoveries on the roles of ncRNAs in DOX-induced cardiotoxicity have prompted extensive interest in exploring candidate ncRNAs for utilization as potential therapeutic targets and/or diagnostic biomarkers.This review presents the frontier studies on the roles of ncRNAs in DOX-induced cardiotoxicity,addresses the possibility and prospects of using ncRNAs as diagnostic biomarkers or therapeutic targets,and discusses the possible reasons for related discrepancies and limitations of their use. | Hong-ge Fa Wen-guang Chang Xue-juan Zhang Dan-dan Xiao Jian-xun Wang | 2021 | Acta Pharmacologica Sinica2021，42，4： | 2 |
| 14 | Tetrabutylammonium salts of tritransition-metal-substituted A-α-tungstogermanate:Halogen-free and single-component catalysts for the coupling reaction of carbon dioxide and epichlorohydrin显示文摘经由二氧化碳和 epichlorohydrin 的联合反应的 chloropropylene 碳酸盐的绿合成用 tritransition-metal-substituted A 的没有卤素、单个部件的催化剂 tetrabutylammonium 盐被完成了 -- tungstogermanate [(n-C4H9 ) 4N ] 没有任何溶剂的 3H7GeW9M3 (H2O ) 3O37 (M = CuII, NiII, CoII 和 MnII ) 。催化活动显著地被取决于在 polyoxometalates 介绍的转变金属。[(n-C4H9 ) 4N ] 3H7GeW9Mn3 (H2O ) 3O37 在 3 h 为 chloropropylene 碳酸盐为 epichlorohydrin 和 98% 选择与 94.9% 变换展出了最高催化的活动。嘴巧的机制基于结果被建议。 | Fa Wang Chen Tao Dong Xiao Fang Li Tie Gang Xu Chang Wen Hu | 2011 | Chinese Chemical Letters2011，22，7： | 2 |
| 15 | A new polyacetylene glycoside from the rhizomes of Atractylodes lancea显示文摘新 polyacetylene glycoside,(1,3Z,11E )-tridecatriene-7,9-diyne-5-hydroxyl-6-O- 尾 -d-glucopyranoside, 从 Atractylodes lancea (Thunb ) 的根茎被孤立 DC。它的结构被阐明根据光谱分析。 | Ying Ji Xu Feng Chao Cheng Xiao Yun Fa Dong Qi Zhi Wang Ming Wang You Yi Zhao | 2010 | Chinese Chemical Letters2010，21，7： | 2 |
| 16 | Synthesis and Absorption Properties of New Na Specific Adsorbent Li_(1+x)Al_xTi_(2-x)(PO_4)_3显示文摘A new kind of adsorbent Li1+xAlxTi2-x(PO4)3 was synthesized by solid state reaction method. The influence of the content of doping aluminum on the adsorbent Li1+xAlxTi2-x(PO4)3 was investigated by XRD, while the morphology of powders was observed by SEM. The investigation of the adsorption properties showed that the adsorbent can selectively adsorb sodium with the adsorption capacity of 11.76 mg/g. The optimum conditions of adsorption are at pH 10.0-11.0 in LiCl solution. | Jian Zhi SUN Xiao Chuan DENG Shu Bin WEI Fa Qiang LI Pei Hua MA | 2005 | Chinese Chemical Letters2005，16，10： | 2 |
| 17 | LncRNA LUCAT1 Activation Mediated by theDown-regulation of DNMT1 Is Involved inCell Apoptosis Induced by PM2.5显示文摘Particulate matter (PM), which is a greatenvironmental concern, has been classified as aGroup 1 human carcinogen by the InternationalAgency for Research on Cancer (IARC).Epidemiological and experimental studies haveindicated that chronic exposure to PM, especiallyPM2.5 (particles with an aerodynamic diameter lessthan 2.5 μm) may lead to an increase in lung cancerincidence. | LING Xiao Xuan ZHANG Hai Qiao LIU Jia Xian LIU Zhi Dong PENG Jian Ming ZHANG Xiao Qing SHAO Jun Li CHEN Zhen Fa LIU Lin Hua | 2018 | Biomedical and Environmental Sciences2018，31，8： | 2 |
| 18 | Spatial patterns and climate drivers of carbon fluxes in terrestrial ecosystems of China显示文摘 | Gui‐Rui Yu Xian‐Jin Zhu Yu‐Ling Fu Hong‐Lin He Qiu‐Feng Wang Xue‐Fa Wen Xuan‐Ran Li Lei‐Ming Zhang Li Zhang Wen Su Sheng‐Gong Li Xiao‐Min Sun Yi‐Ping Zhang Jun‐Hui Zhang Jun‐Hua Yan Hui‐Min Wang Guang‐Sheng Zhou Bing‐Rui Jia Wen‐Hua Xiang Ying‐Nian Li Lia | 2012 | Glob Change Biol2012，，3： | 1 |
| 19 | Microvoid formation of acrylic copolymer (PAC)/cellulose acetate(CA) blend fibers显示文摘 | Xiao Chang fa | 1990 | Journal of Applied Polymer Science1990，41，： | 1 |
| 20 | Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China显示文摘Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan Province.Methods We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan Province.Hematological screening was performed,and molecular parameters were assessed.Results The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-thalassemia.The highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),respectively.Fourα-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in China.Furthermore,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,respectively.Conclusion Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan population.The results should facilitate genetic counselling and the prevention of severe thalassemia in this region. | XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi Hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua | 2023 | Biomedical and Environmental Sciences2023，36，2： | 1 |
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