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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 3 | Atherosclerosis imaging using 3D black blood TSE SPACE vs 2D TSE显示文摘AIM: To compare 3D Black Blood turbo spin echo(TSE)sampling perfection with application-optimized contrast using different flip angle evolution(SPACE) vs 2D TSE in evaluating atherosclerotic plaques in multiple vascular territories. METHODS: The carotid, aortic, and femoral arterial walls of 16 patients at risk for cardiovascular or atherosclerotic disease were studied using both 3D black blood magnetic resonance imaging SPACE and conventional 2D multi-contrast TSE sequences using a consolidated imaging approach in the same imaging session. Qualitative and quantitative analyses were performed on the images. Agreement of morphometric measurements between the two imaging sequences was assessed using a two-sample t-test, calculation of the intra-class correlation coefficient and by the method of linear regression and Bland-Altman analyses. RESULTS: No statistically significant qualitative differences were found between the 3D SPACE and 2D TSE techniques for images of the carotids and aorta. For images of the femoral arteries, however, there were statistically significant differences in all four qualitative scores between the two techniques. Using the current approach, 3D SPACE is suboptimal for femoral imaging. However, this may be due to coils not being optimized for femoral imaging. Quantitatively, in our study, higher mean total vessel area measurements for the 3D SPACE technique across all three vascular beds were observed. No significant differences in lumen area for both the right and left carotids were observed between the two techniques. Overall, a significant-correlation existed between measures obtained between the two approaches. CONCLUSION: Qualitative and quantitative measurements between 3D SPACE and 2D TSE techniques are comparable. 3D-SPACE may be a feasible approach in the evaluation of cardiovascular patients. | Stephanie K Wong Motunrayo Mobolaji-Iawal Leron Arama Joy Cambe Sylvia Biso Nadia Alie Zahi A Fayad Venkatesh Mani | 2014 | World Journal of Radiology2014，6，5： | 3 |
| 4 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 5 | Review of radiographic findings in COVID-19显示文摘The purpose of this study is to review the published literature for the range ofradiographic findings present in patients suffering from coronavirus disease 2019infection. This novel corona virus is currently the cause of a worldwide pandemic.Pulmonary symptoms and signs dominate the clinical picture and radiologists arecalled upon to evaluate chest radiographs (CXR) and computed tomography (CT)images to assess for infiltrates and to define their extent, distribution andprogression. Multiple studies attempt to characterize the disease course bylooking at the timing of imaging relative to the onset of symptoms. In general,plain CXR show bilateral disease with a tendency toward the lung periphery andhave an appearance most consistent with viral pneumonia. Chest CT images aremost notable for showing bilateral and peripheral ground glass and consolidatedopacities and are marked by an absence of concomitant pulmonary nodules,cavitation, adenopathy and pleural effusions. Published literature mentioningorgan systems aside from pulmonary manifestations are relatively less common,yet present and are addressed in this review. Similarly, publications focusing onimaging modalities aside from CXR and chest CT are sparse in this evolving crisisand are likewise addressed in this review. The role of imaging is examined as it iscurrently being debated in the medical community, which is not at all surprisingconsidering the highly infectious nature of Severe Acute Respiratory Syndromecoronavirus 2. | Audrey E Kaufman Sonum Naidu Sarayu Ramachandran Dalia S Kaufman Zahi A Fayad Venkatesh Mani | 2020 | World Journal of Radiology2020，12，8： | 2 |
| 6 | Multifunctional gold nanoparticles for diagnosis and therapy of disease显示文摘 | MIESZAWSKA A J MULDER W J M FAYAD Z A | 2013 | Molecular pharmaceutics2013，10，3： | 1 |
| 7 | Contrast enhancement by multi-scale adaptive histogram equalization显示文摘 | Jin Yingpeng Fayad L Laine A | 2001 | SPIE proceedings series2001，4478，1： | 1 |
| 8 | Inracochlear glandular schwannoma显示文摘 | Fayad JN Markaryan A Linthicum FH | 2011 | Otolaryngol Head Neck Surg2011，144，6： | 1 |
| 9 | Inflammation,Atherosclerosis,and Coronary Artery Disease:PET/CT for the Evaluation of Atherosclerosis and Inflammation显示文摘 | Alie N Eldib M Fayad Z A | 2014 | Clin Med Insights Cardiol2014，8，3： | 1 |
| 10 | High rate of durable remissions after treatment of newly diagnosed ag- gressive mantle - cell lymphoma with rituximab plus hyper - CVAD alternating with rituximab plus high - dose methotrexate and cytara- bine显示文摘 | ROMAGUERA J E FAYAD L RODRIGUEZ M A | 2005 | J Clin Oncol2005，23，28： | 1 |
| 11 | A land surface zoning approach based on three-component risk criteria for groundwater quality protection 显示文摘 | Fadlelmawla A A Fayad M E1-Gamily H | 2011 | Water Resources Management2011，25，6： | 1 |
| 12 | Surgery for intracerebral hemorrhage 显示文摘 | Fayad P B Awad I A | 1998 | Neurolgy1998，，： | 1 |
| 13 | Intensification of Sta- tin Therapy Results in a Rapid Reduction in Atherosclerotic In- flammationResults of a Multicenter Fluorodeoxyglucose-Posi- tron Emission Tomography/Computed Tomography Feasibility Study显示文摘 | Tawakol A Fayad Z A Mogg R | 2013 | Journal of the American College of Cardiology2013，62，10： | 1 |
| 14 | Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques: a 2-year follow-up by noninvasive MRI显示文摘 | Yonemura A Momiyama Y Fayad ZA | 2009 | Eur J Cardiovasc Prev Rehabil2009，16，： | 1 |
| 15 | Clearance of iron oxide particles in rat liver: effect of hydrated particle size and coating material on liver metabolism 显示文摘 | Bjornerud A Fayad ZA Ahlstrom HK | 2006 | Invest Radiol2006，41，7： | 1 |
| 16 | 应激相关的神经生物学途径参与社会经济差异和心血管病的关联显示文摘社会经济地位(socioeconomic status,SES)较低与主要不良心脏事件(major adverse cardiac events,MACE)风险较高相关,其机制尚不清楚。由于社会心理压力在低SES患者中更为普遍,该研究检验了这一假设,即应激相关的神经生物学途径(包括上调相关的炎症因子)介导了低SES和MACE之间的相关性。研究共纳入没有已知的心血管病或活动期癌症的受试者509例,年龄中位数55岁(四分位数间距45~66岁),接受临床指示的全身18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描成像。 | 刘青(译) 叶鹏(审校) Tawakol A Osborne MT Wang Y Hammed B Tung B Patrich T Oberfeld B Ishai A Shin LM Nahrendorf M Warner ET Wasfy J Fayad ZA Koenen K R idker PM Pitman RK Armstrong KA | 2019 | 中华高血压杂志2019，27，8： | 1 |
| 17 | Dose-related safety and immunogenicity of baculovirus - expressed trivalent influenza vaccine: a double-blind, controlled trial in adult patients with non- Hodgkin B cell lymphoma显示文摘 | Safdar A Rodriguez MA Fayad LE | 2006 | J Infect Dis2006，194，10： | 1 |
| 18 | Associations between plasma c-reactive protein levels and the severities of coronary and aortic atherosclerosis显示文摘 | Momiyama Y Ohmori R Fayad Z A | 2010 | J Atheroscler Thromb2010，17，5： | 1 |
| 19 | A rational approach to the ionothermal synthesis of an A1PO4 molecular sieve with an LTA-type framework 显示文摘 | Fayad E J Bats N Kirsehhk C E A | 2010 | Angewandte Chemie-Intemational Edi- tion2010，49，56： | 1 |
| 20 | Efficacy,tolerability, and kinetics of lamotrigine in infants 显示文摘 | Mikati M A Fayad M Koleilat M | 2002 | J Pediatr2002，141，1： | 1 |
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