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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 4 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 5 | Correlation between Weak Ferromagnetism and Crystal Symmetry in Gd2CuO4-Type Cuprates 显示文摘 | Luo H M Hsu Y Y Lin B N | 1999 | Phys Rev B1999，60，13： | 2 |
| 6 | Machine vision and background remover-based approach for PCB solder joints inspection 显示文摘 | B C Jiang C C Wang Y N Hsu | 2007 | Inter national Journal of Production Research2007，45，： | 1 |
| 7 | Generating Finite - state Transducers for Semi-structured Data Extraction from the Web显示文摘 | Hsu C N Dung M T | 1998 | Information Systems1998，23，8： | 1 |
| 8 | A Class of nearly long memory time series models显示文摘 | N Hsu | 2002 | International Journal of Forecasting2002，，18： | 1 |
| 9 | Effect of brain e dema on infarct volume in a focal cerebral ischemia model in rats显示文摘 | Lin T N He Y Y Wu G Khan M Hsu C Y | 1993 | Stroke1993，24，： | 1 |
| 10 | Hypothermia caused by slow and limited-volume fluid resuscitation decreases organ damage by hemorrhagic shock 显示文摘 | SUBEQ Y M HSU B G LIN N T | 2012 | Cytokine2012，60，1： | 1 |
| 11 | A multipurpose reservoir real-time operation model for flood control during typhoon invasion 显示文摘 | HSU N S WEI C C | 2007 | Journal of Hydrology2007，336，34： | 1 |
| 12 | Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction显示文摘 | Paczynski R P He Y Y Diringer M N Hsu C Y | 1997 | Stroke1997，28，： | 1 |
| 13 | Enhanced magnetic eoereivities in Fe nanowires显示文摘 | GROBERT N HSU W K ZHU Y Q | 1999 | Appl Phys Lett1999，75，： | 1 |
| 14 | Quantum dot nanoparticies affect the reproductive system of Caenorhabditis elegans显示文摘 | Hsu P C O'Callaghan M Al- Salim N | 2012 | Environmental Toxicology and Chemistry2012，31，10： | 1 |
| 15 | A dynamic lot sizing problem with multiple customers: customer-specific shipping and backlogging costs 显示文摘 | Suresh C Hsu V N Sethi S Deshpande V | 2007 | IIE Transactions2007，39，： | 1 |
| 16 | Transient global ischemia alters NMDA receptor expression in rat hippocampus: Correlation with decreased immunoreactive protein levels of the NR2A/NR2B subunits, and altered NMDA receptor functionality 显示文摘 | Zhang L Hsu J C Takagi N | 1997 | J Neurochem1997，69，5： | 1 |
| 17 | The design, construction and application of a large aperture lens-less line-focus PVDF transducer 显示文摘 | DENG X HSU N N BLESSING G V | 1996 | Ultrasonics1996，34，： | 1 |
| 18 | Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification显示文摘 | Hsu H H Camaeho N C Tawfik O | 2002 | Atherosclerosis2002，161，1： | 1 |
| 19 | Spatial distribution and sample size estimation of the spiraling whitefly (Aleurodicus disperses Russell) on guava显示文摘 | WEN H C HSU T C CHEN C N | 1994 | J Chinese Entomol1994，14，4： | 1 |
| 20 | A simple mix design method for selfcompacting concrete 显示文摘 | Su N Hsu K Chai H | 2001 | Cement and Concrete Research2001，，31： | 1 |
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