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| 1 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 2 | Synthesis, Characterization and X-ray Structure of N-(4-bromobutanoyl-N'-(2-3-and 4-methylphenyl)thiourea显示文摘N-4-(bromobutanoyl)-N'-(o-, m- and p-tolyl)thioureas 3a, 3b and 3c respectively, were synthesized by the reaction of 4-bromobutanoylisothiocyanate with p-, m- and o-toludine. The products were characterized by IR, and NMR spectroscopic techniques. The two carbonoylthiourea isomers N-(4-bromobutanoyl)-N'-(3-methylphenyl)thiourea(3b) and N-(4-bromobutanoyl)-N'-(4-methylphenyl)thiourea(3c) were obtained in crystalline form by recrystallization from DMSO. Xray crystallographic studies showed that both compounds 3b and 3c crystallize in triclinic system with space group of P1. The molecules adopt trans-cis configuration with respect to the positions of 4-bromobutanoyl and tolyl groups respectively, against the thiono C=S bond across their C–N bonds. The configuration is attributed by the intrahydrogen bond between the carbonyl oxygen and amide hydrogen atoms. Both crystal structures are stabilized by N–H···S intermolecular hydrogen bonds to form dimers and arranged along the b axis. | Hamza M Abosadiya Siti Aishah Hasbullah Bohari M Yamin | 2015 | Chinese Journal of Structural Chemistry2015，34，3： | 3 |
| 3 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
| 4 | Hamstring autograft utilization in reconstructing anterior cruciate ligament:Review of harvesting techniques,graft preparation,and different fixation methods显示文摘Rupture of the anterior cruciate ligament(ACL)is a common orthopedic injury.Various graft options are available for the reconstruction of ruptured ACL.Using the hamstring muscle as an autograft was first described in 1934,and it remains a commonly harvested graft for ACL reconstruction.Hamstring autografts can be harvested using the traditional anteromedial approach or the newer posteromedial technique.An isolated semitendinosus tendon can be used or combined with the gracilis tendon.There are numerous methods for graft fixation,such as intra-tunnel or extra-tunnel fixation.This comprehensive review discusses the different hamstring muscle harvesting techniques and graft preparation options and fixation methods.It provides a comprehensive overview for choosing the optimal surgical technique when treating patients. | Waleed Albishi Baraa Baltow Nora Albusayes Ameer A Sayed Hamza M Alrabai | 2022 | World Journal of Orthopedics2022，13，10： | 2 |
| 5 | Effect of dietary phospholipid levels on performance, enzyme activities and fatty acid composition of pikeperch (Sander lucioperca) larvae显示文摘 | Hamza M Mhetli I Ben K C | 2008 | Aquaculture2008，275，： | 1 |
| 6 | Gold catalyst: Nanoporous gold foams 显示文摘 | ZIELASEK V JURGENS B SCHULZ C BIENER J MONIKA M B HAMZA A V BAUMER M | 2006 | Angew Chem Int Ed2006，45，： | 1 |
| 7 | Comparison of three algorithms for load frequency control 显示文摘 | Hamza M H | 1984 | Electric Power Systems Research1984，7，： | 1 |
| 8 | Automatic determination of refractive index profile, sectional area, and shape of fibers having regular and/or irregular transverse sections显示文摘 | Hamza A A Sokkar T Z N Losrsy M A E | 2008 | Optic Laser Tech2008，40，8： | 1 |
| 9 | New antioxidant bibenzyl derivative and isoflavonoid from the Tunisian Salsola tetrandra Folsk显示文摘 | Ahlem Beyaoui Atef Chaari Hatem Ghouila M’hamed Ali Hamza Hichem Ben Jannet | 2012 | Natural Product Research2012，，3： | 1 |
| 10 | Outcomes of hy- pospadias repair in older children: a prospective study 显示文摘 | Ziada A Hamza A Abdel-Rassottl M | 2011 | J Urol2011，185，6： | 1 |
| 11 | Electrochemical oxidation of 1,3,5-trimethoxybenzene in aqueous solutions at gold oxide and lead dioxide electrodes显示文摘 | Hamza M Ammar S Abdelhedi R | | 0，，： | 1 |
| 12 | Effect of dietary phospholipid levels on performance, enzyme activities and fatty acid composition ofpikeperch (Sander lucioperca) lar- vae 显示文摘 | Hamza N Mhetli M Khemis I B | 2008 | Aquaculture2008，275，14： | 1 |
| 13 | Novel three-phase asymmetrical cascaded multilevel voltage source inverter显示文摘 | Hamza B Saad M Ammar M | 2013 | IET Power Electron2013，6，8： | 1 |
| 14 | Soil compaction in cropping systems: A review of the nature, causes and possible solutions显示文摘 | M A Hamza W K Anderson | 2005 | Soil and Tillage Research2005，82，： | 1 |
| 15 | Cloning and sequencing of SOB3,a human gene coding for a sperm protrin homologous to an antimicrobial protein and potentially involved in zona pellucida binding显示文摘 | Hammami Hamza S Doussau M Bernard J | 2001 | Mol Hum Reprod2001，7，7： | 1 |
| 16 | Soil compaction in cropping systems:A review of the nature,causes and possible solutions显示文摘 | Hamza M A Anderson W K | | 0，，： | 1 |
| 17 | Cytogenetic damage in human blood lymphocytes exposed in vitro to radon 显示文摘 | HAMZA V Z MOHANKUMAR M N | 2009 | Murat Res2009，661，12： | 1 |
| 18 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 19 | Oxygen isotopic fractionation between oxygen of different sites in hydroxyl-bearing silicate minerals显示文摘 | HAMZA M S EPSTEIN S | 1980 | Geochimica et Cosmochimica Acta1980，44，2： | 1 |
| 20 | lmage watermarking scheme using nonnegative matrix factorization and wavelet transform显示文摘 | Ouhsain M Hamza A B | 2009 | Expert Systems with Applications2009，36，2： | 1 |
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