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| 1 | Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression显示文摘AIM To investigate the mechanisms ofsalvianolic acid A(SA-A)against liver fibrosisin vitro.METHODS NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 h.The cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase digestionmethod.The total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α(1)I pro-collagen mRNAexpression was semi-quantitatively analyzedwith RT-PCR.RESULTS 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen secretion.Both 10-5mol/L and10-6mol/L SA-A could decrease α(1)I pro-collagen mRNA expression remarkably.CONCLUSION SA-A had potent action againstliver fibrosis.It inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug. | Liu CH Hu YY Wang XL Liu P Xu LM | 2000 | World Journal of Gastroenterology2000，6，3： | 25 |
| 2 | Yes相关蛋白通过肿瘤坏死因子受体相关因子6控制内皮活化和血管炎症显示文摘继发于异常的内皮激活的微血管炎症和内皮功能障碍在败血症和器官衰竭的病理生理学中起关键作用。抑制内皮细胞过度活化的内在信号传导机制尚未完全明了。该研究旨在确定Yes相关蛋白(Yes-associated protein,YAP)(Hippo通路的主要转录共激活剂)在调节内皮活化和血管炎症的强度和程度中的中心作用。 | 刘青 叶鹏 Lv Y Kim K Sheng Y Cho J Qain Z Zhao YY Hu G Pan D Malik AB | 2018 | 中华高血压杂志2018，26，8： | 20 |
| 3 | Protective actions of salvianolic acid A on hepatocyte injured by peroxidation in vitro显示文摘INTRODUCTION Salvianolic radix,one of the most commonly usedtraditional Chinese herbs,was widely studied aboutits actions against liver injury and fibrosis,and wasone of the focuses of recent research.Salvianolic acid-A(SA-A)was an aqueous solublecomponent of Salvianolic radix.In our | Hu YY Liu CH Wang RP Liu C Liu P Zhu DY | 2000 | World Journal of Gastroenterology2000，6，3： | 15 |
| 4 | Species distribution of polymeric aluminium ferrum——timed complexation colorimetric analysis method of Al-Fe-Ferron显示文摘The effects of the colorimetric buffer solutions were investigated while the two colorimetric reactions of A1 ferron complex and Fe ferron complex occurred individually, and the effects of the testing wavelength and the pH of the solutions were also investigated. A timed complexation colorimetric analysis method of A1 Fe ferron in view of the total concentration of {A1+Fe} was then established to determine the species distribution of polymeric Al Fe. The testing wavelength was recommended at 362 nm and the testing pH value was 5. With a comparison of the ratios of n Al / n Fe , the standard adsorption curves of the polymeric Al Fe solutions were derived from the experimental results. Furthermore, the solutions’composition were various in both the molar n Al / n Fe ratios, i.e. 0/0, 5/5, 9/1 and 0/10, and the concentrations associated with the total [A1+Fe] which ranged from 10 -5 to 10 -4 mol/L. | Hu, YY Tu, CQ Wu, HH | 2001 | Journal of Environmental Sciences2001，13，4： | 8 |
| 5 | Morphology Characteristics of Nd-rich Phase Particles in Melt-quenched Ti-5Al-4Sn-2Zr-1Mo-0.25Si-1Nd Alloy显示文摘The morphology of the melt-equenched Ti-5Al-4Sn-2Zr-1Mo-9.25Si-1Nd alloy is uniformly distributed Nd-rich phase particles in matrix. The particles within grains are spherical, and the particles at grain boundaries are elliptical. The Nd-rich phase particle calculated is 6.6 nm in diameter, which is within the 6-15 nm range of average particle diameter experimentally ob served in the alloy The practical interfsce velocity (0.5 m/s) is much greater than the critical velocity (0.15 m/s), hence the Nd-rich phase particles are trapped by the liquid-solid | LI, GP LI, D LIU, YY HU, ZQ | 1995 | Journal of Materials Science & Technology1995，11，6： | 3 |
| 6 | Powder Microstructure and Overlay Coating Property ofNiCrAlY Alloy显示文摘这被显示出更好(20-30 亩 m ) 粉末粒子经历快速的复辉和热抽取到导致微细胞的结构的环境,而更粗糙(40-50 亩 m ) 因为慢冷却跟随的复辉,粉末粒子展出粗糙的细胞、树枝状的混合结构。另外,这也被显示越好粉末粒子尺寸,越 higher 机械性质并且冶金热稳定性过分,涂层由把同样分裂成原子的粉末扔了,它大概为粉末的好尺寸部分被归因于稠密的好谷物结构和氧化物层的形成。(编辑作者摘要) 9 个裁判员。 | Chang, XC Wang, JQ Hao, YY Hou, WL Hu, ZQ | 1998 | Journal of Materials Science & Technology1998，14，4： | 3 |
| 7 | Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism.显示文摘 | Lin XJ Zhang F Xie YY Bao WJ He JH Hu HY | 2006 | 中国生物学文摘2006，20，9： | 2 |
| 8 | Epidemiology of Heli cobacter pylori in Southern China:identification of early childhood as the critical period for acquisition显示文摘 | Mitchell HM Li YY Hu PJ | 1992 | J Infect Dis1992，166，： | 1 |
| 9 | Hyperhomocysteinaemia,low folate concerntrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis显示文摘 | He JA Hu XH Fan YY | 2010 | Eur J Vasc Endovasc Surg2010，39，4： | 1 |
| 10 | Notch signaling pathway and cancer metastasis 显示文摘 | Hu YY Zheng MH Zhang R | 2012 | Adv Exp Med Biol2012，727，： | 1 |
| 11 | MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neu- ron cell apoptosis post-status epilepticus显示文摘 | Hu K Xie YY Zhang C | 2012 | BMC Neurosci2012，13，： | 1 |
| 12 | Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay 显示文摘 | Hu YY He SS Wang X | 2002 | Am J Pathol2002，160，4： | 1 |
| 13 | A role of periaqueductal grey NR2B- containing NMDA receptor in mediating persistent inflammatory pain 显示文摘 | Hu J Wang Z Guo YY | 2009 | Mol Pain2009，12，5： | 1 |
| 14 | Activation of the central histaminergie system is involved in hypoxia-induced stroke tolerance in adult mice 显示文摘 | Fan YY Hu WW Dai HB | 2011 | J Cereb Blood Flow Metab2011，31，1： | 1 |
| 15 | Cerebral ischemic pre-conditioning enhances the binding characteristics and glutamate uptake of glial glutamate transporter-1 in hippocampal CA1 subfield of rats显示文摘 | Liu AJ Hu YY Li WB | | 0，，： | 1 |
| 16 | Influence of silica particle internalization on adhesion and migration of human dermal fibroblasts 显示文摘 | Zhang YY Hu L Yu DH | 2010 | Biomaterials2010，31，32： | 1 |
| 17 | Disruption of the transcription factorRBP-J results in osteopenia attributable to attenuated osteoclast dif-ferentiation 显示文摘 | Ma J Liu YL Hu YY | 2013 | Mol Biol Rep2013，40，3： | 1 |
| 18 | Helicobacter pylori associated with a high prevalence ofduodenal ulcer disease and a low prevalence of gastric cancer in a developing nation显示文摘 | Hu PJ Li YY Zhou MH | 1995 | Gut1995，36，： | 1 |
| 19 | Interleukin-17A expression in patients with chronic thinosinusitis and its relationship with clinical features显示文摘 | Hu XD Bao YY Zhou SH | 2013 | J Int Med Res2013，41，3： | 1 |
| 20 | Characteristics and risk factors of oxaliplatin -related hypersensitivity reactions显示文摘 | Shao YY Hu FC Liang JT | 2010 | J Formos Med As- soc2010，109，： | 1 |
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