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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A connection between orthogonal polynomials on the unit circle and matrix orthogonal polynomials on the real line显示文摘 | M J Cantero M P Ferrer L Moral L Velazquez | 2003 | Journal of Computational and Applied Mathematics2003，154，2： | 1 |
| 3 | Cephalexin Residue Detection in Milk and Beef by ELISA and Colloidal Gold Based One Step Strip Assay显示文摘 | Chen L B Wang Z F Ferrer M | 2009 | Agric Food Chem2009，，57： | 1 |
| 4 | Study of cross-reactivity between proton pump inhibitors显示文摘 | Sobrevia Elfau MT Garces Sotillos M Ferrer Claveria L | 2010 | J Investig Allergol Clin Immunol2010，20，2： | 1 |
| 5 | Spectral discrimination of wild oat and canary grass in wheat fields for less herbicide application显示文摘 | Gomez-Casero M T Castillejo-Gonzalez I L Garcia- Ferrer A | 2010 | Agronomy for Sustainable Development2010，30，3： | 1 |
| 6 | Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis 显示文摘 | Ferrer J L Jez J M Bowman M E | 1999 | Nat Struct Biol1999，6，： | 1 |
| 7 | Exploratory study on the production of coconut sugar in Quezon Province, Philippines (a research note)显示文摘 | Ledesma V T M Ferrer M L M Carandang E V | 1993 | Philippine Journal of Coconut Studies(Philippines)1993，18，1： | 1 |
| 8 | Random amplified polymorphic DNA and amplified fragment length polymorphism assessment of genetic variation in Nicaraguan populations of Pinus oocarpa 显示文摘 | DIAZ V MUHIIZ L M FERRER E | 2001 | Molecular Ecology2001，10，： | 1 |
| 9 | Dissection of malonyl-coenzyme a decarboxylation from polyketide for marion in the reaction mechanism of a plant polyketide synthase显示文摘 | JEZ J M FERRER J L BOWMAN M E DIXON R A NOEL J P | 2000 | Biochemistry2000，39，5： | 1 |
| 10 | Imaging of the spleen in malaria 显示文摘 | Ferrer M Martin-Jaular L De Niz M | 2014 | Parasitol Int2014，63，： | 1 |
| 11 | Flow-through optical fiber sensor for automatic sulfide determination in waters by muhisyringe flow injection analysis using solid-phase reflectometry显示文摘 | FERRER L DE ARMAS G MIRO M | 2005 | Analyst2005，130，： | 1 |
| 12 | Intensive care adult patients with severe respiratory failure caused by influenza A(H1N1)v in Spain显示文摘 | Rello J Rodríguez A Ibaez P Socias L Cebrian J Marques A Guerrero J Ruiz-Santana S Marquez E Del Nogal-Saez F Alvarez-Lerma F Martínez S Ferrer M Avellanas M Granada R Maraví-Poma E Albert P SierraR Vidaur L Ortiz P Prieto del Portillo I Galván B León-Gil C H1N1SEMICYUC Working Group | 2009 | Crit Care2009，13，5： | 1 |
| 13 | Structure of chalcone syn- thase and the molecular basis of plant polyketide biosynthesis 显示文摘 | Ferrer J L Jez J M Bowman M E | 1999 | Nat Struct Biol1999，6，： | 1 |
| 14 | Cloning and characterizationof resistance gene analogs from Avena species 显示文摘 | Irigoyen M L Ferrer E Loarce Y | 2006 | Genome2006，49，1： | 1 |
| 15 | Structure of chalcone syn- thas e and the molecular basis of plant Polyketide biosynthesis 显示文摘 | FERRER J L JEZ J M BOWMAN M E | 1999 | Nat Struct Bio11999，6，8： | 1 |
| 16 | Structure and func-tion of enzymes involved in the biosynthesis of phenylpro-panoids 显示文摘 | Ferrer J L Austin M B Stewart J C | 2008 | Plant Physiology and Biochemistry2008，46，3： | 1 |
| 17 | Overexpression of semicarbazide sensitive amine oxidase in the cerebral blood vessels in patients with Alzheime's disease and cerebral aautosom al dom inant arteriopathy withsubcortical infarcts and leukoencephalopathy显示文摘 | Ferrer L Lizcano JM Hernandez M | 2002 | Neuroscience Letters2002，321，3： | 1 |
| 18 | Nosocomial Legionnaire's disease in a children's hospital 显示文摘 | CAMPINS M FERRER A CALLIS L | 2000 | Pediatr Infect Dis J2000，19，3： | 1 |
| 19 | Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry:methods and preliminary results including toxicity studies with Vibrio fischeri显示文摘 | FarréM L Ferrer I Ginebreda A | 2001 | Journal of Chromatography A2001，938，12： | 1 |
| 20 | Changes in immunoglobulim livels following adenoidectomy and tonsillectomy显示文摘 | Amoro S Sebastie L I Ferrer Ramirez M J | 2004 | ActaOtorrinolaringoiEsp2004，55，9： | 1 |
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