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| 1 | Virus-induced Gene Silencing in Eggplant(Solanum melongena)显示文摘Eggplant(Solanum melongena)is an economically important vegetable requiring investigation into its various genomic functions.The current limitation in the investigation of genomic function in eggplant is the lack of effective tools available for conducting functional assays.Virus-induced gene silencing(VIGS)has played a critical role in the functional genetic analyses.In this paper,TRV-mediated VIGS was successfully elicited in eggplant.We first cloned the CDS sequence of PDS(PHYTOENE DESATURASE) in eggplant and then silenced the PDS gene.Photo-bleaching was shown on the newly-developed leaves four weeks after agroinoculation,indicating that VIGS can be used to silence genes in eggplant.To further illustrate the reliability of VIGS in eggplant,we selected Chl H,Su and CLA1 as reporters to elicit VIGS using the high-pressure spray method.Suppression of Chl H and Su led to yellow leaves,while the depletion of CLA1 resulted in albino.In conclusion,four genes,PDS,Chl H,Su(Sulfur),CLA1,were down-regulated significantly by VIGS,indicating that the VIGS system can be successfully applied in eggplant and is a reliable tool for the study of gene function. | Haiping Liu Daqi Fu Benzhong Zhu Huaxue Yan Xiaoying Shen Jinhua Zuo Yi Zhu Yunbo Luo | 2012 | Journal of Integrative Plant Biology2012，54，6： | 11 |
| 2 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 3 | Modeling the impact of the viaduct on particles dispersion from vehicle exhaust in street canyons显示文摘In this paper,the impact of the viaduct on flow and traffic exhausting particles dispersion within urban street canyons was nu-merically simulated using a computational fluid dynamics(CFD) model.Two-dimensional flow and dispersion of particles from traffic exhausts were modeled using the standard k-? turbulence model.The street canyons with a viaduct at different widths and different heights above the ground are simulated.The results show that the airflow in street canyon is evidently in-fluenced by the viaduct:The position of the main vortex center is changed,especially there are two strong vortexes when the viaduct is placed at 10 m height above the ground.It is found based on the study of the particles number concentrations(PNCs) that the viaduct may mitigate the pollution level in the street canyon sometimes.The impact of the viaduct width on PNCs is stronger than that of the height.The study of PNDs reveals that the mean PNCs at the wall of upwind building increase when a viaduct is placed in street canyon.In addition,it is found based on the study of mean particles residence time(PRT) that the removal of the particles strongly correlates to the mean PNCs.The results indicate that the viaduct is an important factor to in-fluence the flow patterns and particles dispersion in street canyons. | ZHANG ChuanFu WEN Mou ZENG JianRong ZHANG GuiLin FANG HaiPing LI Yan | 2012 | Science China(Technological Sciences)2012，55，1： | 5 |
| 4 | Ischemic stroke susceptibility gene in a Northern Han Chinese population显示文摘Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the -607C allele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affiliated Hospital of Qingdao University Medical College, China, and 226 healthy controls. Both patients and controls were from the Han population in northern China. Immunoresonance scattering assays detected increased serum amyloid A protein, C-reactive protein, and interleukin-18 levels in ischemic cerebrovascular disease patients compared with healthy controls. Analysis of the -607C/A (rs1946518) polymorphism in the interleukin-18 gene promoter showed ischemic cerebrovascular disease patients exhibited increased frequencies of the CC genotype and C alleles than healthy controls. Genotype and allele frequencies of the interleukin-18 -137G/C (rs187238) polymorphism and the -13T/C (rs11024595) polymorphism in the 5'-flanking region of serum amyloid A, showed no significant difference between the two groups. Multivariate logistic regression analysis on the interleukin-18 promoter A/C genetic locus, for correction of age, gender, history of smoking, hypertension, diabetes mellitus, hypercholesteremia, and an ischemic stroke family history, showed ischemic cerebrovascular disease risk in individuals without the A allele (C homozygotes) was 2.2-fold greater than in A allele carriers. Overall, our findings suggest that the -13T/C (rs11024595) polymorphism in the 5′-flanking region of serum amyloid A has no correlation with ischemic cerebrovascular disease, but the C allele of the -607C/A (rs1946518) polymorphism in the interleukin-18 promoter is a high-risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A allele is likely a protective gene for ischemic cerebrovascular disease. | Haiping Wang Shujuan Shi Wenjing Yan Yan Song Jingjing Zhan Chen Zhang Haiji Wang | 2013 | Neural Regeneration Research2013，8，20： | 4 |
| 5 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 6 | Characteristics of hemicellulose, cellulose and lignin pyrolysis显示文摘 | Haiping Yang Rong Yan Hanping Chen Dong Ho Lee Chuguang Zheng | 2006 | Fuel2006，，12： | 3 |
| 7 | Identification and characterization of Mini1, a gene regulating rice shoot development显示文摘The aerial parts of higher plants are generated from the shoot apical meristem(SAM). In this study, we isolated a small rice(Oryza sativa L.) mutant that showed premature termination of shoot development and was named mini rice 1(mini1). The mutant was first isolated from a japonica cultivar Zhonghua11(ZH11) subjected to ethyl methanesulfonate(EMS)treatment. With bulked segregant analysis(BSA) and map-based cloning method, Mini1 gene was finally fine-mapped to an interval of 48.6 kb on chromosome 9. Sequence analyses revealed a single base substitution from G to A was found in the region, which resulted in an amino acid change from Gly to Asp.The candidate gene Os09g0363900 was predicted to encode a putative adhesion of calyx edges protein ACE(putative HOTHEAD precursor) and genetic complementation experiment confirmed the identity of Mini1. Os09g0363900 contains glucose-methanol-choline(GMC) oxidoreductase and NAD(P)-binding Rossmann-like domain, and exhibits high similarity to Arabidopsis HOTHEAD(HTH). Expression analysis indicated Mini1 was highly expressed in young shoots but lowly in roots and the expression level of most genes involved in auxin biosynthesis and signal transduction were reduced in mutant.We conclude that Mini1 plays an important role in maintaining SAM activity and promoting shoot development in rice. | Yunxia Fang Jiang Hu Jie Xu Haiping Yu Zhenyuan Shi Guosheng Xiong Li Zhu Dali Zeng Guangheng Zhang Zhenyu Gao Guojun Dong Meixian Yan Longbiao Guo Yonghong Wang Qian Qian | 2015 | Journal of Integrative Plant Biology2015，57，2： | 3 |
| 8 | p38α MAP kinase phosphorylates RCAN1 and regulates its interaction with calcineurin显示文摘RCAN1,also known as DSCR1,is an endogenous regulator of calcineurin,a serine/threonine protein phosphatase that plays a critical role in many physiological processes.In this report,we demonstrate that p38 MAP kinase can phosphorylate RCAN1 at multiple sites in vitro and show that phospho-RCAN1 is a good protein substrate for calcineurin.In addition,we found that unphosphorylated RCAN1 noncompetitively inhibits calcineurin protein phosphatase activity and that the phosphorylation of RCAN1 by p38 MAP kinase decreases the binding affinity of RCAN1 for calcineurin.These findings reveal the molecular mechanism by which p38 MAP kinase regulates the function of RCAN1/calcineurin through phosphorylation. | MA Lei TANG HaiPing REN Yan DENG HaiTeng WU JiaWei WANG ZhiXin | 2012 | Science China(Life Sciences)2012，55，7： | 2 |
| 9 | Effects of greenness on preterm birth: A national longitudinal study of 3.7 million singleton births显示文摘Exposure to greenness may lead to a wide range of beneficial health outcomes.However,the effects of greenness on preterm birth(PTB)are inconsistent,and limited studies have focused on the subcategories of PTB.A total of 3,751,672 singleton births from a national birth cohort in China's Mainland were included in this study.Greenness was estimated using the satellitebased Normalized Difference Vegetation Index(NDVI)and Enhanced Vegetation Index with 500-m and 1,000-m buffers around participants’addresses.The subcategories of PTB(20-36 weeks)included extremely PTB(EPTB,20-27 weeks). | Lina Zhang Shuyan Shi Shenpeng Wu Ying Yang Jihong Xu Ya Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Zuoqi Peng Cong Liu Weidong Wang Yixuan Jiang Su Shi Renjie Chen Haidong Kan Yuan He Xia Meng Xu Ma | 2022 | The Innovation2022，3，3： | 2 |
| 10 | A core-shell composite pigment with rutile TiO_(2) intensification for UV inhibition显示文摘Organic pigments generlly have bright colors but poor ultraviolet(UV)resistance.To improve the UV for UVinhibition is proposed by afacile sol-gel method inthis work.Acore-shellstructure,witha homo resistance and extend the applications,a core-shell composite pigment with rutile Tio intensification geneous sol-gel TiO_(2) shell containing additional nanosized rutile TiO2 particles and with the pigment as the core,was established taking advantage of UV resistance of TiO2 and binding ability of sol-gel.While the sol-gel TiO2 shell alone has already shown obvious ultraviolet shielding effect,as tested over different sol-gel aging times and Tio2 loadings,the UV resistance of the fluorescent pigments was further enhanced by binding the nanosized rutile TiO2 in the sol-gel shell At a sol-gel TiO2 to rutile TiO2 ratio of 2:1,the UV exposure time is extended about eight times compared with that of the original pigment and twice as that of the modifed pigment with pure sol-gel TiO2 for the same color change.Therefore,the novel core-shell composite pigment intensified with nanosized rutile Tio2 particles is proved to be effcient in improving the uV resistance of organic pigments. | Xiao Lv Baowei Yan Yuanyuan Shao Haiping Zhang Hui Zhang Jesse Zhu | 2022 | Particuology2022，20，8： | 2 |
| 11 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 12 | Characteristics of hemicellulose, cellulose, and lignin pyrolysis显示文摘 | Haiping Yang Rong Yan Hanping Chen | 2007 | BB Fuel2007，86，1213： | 1 |
| 13 | Thermogravimetric analysis-Fourier transform infrared analysis of palm oil waste pyrolysis显示文摘 | Yang Haiping Yan Rong Chin Terence | 2004 | Energy&Fuels2004，18，6： | 1 |
| 14 | Characteristics of hemicellulose, cellulose and lignin pyrolysis显示文摘 | Haiping Yang Rong Yan Hanping Chen Dong Ho Lee Chuguang Zheng | 2006 | Fuel2006，，12： | 1 |
| 15 | Fermentation characteristics of six probiotic strains in soymilk显示文摘 | Haiping Li Liya Yan Jicheng Wang Qing Zhang Qi Zhou Tiansong Sun Wei Chen Heping Zhang | 2012 | Annals of Microbiology2012，，4： | 1 |
| 16 | In vitro screen of Lactobacillus plantarum as probiotic bacteria and their fermented characteristics in soymilk显示文摘 | Yan Bao Yong Zhang Haiping Li Yong Liu Shuiquan Wang Ximei Dong Fang Su Guoqiang Yao Tiansong Sun Heping Zhang | 2012 | Annals of Microbiology2012，，3： | 1 |
| 17 | Validation and application of an LC–ESI-MS method for simultaneous determination of astilbin and its major metabolite 3′-O-methylastilbin in rat plasma显示文摘 | Yan Liang Qiang Xu An Kang Yuan Xie Tong Xie Li Liu Haiping Hao Lin Xie Guang-ji Wang | 2009 | Journal of Chromatography B2009，，18： | 1 |
| 18 | Thermal dissolution of shenfu coal in different solvents显示文摘 | Shui Hengfu Zhou Yan Li Haiping | 2013 | Fuel2013，108，11： | 1 |
| 19 | Characteristics of hemicellulose, cellulose and lignin pyrolysis显示文摘 | Yang Haiping Yan Rong Chen Hanping | 2007 | Fuel2007，86，15： | 1 |
| 20 | Characteristics of Hemicellulose, Cellulose and Lignin Pyrolysis显示文摘 | Yang Haiping Yan Rong Chen Hanping | 2007 | Fuel2007，86，213： | 1 |
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