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| 1 | Small Ubiquitin-Like Modifier Conjugating Enzyme with Active Site Mutation Acts as Dominant Negative Inhibitor of SUMO Conjugation in Arabidopsis显示文摘Small ubiquitin-like modifier (SUMO) conjugation affects a broad range of processes in plants, including growth, flower initiation, pathogen defense, and responses to abiotic stress. Here, we investigate in vivo and in vitro a SUMO conjugating enzyme with a Cys to Ser change in the active site, and show that it has a dominant negative effect. In planta expression significantly perturbs normal development, leading to growth retardation, early flowering and gene expression changes. We suggest that the mutant protein can serve as a probe to investigate sumoylation, also in plants for which poor genetic infrastructure precludes analysis via loss-of-function mutants. | Konstantin Tomanov Christian Hardtke Ruchika Budhiraja Rebecca Hermkes George Coupland Andreas Bachmair | 2013 | Journal of Integrative Plant Biology2013，55，1： | 4 |
| 2 | Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel reg- ulator of cell proliferation and elongation in the root 显示文摘 | Mouchel C F Briggs G C Hardtke C S | 2004 | Genes Development2004，18，6： | 1 |
| 3 | Intrahepatic regulatory T cells in autoimmune hepatitis are as-sociated with treatment response and depleted with currenttherapies显示文摘 | TAUBERT R HARDTKE -WOLENSKI M NO YAN F | 2014 | J Hepatol2014，61，5： | 1 |
| 4 | Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help显示文摘 | Hardtke S Ohl L Forster R | 2005 | Blood2005，106，6： | 1 |
| 5 | Ribavirin treatment of acute and chronic hepatitis E: a single-centre experience 显示文摘 | Pischke S Hardtke S Bode U | 2013 | Liver Int2013，33，5： | 1 |
| 6 | A general concept for design modification of shell meshes in structural-acoustic optimization, Part Ⅱ显示文摘 | MARBURG S HARDTKE H-J | 2002 | Finite Elements in Analysis and Design2002，38，5： | 1 |
| 7 | Efficient optimization of a noise transfer function by modification of a shell geometry Part I : Theory 显示文摘 | Marburg S Hardtke H J | 2002 | Struct Multidisc Optim2002，24，1： | 1 |
| 8 | Efficient optimization of a noise transfer function by modification of a shell geometry Part Ⅱ :Application to a vehicle dashboard 显示文摘 | aMarburg S Hardtke H J | 2002 | Struct Multidisc Optim2002，24，3： | 1 |
| 9 | The Arabidopsis gene MONOPTEROS encodes a transcription factor mediating embryo axis formation and vascular development显示文摘 | HARDTKE C S BERLETH T | 1998 | EMBO J1998，17，5： | 1 |
| 10 | A general concept for design modi!cation of shell meshes in structural-acoustic optimization -Part Ⅱ:Application to a floor panel in sedan interior noise problems显示文摘 | Steffen Marburg Hans Jurgen Hardtke | 2002 | Finite Elements in Analysis and Design2002，38，： | 1 |
| 11 | The cell biology of the COP/DET/FUS proteins:Regulating proteolysis in photomorphogenesis and beyond显示文摘 | Hardtke C S Deng X W | | 0，，： | 1 |
| 12 | BRX mediates feedback between brassinosteroid levels and auxinsignalling in root growth显示文摘 | Mouchel C F Osmont K S Hardtke C S | 2006 | Nature2006，443，7110： | 1 |
| 13 | HY5 stability and activity in arabidopsis is regulated by phosphorylation in its COP1 binding domain显示文摘 | Hardtke C S Gohda K | 2000 | Embo J2000，19，18： | 1 |
| 14 | Targeted destabilization of HY5 during light-regulated development of Arabidopsis显示文摘 | Osterlund M T Hardtke C S | 2000 | Nature2000，405，： | 1 |
| 15 | The cell biology of the COP/DET/ FUS proteins regulating proteolysis in photomorphogenesis and beyond 显示文摘 | Hardtke C S Deng X W | 2000 | Plant Physiology2000，124，： | 1 |
| 16 | The narrative processes coding system:research applications and implications for psychotherapy practice显示文摘 | Angus L Levitt H Hardtke K | 1999 | J Clin Psychol1999，55，10： | 1 |
| 17 | Targeted destabilization of HY5 during light-regulated development of Arabidopsis显示文摘 | OSTERLUND M T HARDTKE C S WEI N | 2000 | Nature2000，405，： | 1 |
| 18 | Targeted destabilization of HY5 during light-regulated development of Arabidopsis显示文摘 | Osterlund M T Hardtke C S Wei N Deng X W | | 0，，： | 1 |
| 19 | In vitro stimulation with HBV therapeutic vaccine candidate Nasvac activates B and T cells from chronic hepatitis B patients and healthy donors显示文摘 | Lobaina Y Hardtke S Wedemeyer H | 2015 | Mol Immunol2015，63，2： | 1 |
| 20 | In vitro stimulation with HBV therapeutic vaccine candidate Nasvac activates B and T cells from chronic hepatitis B patients and healthy donors显示文摘 | Yadira Lobaina Svenja Hardtke Heiner Wedemeyer Julio Cesar Aguilar Verena Schlaphoff | 2014 | Molecular Immunology2014，，： | 1 |
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