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| 1 | Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease显示文摘原子磁性的回声光谱学允许细胞的生物化学和新陈代谢的学习,在整个身体在活体内并且在更高的磁场力量在试管内。因为这种技术非侵略、非选择,磁性的回声光谱学方法论广泛地在生物化学和药被使用了。房间,身体液体和纸巾的在试管内磁性的回声光谱学研究在医药生物化学被使用了调查 pathophysiological 过程,更最近,这种技术被医生使用了决定疾病畸形在活体内。这个加亮的话题说明在试管内的潜力在学习肝胆管系统的磁性的回声光谱学。在恶意、非恶意的肝疾病和胆汁作文的学习的磁性的回声光谱学学习的在试管内质子和磷的角色被讨论,特别地与关联词在活体内的参考整个身体的磁性的回声光谱学应用。在摘要,磁性的回声光谱学技术能在到内在的 pathophysiological 过程的疾病严厉和指针上提供非侵略的生物化学的信息。磁性的回声光谱学为疾病简历标记,以及估计的治疗学的反应作为一个屏蔽工具保持潜在的诺言。 | I Jane Cox Amar Sharif Jeremy FL Cobbold Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，30： | 10 |
| 2 | Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy显示文摘肝的脑病(他) 普通 neuro 精神病学的畸形,它从肝细胞失败或 portosystemic 与肝疾病和结果复杂化病人的功课正在推延。表明他是广泛地可变的并且从温和无临床症状的骚乱包含一个系列到深昏迷。研究兴趣集中于传播导出勇气的毒素的角色,特别地氨,胀大的大脑的开发和在导致全球 CNS 消沉和混乱功能的服的 neurotransmitter 系统的变化。直到最近,服的功能的直接调查有在人是困难的。然而,当磁性的回声光谱学( 1H 太太)检测的质子在大脑生物化学变化时,新磁性的回声成像( MRI )技术在大脑体积( coregistered MRI )和损害大脑功能( fMRI )提供对变化的评价的一个非侵略的工具,包括服的 osmolytes 的直接测量,例如 myoinositol ,充斥管理对细胞的动态平衡内在的过程的使挫折和夫酸安,包括细胞内部的水的累积。这些细胞内部的 osmolytes 的集中与 hyperammonaemia 改变。有 neuropsychiatric 缺陷并且自从先生系列的严厉的检测太太的代谢物畸形相互关联向正常术后疗法回来,技术可能具有在客观耐心的监视并且在估计各种各样的治疗政体的有效性的使用。 | VP Bob Graver M Alex Dresner Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，19： | 8 |
| 3 | Cholangiocarcinoma显示文摘 | Shahid A Khan Howard C Thomas Brian R Davidson Simon D Taylor-Robinson | 2005 | The Lancet . 2005 (9493)2005，，： | 3 |
| 4 | Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature显示文摘Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals,including solid organ transplant recipients,but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy,and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous ampicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis,and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis. | Shugo Mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita | 2007 | World Journal of Gastroenterology2007，13，32： | 2 |
| 5 | Role of microbubble ultrasound contrast agents in the non-invasive assessment of chronic hepatitis C-related liver disease显示文摘长期地感染丙肝病毒的病人经常得长期的肝疾病,对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的成像形式之一并且已经是为肝疾病的一个首要的诊断工具。Microbubble 超声对比代理人允许更高的分辨率要获得的图象和对要执行的微脉管的变化的功能的评价。在确定的这些代理人的角色肝的损害的状态作为与丙肝在病人决定肝疾病的阶段和等级的一个可行方法被讨论。尽管当前限制了到专家中心,提高对比的超声将不可避免地在临床的背景增加的微水泡的可获得性。 | Scott Grier Adrian KP Lim Nayna Patel Jeremy FL Cobbold Howard C Thomas Isobel J Cox Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，22： | 2 |
| 6 | Cholangiocarcinoma显示文摘 | Shahid A Khan Howard C Thomas Brian R Davidson Simon D Taylor-Robinson | 2005 | The Lancet2005，，9493： | 2 |
| 7 | Preferential induction of apoptosis for primary human leukemic stem cells显示文摘 | GUZMAN M L SWIDERSKI C F HOWARD D S | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 8 | Are there other persistent organic pollutants? A challenge for environmental chemists显示文摘 | MUIR D C G HOWARD P H | 2006 | Environmental Science & Technology2006，40，23： | 1 |
| 9 | Research strategies for safety evaluation of nanomaterials, Part IV : Risk assessment of nanopartlcles显示文摘 | TSUJI J S MAYNARD A D HOWARD C P | 2006 | Toxicological Sciences2006，89，1： | 1 |
| 10 | Effect of cryoprotective diluent and method of freeze - thawing on survival and acrosomal of ram spermatozoa显示文摘 | Pontbriand D J G Howard M C Schiewe | 1989 | Cryobiology1989，26，： | 1 |
| 11 | A risk-return measure of hedging effectiveness: A reply显示文摘 | Howard C D'Antonio L | 1987 | Journal of Financial and Quantitative Analysis1987，22，3： | 1 |
| 12 | Randomized, placebo-controlled, double blinded trial of dexamethesone in African children with sepsis显示文摘 | Gbadero D Howard C | 1996 | Pediatr Infect Dis J1996，15，7： | 1 |
| 13 | A risk-return measure of hedging effectiveness显示文摘 | d' AntonioL J | 1984 | Journal of Financial and Quantitative Analysis1984，，19： | 1 |
| 14 | Double-blind,randomized,controlled trial of atosiban and rito drine in the treatment of pretterm labor: a multicenter effectiveness and safety study显示文摘 | Moutquin J M herman D S Howard C | | Am J Obstet Gynecol0，182，5： | 1 |
| 15 | A Risk-return measure of hedging effectiveness显示文摘 | Howard C T Antonio L J D | 1984 | Journal of Financial and Quantitative Analysis1984，19，3： | 1 |
| 16 | The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in typel diabetes显示文摘 | B C Bergman D Howard I E Schauer | 2013 | Journal of Clinical Endocrinology&Metabolism2013，98，1： | 1 |
| 17 | On-line immunoaffinity capture, coupled with HPLC and electrospray ionization mass spectrometry, for automated determination of fumonisins显示文摘 | NEWKIRK D K BENSON R W HOWARD P C | 1998 | J Agile and Food Chemisty1998，46，4： | 1 |
| 18 | Dynamic response and wave propagation in plane masses and frames显示文摘 | PAO Y H KEH D C HOWARD S M | 1999 | AIAA J1999，37，： | 1 |
| 19 | Greenhouse gas foottprinting for small business-The use of input-output data 显示文摘 | Berners-Lee M Howard D C Moss J | 2011 | Science of the Total Environment2011，409，5： | 1 |
| 20 | A risk-return measure of hedging effectiveness显示文摘 | Howard C T D' Antonio L J | 1984 | Journal of Financial and Quantitative Analysis1984，19，1： | 1 |
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