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| 1 | Endothelial progenitor cells in peripheral blood may serve as a biological marker to predict severe acute pancreatitis显示文摘AIM To investigate the significance of endothelial progenitor cells(EPCs) in predicting severe acute pancreatitis(SAP).METHODS We recruited 71 patients with acute pancreatitis(AP) and excluded 11 of them; finally, cases of mild acute pancreatitis(MAP)(n = 30) and SAP(n = 30), and healthy volunteers(n = 20) were internalized to investigate levels of EPCs, C-reactive protein(CRP), tumor necrosis factor-alpha(TNF-α), fibrinogen(FIB)and white blood cells(WBC) in peripheral blood. RESULTS The levels of TNF-α, WBC, FIB and CRP were higher both in SAP and MAP cases than in healthy volunteers(P < 0.05, all). Interestingly, the level of EPCs was higher in SAP than MAP(1.63% ± 1.47% vs 6.61% ± 4.28%, P < 0.01), but there was no significant difference between the MAP cases and healthy volunteers(1.63% ± 1.47% vs 0.55% ± 0.54%, P > 0.05). Receiver operating characteristics curve(ROC) showed that EPCs, TNF-α, CRP and FIB were significantly associated with SAP, especially EPCs and CRP were optimal predictive markers of SAP. When the cut-off point for EPCs and CRP were 2.26% and 5.94 mg/d L, the sensitivities were 90.0% and 73.3%, and the specificities were 83.3% and 96.7%. Although, CRP had the highest specificity, and EPCs had the highest sensitivity and highest area under the curve value(0.93). CONCLUSION Data suggest that EPCs may be a new biological marker in predicting SAP. | Xiao-Qin Ha Yue-Juan Song Hong-Bin Zhao Wei-Wei Ta Hong-Wei Gao Qiang-Sheng Feng Ju-Zi Dong Zhi-Yun Deng Hong-Yan Fan Jun-Hua Peng Zhi-Hua Yang Yong Zhao | 2017 | World Journal of Gastroenterology2017，23，14： | 15 |
| 2 | Cholangiocarcinoma: a spectrum of intrahepatic, perihilar, and distal tumors 显示文摘 | Nakeeb A Pitt HA Sohn TA | 1996 | Ann Surg1996，224，46： | 1 |
| 3 | Immunopathogenesis of atherosclerosis:endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet显示文摘 | Lehr HA Sagban TA Ihling C | 2001 | Circulation2001，104，8： | 1 |
| 4 | Identifying stone composition using infrared analysis of filtered urine after ureleroscopic lithotripsy显示文摘 | Wollin TA Razvi HA Denstedt JD | 1999 | J Endourol1999，13，7： | 1 |
| 5 | Future management of carotid stenosis:role of urgent carotid interventions in the acutely symptomatic carotid patient and best medical therapy for asymptomatic carotid disease 显示文摘 | Bazan HA Smith TA Donovan MJ | 2014 | Ochsner J2014，14，4： | 1 |
| 6 | Quality of life and long-term survival after surgery for chronic pancreatitis显示文摘 | Sohn TA Campbell KA Pitt HA | 2000 | J Gastrointest Surg2000，4，4： | 1 |
| 7 | Identifying stone composition using infrared analysis of filtered urine after ureteroscopic lithotripsy显示文摘 | Razvi HA Densteds JD | 1998 | J Endourol1998，12，： | 1 |
| 8 | Identifyings tone composition using infrared analysis of filtered urine after ureteroscopic lithotripsy显示文摘 | Wollin TA Razvi HA denstedt JD | 1999 | J Endourol1999，13，： | 1 |
| 9 | Identifying stone composition using infrared analysis of filtered urine after ureteroscopic lithotripsy显示文摘 | Wollin TA Razvi HA Denstedt JD | 1999 | J Endourol1999，13，7： | 1 |
| 10 | Bone grafts prepared with selective cell retention technology heal canine segmental defects as effectively as autograft显示文摘 | Pedrozo HA Kaput TA | 2006 | J Orthop Res2006，24，5： | 1 |
| 11 | Cholangiocarcinoma: A spectrum of intrallepatic, perihilar, and distal tumors显示文摘 | Nakeeb A Pitt HA Sohn TA | 1996 | Ann Surg1996，224，4： | 1 |
| 12 | hnage-guided, endoscopic, transcervical resection of cervical chordoma 显示文摘 | Hsu W Kosztowski TA Zaidi HA | 2010 | J Neurosurg Spine2010，12，4： | 1 |
| 13 | Identifying stone composition using infrared analysis of filtered urine after ureteroscopic lithotripsy显示文摘 | Wollin TA Razvi HA Denstedt JD | 1999 | J Endourol1999，13，7： | 1 |
| 14 | Bone grafts prepared with selective cell retention technology heal canine segmental defects as effectively as autograft显示文摘 | Brodke D Pedrozo HA Kaput TA | 2006 | J Orthop Res2006，24，5： | 1 |
| 15 | Identifying stone composition using infared analysis of filtered urine after ureteroscopic lithotripsy显示文摘 | Wollin TA Razvi HA Denstedt JD | 1999 | J Endourol1999，13，： | 1 |
| 16 | Probability and the westgard rules D显示文摘 | Carrou TA Pinnick HA Carroll WE | 2003 | Ann Clin Lab Sci2003，33，1： | 1 |
| 17 | Identifying stone composition using infrared analysis of filtered urine after ureteroscopic lithotripsy 显示文摘 | Wollin TA Razvi HA Denstedt JD | 1999 | J Endourol1999，13，7： | 1 |
| 18 | The antiestrogen toremifene protects against alcoholic liver injury in female rats显示文摘 | Jarvelainenl HA Lukkaril TA Heinaro S | 2001 | J Hepatol2001，35，： | 1 |
| 19 | Immuno pathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet显示文摘 | Sagban TA Ihling C | 2001 | Circulation2001，104，： | 1 |
| 20 | Cholangiocarcinoma: a spectrum of intrahepatic,perihilar, and distal tumors显示文摘 | Nakeeb A Pitt HA Sohn TA | 1996 | Ann Surg1996，224，： | 1 |
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