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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. | Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun | 2015 | Bone Research2015，3，3： | 4 |
| 3 | Mechanical properties of a biodegradable bone regeneration scaffold显示文摘 | Porter B D Oldham J B He S L | 2000 | J Biomech Eng2000，122，3： | 2 |
| 4 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 5 | Hydrothermal preparation of boehmite nanorods by selective adsorption of sulfate显示文摘 | He T B Xiang L Zhu S L | 2008 | Langmuir2008，24，： | 1 |
| 6 | A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells显示文摘 | He B You L Uematsu K | 2004 | Neoplasia2004，6，1： | 1 |
| 7 | Effect of food on the pharmacokinetics of a vildagliptin/metfor rain (50/1 000 rag) fixed-dose combination tablet in healthy volunteers 显示文摘 | HE Y L FLANNERY B CAMPESTRINI J | 2008 | Curr Med Res Opin2008，24，6： | 1 |
| 8 | lntracellular trehalose improves the survival of human red blood cells by freeze-drying显示文摘 | He H Liu B L Hua Z Z et aI | 2007 | Ener- gy Power Eng2007，1，1： | 1 |
| 9 | Hepatitis B virus with a pro- posed genotype I was found in sichuan province,China显示文摘 | TONG W B HE J L SUN L | 2012 | J Med Viro12012，84，6： | 1 |
| 10 | Age and dura tion of the Emeishan flood volcanism, SW China: Geochemistry and SHRIMP zircon U-Pb dating of silicic ignimbrites, post-volcanic Xuanwei Formation and clay tuff at the Chaotian section显示文摘 | He B Xu Y G Huang L X | 2007 | Earth and Planetary Science Letters2007，255，： | 1 |
| 11 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 12 | Compliant needle modeling and steerable insertion simulation 显示文摘 | Tang L B Chen Y H He X J | 2008 | Computer-Aided Design and Applications2008，5，1234： | 1 |
| 13 | Determination of Sudan Dye Residues in Eggs by Liquid Chromatography and Gas Chromatography mass Spectrometry显示文摘 | He L Su Y Fang B | 2007 | Anal Chim Acta2007，594，1： | 1 |
| 14 | Experimental study on the performance of CO2 residential air-conditioning system with anInternal heat exchanger显示文摘 | Tao Y B He Y L Tao W Q Wu Z G | | 0，，01： | 1 |
| 15 | Emergence, circulation, and spatiotemporal phylogenetie analysis of eoxsaekievirus a6 - and coxsackievirus al0 - associated hand, foot, and mouth disease infections from 2008 to 2012 in shenzhen, china显示文摘 | He Y Q Chen L Xu W B | 2013 | J Clin Microbiol2013，51，11： | 1 |
| 16 | Percutaneous ethanol injection therapy in the treatment ofthyroid and parathyroid diseases显示文摘 | B E N N E D B A E K F N K A R S T R U P S HE G E D U S L | 1997 | Eur J Endocrinol1997，136，3： | 1 |
| 17 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 18 | Synthesis of pure phase BiFeO3 powders in molten alkali metal nitrates 显示文摘 | He X B Gao L | 2009 | eram Int2009，35，3： | 1 |
| 19 | A continuum model for size-dependent deformation of elastic films of nanoscale thickness显示文摘 | He L H Lim C W Wu B S | 2004 | International Journal of Solids and Structures2004，41，： | 1 |
| 20 | Mango malformation disease in South China caused by Fus arium p roliferotum显示文摘 | ZHAN R L YANG S J HO H H LIU F ZHAO Y L CHANG J M HE Y B | 2010 | Journal of Phytopathology2010，158，： | 1 |
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