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| 1 | Malnutrition in cirrhosis:More food for thought显示文摘Malnutrition is highly prevalent in liver cirrhosis and its presence carries important prognostic implications.The clinical conditions and pathophysiological mechanisms that cause malnutrition in cirrhosis are multiple and interrelated.Anorexia and liver decompensation symptoms lead to poor dietary intake;metabolic changes characterised by elevated energy expenditure,reduced glycogen storage,an accelerated starvation response and protein catabolism result in muscle and fat wasting;and,malabsorption renders the cirrhotic patient unable to fully absorb or utilise food that has been consumed.Malnutrition is therefore a considerable challenge to manage effectively,particularly as liver disease progresses.A high energy,high protein diet is recognised as standard of care,yet patients struggle to follow this recommendation and there is limited evidence to guide malnutrition interventions in cirrhosis and liver transplantation.In this review,we seek to detail the factors which contribute to poor nutritional status in liver disease,and highlight complexities far greater than“poor appetite”or“reduced oral intake”leading to malnutrition.We also discuss management strategies to optimise nutritional status in this patient group,which target the inter-related mechanisms unique to advanced liver disease.Finally,future research requirements are suggested,to develop effective treatments for one of the most common and debilitating complications afflicting cirrhotic patients. | Brooke Chapman Marie Sinclair Paul J Gow Adam G Testro | 2020 | World Journal of Hepatology2020，12，11： | 8 |
| 2 | Hydrologically defined niches reveal a basis for species rich ness in plant communities显示文摘 | SILVERTOWN J DODD M E GOWING D J G | 1999 | Nature1999，400，6739： | 1 |
| 3 | Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats显示文摘 | Ellis G S Lanza-Jacoby S Gow A | 1994 | J Appl Physiol1994，77，1： | 1 |
| 4 | Selective ablation of proliferating microglia cells exacerbates ischemic injury in the brain显示文摘 | Lalancette- Hebert M Gowing G Simard A et a! | 2007 | Neurosci2007，27，： | 1 |
| 5 | Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease显示文摘 | Simard AR Soulet D Gowing G | 2006 | Neuron2006，49，4： | 1 |
| 6 | Nottinghamshire's road ramp scheme显示文摘 | THOMPSON S J GOW P COLES G | 1990 | Traffic Engineering and Control1990，31，10： | 1 |
| 7 | Macrophage colony stimulating factor(M-CSF)exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase显示文摘 | Gowing G Lalancette-Hebert M Audet JN | 2009 | Exper Neurol2009，220，2： | 1 |
| 8 | Pattern recognition:recentinsights from Dectin-1显示文摘 | REID D M GOW N A R BROWN G D | 2009 | Current Opinion in Immunology2009，21，1： | 1 |
| 9 | Bone marrow-derived mieroglia play a eritical role in restrieting senile plaque formation in Alzheimer's disease 显示文摘 | Simard AR Soulet D Gowing G | 2006 | Neuron2006，49，4： | 1 |
| 10 | A positive root sourcedsignal as an indicator of soil drying in apple显示文摘 | Gowing D J Davies W J Johes H G | 1990 | J Exp Bot1990，41，223： | 1 |
| 11 | An integrated model of the recognition of Candida albicans by the innate immune system显示文摘 | Netea M G Brown G D Kullberg B J Gow N A R | | 0，，： | 1 |
| 12 | A positive root-sourced signal as an indicator of soil drying in apple Malus x domestica Borkh显示文摘 | Gowing G Davies W J Jones H G | 1990 | J Exp Bot1990，41，233： | 1 |
| 13 | Adult Wilms tumor: review of 14 patients显示文摘 | Williams G Colbeck RA Gowing NF | 1992 | BrJ Urol1992，70，3： | 1 |
| 14 | A positive root sourced signal as an indicator of soil drying in apple 显示文摘 | Gowing D J Davies W J Johes H G | 1990 | J Exp Bot1990，41，233： | 1 |
| 15 | Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease显示文摘 | Simard AR Soulet D Gowing G | 2006 | Neuron2006，49，4： | 1 |
| 16 | Interferometric null method for measuring stress-induced birefringence显示文摘 | BIRNBAUM G CORY E GOW K | 1974 | Appl Opt1974，13，7： | 1 |
| 17 | Pattern recognition: recent in-sights from Dectin-1 显示文摘 | Reid D M Gow N A Brown G D | 2009 | Curr Opin Immunol2009，21，1： | 1 |
| 18 | Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma显示文摘 | Wu S G Gow C H Yu C J | 2008 | Eur Respir J2008，32，4： | 1 |
| 19 | Increased expression of urotensin 1]显示文摘 | LANGHAM R G KELLY D J GOW R M | 2004 | American Journal of Kidney Disea- ses: the Official Journal of the National Kidney Foundation2004，44，5： | 1 |
| 20 | Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma显示文摘 | Wu S G Gow C H Yu C J | | 0，，04： | 1 |
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