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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep显示文摘Osteopontin(OPN; also known as Secreted Phosphoprotein 1, SPP1) is a secreted extra-cellular matrix(ECM) protein that binds to a variety of cell surface integrins to stimulate cell-cell and cell-ECM adhesion and communication. It is generally accepted that OPN interacts with apically expressed integrin receptors on the uterine luminal epithelium(LE)and conceptus trophectoderm to attach the conceptus to the uterus for implantation. Research conducted with pigs and sheep has significantly advanced understanding of the role(s) of OPN during implantation through exploitation of the prolonged peri-implantation period of pregnancy when elongating conceptuses are free within the uterine lumen requiring extensive paracrine signaling between conceptus and endometrium. This is followed by a protracted and incremental attachment cascade of trophectoderm to uterine LE during implantation, and development of a true epitheliochorial or synepitheliochorial placenta exhibited by pigs and sheep, respectively. In pigs, implanting conceptuses secrete estrogens which induce the synthesis and secretion of OPN in adjacent uterine LE. OPN then binds to αvβ6 integrin receptors on trophectoderm, and the αvβ3 integrin receptors on uterine LE to bridge conceptus attachment to uterine LE for implantation. In sheep, implanting conceptuses secrete interferon tau that prolongs the lifespan of CL. Progesterone released by CL then induces OPN synthesis and secretion from the endometrial GE into the uterine lumen where OPN binds integrins expressed on trophectoderm(αvβ3) and uterine LE(identity of specific integrins unknown) to adhere the conceptus to the uterus for implantation. OPN binding to the αvβ3 integrin receptor on ovine trophectoderm cells induces in vitro focal adhesion assembly, a prerequisite for adhesion and migration of trophectoderm, through activation of: 1) P70S6 K via crosstalk between FRAP1/MTOR and MAPK pathways; 2) MTOR,PI3 K, MAPK3/MAPK1(Erk1/2) and MAPK14(p38) signaling to stimulate trohectoderm cell migration; and 3) focal adhesion assembly and myosin II motor activity to induce migration of trophectoderm cells. Further large in vivo focal adhesions assemble at the uterine-placental interface of both pigs and sheep and identify the involvement of sizable mechanical forces at this interface during discrete periods of trophoblast migration, attachment and placentation in both species. | Greg A Johnson Robert C Burghardt Fuller W Bazer | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 4 |
| 3 | Uterine biology in pigs and sheep显示文摘There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL) which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species. | Fuller W Bazer Gwonhwa Song Jinyoung Kim Kathrin A Dunlap Michael Carey Satterfield Gregory A Johnson Robert C Burghardt Guoyao Wu | 2012 | Journal of Animal Science and Biotechnology2012，3，3： | 3 |
| 4 | Regulation of putative fatty acid transpoters and acyl-CoA synthetase in liver and adipose tissue in ob/ob Mice显示文摘 | Memon R A Fuller J Moser A H | 1999 | Diabetes1999，48，2： | 2 |
| 5 | Psychological benefits of greenspace increase with biodiversity显示文摘 | Fuller Richard A Irvine Katherine N Devine-Wright Patrick Warren Philip H Gaston Kevin J | 2007 | Biology Letters2007，，4： | 2 |
| 6 | Thea attachment of bacteria to the gastric epithelium of the pig and its importance in the microecology of the intestinal 显示文摘 | Brooker B E Fuller R | 1980 | Journal of Applied Bacteriology1980，48，： | 1 |
| 7 | Coupled-resonatorinduced transparency 显示文摘 | Smith D Chang H Fuller K A | 2004 | Phys Rev A2004，69，06： | 1 |
| 8 | Control of mitochondrial morphology by a human mitofusin显示文摘 | SANTEL A FULLER M T | 2001 | J Cell Sci2001，114，5： | 1 |
| 9 | Content-based image and video retrieval显示文摘 | Bach J Fuller C Gupta A | 2005 | Signal Processing2005，85，2： | 1 |
| 10 | Sonic testing a simple nondestructive testing for verifying casting quality 显示文摘 | Fuller A G Emerson P J Rew R | 1963 | BCIRA Journal1963，，11： | 1 |
| 11 | A novel Syk- dependent mechanism of platelet activation by tile C-type lectin receptor CLEC-2显示文摘 | Suzuki-Inoue K Fuller GL Garcia A | 2006 | Blood2006，107，2： | 1 |
| 12 | Distribution of the esti- mators for autoregressive time series with a unit root 显示文摘 | DICKEY D A Fuller W A | 1979 | Journal of the American Statistical Association1979，366，74： | 1 |
| 13 | Investigation into an outbreak of encephalomyelitis caused by a neuroinvasive porcine sapelovirus in the United Kingdom显示文摘 | SCHOCK A GURRALA R FULLER H | 2014 | Vet Microbiol2014，172，34： | 1 |
| 14 | Control of mitochondrial morphology by a human mitofusin 显示文摘 | Santel A Fuller MT | 2001 | J Cell Sci2001，114，5： | 1 |
| 15 | Hysteresis properties of titaimagnetities: Grain-size and compositional dependence 显示文摘 | Day R Fuller M Schmidt V A | 1977 | Physics of the Earth and Planetary Interiors1977，13，4： | 1 |
| 16 | Likelihood Ratio Statistics for Autoregreesive Time Series with a Unit Root显示文摘 | Dickey D A Fuller W A | 1981 | Econometrica1981，49，4： | 1 |
| 17 | Video-assisted thoracic surgery sleeve lobectomy:a case series显示文摘 | Mahtabifard A Fuller CB McKenna RJ Jr | 2008 | Ann Thorac Surg2008，85，2： | 1 |
| 18 | Distribution of the estimators for autoregressive time series with a unit root显示文摘 | Dickey D A Fuller W A | 1979 | Journal of the American Statistical Association1979，74，366： | 1 |
| 19 | Imaging Techniques for the Assessment of Body Composition 显示文摘 | Fuller M F Fowler P A McNeil1 G | 1994 | Nutr1994，124，： | 1 |
| 20 | Proposal: the leopard cat ( Felisben- galensis) in China: ecology and management for sustainable utiliza- tion显示文摘 | JOHNSON K A FULLER T K | 2004 | J Forestry Res2004，15，4： | 1 |
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