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| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | 亚洲地区硫肥经营管理的重要思考显示文摘亚太地区对于植物S营养给农业带来的效益已广为人知.本地区一些主要国家所进行的大量田间试验清楚地表明,投入足够的硫肥给作物所带来的产出是令人满意的.在亚太绝大部分地区,普通过磷酸钙(SSP)多年来一直是当作基本的P肥使用.继续使用这种肥料将自然而然地改善和防止缺硫现象.对中国缺硫土壤的地区和缺硫程度的评估说明,有效硫含量低的土壤决不仅仅在中国南方存在,而且也广泛地分布在中国北方.已有不少报道指出,施用硫肥明显地增加了作物产量.这些作物既包括了粮食作物、蔬菜、水果,还包括了工业用作物和经济作物.对中国历来生产和消费的硫酸铵和过磷酸钙(普钙)的一项调查表明,施用普钙既是土壤的主要P,又是S的来源.近年来, 由于普钙的施用, 每年大约可提供270万吨植物S营养. 尽管普钙的生产预计会逐渐减少, 但这种肥料仍将继续成为中国农田的重要硫源.由于普钙作为一种肥料有着不可避免的缺点,在中国人们注意到了在普钙的普遍施用中存在的问题.比如,在亚太地区足P土壤或持S 力弱或淋S多或淋S(SO4)力强的土壤,普钙就不是一种理想的肥料.基于这些认识,就生产出种种新型的或改良的(缓和的)硫肥.这些肥料主要包括元素硫(S0)的添加.这就需要根据特定土壤P、S肥力状况有选择地安排生产,并激励硫肥生产技术的不断改进.本文列举了许多例子描述了此类作为植物S营养的新型和改良的S肥,阐明了它们的生产、性质和特效.在亚太地区,长期以来把元素S看作作物的有效硫源.它的优点在于其含S成分非常高,运、储、使用既经济又便当,分解缓慢肥效长;与N、P、K肥配合施用时可灵活地调节S 的浓度.本文同时将参比粗粒元素S在农艺上的无效性,介绍了元素S在氧化成SO42-过程中的细度问题. 本文简要介绍了现有的两种商品粒状硫肥(S0)的制造技术.这种肥料的优点是具有一定的分散性,粒径几微米,颗粒大小适中.文章并着重强调了这种含S颗粒肥料在平衡施肥项目中以及作为复合肥(复混肥)配料的优越性.本文同时讨论了从有效硫含量高低悬殊很大的土样中获得的平均值用来估计需硫量,往往会作出过高或过低的判断等问题. | J D Beaton A M Henderson | 2000 | 安徽农业大学学报2000，27，z1： | 5 |
| 3 | 将安装于CON EDISON电网的带故障限流功能的高温超导电缆现状和进展显示文摘介绍了Hydra超导电缆项目的总体目标、设计准则、现状和进展,重点介绍了25 m原型电缆的结构设计、生产制造及型式试验。 | Maguire J Folts D Yuan J Henderson N Lindsay D Knoll D Rey C Duckworth R Gouge M Wolff Z Kurtz S | 2011 | 电网与清洁能源2011，27，5： | 3 |
| 4 | 牦牛坪钙稀土氟碳酸盐多体矿物的成分特征及其成因意义显示文摘牦牛坪矿床中钙稀土氟碳酸盐多体矿物 ,经扫描电镜观察和电子探针分析 ,表明氟碳铈矿可由矿液直接结晶或通过多体矿物的分解反应形成。与多体矿物相比较 ,氟碳铈矿的稀土配分模式以富La为特点。多体矿物的CaO/REE2 O3 (重量比 )的平均值为 0 131(测试值 )和 0 14 1(计算值 ) ,低于氟碳钙铈矿的理论值 0 171。根据多体系列化学计量的线性关系 ,证明多体矿物形成于Ca2 +和CO2 - 3 活度较低的矿液中。 | 杨主明 Smith M Henderson P Le Bas MJ 陶克捷 张培善 | 2002 | 中国稀土学报2002，20，1： | 2 |
| 5 | The basic he lix loop helix transcription factor HESR1 regulates endothelial cell tube formation 显示文摘 | Henderson A M Wang S J Taylor A C | 2001 | J Biol Chem2001，276，： | 1 |
| 6 | Pharmacokinetics of paraeetamol (acetaminophen) after intravenous and oral administration显示文摘 | Rawlins M D Henderson D B Hiiab A R | 1977 | Eur J Clin Pharmacol1977，11，4： | 1 |
| 7 | Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson' s disease : clinical and therapeutic implications 显示文摘 | Henderson J M Carpenter K Cartwright H | 2000 | Brain2000，123，7： | 1 |
| 8 | Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations 显示文摘 | Jaffe A B Trajtenberg M Henderson R | 1993 | Quarterly Journal of Economics1993，，108： | 1 |
| 9 | An HREELS and TPD study of water on TiO2 (110):the extent of molecular versus dissociative adsorption显示文摘 | HENDERSON M A | 1996 | Surf Sci1996，355，： | 1 |
| 10 | Quantification of Halocene Asian monsoon rainfall from spatially separated cave record 显示文摘 | Hu C Y Henderson G M Huang J H | 2008 | Earth Planet Sci Lett2008，266，： | 1 |
| 11 | Taking China' s temperature: Daily range, warming trends, and regional variations, 1955-2000显示文摘 | Liu Binhui Xu Ming Henderson M | 2004 | Journal of Climate2004，17，： | 1 |
| 12 | The Structure of Glasses Along the Na20-GeO2 Join 显示文摘 | Henderson G S Fleet M E | 1991 | Journal of Non-crystalline Solids1991，134，： | 1 |
| 13 | Oscillation and nonoscillation for impulsive dynamic equations on certain time scales显示文摘 | BENCHOHRA M HAMANI S HENDERSON J | 2006 | Advances in Difference Equ2006，2006，1： | 1 |
| 14 | Geographic localization of knowledge spillovers as evidenced by patent citations 显示文摘 | Jaffe A Trajtenberg M Henderson R | 1993 | Quarterly Journal of Economics1993，108，3： | 1 |
| 15 | SSRIs versusnon-SSRIs in posttraumatic stress disorder: an update with recommendations 显示文摘 | Asnis GM Kohn SR Henderson M | 2004 | Drugs2004，64，4： | 1 |
| 16 | Untangling the Ori- gins of Competitive Advantage显示文摘 | Cockbum A M Henderson R M Stem S | 2000 | Strategic Management Journal2000，，21： | 1 |
| 17 | Partnership nursing home care for dementia:the Glasgow experience one-year follow up 显示文摘 | Lyons D Cohen M Henderson T et a l | 1997 | Int-J-Geriatr Psychiatry1997，12，8： | 1 |
| 18 | Baculoviral expression and characterization of rodent cathepsin S显示文摘 | Mason C S Lamers M B Henderson I M | 2001 | Protein Expression and Purication2001，23，： | 1 |
| 19 | Coherent laser radar at 2μm using solid-state lasers显示文摘 | HENDERSON S W SUNI P J M HALE C P | 1993 | IEEE Transactions on Geoscience and Remote Sensing1993，31，1： | 1 |
| 20 | Geographic locatization of knowledge spillovers as evidencedby patent citations显示文摘 | Jaffe A B Trajtenberg M Henderson R | 1993 | Quarterly Journal of Economics1993，，108： | 1 |
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