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| 1 | 获得性单纯无巨核细胞性血小板减少性紫癜显示文摘本症简称APATP,是一种较少见的骨髓衰竭,其特点是严重的血小板减少伴骨髓巨核细胞数绝对缺乏或显著减少。许多疾病,包括再障、急性白血病、骨髓增生异常征及化疗效疗后,常引起巨核细胞和血小板减少,但它们大多伴有其他造血系的明显异常,而APATP其他造血细胞的改变轻微。 | Hoffman R 陆德炎 | 1993 | 国外医学(输血及血液学分册)1993，16，1： | 4 |
| 2 | Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006显示文摘AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5'noncoding (5'NC) sequencing was performed. We compared categorical data using the Fisher's exact F-test and odds ratios (OR) were calculated for evaluating association of HCV genotype and risk factors. RESULTS:The sex ratio was predominantly male (2.2) and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant (53.4%) followed by genotype 3 (33%). Among risk factors, intravenous drug usage (IVDU) was the most frequently reported (71.4%) followed by medical-related transmission (17.6%) including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU (OR = 4.84, P < 0.0001) whereas genotype 1 was significantly associated with a medical procedure (OR = 2.42, P < 0.001). The HCV genotype distribution from inmate patients differed significantly from the rest of the population (Chi-square test with four degrees of freedom, P < 0.0001) with a higher frequency of genotype 3 (46.5% vs 27.5%) and a lower frequency of genotype 1 and 4 (44.7% vs 56.8% and 5.3% vs 9.6%, respectively). IVDU was nearly exclusively reported as a risk factor in prison. CONCLUSION:We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European countries, with one of the highest European prevalence rates of genotype 3 (33%). Since serology screening became available in 1991, IVDU remains the most common way of HCV transmission in Luxembourg. | Francois Roman Karin Hawotte Daniel Struck Anne-Marie Ternes Jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux Jean-Claude Schmit | 2008 | World Journal of Gastroenterology2008，14，8： | 3 |
| 3 | Skin toxicity determined in vitro by three- dimensional,native-state histoculture显示文摘 | Li L N Margolis L B Hoffman R M | 1991 | Proc Natl Acad Sci USA1991，88，： | 2 |
| 4 | Photocatalytic degradation of pentachlorophenol on TiO2 particles: identification of intermediates and mechanisms of reaction 显示文摘 | GERMAN M HOFFMAN M R | 1993 | Environ Sci Technol1993，27，： | 1 |
| 5 | A typical features in pleomorphic adenoma clinicopathologic study and implications for management显示文摘 | Ethunandan M Witton R Hoffman G el al | 2006 | Int J Oral Maxillofae Surg2006，35，7： | 1 |
| 6 | Cerebrospinal fluid leak following acoustic neuromaremoval显示文摘 | | 1994 | Laryngoscope1994，104，1： | 1 |
| 7 | Changing patterns of practice in the management of nasopharynx carcinoma ( NPC ) : analysis of the National Cancer Database ( NCDB ) 显示文摘 | Hoffman H Cooper JS Weber R | 2004 | J Clin Oncol2004，22，5： | 1 |
| 8 | The interrelationships among sex hormone concentrations, motoneuron excitability, and anterior tibial displacement in women and men显示文摘 | Hoffman M Harter R A Hayers B T | 2008 | J Athletic Training2008，43，： | 1 |
| 9 | Morphology and rheology of polystyrene nanocomposites based upon organoclay显示文摘 | Hoffman B Dietrich C Thomann R | 2000 | Macromol Rapid Commun2000，21，： | 1 |
| 10 | Earliest presence of humans in northeast Asia显示文摘 | Zhu R X Hoffman K A Potts R | 2001 | Nature2001，413，： | 1 |
| 11 | Electrophysiology and pharmacyology of cardic arrhythmias (IX): Cardiac electrophysiologic effects of betaadrenergic receptor stimulation and blockade Parta A显示文摘 | Wit A L Hoffman B F Rosen M R | 1975 | Am Heart J1975，90，4： | 1 |
| 12 | Photocatalytic degradation of pentachlorophenol on TiO2 particles:identification of intermediates and mechanism of reaction 显示文摘 | MILLS G HOFFMAN M R | 1993 | Environ Sci Teehnol1993，27，8： | 1 |
| 13 | Environmental applications of semiconductor photocatalysis显示文摘 | HOFFMAN M R MARTIN S T CHOI W | 1995 | Chemical Reviews1995，95，1： | 1 |
| 14 | Paget's disease of the vulva显示文摘 | Tebes S Cardosi R Hoffman M | 2002 | Am J Obstet Gynecol2002，187，2： | 1 |
| 15 | An examination of response-surface methodologies for uncertainty analysis in assessment models 显示文摘 | Downing D J Gardner R H Hoffman F O | 1985 | Technometrics1985，27，： | 1 |
| 16 | Multiple primary breast andthyroid cancer 显示文摘 | Ron E Curtis R Hoffman DA | 1984 | Br J Cancer1984，49，1： | 1 |
| 17 | Axonal transport of the cy toskeleton in regenerating neurons: constancy and change 显示文摘 | Hoffman P N Lasek R J | 1980 | Brain Res1980，202，2： | 1 |
| 18 | Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model显示文摘 | Hoffman GM Nowakowski R Troshynski T | 2002 | Pediatrics2002，109，2： | 1 |
| 19 | Experienced emergency medicine physicians cannot safely inflate or estimate endo- tracheal tube cuff pressure using standard techniques 显示文摘 | Hoffman R J Parwani V Hahn IH | 2006 | Am J Emerg Med2006，24，2： | 1 |
| 20 | Thallium toxicity and the role of Prussian blue in therapy显示文摘 | Hoffman R S | 2003 | Toxicol Rev2003，22，1： | 1 |
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