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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Clinical transplantation of a tissue- engineered airway 显示文摘 | Macehiarini P Jungebluth P Go T | 2008 | Lancet2008，9655，： | 1 |
| 3 | Study of the specificity of cross-povidone(PVPP) as binding agent in the quantification of polyphenolic compounds显示文摘 | Simone GV Cabral P George GO | 2008 | Braz Chem Soc2008，19，8： | 1 |
| 4 | Loss of heterozygosity on hromosome 11 and 17 are markers of re curence in TCC of the bladder显示文摘 | Edwards J Duncan P Going J J | 2001 | Br J Cancer2001，85，12： | 1 |
| 5 | Clinical transplantation of a tissue-engineered airway显示文摘 | Macchiarini P Jungebluth P Go T | | 0，，： | 1 |
| 6 | WMO's Role in the international decade for national disaster reduction显示文摘 | Obasi GO P | 1994 | Bull Amer Meteor Soc1994，75，9： | 1 |
| 7 | Structural and morphologic evaluation of a novel detergent-enzymatic tissue-engineered tracheal tubular matrix显示文摘 | Jungebluth P Tetsuhiko Go M Asnaghi A | | 0，，： | 1 |
| 8 | The LatrorefStudy: Med- ical Errors are Associated with ,Symptoms of Depression in ICU Staff but not Burnout or Safety Culture 显示文摘 | Maite GO Marion P Lilia S | 2015 | Intensive Care Medicine2015，41，2： | 1 |
| 9 | Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs显示文摘 | Go T Jungebluth P Baiguero S | | 0，，： | 1 |
| 10 | Scasonal patterns of nitriogen and denitrification in a natural and a restored salt marsh 显示文摘 | Paerl H W Go M C | 1995 | Estuaries1995，18，： | 1 |
| 11 | Evidence for the electrolysis'of water by atmospheric-pressure plasmas formed at the surface of aqueous solutions显示文摘 | Witzke M Rumbach P Go D B | 2012 | Journal of Physics D: Applied Physics2012，45，44： | 1 |
| 12 | Review of the physico -chemical characteristics and properties of konjac mannan显示文摘 | Nishinari K Williams P A Phillips GO | 1992 | Food Hydrocolloids1992，6，： | 1 |
| 13 | Extraction of gelatin from fish skins by high pressure treatment显示文摘 | M C Go'mez-Guille'n B Gime'nez P Montero | 2005 | Food hydrocolloids2005，19，： | 1 |
| 14 | Does closure of camper fascia reduce the incidence of post-cesarean superficial wound disruption显示文摘 | De Valle GO Combs P Qualis C | 1992 | Obstet Gyncol1992，80，6： | 1 |
| 15 | Seasonal patterns of nitrification and denitrification in a natural and a restored salt marsh显示文摘 | Thompson S P Paeri H W Go M C | 1995 | Estuaries1995，18，2： | 1 |
| 16 | Phlebectasia of internal jugular vein显示文摘 | Bindal SK Vasisth GO Chibber P | 2012 | Journal of surgical technique and case report2012，4，： | 1 |
| 17 | Anatomic crown width/length ratios of unworn and worn maxillary teeth in whitesubjects显示文摘 | Magne P Gallucci GO Belser UC | 2003 | J Prosthet Dent2003，89，5： | 1 |
| 18 | Microbial transglutaminase as a tool to restore the functionality of gluten from insect - damaged wheat 显示文摘 | Bonet A Caballero P A Go'mez M | 2005 | Cereal Chemistry2005，82，4： | 1 |
| 19 | Interactions between intraluminal bile acids and digestive products on pancreatic and gallbladder function显示文摘 | Malagelada J R Go V L DiMagno E P | 1973 | J Clin Invest1973，52，9： | 1 |
| 20 | Does closure of camper fascia reduce the incidence of post - cesarean superficial wound disruption? 显示文摘 | De Valle GO Combs P Qualis C | 1992 | Obstet Gyncol1992，80，6： | 1 |
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