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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Prepara- tion and characterization of foams from sheet glass and fly ash using carbonates as foaming agents 显示文摘 | Fernandes H R Tulyaganov D U Ferreira J M F | 2009 | Ceram Int2009，35，1： | 1 |
| 4 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 5 | Room temperature PL characterization of micro and nanocrystalline diamond grown by MPCVD from Ar/H2/CH4 mixtures 显示文摘 | NET() M A FERNANDES A J S SILVA R F | 2007 | Vacuum2007，81，： | 1 |
| 6 | Impact of EGFR genet- ic vanriants on glima risk and patient outcome显示文摘 | Costa BM Viana-pereia M Fernandes R | 2011 | Cance Epidermiol Biomarkers2011，20，12： | 1 |
| 7 | Short-term clinical of peel-off facial mask moisturizers显示文摘 | Velasco M V R Vieira R P Fernandes A R | 2014 | International Jour- nal of Cosmetic Science2014，36，： | 1 |
| 8 | Methodology comparison for canopy structure parameters extraction from digital hemispherical photography in boreal forests显示文摘 | Leblanc S G Chen J M Fernandes R | 2005 | Agricultural and Forest Meteorology2005，129，： | 1 |
| 9 | Treatment of human monocytes with interleukin(IL)-18 increases TLR4 and mannose receptor expression and modulates cytokine production显示文摘 | Dias-Melicio L A Fernandes R K Golim M A | | 0，，1： | 1 |
| 10 | Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal显示文摘 | Fernandes J V Meissner R de V Carvalho M G | 2011 | Brazil Mol Med Rep2011，4，6： | 1 |
| 11 | The effects of the sumter wastewater treatment plant on the survival and reproduction of Ceriodaphnia dubia in chronic toxicity tests 显示文摘 | WORLEY E FERNANDES P R HARMON S M | 2010 | Journal of the South Carolina Academy of Science2010，8，1： | 1 |
| 12 | Design of a Steam - heated Sterilizer Based on Finite Element Method Stress Analysis显示文摘 | R M Natal Jorge A A Fernandes | 2001 | International Journal of Pressure Vessels and Piping2001，78，： | 1 |
| 13 | Effects of Si speciation on the in vitro evaluation of bioactivity of glasses显示文摘 | OLIVERIRA J M CORREIA R N FERNANDES M H | 2002 | Biomaterials2002，23，2： | 1 |
| 14 | Pentacyclic triterpenes from Chrysobalanaceae species: cytotoxiccity on multidrug resistant and sensitive leukemia cell lines显示文摘 | Fernandes J Castilho R O da Costa M R | 2003 | Cancer Lett2003，190，2： | 1 |
| 15 | The effect of an infusion of esmolol on the incidence of myocardial ischaemia during tracheal extubation following coronary artery surgery显示文摘 | Kurian S M Evans R Fernandes N O | 2001 | Anaesthesia2001，56，12： | 1 |
| 16 | Surgical removal of small petroclival meningiomas显示文摘 | Ramina R Neto M C Fernandes Y B | 2008 | Acta Neurochir (Wien)2008，150，4： | 1 |
| 17 | The influence of sea- sonal signals on the estimation of the tectonic motion in short continuous GPS time-series 显示文摘 | Bos M S Bastos L Fernandes R M S | 2010 | Journal of Geodynamics2010，49，3： | 1 |
| 18 | Influence of blending soybean, sunflower, colza, corn, cottonseed, and residual cooking oil methyl biodiesels on the oxidation stability 显示文摘 | Serqueira D S Fernandes D M Cunha R R | 2014 | Fuel2014，118，： | 1 |
| 19 | Study of sintering variables of tungsten carbide particles sputter-deposited with stainless steel显示文摘 | Fernandes C M Senos A M R Vieira M T | 2004 | Materials Science Forum2004，455，1： | 1 |
| 20 | Estabilidade Fisico-qutmica,Mierobiol6giea E Sensorial De Came Ovina Embalada a Vaeuo Estocada Sob Refrigeraqao 显示文摘 | FERNANDES R P P FREIRE M T A GUERRA C C G | 2012 | Ciencia Rural Santa Maria2012，42，4： | 1 |
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