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| 1 | Minimally invasive spleen-preserving distal pancreatectomy: Does splenic vessel preservation have better postoperative outcomes? A systematic review and meta-analysis显示文摘BACKGROUND: Minimally invasive spleen-preserving distal pancreatectomy(SPDP) can be performed with either splenic vessel preservation(SVP) or resection [Warshaw procedure(WP)]. The aim of this study was to evaluate the postoperative clinical outcomes of patients undergoing both methods.DATA SOURCES: Database search of PubM ed, Embase, Scopus,Cochrane, and Google Scholar was performed(2000-2014); key bibliographies were reviewed. Qualified studies comparing patients undergoing SPDP with either SVP or WP, and assessing postoperative complications were included. Calculated pooled risk ratio(RR) with the corresponding 95% confidence interval(CI) by random effects methods were used in the meta-analyses. RESULTS: The search yielded 215 studies, of which only 14 observational studies met our selection criteria. The studies included 943 patients in total; 652(69%) underwent SVP and 291(31%) underwent WP. Overall, there was a lower incidence of splenic infarction(RR=0.17; 95% CI: 0.09-0.33; P<0.001),gastric varices(RR=0.16; 95% CI: 0.05-0.51; P=0.002), and intra/postoperative splenectomy(RR=0.20; 95% CI: 0.08-0.49; P<0.001) in the SVP group. There was no difference in incidence of pancreatic fistula(WP vs SVP, 23.6% vs 22.9%;P=0.37), length of hospital stay, operative time or blood loss. There was moderate cross-study heterogeneity.CONCLUSIONS: SVP is a safe, efficient and feasible technique that may be used to preserve the spleen. WP may be more suitable for large tumors close to the splenic hilum or those associated with splenomegaly. Randomized clinical trials are justified to examine the long-term benefits of SVP-SPDP. | Fady Elabbasy Rahul Gadde Mena M Hanna Danny Sleeman Alan Livingstone Danny Yakoub | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 2 |
| 2 | Microorganisms and heavy metal toxicity 显示文摘 | Gadd G M Griffiths A J | 1978 | Microb Ecol1978，4，： | 1 |
| 3 | 显示文摘 | Gadd G M | 2009 | J Chem Technol Biot2009，84，1： | 1 |
| 4 | Strain and medium-related variability in the yeast-mycelial transition of Aureobasidium pullulans显示文摘 | Gadd G M Cooper L A | 1984 | FEMS Microbiology Letters1984，23，1： | 1 |
| 5 | Interaction of fungi with toxic metals显示文摘 | 1993 | 1993 | New Phytol1993，124，： | 1 |
| 6 | Bupropion SR vs placebo for weight loss in obese patients with depressive symptoms 显示文摘 | JAIN A K KAPLAN R A GADDE K M | 2002 | Obes Res2002，10，10： | 1 |
| 7 | Microbial influence on metal mobility and application for bioremediation显示文摘 | Gadd G M | 2004 | Geoderma2004，122，： | 1 |
| 8 | Fungal degradation of calcium-lead and silicon - beating minerals 显示文摘 | Adeyemi A O Gadd G M | 2005 | Biometals2005，18，3： | 1 |
| 9 | Fungal involvement in bioweathering and biotransformation of rocks and minerals显示文摘 | Burford E P Fomina M Gadd G M | 2003 | Mineral Magaz2003，67，6： | 1 |
| 10 | Geomycology: biogeochemical transforma- tions of rocks, minerals, metals and radionuclides by fungi, bioweathering and bioremediation 显示文摘 | GADD G M | 2007 | Mycologi- cal Research2007，111，： | 1 |
| 11 | Metals, minerals and microbes: geomicrobi- ology and bioremediation 显示文摘 | GADD G M | 2010 | Microbiology2010，156，3： | 1 |
| 12 | Reduction and precipitation of chromate by mixed culture sulphate-reducing bacterial biofilms显示文摘 | Smith W L Gadd G M | 2000 | Journal of Applied Microbiology2000，88，6： | 1 |
| 13 | Structure-guideddesign and optimization of small molecules targeting theprotein- protein interaction between the von Hippel -Lindau (VHL) E3 ubiquitin ligase and the hypoxia in-ducible factor (HIF) alpha subunit with in vitro nano-molar affinities显示文摘 | GaldeanoC?Gadd M S Soar | 2014 | J Med Chem2014，57，20： | 1 |
| 14 | A novel biomonitoring system using microbial fuel cells显示文摘 | Kim M Hyun MS Gadd GM | 2007 | Journal of Environmental Monitoring2007，9，12： | 1 |
| 15 | Removal of thorium from simulated acid process streams by fiingal biomass显示文摘 | Gadd G M White C | 1989 | Biotechnology and Bioengineering1989，33，5： | 1 |
| 16 | Geomycology: fungi in mineral substrata 显示文摘 | Burford E P Kierans M Gadd G M | 2003 | Mycologist2003，17，： | 1 |
| 17 | Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production显示文摘 | Haynes D R Gadd S J Whitehouse M W | 1996 | Inflamm Res1996，45，： | 1 |
| 18 | Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA espression and NF-kappaB activity显示文摘 | Gadd S L Hobbs G Miller M R | 2002 | Toxicol Sci2002，66，2： | 1 |
| 19 | Oxalate pro-duction by wood-rotting fungi growing in toxic metal-a- mended medium 显示文摘 | JAROSZ-WILKOLAZKA A GADD G M | 2003 | Chemosphere2003，52，3： | 1 |
| 20 | Metal accumulation by fungi: application in environmental biotechnology显示文摘 | White C Gadd G M 1994 | 1994 | J Ind Microbial1994，13，： | 1 |
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