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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Hepatic cytochromes P450 2E1 is increased in patients with nonalocholic steatohepatitis显示文摘 | Weltman M D Farrekk G C Hall P | 1998 | Hepatology1998，27，2： | 2 |
| 3 | Analytical perspective on trace element species of interest in exploration 显示文摘 | Hall G E M | 1998 | Journal of Geochemical Exploration1998，61，13： | 1 |
| 4 | Characterization of randomly-obtained matrix attachment regions (MARs) from higher plants显示文摘 | Michalowski S M Alien G C Hall G E Thompson W F Spiker S | 1999 | Biochemistry1999，38，12： | 1 |
| 5 | Role of sediment composition in tracemetal distribution in lake sediments显示文摘 | Blilali L El Rasmussen P E Hall G E M | 2002 | Applied Geochemistry2002，17，： | 1 |
| 6 | The burden of respiratory syncytial virus infection in young children 显示文摘 | Hall C B Weinberg G A Iwane M K | 2009 | New England Journal of Medicine2009，360，6： | 1 |
| 7 | Maximizing the value of a space mission显示文摘 | Hall N G Magazine M J | 1994 | European Journal of Operational Research1994，78，2： | 1 |
| 8 | Origin of themobile gene cassettes found in integrons显示文摘 | Recchia G D Hall R M | 1997 | Trends Microbio1997，5，10： | 1 |
| 9 | Guideline for the management of nonmusele invasive bladder cancer (stages Ta, T1, and Tis): 2007 Update显示文摘 | Hall M C Chang S S Dalbagni G | 2007 | J Urol2007，178，6： | 1 |
| 10 | Central and peripheral dopamine D1/DA 1 receptor modulation of gastric secretion and experimental gastric mucosal injury显示文摘 | Glavin G B Hall A M | 1995 | General Pharmacology1995，26，6： | 1 |
| 11 | Risk Analysis Techniques and Their Application to Software Development 显示文摘 | BENNETT J C BOHORIS G A ASHNWALL E M HALL R C | 1996 | European Journal of Operational Research1996，95，： | 1 |
| 12 | Benchmarking Attribute Selection Techniques for Discrete Class Data Mining显示文摘 | Hall M A Holms G | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，6： | 1 |
| 13 | Analytical perspectives on trace element species of interest in exploration显示文摘 | Hall G E M | 1998 | Journal of Geochemical Exploration1998，61，： | 1 |
| 14 | Near infrared reflectance prediction of quality, theaflavin content and moisture content of black tea显示文摘 | M N Hall A Robertson C N G Scotter | 1988 | Food Chem1988，，27： | 1 |
| 15 | X-ray line broadening from filed aluminium and wolfram 显示文摘 | WILLIAMSON G K HALL W M | 1953 | Acta Materialia1953，1，： | 1 |
| 16 | The use of partial extraction geochemistry for copper esploration in northern Chile显示文摘 | Kelley D L Hall G E M Graham Closs L | 2003 | Geochemistry: Exploration Environment Analysis2003，3，1： | 1 |
| 17 | Regeneration of adult axons in white matter tracts of the central nervous system显示文摘 | Davies S J Fitch M T Memberg S P Hall A K Raisman G Silver J | 1997 | Nature1997，390，： | 1 |
| 18 | Genetic alterations of cyclins, cyclin-dependent kinase, and CDK inhibitors in human cancer 显示文摘 | Hall M Peters G | 1996 | Adv Cancer Res1996，68，： | 1 |
| 19 | Integrated processing equipment显示文摘 | Bader M E Hall R P Strasser G | 1990 | Solid State Technology1990，33，5： | 1 |
| 20 | Health-related quality of life measurement in women with polycystic ovary syndrome:a systematic review显示文摘 | Jones G L Hall J M Balen A H | 2008 | Hum Reprod Update2008，14，1： | 1 |
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