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| 1 | Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi. | Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 80 |
| 2 | Influence of Sediment Dredging on Chemical Forms and Release of Phosphorus显示文摘A laboratory experiment was carried out through a six-month incubation of undredged (control) and dredged cores to study the effect of sediment dredging on phosphorus (P) release from the sediment in the Taihu Lake.During the experiment,dredging the upper 30 cm layer could efficiently reduce the interstitial PO_4^(3-)-P concentration and different P forms in the sediment.The P fluxes of the undredged and dredged cores ranged from-5.1 to 3047.6 and-60.7 to 14.4μg m^(-2) d^(-1),respectively.The fluxes of the dredged cores were generally lower than those of the control.Differences in the fluxes between the dredged and undredged cores were statistically significant (P<0.05) from March to June 2006. The sediment P in the dredged cores had a lower release potential than that in the control.Dredging can be considered as a useful measure for rehabilitating the aquatic ecosystem after the external P loading in the Taihu Lake catchment was efficiently reduced. | ZHONG Ji-Cheng YOU Ben-Sheng FAN Cheng-Xin LI Bao ZHANG Lu DING Shi-Ming | 2008 | Pedosphere2008，18，1： | 27 |
| 3 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 4 | Effects of hydrodynamics processes on phosphorus fluxes from sediment in large,shallow Taihu Lake显示文摘在湖沉积,超营养作用的一个主要原因和水质的随后的恶化的磷(P) 的周转,需要深理解。在这研究, P 版本上的暂停的效果与 Y 形状仪器在圆柱的缩影被学习。结果显示在越过沉积水接口(Fss ) 和风速度的推迟的物质的流动之间有一道正相关,并且增加的 FSS 在各个期间弯屈由一个稳定的状态跟随的过程。在轻、中等、大的风条件下面的最大的 FSS 是 299.9 ± 4 1.1, 573.4 ± 6 1.7,和 2093.8 ± 2 15.7 g/m2 分别地。然而,越过沉积水接口(FP ) 的 P 的流动没作为反应弯屈紧张的 Fss 跟随一个类似的模式,它增加了并且到达最大值在起始为光的 120 min 弯屈,然后逐渐地减少了,与 9.4 ± 1 .9 mg/m2 的最大的流动。在开始的 30 min 的 FP 的快速的增加在中等的风下面被观察,与 11.2 ± 0 .6 mg/m2 的最大的流动。令人惊讶地,大风与 3.5 ± 0 .9 mg/m2 的最大的流动比在轻、中等的风条件下面引起了更少的 FP。在水列的 Fss 在风以后在沉积过程期间显然衰退了,但是 FP 与风政体变化了。没有明显的差别在 8 h 沉积过程以后在 FP 上被检测,与起始的值相比,它意味着小冗余的 P 在风以后在水列离开了。 | YOU Ben-sheng ZHONG Ji-cheng FAN Cheng-xin WANG Tong-cheng ZHANG Lu DING Shi-ming | 2007 | Journal of Environmental Sciences2007，19，9： | 23 |
| 5 | MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression显示文摘背景侵略生长是 glioblastoma 的最典型的生物显型,但是在 glioma 房间侵略的分子的机制是糟糕, understood.Recent 数据证明了 microRNA 在学习试图探索涉及 glioblastoma 房间 invasion.Methods Glioma 房间侵略的控制的 miR-7 的机制的肿瘤 invasion.Our 起一个必要作用被 transwell 评估并且用 miR-7 在 miR-7 的起来规定以后抓试金模仿在 U87 和 U251 cells.Luciferase | WU De-gang WANG Ying-yi FAN Li-gang LUO Hui HAN Bin SUN Li-hua WANG Xie-feng ZHANG Jun-xia CAO Lei WANG Xi-rui YOU Yong-ping LIU Ning | 2011 | Chinese Medical Journal2011，，17： | 23 |
| 6 | Screening for gastric cancer in China:Advances,challenges and visions显示文摘Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening. | Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan | 2021 | Chinese Journal of Cancer Research2021，33，2： | 21 |
| 7 | Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway显示文摘瞄准:主要压抑的混乱(MDD ) 是削弱与 neurotransmitter-neuroendocrine 系统和 neuroinflammatory 回答的机能障碍联系的心理混乱。Salvianolic 酸 B (SalB ) 显示出许多药理学活动,包括反煽动性,抗氧化剂和 neuroprotective 效果。在这研究,我们检验了 SalB 是否在一个长期的温和压力(厘米) 产生了像抗抑郁剂的行动老鼠模型,并且探索了位于 SalB.Methods 的像抗抑郁剂的行动下面的机制:老鼠受到一个厘米范例 6 个星期。在最后 3 个星期内,老鼠是每天管理的 SalB (20 mg· kg −1·d−1, ip ) 或积极控制药 imipramine (20 mg· kg −1·d−1, ip ) 。像镇静剂的行为用蔗糖偏爱测试,强迫的游泳测试(FST ) ,和尾巴暂停测试(TST ) 被评估。在马头鱼尾的怪兽和外皮的 cytokines 的基因表示与 RT-PCR 被分析。血浆皮质脂酮(CORT ) 和服的 cytokines 层次是有一个 ELISA 工具包的 assayed。在大脑纸巾的神经 apoptosis 和 microglial 激活用 immunofluorescence staining.Results 被检测:SalB 或 imipramine 的管理颠倒了对待厘米的老鼠的减少的蔗糖偏爱比率,并且显著地减少了他们在 FST 和 TST 的不动时间。SalB 的管理显著地减少了支持 inflammatory cytokines IL-1β 的表示;并且 TNF-α,并且显著地增加了反煽动性的 cytokines IL-10 和 TGF-β 的表示;在对待厘米的老鼠的马头鱼尾的怪兽和外皮,并且使他们的提高的血浆 CORT 层次正常化,而 imipramine 的管理显著地没在对待厘米的老鼠的马头鱼尾的怪兽和外皮影响在支持 inflammatory 和反煽动性的 cytokines 之间的不平衡。最后, SalB 的管理显著地减少了在马头鱼尾的怪兽和外皮的导致厘米的 apoptosis 和 microglia 激活,而 imipramine 的管理没在马头鱼尾的怪兽和 cortex.Conclusion 在导致厘米的 apoptosis 和 microglia 激活上有重要效果:SalB 施加在导致厘米的老鼠的像抗抑郁剂的效果消沉建模的有势力,它与禁止被联系在马头鱼尾的怪兽和外皮的 microglia 相关的 apoptosis。 | Jin-qiang ZHANG Xiao-hui WU Yi FENG Xiao-fang XIE Yong-hua FAN Shuo YAN Qiu-ying ZHAO Cheng PENG Zi-li YOU | 2016 | Acta Pharmacologica Sinica2016，37，9： | 19 |
| 8 | Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma显示文摘Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients.Endoscopic nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical costs.In this study,we examined whether ENPG could be an effective treatment for localized stage I NPC.Methods:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center.Simultaneously,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort.The survival outcomes,quality of life(QOL),and medical costs between two groups were compared.Results:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with ENPG.The 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy.However,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results. | You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui Sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen | 2019 | Cancer Communications2019，39，1： | 17 |
| 9 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 10 | HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module显示文摘AIM:To investigate the possible mechanism by which hepatitis B virus X protein(HBx)mediates apoptosis of HepG2 cells.METHODS:HBx expression vector pcDNA3.1-X was transfected into HepG2 cells to establish an HBx highexpression cellular model as pcDNA3.1-X transfected group.The pcDNA3.1-X and pSilencer3.1-shHBX(HBx antagonist)were cotransfected into HepG2 cells to establish an HBx low-expression model as RNAi group.Untransfected HepG2 cells and HepG2 cells transfected with negative control plasmid were used as controls.Apoptosis rate,the expression of Fas/FasL signaling pathway-related proteins and the phosphorylation levels of MLK3,MKK7 and JNKs,which are upstream molecules of death receptor pathways and belong to the family of mitogen-activated protein kinases(MAPKs),were measured in each group.RESULTS:Compared with HepG2 cell group and RNAi group,apoptosis rate,the expression of Fas and FasL proteins,and the activation of MLK3,MKK7 and JNKs were increased in the pcDNA3.1-X transfected group.The activation of JNKs and expression of FasL protein were inhibited in the pcDNA3.1-X transfected group when treated with a known JNK inhibitor,SP600125.When authors treated pcDNA3.1-X transfected group with K252a,a known MLK3 inhibitor,the activation of MLK3,MKK7 and JNKs as well as expression of FasL protein was inhibited.Furthermore,cell apoptosis rate was also significantly declined in the presence of K252a in the pcDNA3.1-X transfected group.CONCLUSION:HBx can induce HepG2 cell apoptosis via a novel active MLK3-MKK7-JNKs signaling module to upregulate FasL protein expression. | Ren-Xian Tang Fan-Yun Kong Bao-Feng Fan Xiao-Mei Liu Hong-Juan You Peng Zhang Kui-Yang Zheng | 2012 | World Journal of Gastroenterology2012，18，13： | 14 |
| 11 | Association between Chinese Medicine Therapy and Survival Outcomes in Postoperative Patients with NSCLC: A Multicenter, Prospective, Cohort Study显示文摘Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospective cohort study was conducted in 13 medical centers in China.Patients with stage I,II,or IDA NSCLC who had undergone radical resection and received conventional postoperative treatment according to the National Comprehensive Cancer Network(NCCN)guidelines were recruited.The recruited patients were divided into a CM treatment group and a control group according to their wishes.Patients in the CM treatment group received continuous CM therapy for more than 6 months or until disease progression.Patients in the control group received CM therapy for less than 1 month.Follow-up was 8nducted over 3 years.The primary outcome was DFS,with recurrence/metastasis rates as a secondary outcome.Results:Between May 2013 and August 2016,503 patients were enrolled into the cohort;266 were classified in the CM treatment group and 237 in the control group.Adjusting for covariates,high exposure to CM was associated with better DFS[hazard ratio(HR)=0.417,95%confidential interval(Cl):0.307-0.567)].A longer duration of CM therapy(6-12 months,12-18 months,>24 months)was associated with lower recurrence and metastasis rates(HR=0.225,0.119 and 0.083,respectively).In a subgroup exploratory analysis,CM therapy was also a protective factor of cancer recurrence and metastasis in both stage n-MA(HR=0.50,95%Cl:0.37-0.67)and stage IDA NSCLC postoperative patients(HR=0.48,95%Cl:0.33-0.71),DFS was even longer among CM treatment group patients.Conclusions:Lon ger duration of CM therapy could be 8nsidered a protective factor of cancer recurrence and metastasis.CM treatment is associated with improving survival outcomes of postoperative NSCLC patients in China. | WANG Xue-qian ZHANG Ying HOU Wei WANG Ying-tian ZHENG Jia-bin LI Jie LIN Li-zhu JIANG Yi-lan WANG Shen-yu XIE Ying ZHANG Hong-liang SHU Qi-jin LI Ping WANG Wei YOU Jian-liang LI Ge LIU Jie FAN Hui-ting ZHANG Mei-ying LIN Hong-sheng | 2019 | Chinese Journal of Integrative Medicine2019，25，11： | 12 |
| 12 | 17β-estradiol contributes to the accumulationof myeloid-derived suppressor cells in bloodby promoting TNF-αsecretion显示文摘雌激素被影响有免疫力的房间的发展和激活强烈在有免疫力的回答处于性差别含有。最近的研究显示出那导出 myeloid 的 suppressor 房间(MDSC ) ,源于 CD11b + 在病理学的条件下面的 Gr-1 + myeloid 房间,在 modulating 免疫者回答起重要作用。然而,它仍然是未知的 MDSC 上的雌激素的效果。在现在的学习,我们在调整 MDSC 的累积上调查了雌激素的效果和机制。与有全身的豺狼座 erythematosus (SLE ) 的男病人相比,有 SLE 的女病人在浆液在外部血 mononuclear 房间和肿瘤坏死因素(TNF-) 的高水平显示出 MDSC 的更高的频率,这被发现。尤其是,在有 SLE 的女病人的浆液的 estradiol 水平断然与 MDSC 的频率被相关。而且, 17-estradiol 能支持 TNF -- 在由增加 CD11b + Gr-1 + 房间。而且, 17-estradiol 在 vivo 支持了 TNF- 的分泌物,它贡献了 CD11b + Gr-1 + 房间。另外,雌老鼠显示出 CD11b + Gr-1 + 房间和更高的 TNF- 比匹配年龄的雄的老鼠在血铺平。这些数据显示 17-estradiol 由支持 TNF- 分泌物在血贡献 MDSC 的累积,它增加 CD11b + Gr-1 + 房间。我们的调查结果在发炎和自体免疫的疾病的流行提供新卓见进性差别的机制。 | Guanjun Dong Ming You Hongye Fan Jianjian Ji Liang Ding Pengfei Li Yayi Hou | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 11 |
| 13 | Plumbagin inhibits cell growth and potentiates apop-tosis in human gastric cancer cells -in vitro through the NF-KB signaling pathway显示文摘 | Jing LI Lin SHEN Fu-rong LU You QIN Rui CHEN Jia LI fan LI Han-zi ZHAN Yuan-qiao HE | 2012 | Acta Pharmacologica Sinica2012，33，2： | 11 |
| 14 | Adsorption behavior of carbon dioxide and methane in bituminous coal:A molecular simulation study显示文摘The adsorption behavior of CO_2, CH_4 and their mixtures in bituminous coal was investigated in this study. First, a bituminous coal model was built through molecular dynamic(MD) simulations, and it was confirmed to be reasonable by comparing the simulated results with the experimental data. Grand Canonical Monte Carlo(GCMC)simulations were then carried out to investigate the single and binary component adsorption of CO_2 and CH_4with the built bituminous coal model. For the single component adsorption, the isosteric heat of CO_2 adsorption is greater than that of CH_4 adsorption. CO_2 also exhibits stronger electrostatic interactions with the heteroatom groups in the bituminous coal model compared with CH_4, which can account for the larger adsorption capacity of CO_2 in the bituminous coal model. In the case of binary adsorption of CO_2 and CH_4mixtures, CO_2 exhibits the preferential adsorption compared with CH_4 under the studied conditions. The adsorption selectivity of CO_2 exhibited obvious change with increasing pressure. At lower pressure, the adsorption selectivity of CO_2 shows a rapid decrease with increasing the temperature, whereas it becomes insensitive to temperature at higher pressure. Additionally, the adsorption selectivity of CO_2 decreases gradually with the increase of the bulk CO_2 mole fraction and the depth of CO_2 injection site. | Jing You Li Tian Chao Zhang Hongxing Yao Wu Dou Bin Fan Songqing Hu | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 10 |
| 15 | Tumorigenesis and spontaneous metastasis by luciferase-labeled human xenograft osteosarcoma cells in nude mice显示文摘 | DU Lin XU Wen-ting FAN Qi-ming TU Bing SHEN Yang YAN Wei TANG Ting-ting WANG You | 2012 | Chinese Medical Journal2012，，22： | 9 |
| 16 | Spatial distribution of heavy metals(Cu, Pb, Zn, and Cd)in sediments of a coastal wetlands in eastern Fujian, China显示文摘We investigated the spatial distribution(horizontal and vertical concentrations) of copper(Cu),lead(Pb), zinc(Zn), and cadmium(Cd) in five wetland types(mudflat, aquaculture wetland, water area, farmland wetland and mangrove) from three areas(Ningde, Fuding,and Xiapu), China. Cu concentrations in five wetland types descended in the order: farm wetland, mudflat, aquaculture,water area and mangrove. Pb concentrations decreased in the order: aquaculture, mangrove, farm wetland, mudflat,and water area. Zn content decreased in the order: farm wetland, water area, aquaculture, mudflat and mangrove,and Cd content decreased as follows: mangrove, aquaculture, water area, mudflat, and farm wetland. Comparison of the concentrations of the same heavy metals in different areas showed that the highest Cu(63.75 mg kg^-1) and Zn(152.32 mg kg^-1) concentrations occurred in Ningde coastal wetlands; Pb(110.58 mg kg^-1) and Cd(2.81 mg kg^-1) contents were highest in Fuding wetlands,and the average contents of all heavy metals were very low in Xiapu wetlands. Examination of the vertical distribution showed that the Cu content was high in all mudflat layers;Pb and Cd concentrations were highest in aquaculture and mangrove wetlands, respectively, and Zn content was highest in farm wetlands. The spatial distribution of Cu and Zn contents for different areas decreased as follows:Ningde [ Fuding [ Xiapu, for Pb and Cd were most concentrated in Fuding coastal wetlands. Concentrations of Zn and Cu were highly correlated, while Zn and Cu were not significantly correlated with Pb. | Lili Zhao Weibin You Haiqing Hu Wei Hong Xiaojuan LIAO Shihong Xiao Ren Wang Jinbiao Cai Xuncheng Fan Yong Tan Dongjin He | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 17 | Two VOZ transcription factors link an E3 ligase and an NLR immune receptor to modulate immunity in rice显示文摘Nucleotide-binding leucine-rich repeat(NLR)proteins play critical roles in plant immunity.However,how NLRs are regulated and activate defense signaling is not fully understood.The rice(Oryza sativa)NLR receptor Piz-t confers broad-spectrum resistance to the fungal pathogen Magnaporthe oryzae and the RING-type E3 ligase AVRPIZ-T INTERACTING PROTEIN 10(APIP10)negatively regulates Piz-t accumulation.In this study,we found that APIP10 interacts with two rice transcription factors,VASCULAR PLANT ONEZINC FINGER 1(OsVOZ1)and OsVOZ2,and promotes their degradation through the 26S proteasome pathway.OsVOZ1 displays transcriptional repression activity while OsVOZ2 confers transcriptional activation activity in planta.The osvoz1 and osvoz2 single mutants display modest but opposite M.oryzae resistance in the non-Piz-t background.However,the osvoz1 osvoz2 double mutant exhibits strong dwarfism and cell death,and silencing of both genes via RNA interference also leads to dwarfism,mild cell death,and enhanced resistance to M.oryzae in the non-Piz-t background.Both OsVOZ1 and OsVOZ2 interact with Piz-t.Double silencing of OsVOZ1 and OsVOZ2 in the Piz-t background decreases Piz-t protein accumulation and transcription,reactive oxygen species-dependent cell death,and resistance to M.oryzae containing AvrPiz-t.Taken together,these results indicate that OsVOZ1 and OsVOZ2 negatively regulate basal defense but contribute positively to Piz-t-mediated immunity. | Jiyang Wang Ruyi Wang Hong Fang Chongyang Zhang Fan Zhang Zeyun Hao Xiaoman You Xuetao Shi Chan Ho Park Kangyu Hua Feng He Maria Bellizzi Kieu Thi Xuan Vo Jong-Seong Jeon Yuese Ning Guo-Liang Wang | 2021 | Molecular Plant2021，14，2： | 8 |
| 18 | Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China显示文摘Background:Gestational diabetes mellitus(GDM)brings health issues for both mothers and offspring,and GDM prevention is as important as GDM management.It was shown that a history of GDM was significantly associated with a higher maternal risk for GDM recurrence.The incidence of GDM recurrence was unclear because of the incidence of second-child was low before 2016 in China.We aim to investigate the prevalence of GDM recurrence and its associated high-risk factors which may be useful for the prediction of GDM recurrence in China.Methods:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research centers.All participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of GDM were analyzed further.All participants enrolled in the study had an oral glucose tolerance test(OGTT)result at 24 to 28 weeks and were diagnosed as GDM in the first pregnancy according to the OGTT value(when any one of the following values is met or exceeded to the 75-g OGTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of GDM recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were analyzed.Results:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of GDM and 5202 women(5202/6204,83.85%)without a history of GDM.There are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,P<0.001),pregnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BMI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),P<0.001),history of delivered macrosomia(22.7%vs.11.0%vs.6.2%,P<0.001)among the development of diabetes mellitus(DM),recurrence of GDM,and normal women.Moreover,it seems so important in the degree of abnormal glucose metabolism in the first pregnancy to the recurrence of GDM and the development of DM.There are significant differences in OGTT levels of the first pregnancy such as area under the curve of OGTT value(18.31±1.90 mmol/L vs.16.27±1.93 mmol/L vs.15.55±1.92 mmol/L,P<0.001),OGTT fasting value(5.43±0.48 mmol/L vs.5.16±0.49 mmol/L vs.5.02±0.47 mmol/L,P<0.001),OGTT 1-hour value(10.93±1.34 mmol/L vs.9.69±1.53 mmol/L vs.9.15±1.58 mmol/L,P<0.001),OGTT 2-hour value(9.30±1.66 mmol/L vs.8.01±1.32 mmol/L vs.7.79±1.38 mmol/L,P<0.001),incidence of impaired fasting glucose(IFG)(fasting plasma glucose≥5.6 mmol/L)(31.3%vs.14.6%vs.8.8%,P<0.001),and incidence of two or more abnormal OGTT values(68.8%vs.39.7%vs.23.9%,P<0.001)among the three groups.Using multivariate analysis,the factors,such as age(1.07[1.02-1.12],P=0.006),prepregnancy BMI(1.07[1.02,1.12],P=0.003),and area under the curve of OGTT in the first pregnancy(1.14[1.02,1.26],P=0.02),have an effect on maternal GDM recurrence;the factors,such as age(1.28[1.01-1.61],P=0.04),pre-pregnancy BMI(1.26[1.04,1.53],P=0.02),and area under the curve of OGTT in the first pregnancy(1.65[1.04,2.62],P=0.03),have an effect on maternal DM developed further.Conclusions:The history of GDM was significantly associated with a higher maternal risk for GDM recurrence during follow-up after the first pregnancy.The associated risk factors for GDM recurrence or development of DM include age,high pre-pregnancy BMI,history of delivered macrosomia,the OGTT level in the first pregnancy,such as the high area under the curve of OGTT,IFG,and two or more abnormal OGTT values.To prevent GDM recurrence,women with a history of GDM should do the preconception counseling before preparing next pregnancy. | Yumei Wei Juan Juan Rina Su Geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia Meng Yan Cai Cuilin Zhang Huixia Yang | 2022 | Chinese Medical Journal2022，，6： | 7 |
| 19 | Recent Progress and Development in Extrusion of Rare Earth Free Mg Alloys: A Review显示文摘Mg and its alloys are the lightest structural metals available and are extremely attractive for applications as lightweight components, particularly in the automobile, electronic, and aerospace industries. The global market for wrought Mg alloys has steadily expanded over the past decade. And numerous studies have been carried out to meet this increasing demand of high-performance Mg alloys. However, Mg extrusion alloys have had a very limited usage so far. To overcome existing industrial challenges, one desirable approach is the development of low-cost rare earth(RE) free Mg extrusion alloys with superior mechanical properties. This review will introduce the recent research highlights in the extrusion of Mg alloys, specifi cally focusing on low-cost RE-free Mg alloy. The results from both the literature and our previous study are summarized and critically reviewed. Several aspects of RE-free Mg extrusion alloys are described in detail:(1) novel alloying designs including Mg–Al-, Mg–Zn-, Mg–Ca-, Mg–Sn-, and Mg–Bi-based alloys,(2) advanced extrusion techniques, and(3) extrusion-related severe plastic deformation(SPD) processing. Accordingly, considering the large gap in mechanical properties between the current RE-free Mg alloys and high-performance aluminum alloys, new alloy design, processing route control, and recommendations for future research on RE-free Mg extrusion alloys are also proposed. We hope this review will not only off er insightful information regarding the extrusion of RE-free Mg alloys but also inspire the development of new Mg extrusion technologies. | Shuai-Ju Meng Hui Yu Shao-Da Fan Qi-Zhi Li Sung Hyuk Park Joung Sik Suh Young Min Kim Xiao-Long Nan Ming-Zhe Bian Fu-Xing Yin Wei-Min Zhao Bong Sun You Kwang Seon Shin | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，2： | 6 |
| 20 | Fano resonance boosted cascaded optical field enhancement in a plasmonic nanoparticle-in-cavity nanoantenna array and its SERS application显示文摘Cascaded optical field enhancement(CFE)can be realized in some specially designed multiscale plasmonic nanostructures,in which the generation of extremely strong fields at nanoscale volume is crucial for many applications,for example,surface-enhanced Raman spectroscopy(SERS).In this paper,we propose a strategy for realizing a high-quality plasmonic nanoparticle-in-cavity(PIC)nanoantenna array,in which strong coupling between a nanoparticle(NP)dark mode with a high-order nanocavity bright mode can produce strong Fano resonance at the target wavelength.The Fano resonance can effectively boost the CFE in a PIC.A cost-effective and reliable nanofabrication method is developed using room temperature nanoimprinting lithography to manufacture high-quality PIC arrays.This technique guarantees the generation of only one gold NP at the bottom of each nanocavity,which is crucial for the generation of the expected CFE.To demonstrate the performance and application of the PIC array,the PIC array is employed as an active SERS substrate for detecting 4-aminothiophenol molecules.An experimental SERS enhancement factor of 2×10^(7) is obtained,which verifies the field enhancement and the potential of this device. | Zhendong Zhu Benfeng Bai Oubo You Qunqing Li Shoushan Fan | 2015 | Light(Science & Applications)2015，4，1： | 5 |
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