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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Prepara- tion and characterization of foams from sheet glass and fly ash using carbonates as foaming agents 显示文摘 | Fernandes H R Tulyaganov D U Ferreira J M F | 2009 | Ceram Int2009，35，1： | 1 |
| 3 | Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction显示文摘 | Sordi R Fernandes D Heckert BT | 2011 | Br J Pharmaco12011，163，6： | 1 |
| 4 | Environmental friendly management of CRT glass by foaming with waste egg shells, calcite or dolomite 显示文摘 | Fernandes H R Ferreira D D Andreola F | 2014 | Ceramics International2014，40，13： | 1 |
| 5 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 6 | Thermal analysis of the defrost cycle in a domestic freezer显示文摘 | Bansal B Fothergill D Fernandes R | 2010 | International Journal of Refrigeration2010，33，3： | 1 |
| 7 | Mo?lecular phy logenetics and biogeography of Pollicipes (Crustacea: Cirripedia), a Tethyan relict显示文摘 | VanSyoc R J Fernandes J N Carrison D A et a1 | 2010 | Elsevier2010，392，： | 1 |
| 8 | A GIS-based tool for stor- age, selection and visualization of time series 4D marine datasets 显示文摘 | FERNANDES R N VALAVANIS V D | 2008 | Hydrobiologia2008，612，1： | 1 |
| 9 | Instantaneous sequence-component resolution of 3-phase variables and its application to dynamic voltage restoration显示文摘 | Fernandes D A Naidu S R Coura C A E | 2009 | IEEE Transactions on Instrumentation andMeasurement2009，58，8： | 1 |
| 10 | Dynamic modelling and simulation of a cogeneration system integrated with a salt recrystallization process 显示文摘 | Moita R D Matos H A Fernandes C | 2005 | Computers & Chemical Engineering2005，29，6： | 1 |
| 11 | Influence of blending soybean, sunflower, colza, corn, cottonseed, and residual cooking oil methyl biodiesels on the oxidation stability 显示文摘 | Serqueira D S Fernandes D M Cunha R R | 2014 | Fuel2014，118，： | 1 |
| 12 | Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model显示文摘 | Fernandes D Sordi R Pacheco LK | 2009 | J Pharmacol Exp Ther2009，328，3： | 1 |
| 13 | Early potassium channelblockade improves sepsis-induced organ damage and cardiovasculardysfunction 显示文摘 | Sordi R Fernandes D He<-kert BT | 2011 | Br J Pharmacol2011，163，6： | 1 |
| 14 | Universal correlation of self-diffusion coefficients of model and real fluids based on residual entropy scaling law 显示文摘 | VAZ R V MAGALHAES A L FERNANDES D L A | 2012 | Chemical Engineering Science2012，79，： | 1 |
| 15 | Replacement of fish meal by plant protein sources up to 75% induces good growth performance without affecting flesh quality in ongrowing Senegalese sole 显示文摘 | CABRAL E M FERNANDES T J R CAMPOS S D | 2013 | Aquaculture2013，，： | 1 |
| 16 | Time-dependent effects of training on cardiovascular control in sponta- neously hypertensive rats: role for brain oxidative stress and inflammation and baroreflex sensitivity显示文摘 | Masson G S Costa T S Yshii L Fernandes D C Soares P P Laurindo F R | 2014 | PLoS One2014，9，94： | 1 |
| 17 | Nanostructured polyaniline thin films as pH sensing membranes in FET-based devices 显示文摘 | Vieira N C S Fernandes E G R Faceto A D | 2011 | Sensors and Aetuators B2011，160，： | 1 |
| 18 | Changes in lipid content and fatty acid composition along the reproductive cycle of the freshwater mussel Dreissena polymorpha: its modulation by clofibrate exposure显示文摘 | Lazzara R Fernandes D Faria M | 2012 | Science of the Total Environment2012，432，： | 1 |
| 19 | Latin American Applied Research 显示文摘 | Carvalho D A Bezerra-Rocha J H Fernandes N S Dasilva D R Martinez-Huitle C A | 2011 | 41 :1272011，41，： | 1 |
| 20 | Using gas pipeline pressure to liquefy natural gas or generate electricity 显示文摘 | Shen D M Fernandes F Simoes - moreira J R | 2006 | Gas Processing Developments2006，85，1： | 1 |
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