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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Temporal and spatial association of matrix metalloproteinases with focal endometrial breakdown and bleeding upon progestin-only contraception显示文摘 | Galant C Vekemans M Lemoine P | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 3 | Focal expression and final activity of matrix metalloproteinases may explain irregular dysfunctional endometrial bleeding显示文摘 | Galant C Berliere M Dubois D | 2004 | Am J Pathol2004，165，： | 1 |
| 4 | Regulation of matrix metalloproteinase-9/gelatinase B expression and activation by ovarian steroids and lefty-a/endometrial bleeding-associated factor in the human endometrium显示文摘 | Comet P B Galant C Eeckhout Y | 2005 | J Clin Endocrinol Metab2005，90，： | 1 |
| 5 | ORMDL3 gene isassociated with asthma in three ethnically diverse populations显示文摘 | Galanter J Choudhry S Eng C | 2008 | Am J Respir Crit Care Med2008，177，11： | 1 |
| 6 | Identification of dis- tinct gene expression profiles in the synovium of patients with sys- temic lupus erythematosus 显示文摘 | Nzeusseu Toukap A Galant C Theate I | 2007 | Arthritis Rheum2007，56，5： | 1 |
| 7 | Development of an animal experimental model to study the effects of levonorgestrel on the human endometrium 显示文摘 | Alvarez Gonzalez ML Galant C Frankenne F | 2009 | Hutu Reprod2009，24，3： | 1 |
| 8 | Contribution of sonoelas- tography to the characterization of breast lesions显示文摘 | Vanhoutte A Fellahl Galant C | 2008 | JBR-BTR2008，91，5： | 1 |
| 9 | Novel nucle otide-calixarene conjugates via phosphoester linkage显示文摘 | Grazia M L C Granata G Galante E | 2006 | Tetrahedron Lett2006，47，： | 1 |
| 10 | Regulation of matrix metallopro-teinase-9/gelatinaseB expression and activation by ovarian steroids and LEFTY-A/endometrial bleeding-associated factor in the human endometrium显示文摘 | Cornet PB Galant C Eeckhout Y | 2005 | J Clin Endocrinol Metab2005，90，2： | 1 |
| 11 | A reversible polyelectrolyte involving a β-cyclodextrin polymer and a cationic surfactant显示文摘 | Galant C Wintgens W Amiel C | | 0，，12： | 1 |
| 12 | Normal variants and frequent marrow alterations that simulate bone marrow lesions at MR imaging显示文摘 | Vande Berg BC Lecouvet FE Galant C | 2005 | Radiol Clin North Am2005，43，： | 1 |
| 13 | Development of an animal experimental model to study the effects of levonorgestrel on the human endometrium 显示文摘 | M-L ALVAREZ GONZALEZ C GALANT F FRANKENNE | 2009 | Hum Reprod2009，24，3： | 1 |
| 14 | Effects of consuming foods containing oat β-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with evaluated blood pressure显示文摘 | MAKI K C GALANT R SAMUEL P | 2007 | European Journal of Clinical Nutrition2007，61，： | 1 |
| 15 | Benign vertebral hemangioma: MR-histological correlation 显示文摘 | Baudrez V Galant C Vande Berg BC | 2011 | Skeletal Radiol2011，30，8： | 1 |
| 16 | Mammography and subsequent whole -breast sonography of nonpalpable breast cancer:the impor- tance of radiologic breast density 显示文摘 | Leconte I Feger C Galant C | 2003 | A JR2003，180，6： | 1 |
| 17 | Uterine side effects of tamoxifen: a need for systematic pretreatment screening显示文摘 | Berliere M Charles A Galant C | 1998 | Obstet Gynecol1998，91，1： | 1 |
| 18 | Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas显示文摘 | Galanter J M Fernandez-Lopez J C Gignoux C R | 2012 | PLo S Genet2012，8，3： | 1 |
| 19 | Focal nodular hyperplasia of the hematopoietic marrow simulating vertebral metastasis on FDG positron emission tomography 显示文摘 | Bordalo-Rodrigues M Galant C Lonneux M | 2003 | AJR Am J Roentgenol2003，180，3： | 1 |
| 20 | Normal variants and frequent marrow alterations that simulate bone marrow lesions at MR imaging显示文摘 | Lecouvet FE Galant C | 2005 | Radiol Clin North Am2005，43，4： | 1 |
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