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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Detection of asymmetric giaucomatous damage using automated pupillography, the swinging flashlight method and the magnified-assisted swinging flashlight method 显示文摘 | WAISBOURD M LEE B ALI MH LU L MARTINEZ P FARIA B | 2015 | Eye (Lond)2015，29，10： | 1 |
| 3 | Cell-assisted lipo- transfer显示文摘 | Sterodimas A de Faria J Nicaretta B | 2010 | Aesthet Surg J2010，30，1： | 1 |
| 4 | The linear programming approach to approximate dynamic programming显示文摘 | De Farias D P Van Roy B | 2003 | Operations Research2003，51，6： | 1 |
| 5 | A Theoretical Analysis of the Bifurcated Fiber Bundle Displacement Sensor显示文摘 | Faria J B | 1998 | IEEE Transactions on Instrumentation and Measurement1998，47，3： | 1 |
| 6 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 7 | Symp tomatic retrograde arterial thrombosis A rare complication af ter microsurgical removal of cerebral arteriovenous malforma tions显示文摘 | Costa B L Faria M H G Lopes J L | 2013 | Clinical Neurology and Neurosurgery2013，115，： | 1 |
| 8 | Scheimpflug - based tomography and biomechanical assessment in pressure - induced stromal keratopathy 显示文摘 | Faria - Correia F Ramos I Valbon B | 2013 | J Refract Surg2013，29，5： | 1 |
| 9 | A theoretical analysis of the bifurcated fiber bundle displacement sensor显示文摘 | Faria J B | 1998 | IEEE Transactions on Instrumentation and Measurement1998，47，3： | 1 |
| 10 | Groundwater arsenic in the Chacopampean Plain,Argentina: Case study from Robles county,Santiago del Estero Province显示文摘 | Bundschuh J Farias B Martin R | 2004 | Applied Geochemistry2004，19，： | 1 |
| 11 | Prevalence of anti Toxoplasma gondii and anti-Neospora caninum antibodies in goats slaughtered in the public slaughterhouse of Paros city, Paraliba State, Northeast region of Brazil显示文摘 | Faria E B Gennari S M Pena H F J | 2007 | Veterinary Parasitology2007，149，： | 1 |
| 12 | Uhrasonographic differentiation between metastatic and benign lymphnodes in patients with papillary thyroid carcinoma显示文摘 | Rosario PW de Faria S B icalho L | 2005 | J Ultrasound Med2005，24，10： | 1 |
| 13 | Genetic diversityof Brazilian pig breeds evidenced by microsatellitemarkers 显示文摘 | Sollero B P Paiva S R Faria D A | 2009 | Livest Sci2009，123，1： | 1 |
| 14 | Adsorptive striooing voltammetric behavior of UO2(II) complexed with the Schiff base N, N-prime-ethylenebis in 4-( 2-hydrox- ygthyl)-1-piperazine ethanesulfonic acid medium显示文摘 | Bastod M B R Moreira J C Farias P A M | 2000 | Anal Chim Acta2000，408，1： | 1 |
| 15 | A theoretical analysis of the bifurcated fiber bundle displacement sensor显示文摘 | FARIA J B | 1998 | IEEE Transac- tions on Instrumentation and Measurement1998，47，3： | 1 |
| 16 | Structural phase transitions and unusual melting behavior in a classical twodimensional Coulomb bound cluster显示文摘 | Ferreira W P Partoens B Peeters F M Farias G A | 2005 | Phys Rev E2005，71，02： | 1 |
| 17 | Genetic diversity of Brazilian pig breeds evidenced by microsatellite markers显示文摘 | SOLLERO B P PAIVA S R FARIA D A | | 0，，01： | 1 |
| 18 | Driving force distillation and exergy loss in the thermodynamic analysis of distillation columns 显示文摘 | ZEMP R J DE FARIA S H B DE L OLIVEIRA MAIA M | 1997 | Comp Chem Eng1997，，： | 1 |
| 19 | Adsorptive stripping voltammetric behaviour of UO2 (Ⅱ) complexed with the Schiff base N , N - prime - ethylenebis (salicylidenimine) in aqueous 4 - (2 - hydroxyethy) - 1 - piperazme ethanesulfonic acid medium 显示文摘 | Bastos M B R Moreira J C Farias P A M | 2000 | Analytica Chimica Acta2000，408，： | 1 |
| 20 | Adsorptive stripping voltammetric behaviour of UO2 (II) complexed with the Schiff base N,N-prime-ethylenebis (salicylidenimine) in aqueous 4-(2-hydroxyethy)-1-piperazine ethanesulfonic acid medium显示文摘 | Bastos M B R Moreira J C Farias P A M | 2000 | Analytica Chimica Acta2000，408，： | 1 |
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