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| 1 | Aetiology and mechanisms of injury in medial tibial stress syndrome: Current and future developments显示文摘Medial tibial stress syndrome(MTSS) is a debilitating overuse injury of the tibia sustained by individuals whoperform recurrent impact exercise such as athletes and military recruits. Characterised by diffuse tibial anteromedial or posteromedial surface subcutaneous periostitis, in most cases it is also an injury involving underlying cortical bone microtrauma, although it is not clear if the soft tissue or cortical bone reaction occurs first. Nuclear bone scans and magnetic resonance imaging(MRI) can both be used for the diagnosis of MTSS, but the patient's history and clinical symptoms need to be considered in conjunction with the imaging findings for a correct interpretation of the results, as both imaging modalities have demonstrated positive findings in the absence of injury. However, MRI is rapidly becoming the preferred imaging modality for the diagnosis of bone stress injuries. It can also be used for the early diagnosis of MTSS, as the developing periosteal oedema can be identified. Retrospective studies have demonstrated that MTSS patients have lower bone mineral density(BMD) at the injury site than exercising controls, and preliminary data indicates the BMD is lower in MTSS subjects than tibial stress fracture(TSF) subjects. The values of a number of tibial geometric parameters such as cross-sectional area and section modulus are also lower in MTSS subjects than exercising controls, but not as low as the values in TSF subjects. Thus, the balance between BMD and cortical bone geometry may predict an individual's likelihood of developing MTSS. However, prospective longitudinal studies are needed to determine how these factors alter during the development of the injury and to find the detailed structural cause, which is still unknown. Finite element analysis has recently been used to examine the mechanisms involved in tibial stress injuries and offer a promising future tool to understand the mechanisms involved in MTSS. Contemporary accurate diagnosis of either MTSS or a TSF includes a thorough clinical examination to identify signs of bone stress injury and to exclude other pathologies. This should be followed by an MRI study of the whole tibia. The cause of the injury should be established and addressed in order tofacilitate healing and prevent future re-occurrence. | Melanie Franklyn Barry Oakes | 2015 | World Journal of Orthopedics2015，6，8： | 7 |
| 2 | 由纵波和转换波资料估计横波速度显示文摘<正> Tessmer和Behle(1988)指出,如果能获得正常的P波和转换波(P-SV)资料,就可以从地面地震资料估计横波速度。Tessmer和Behle关系式为 V_(sv)=V_(p-sv)~2/V_p (1)式中,V_(sv)为横波速度,V_p,为纵波速度,y_(p-sv)为转换波速度。公式(1)是用来求随深度改变的速度的,转换波资料的增长部分对公式(1)的有效性提供了主要的验证。 | Franklyn K.Levin 张仪宁 | 1999 | 石油物探译丛1999，，5： | 6 |
| 3 | Non-AIDS definings malignancies among human immunodeficiency virus-positive subjects: Epidemiology and outcome after two decades of HAART era显示文摘Highly active antiretroviral therapy(HAART) for humanimmunodeficiency virus(HIV) infection has been widely available in industrialized countries since 1996; its widespread use determined a dramatic decline in acquired immunodeficiency syndrome(AIDS)-related mortality, and consequently, a significant decrease of AIDS-defining cancers. However the increased mean age of HIV-infected patients, prolonged exposure to environmental and lifestyle cancer risk factors, and coinfection with oncogenic viruses contributed to the emergence of other malignancies that are considered non-AIDS-defining cancers(NADCs) as a relevant fraction of morbidity and mortality among HIV-infected people twenty years after HAART introduction. The role of immunosuppression in the pathogenesis of NADCs is not well defined, and future researches should investigate the etiology of NADCs. In the last years there is a growing evidence that intensive chemotherapy regimens and radiotherapy could be safely administrated to HIV-positive patients while continuing HAART. This requires a multidisciplinary approach and a close cooperation of oncologists and HIV-physicians in order to best manage compliance of patients to treatment and to face drug-related side effects. Here we review the main epidemiological features, risk factors and clinical behavior of the more common NADCs, such as lung cancer, hepatocellular carcinoma, colorectal cancer and anal cancer, Hodgkin's lymphoma and some cutaneous malignancies, focusing also on the current therapeutic approaches and preventive screening strategies. | Pierluigi Brugnaro Erika Morelli Francesca Cattelan Andrea Petrucci Sandro Panese Franklyn Eseme Francesca Cavinato Andrea Barelli Enzo Raise | 2015 | World Journal of Virology2015，4，3： | 4 |
| 4 | Experimental and finite element analysis of tibial stress fractures using a rabbit model显示文摘AIM: To determine if rabbit models can be used to quantify the mechanical behaviour involved in tibial stress fracture(TSF) development.METHODS: Fresh rabbit tibiae were loaded under compression using a specifically-designed test apparatus. Weights were incrementally added up to a load of 30 kg and the mechanical behaviour of the tibia was analysed using tests for buckling, bone strain and hysteresis. Structural mechanics equations were subsequently employed to verify that the results were within the range of values predicted by theory. A finite element(FE) model was developed using cross-sectional computer tomography(CT) images scanned from one of the rabbit bones, and a static load of 6 kg(1.5 times the rabbit's body weight) was applied to represent running. The model was validated using the experimental strain gauge data, then geometric and elemental convergence tests were performed in order to find the minimum number of cross-sectional scans and elements respectively required for convergence. The analysis was then performed using both the model and the experimental results to investigate the mechanical behaviour of the rabbit tibia under compressive load and to examine crack initiation.RESULTS: The experimental tests showed that un der a compressive load of up to 12 kg, the rabbit tibia demonstrates linear behaviour with little hysteresis Up to 30 kg, the bone does not fail by elastic buckling however, there are low levels of tensile stress which predominately occur at and adjacent to the anterio border of the tibial midshaft: this suggests that fatigue failure occurs in these regions, since bone under cycli loading initially fails in tension. The FE model predic tions were consistent with both mechanics theory and the strain gauge results. The model was highly sensi tive to small changes in the position of the applied load due to the high slenderness ratio of the rabbit s tibia. The modelling technique used in the curren study could have applications in the development o human FE models of bone, where, unlike rabbit tibia the model would be relatively insensitive to very sma changes in load position. However, the rabbit mode itself is less beneficial as a tool to understand the me chanical behaviour of TSFs in humans due to the sma size of the rabbit bone and the limitations of human scale CT scanning equipment.CONCLUSION: The current modelling technique could be used to develop human FE models. However, the rabbit model itself has significant limitations in under standing human TSF mechanics. | Melanie Franklyn Bruce Field | 2013 | World Journal of Orthopedics2013，4，4： | 3 |
| 5 | 基于BSIM深亚微米级MOSFET短沟道效应建模和特征提取方法研究显示文摘本文基于BSIM标准研究了现代深亚微米级MOSFET器件的建模和特征提取方法 ,着重在于短沟道效应方面 ,其中测试样品由MicronTM公司提供 ,最短沟道长度仅为 0 16微米 .内容包括一般短沟道效应、基板效应和漏极感应势垒降低效应 (简称DIBL效应 )等 .研究表明 ,实验数据和BSIM模型结果较好吻合 ,证明文中方法的有效性以及较好的应用前景 . | 赵阳 Parke Stephen Burke Franklyn | 2004 | 电子学报2004，32，5： | 2 |
| 6 | Rethinking Global Health Governance in a Changing World Order for Achieving Sustainable Development:The Role and Potential of the'Rising Powers'显示文摘The idea of this paper is inspired by the dismal experience and lessons from the initially ineffective global(WHO-led)response to the 2014-2016 West African Ebola virus epidemic.It charts the evolution of global health policy and governance in the post-World War II international order to the current post-2015 UN Sustainable Development Goals era.In order to respond adequately existing and emerging health and development challenges across developing regions,the paper argues that global health governance and related structures and institutions must adapt to changing socio-economic circumstances at all levels of decision-making.Against the background of a changing world order characterised by the decline of US-led Western international liberalism and the rise of the emerging nations in the developing world,it identifies the 4 Rising Powers'(RPs)among the emerging economies and their soft power diplomacy and international development cooperation strategy as important tools for responding to post-2015 global health challenges.Based on analysis of illustrative examples from the'BRICS;a group of large emerging economies-Brazil,Russia,India,China and South Africa-the paper develops suggestions and recommendations for the RPs with respect to:(1)stimulating innovation in global health governance and(2)strengthening health systems and health security at country and regional levels.Observing that current deliberations on global health focus largely,but rather narrowly,on what resource inputs are needed to achieve the SDG health targets,this paper goes further and highlights the importance of the in terms of a leadership and driving role for the RPs:How can the RPs champion global governance reform and innovation aimed at producing strong,resilient and equitable global systems?How can the RPs use soft power diplomacy to enhance disease surveillance and detection capacities and to promote improved regional and international coordination in response to health threats?How can they provide incentives for investment in R&D and manufacturing of medicines to tackle neglected and poverty-related diseases in developing countries? | Franklyn Lisk Annamarie Bindenagel Sehovic | 2020 | Fudan Journal of the Humanities and Social Sciences2020，13，1： | 2 |
| 7 | Pituitary tumor transforming gene regulates multiple downstream angiogenic genes in thyroid cancer显示文摘 | KIM D S FRANKLYN J A STRATFORD A L | 2006 | J Clin Endocrinol Metab2006，91，3： | 1 |
| 8 | Detection and surgical treatment of cervical lymph nodes in differentiated thyroid cancer显示文摘 | Watkinson JC Franklyn JA Olliff JF | 2006 | Thyroid2006，16，2： | 1 |
| 9 | Aging of the adult human brain:in vivo quantitation of metabolite content with proton magnetic resonance spectroscopy显示文摘 | Dawn E Saunders MD Franklyn A | 1999 | JMRI1999，5，： | 1 |
| 10 | Pituitary tumor transfor- ming gene (PTTG) stimulates thyroid cell proliferation via a vas- crlar endothelial growth factor/kinase insert domain receptor/inhib- itor of DNA binding-3 autocrine pathway 显示文摘 | Kim DS Franklyn JA Boelaert K | 2006 | J Clin Endocrinol Metab2006，91，11： | 1 |
| 11 | The management of hyperthyroidism显示文摘 | Franklyn JA | 1994 | N Engl J Med1994，330，： | 1 |
| 12 | Innovation, Marketing Stratege, Environment and Performance 显示文摘 | Franklyn Manu Ven Sriram | 1996 | Journal of Business Research1996，35，3： | 1 |
| 13 | Long-teen follow-up of treatment of thyrotoxicosis by three different methods 显示文摘 | Franklyn JA Daykin J Drolc Z | 1991 | Clinical Endocrinnlngy1991，34，： | 1 |
| 14 | Management guidelines for hyperthyroidism 显示文摘 | Franklyn JA | 1997 | Clin Endoeri Met1997，11，3： | 1 |
| 15 | Prevalence and follow-up of abnormal thyrotropin (TSH) concentrations in the elderly in the United Kingdom显示文摘 | Parle JV Franklyn JA Cross KW | 1991 | Clin Endocrinol(Oxf)1991，34，11： | 1 |
| 16 | Thyroid hormone receptor expression in the 'sick euthyroid' syndrome显示文摘 | Williams GR Franklyn JA Neuberger JM | 1989 | Lancet1989，2，： | 1 |
| 17 | Detection and surgical treatment of cervical lymph nodes in differentiatedthyroid cancer显示文摘 | Watkinson JC Franklyn JA Olliff JF | 2006 | Thyroid2006，16，2： | 1 |
| 18 | Thyroid hormone receptor expression in the 'sick euthyroid' syndrome 显示文摘 | Williams GR Franklyn JA Neuberger JM | 1989 | Lance1989，2，： | 1 |
| 19 | Application of magnetic resonance neurography in the evaluation of patient with peripheral nerve pathology显示文摘 | Filler AG Kilot M Franklyn AH | 1996 | Neurosurg1996，85，2： | 1 |
| 20 | Drug therapy :The management of hyperthyroidism显示文摘 | Franklyn JA | 1994 | N Engl J Med1994，330，24： | 1 |
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