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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?显示文摘Major depressive disorder is a debilitating disorder affecting millions of people each year.Brain-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention.Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression.However,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous system.Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant response.Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the brain.Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction. | Grace A Porter Jason C O’Connor | 2022 | World Journal of Psychiatry2022，12，1： | 4 |
| 3 | The synthetic form of a novel chicken β-defensin identified in silico is predominantly active against intestinal pathogens显示文摘 | Rowan Higgs David J. Lynn Susan Gaines Jessica McMahon Joanna Tierney Tharappel James Andrew T. Lloyd Grace Mulcahy Cliona O’Farrelly | 2005 | Immunogenetics (-)2005，，1： | 3 |
| 4 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019，，4： | 3 |
| 5 | Recrudescent Plasmodium falciparum infections in children in an endemic area following artemisinin–based combination treatments: Implications for disease control显示文摘 | Grace O Gbotosho Titilope M Okuboyejo Christian T Happi Akintunde Sowunmi | 2011 | Asian Pacific Journal of Tropical Disease2011，，3： | 2 |
| 6 | Examining the effects of service brand communications on brand evaluation显示文摘 | Debra Grace Aron O’Cass | 2005 | Journal of Product & Brand Management2005，，2： | 2 |
| 7 | Assessment of lead, cadmium, and zinc contamination of roadside soils, surface films, and vegetables in Kampala City, Uganda 显示文摘 | Grace N Hannington O Miriam D | 2006 | Environmental Research2006，101，1： | 1 |
| 8 | Oscillation criteria for certain nth order differential equations with deviating arguments显示文摘 | Agarwal R P Grace S R O'regan D | 2001 | J Math Anal Appl2001，262，： | 1 |
| 9 | Acute lym-phoblastic leukemia and Klinefelter's syndrome 显示文摘 | SHAW M P EDEN O B GRACE E | 1992 | Pediatr Hematol Oncol1992，9，： | 1 |
| 10 | Oscillation criteria for certain n th order differential equations with deviating arguments显示文摘 | Agarwal R P Grace S R O Regan D | 2001 | J Math Anal Appl2001，262，： | 1 |
| 11 | Phenolic content and antioxidant capacity of Philippine sweet potato(ipomoea batatas) varieties显示文摘 | Rowena Grace O Rumbao Djanna F Cornago Inacrist M Geroni- too | 2009 | Food Chemistry2009，，113： | 1 |
| 12 | Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input显示文摘 | O' Donnell P Grace AA | 1995 | J Neurosci1995，15，： | 1 |
| 13 | Comparison of Animals Used in Disc Research to Human Lumbar Disc Geometry显示文摘 | Grace D O' Connell BS Edward J | 2007 | Spine2007，32，3： | 1 |
| 14 | Circumferential waves on solid cylinders显示文摘 | GRACE O GOODMAN R | | 0，，01： | 1 |
| 15 | XCMS:Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment,Matching and Identification显示文摘 | Colin A Smith Elizabeth J Want Grace O'Maille | 2006 | Analytical Chemistry2006，78，3： | 1 |
| 16 | Assessment of lead, cadmium, and zinc contamination of roadside soils, surface films and vegetables in Kampala City, Uganda显示文摘 | Grace N Hannington O O Miriam D | 2006 | Environmental Research2006，101，1： | 1 |
| 17 | Assessment of Lead, Cadmium, and Zinc Contamination of Roadside Soils, Surface Films, and Vegetables in Kampala City, Uganda 显示文摘 | GRACE N HANNINGTON O O MIRIAM D | 2006 | Environmental Research2006，，101： | 1 |
| 18 | Intraoral measurement of tactile and filament-prick pain threshold using shortened Semmes-Weinstein monofilaments显示文摘 | Komiyama O Gracely R Kawara M | | 0，，： | 1 |
| 19 | An Exploratory Perspective of Service Brand Associations显示文摘 | Aron and Grace Debral | 2003 | Journal of Services Marketing2003，，5： | 1 |
| 20 | Significance of amount and form of dietary selenium on blood, milk, and casein selenium concentrations in grazing cows显示文摘 | Knowles S O Grace N D Wurms K | 1999 | J Dairy Sci1999，82，： | 1 |
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