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| 1 | Macrophage polarization in response to wear particles in vitro显示文摘全部的联合代替是为有停用关节炎和联合机能障碍的病人的治疗的一个高度成功的外科的过程。随着时间的过去,与活动的高水平和关节的用法,然而植入穿粒子从明白表示的表面被产生。这些穿粒子能在 implant (periprosthetic osteolysis ) 附近导致煽动性的反应,和随后的骨头再吞的激活。单核白血球 / 巨噬细胞系的房间安排这长期的煽动性的回答,它被支持 inflammatory (M1 ) 统治巨噬细胞显型而非一反煽动性的支持织物的愈合(M2 ) 巨噬细胞显型。当它被显示出时,那 interleukin-4 (IL-4 ) 有选择地极化向支持骨头愈合的 M2 反煽动性的显型的巨噬细胞,而非发炎,很少对这在通过 IL-4 的极化在哪个是很有效的在发生或调节的时间功课被知道。这个工作的目标是与 polymethyl methacrylate (PMMA ) 的联合响应挑战学习鼠科的巨噬细胞极化和 cytokine 版本的时间功课粒子, lipopolysaccharide (LPS ) 和在 vitro 的 IL-4。有 IL-4 的质问粒子的单核白血球 / 巨噬细胞的处理导致了支持 inflammatory cytokines 和可诱导的氮的氧化物 synthase (iNOS ) 的起始的抑制生产和随后的极化进 M2 反煽动性的显型。当 IL-4 在 PMMA 粒子挑战前被交付时,这结果被优化,到 M1 显型而非到未遂(M0 ) 巨噬细胞。这极化的效果在一堂 5 天的时间功课上被支撑。进 M2 显型的 M1 巨噬细胞的极化可以是策略减轻穿粒子联系 periprosthetic osteolysis。 | Joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart B Goodman | 2013 | Cellular & Molecular Immunology2013,10,6: | 10 |
| 2 | 恩替卡韦治疗中重度肝纤维化慢性乙型肝炎患者48周的疗效分析显示文摘目的III期临床研究结果显示恩替卡韦(ETV)治疗48周,在组织学改善、ALT复常和HBVDNA抑制方面均优于拉米夫定(LMV);肝纤维化的改善在核苷类似物初治患者中2个治疗组相似,在拉米夫定失效患者中,ETV明显优于LMV。对基线时表现为中重度肝纤维化/硬化患者(Ishak评分:4-6)进行亚组分析,评估ETV或LMV治疗48周的疗效。方法纤维化评分是由1位病理学家对基线和48周时标本进行评估,治疗组及标本先后顺序均对他设盲。结果对HBeAg(+)核苷类似物初治的患者,48周时肝纤维化发生改善的患者比例ETV组为57%,LMV组为49%;肝纤维化没变化的患者比例ETV组35%,LMV组为28%;肝纤维化恶化的患者比例ETV组为0,LMV组为6%;对HBeAg(-)核苷类似物初治的患者,48周时肝纤维化发生改善的患者比例ETV组为59%,LMV组为53%;肝纤维化没变化的患者比例ETV组为31%,LMV组为18%;肝纤维化恶化的患者比例ETV组为2%,LMV组为5%;对HBeAg(+)LMV失效的患者,48周时肝纤维化发生改善的患者比例ETV组为43%,LMV组为33%;肝纤维化没变化的患者比例ETV组为35%,LMV组为29%;肝纤维化恶化的患者比例ETV组为0,LMV组为19%。结论接受ETV治疗的中重度肝纤维化/硬化患者比接受LMV治疗更可能获得纤维化改善或不变,这些数据与其他治疗终点(全组人群的病毒学、生化学和Knodell评价的组织学改善情况)结果一致,均为ETV优于LMV。 | Simsek H Schiff E Goodman Z Brett-Smith H Klesczewski K Kreter B 王蔚 | 2006 | 传染病信息2006,19,5: | 2 |
| 3 | Long - term efficacy of nonsurgical urinary incontinence treatment in el derly wonlen显示文摘 | Weinberger M W Goodman B M Cames M | 1999 | J Gerontoi A Biol sci Med Sci1999,54,: | 1 |
| 4 | Efficient power control via pricing in wireless data network 显示文摘 | SARAYDAR C U MANDAYAM N B GOODMAN D J | 2002 | IEEE Trans- actions on Communications2002,50,2: | 1 |
| 5 | Efficient power control via pricing in wireless data networks显示文摘 | SARAYDAR C MANDAYAM N B GOODMAN D J | | 0,,02: | 1 |
| 6 | Validation of the global registry of acute coronary event (GRACE) risk score for in-hospital mortality in patients with acute coronary syndrome in Canada显示文摘 | Elbarouni B Goodman SG Yan RT | | 0,,03: | 1 |
| 7 | Effects of ionizing radiation on a plant genome: Analysis of two Arabidopsis transparent testa mutations显示文摘 | Shirley B W Hanley S Goodman H M | 1992 | Plant Cell1992,4,: | 1 |
| 8 | Services:business demand rivals consumer demand in driving job growth 显示文摘 | GOODMAN B STEADMAN R | 2002 | Monthly Labor Review2002,125,4: | 1 |
| 9 | Validation ofthe Global Registry of Acute Coronary Event (GRACE) risk score for in-hospital mortality in patients with acute coronary syndrome in Canada 显示文摘 | Elbarouni B Goodman S G Yan R T | 2009 | Am Heart J2009,158,3: | 1 |
| 10 | Pricing and Power Control in a Multicell Wireless Data Network显示文摘 | Saraydar C D Mandayam N B Goodman D J | 2001 | IEEE Journal on Selected Areas in Communication2001,19,10: | 1 |
| 11 | Inflammatory cytokines in patient with persistence of ARDS显示文摘 | Goodman R B Martin D P Walz A | 1996 | Am J Respir Crit Care Med1996,154,: | 1 |
| 12 | The public health impact of socioeconomic status on adolescent depression and obesity 显示文摘 | GOODMAN E SLAP G B HUANG B | 2003 | Am J Public Health2003,93,11: | 1 |
| 13 | Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hyppocampal neurons显示文摘 | Goodman Y Bruce AJ Cheng B | 1996 | Neurochem1996,66,: | 1 |
| 14 | Prevalence of child and adolescent psychiatric disorders in southeast brazil显示文摘 | Fleitlich B Goodman Robert | 2004 | Journal of the American Academy of Child & Adolescent Psychiatry2004,43,6: | 1 |
| 15 | Local infusion of FGF-2 enhances bone ingrowth in rabbit chambers in the presence of polyethylene particles 显示文摘 | Goodman S B Song Y Yoo J Y | 2003 | Journal of Biomed- ical Materials Research Part A2003,65,4: | 1 |
| 16 | Socioeconomic status, depressive symptoms, and adolescent substance use 显示文摘 | GOODMAN E HUANG B | 2002 | Arch Pediatr Adolesc Med2002,156,5: | 1 |
| 17 | Efficient power control via pricing in wireless data networks 显示文摘 | Saraydar C U Mandayarn N B Goodman D J | 2002 | IEEE Trans Communication2002,50,2: | 1 |
| 18 | Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation显示文摘 | LOWELL B B RUDERMAN N B GOODMAN M N | 1986 | Metabolism1986,35,: | 1 |
| 19 | The structures and reversible polymerization of cyclic oligomers from poly (ethylene terephthalate) 显示文摘 | Goodman J Nesbitt B F | 1960 | Polymer1960,,1: | 1 |
| 20 | Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans 显示文摘 | Chalasani S H Chronis N Tsunozaki M Gray J M Ramot D Goodman M B et aI | 2007 | Nature2007,450,: | 1 |