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| 1 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 2 | Comparison of long-term effects between intra-arterially delivered ethanol and Gelfoam for the treatment of severe arterioportal shunt in patients with hepatocellular carcinoma显示文摘AIM:To evaluate long-term effect of ethanol embolization for the treatment of hepatocellular carcinoma (HCC) with severe hepatic arterioportal shunt (APS), compared with Gelfoam embolization.METHODS:Sixty-four patients (ethanol group) and 33 patients (Gelfoam group) with HCC and APS were respectively treated with ethanol and Gelfoam for APS before the routine interventional treatment for the tumor. Frequency of recanalization of shunt, complete occlusion of the shunt,side effects, complications, and survival rates were analyzed between the two groups.RESULTS: The occlusion rate of APS after initial treatment in ethanol group was 70.3%(45/64), and recanalization rate of 1 month after embolization was 17.8%(8/45),and complete occlusion rate was 82.8%(53/64).Those in Gelfoam group were 63.6%(21/33), 85.7%(18/21), and 18.2%(6/33).There were significant differences in recanalization rate and complete occlusion rate between the two groups (P<0.05).The survival rates in ethanol group were 78% at 6 months,49% at 12 months, 25% at 24 months, whereas those in Gelfoam group were 58% at 6 months, 23% at 12 months,15% at 24 months.The ethanol group showed significantly better survival than Gelfoam group (P<0.05). In the ethanol group, there was a significant prolongation of survival in patients with monofocal HCC (P<0.05) and Child class A (P<0.05).There were no significant differences in survival rate in the Gelfoam group with regard to the number of tumor and Child class (P>0.05). The incidence rate of abdominal pain during procedure in ethanol group was 82.8%.There was no significant difference in postembolization syndromes between two groups. Procedure-related hepatic failure did not occur in ethanol group.CONCLUSION: Ethanol embolization for patients with HCC and severe APS is efficacious and safe, and may contribute to prolongation of the life span versus Gelfoam embolization. | Ming-ShengHuang QuLin Zai-BoJiang Kang-ShunZhu Shou-HaiGuan Zheng-RanLi HongShan | 2004 | World Journal of Gastroenterology2004，10，6： | 30 |
| 3 | Transjugular intrahepatic portosystemic shunt for palliative treatment of portal hypertension secondary to portal vein tumor thrombosis显示文摘AIM: To evaluate the palliative therapeutic effects of transjugular intrahepatic portosystemic shunt (TIPS) in portal vein tumor thrombosis (Pv-n-) complicated by portal hypertension.METHODS: We performed TIPS for 14 patients with PVTT due to hepatocellular carcinoma (HCC). Of the 14 patients,8 patients had complete occlusion of the main portal vein,6 patients had incomplete thrombosis, and 5 patients had portal vein cavernous transformation. Clinical characteristics and average survial time of 14 patients were analysed.Portal vein pressure, ascites, diarrohea, and variceal bleeding and circumference of abdomen were assessed before and after TIPS.PESULTS: TIPS was successful in 10 cases, and the successful rate was about 71%. The mean portal vein pressure was reduced from 37.2 mmHg to 18.2 mmHg. After TIPS, the ascites decreased, hemorrhage stopped and the clinical symptoms disappeared in the 10 cases. The average survial time was 132.3 d. The procedure failed in 4 cases because of cavernous transformation in portal vein and severecirrhosis.CONCLUSION: TIPS is an effective palliative treatment to control hemorrhage and ascites due to HCC complicated by PVTT. | Zai-BoJiang HongShan Xin-YingShen Ming-ShengHuang] Zheng-RanLi Kang-ShunZhu Shou-HaiGuan | 2004 | World Journal of Gastroenterology2004，10，13： | 14 |
| 4 | Depletion of activated hepatic stellate cell correlates with severe liver damage and abnormal liver regeneration in acetaminophen-induced liver injury显示文摘肝的星形的房间(HSC ) 是为肝的祖先房间(HPC ) 和 hepatocytes 的本地干细胞壁龛的重要部分。然而,它至于激活的 HSC 的产品是否被要求稀释 hepatocyte 损害是不清楚的,提高肝新生,或两个。在这研究,我们由弄空执行了功能研究的损失有 gliotoxin 的激活的 HSC。显著地严重的肝损坏和拒绝的幸存率与激活的 HSC 的弄空被相关,这被表明。而且,减少 HSC 激活导致了增殖的 hepatocytes 的数字的 hepatocyte apoptosis 和 66% 减少的 3 褶层增加。这被戏剧的减少在知道在 hepatocyte 复制期间起来调整的五基因的表示层次伴随。特别地,激活的 HSC 的弄空禁止了被 Pank 积极的房间的减少的数字在道和降低的基因表示 cytokeratin 铺平的门附近证实的卵形的房间反应,这被发现 19 (CK19 ) 在对待 gliotoxin 的肝。这些数据提供激活的 HSC 涉及 hepatocyte 死亡和 hepatocytes 的增长,在 acetaminophen (APAP ) 的 HPC 导致了尖锐的肝损害的清楚的证据。 | Kuntang Shen Wenju Chang Xiaodong Gao Hongshan Wang Weixin Niu Lujun Song Xinyu Qin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 13 |
| 5 | Fault diagnosis of wind turbine bearing based on stochastic subspace identification and multi-kernel support vector machine显示文摘In order to accurately identify a bearing fault on a wind turbine, a novel fault diagnosis method based on stochastic subspace identification(SSI) and multi-kernel support vector machine(MSVM) is proposed. Firstly, the collected vibration signal of the wind turbine bearing is processed by the SSI method to extract fault feature vectors. Then, the MSVM is constructed based on Gauss kernel support vector machine(SVM) and polynomial kernel SVM. Finally, fault feature vectors which indicate the condition of the wind turbine bearing are inputted to the MSVM for fault pattern recognition. The results indicate that the SSI-MSVM method is effective in fault diagnosis for a wind turbine bearing and can successfully identify fault types of bearing and achieve higher diagnostic accuracy than that of K-means clustering, fuzzy means clustering and traditional SVM. | Hongshan ZHAO Yufeng GAO Huihai LIU Lang LI | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，2： | 12 |
| 6 | MiR-320a downregulation is associated with imatinib resistance in gastrointestinal stromal tumors显示文摘胃肠的 stromal 肿瘤(大意) 是胃肠的道的最普通的间充质的肿瘤之一。尽管 imatinib 改进结果,药抵抗为扩大耐心的幸存仍然是主要问题。药目标的基因变化是为 imatinib 抵抗的已知的机制。然而,它不能 imatinib 抵抗的现象解释所有,并且众多的另外的机制被建议了在各种各样的模型系统说明 imatinib 抵抗。在这研究,我们使用了屏蔽差别的基于反应的数组途径表示了的 SYBR 绿的量的聚合酶链在主要大意病人和 imatinib 抵抗的病人之间的 miRNAs。选择候选人 miRNAs 在 12 个大意病人的一个队被验证。我们发现 miR-320a 的那低表情与 imatinib 抵抗的短时间被相关,并且为 imatinib 抵抗建议了 miR-320a 的潜在的机制。 | Xiaodong Gao Kuntang Shen Cuizhong Wang Jiaqian Ling Hongshan Wang Yong Fang Yuan Shi Yingyong Hou Jin Qin Yihong Sun Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 9 |
| 7 | Fluvial terraces and their implications for Weihe River valley evolution in the Sanyangchuan Basin显示文摘Fluvial terraces are important geomorphic markers for modern valley development.When coupled with numeric ages,terraces can provide abundant information about tectonic,climatic,paleohydrological and the paleoenvironmental changes.On the basis of the paleomagnetic,electron spin resonance(ESR) and optically stimulated luminescence(OSL) dating,in addition to an investigation of local loess-paleosol sequences,we confirmed that 13 fluvial terraces were formed,and then preserved,along the course of the Upper Weihe River in the Sanyangchuan Basin over the past 1.2 Ma.Analyses of the characteristics and genesis of these terraces indicate that they resulted from the response of this particular river system to climate change over an orbital scale.These changes can further be placed within the context of local and regional tectonic uplift,and represent an alternation between lateral migration and vertical incision,dependent upon the predominance of climatic and tectonic controls during different periods.Most of the terraces are strikingly similar in that they have several meters of paleosols which have developed directly on top of fluvial deposits located on the terrace treads,suggesting that the abandonment of terraces due to river incision occurred during the transitions from glacial to interglacial climates.The temporal and spatial differences in the distribution patterns of terraces located on either side of the river valley indicate that a tectonic inversion occurred in Sanyangchuan Basin at-0.62 Ma,and that this was characterized by a transition from overall uplift to depression induced by fault activity.Synthesized studies of the Basin's terraces indicate that formation of the modern valley of the Upper Weihe River may have begun in the late Early Pleistocene between1.4-1.2 Ma. | GAO HongShan LI ZongMeng LIU XiaoFeng PAN BaoTian WU YaJie LIU FenLiang | 2017 | Science China Earth Sciences2017，60，3： | 9 |
| 8 | Terrace dating as an archive of the run-through of the Sanmen Gorges显示文摘Analysis of morphological properties in the Sanmen Gorges region of the Yellow River shows that four river terraces have been developed at the entrance to the gorges. Commonly, thick aeolian loess-paleosol sequence was deposited on the terraces, which makes it easy to date the terraces. The dating of paleomagnetic, loess-paleosol sequence matching and thermoluminescence show that terraces T2, T3 and T4 were formed 0. 129 Ma, 0. 625 Ma and 0. 865 Ma ago, respectively. The formation of these terraces in this region indicates that the Yellow River has experienced four intensive downcutting events during the last 0.9 Ma. The Yellow River cut through the Sanmen Gorges and inpoured into the East China Sea no later than 0. 865 Ma. | PAN Baotian WANG Junping GAO Hongshan CHEN Yingying LI Jijun LIU Xiaofeng | 2005 | Progress in Natural Science:Materials International2005，15，12： | 9 |
| 9 | DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells显示文摘染色质改变为人的初发的细菌房间的 epigenetic reprogramming 是重要的。然而,全面染色质状态还没为人的胎儿的细菌房间(FGC ) 被分析了。这里,我们使用 nucleosome 占有和 methylation 定序方法在人和老鼠在胎儿的细菌房间开发期间在一系列关键时间点分析染色体宽的染色质可接近性和 DNA methylome。我们在人和老鼠 FGC 发现 116 887 和 137 557 个弄空 nucleosome 的区域(NDR ) ,盖住 germline 特定、高度有活力的规章的 genomic 元素的一个大集合,例如 enhancers。而且,我们发现远侧的 NDR 在人的 FGC 为象 NANOG , SOX17 , AP2 和 OCT4 那样的 pluripotency 和细菌房间主人管理者的有约束力的主题明确地被充实,显示在pluripotency相关的基因和细菌之间的精细的规章的平衡的存在在人的 FGC 的房间特定的基因,并且为在 vivo 的细菌房间开发的这些基因的功能的意义。我们的工作为把提供一张全面、高分辨率的路线图染色质状态转变动力学在人和老鼠 FGC 的 epigenomic reprogramming 期间。 | Hongshan Guo Boqiang Hu Liying Yan Jun Yong Yan Wu Yun Gao Fan Guo Yu Hou Xiaoying Fan Ji Dong Xiaoye Wang Xiaohui Zhu Jie Yan Yuan Wei Hongyan Jin Wenxin Zhang Lu Wen FuchouTang Jie Qiao | 2017 | Cell Research2017，27，2： | 9 |
| 10 | Expanded endoscopic therapy criteria should be cautiously used in intramucosal gastric cancer显示文摘Objective: Accurate estimation of lymph node metastasis(LNM) in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM.Methods: A retrospective review of data from 386 intramucosal gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed.Results: LNM was detected in 40(10.4%) of the 386 patients. Histological type and vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection(ESD) indication also revealed that the undifferential type was the only significant factor for LNM.Conclusions: It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients. | Hongshan Wang Heng Zhang Cong Wang Yong Fang Xuefei Wang Weidong Chen Fenglin Liu Kuntang Shen Xinyu Qin Zhenbin Shen Yihong Sun | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 11 | Capability of multidetector CT to diagnose hepatocellular carcinoma-associated arterioportal shunt显示文摘AIM: To investigate the capability of multidetector CT (MDCT) to diagnose HCC-associated arterioportal shunt (APS).METHODS: Two hundred and eighty-two patients with HCC received both thin-slice and enhancement MDCT scanning at early hepatic arterial phase, late hepatic arterial phase and portal venous phase, and digital subtract angiography (DSA) examination. Images were analyzed jointly by two experienced radiologists blinded to the opposite examination results, including the existence or not of APS, shunt locations, types and degrees of APS, with or without thrombosis. RESULTS: There were 56 APS associated with HCC, including 48 central, seven peripheral and one mixed, or 42 severe, seven moderate, seven mild APS. Fortyone severe, seven moderate and central APS were all revealed with MDCT and DSA. Seven mild and peripheral APS were all displayed with MDCT; only five of them displayed DSA, two faint shunt APS associated with massive HCC were missed. One mixed APS was demonstrated as severe combined with mild shunt with both MDCT and DSA.CONCLUSION: MDCT could diagnose not only DSA revealed APS, but also missed mild and peripheral APS with DSA due to faint shunt associated with massive HCC, is a simple, effective and noninvasive new technique for diagnosis of HCC-associated APS. | Ming-YueLuo HongShan Zai-BoJiang Wen-WeiLiang Jian-ShengZhang Lu-FangLi | 2005 | World Journal of Gastroenterology2005，11，17： | 8 |
| 12 | Quantitative analysis of planation surfaces of the upper Yangtze River in the Sichuan-Yunnan Region, Southwest China显示文摘Identification of the planation surfaces (PSs)is key for utilizing them as a reference in studying the long- term geomorphological evolution of the Upper Yangtze River Basin in the Sichuan-Yurman region,Southwest China.Using a combined method of DEM-based fuzzy logic and topographic and fiver profiles analysis and based on a comprehensive analysis of four morphometfic parameters:slope,curvature,terrain raggedness index, and relative height,we established the relevant fuzzy membership functions,and then calculated the membership degree (MD)of the study area.Results show that patches with a MD>80% and an area>0.4 km^2 correspond well to the results of Google Earth and field investigation,representing the PS remnants.They consist of 1764 patches with an altitude,area,mean slope,and relief of mostly 2000-2500 m above sea level (asl),0-10 km^2,4°-9°,0-500 m,respectively,covering 9.2% of the study area's landscape,dipping to southeast,decreasing progressively from northwest to southeast in altitude,and with no clear relation between each patch's altitude and slope,or relief.All these results indicate that they are remnants of once regionally continuous PSs which were deformed by both the lower crust flow and the faults in upper crust,and dissected by the network of Upper Yangtze River.Additionally,topographic and river profiles analysis show that three PSs (PS1-PS3)well developed along the main valleys in the Yongren-Huili region, indicating several phases of uplift then planation during the Late Cenozoic era.Based on the incision amount deduced from projection of relict river profiles on PSs, together with erosion rates,breakup times of the PS 1,PS2,and PS3 were estimated to be 3.47 Ma,2.19 Ma,and 1.45 Ma,respectively,indicating appearance of modem Upper Yangtze River valley started between the Pliocene to early Pleistocene. | Fenliang LIU Hongshan GAO Baotian PAN Zongmeng LI Huai SU | 2019 | Frontiers of Earth Science2019，13，1： | 7 |
| 13 | A New Species of Phoenicopsis Subgenus Windwardia(Florin) Samylina(Czekanowskiales) from the Middle Jurassic of Inner Mongolia, China显示文摘A new species of Phoenicopsis subgenus Windwardia(Florin) Samylina, Phoenicopsis neimengguensis sp.nov., is recognized from the Middle Jurassic Zhaogou Formation in the Shiguai Basin, a Jurassic coal-bearing sedimentary basin in Inner Mongolia, China. Linear leaves are in bundles of six to eight and are attached on a short shoot. The leaf is amphistomatic with one or two irregular rows of longitudinally oriented stomata in each intercostal zone on the upper epidermis and three or four(occasionally six) rows of stomata in each intercostal zone on the lower epidermis. Each stomata is surrounded by four to six subsidiary cells with unevenly developed papillae. The anticlinal walls of epidermal cells are straight. Cuticular thickenings or papillae are present on the outer surface of the periclinal walls. This is the first time that Phoenicopsis subgenus Windwardia(Florin) Samylina is recognized from the Middle Jurassic of Inner Mongolia, China. The occurrence of the new species is noteworthy because it extends the geological and geographic distribution of Phoenicopsis subg. Windwardia in China and Eurasia. The discovery is significant as it increases our knowledge of Phoenicopsis subg. Windwardia by providing new data on morphological and epidermal features. | SUN Chunlin NA Yuling David L.DILCHER WANG Hongshan LI Tao LI Yunfeng | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 7 |
| 14 | Dating and genesis of the upper Weihe River terraces in Longxi basin,China显示文摘Seven terraces along the Weihe River in Longxi basin have been investigated. These terraces all consist of archetypal duality in structure, namely the floodplain deposits and the layer of gravels overlaid by varying thickness of the loess. By resorting to various dating approaches such as palaeomagnetic, optically stimulated luminescenece (OSL), 14C and loess-paleosol sequence, we provide preliminary timing of these seven terraces along upper Weihe River. Analysis on sedimentation characteristics and dating of these terraces showed that seven terraces may be jointly generated by tectonic uplifts and climatic changes. Tectonic uplifts may accommodate initial river incision, and climatic change may be responsible for processes of subsequent channel widening and aggradation. Aggradation normally occurs during glacial periods, in contrast to down-cuttings during transitions from glacial to interglacial period. Moreover, on the basis of the timings and heights of these terraces, we infer that the long-term rate of river incision was determined to be 0.2 m/kyr during the last 870 kyr, which differs from other river incision rates. This discrepancy may reflect spatio-temporal differentiation of tectonic activities in the Qinling orogenic belt during the Pleistocene. | Pan Baotian Liu Xiaofeng Gao Hongshan Wang Yong Li Jijun | 2007 | Progress in Natural Science:Materials International2007，17，11： | 7 |
| 15 | Sulfide mineral dissolution microbes: Community structure and function in industrial bioleaching heaps显示文摘Heap bioleaching is one of the most clean and economical processes for recovery of low-grade and complex ores, because the sulfide minerals are natural habitats for acidophiles capable of iron-and sulfur-oxidation. The most exciting advances in heap bioleaching are occurring in the field of microbiology, especially with the development of advanced molecular biology approaches. These chemolithotrophic microorganisms living in the acid mine environment fix N_2 and CO_2 and obtain energy for growth from soluble ferrous iron and reduced inorganic sulfur compounds during oxidation of sulfide minerals. The ferric iron as oxidant and sulfuric acid are a result of microbial activity and provide favorable conditions for the dissolution of sulfide minerals. Various microbial consortia were applied successfully in commercial bioleaching heaps around the world, and microbial community and activity were adapted related to the local climatic conditions, ore characteristics and engineering configuration. This review focuses on diversity of bioleaching microbes, their role in heap bioleaching processes, their community structure and function in industrial heaps and the relation to the ore characteristics and the engineering configuration, to give implications for optimizing leaching efficiency of heap bioleaching. | Yan Jia Qiaoyi Tan Heyun Sun Yupeng Zhang Hongshan Gao Renman Ruan | 2019 | Green Energy & Environment2019，4，1： | 6 |
| 16 | Isolation and culture of hepatic stellate cells from mouse liver显示文摘肝的星形的房间(HSC ) 是在肝以内的主要细胞外的生产矩阵的房间并且有众多的 vitalfunctions。为 HSC 的隔离和文化的一个柔韧的协议是重要的因为房间 functionsand 的进一步的调查在肝疾病联系了机制。鼠标肝的卷比老鼠肝的小得多,哪个对更困难的 makesit 比老鼠 HSC 孤立鼠标 HSC (mHSCs ) 。目前,孤立 mHSCs 仍然是挑战 becausethere 不是有效、柔韧的方法孤立并且文化这些房间。在现在的学习, C57BL/6J 老鼠是有包含 liposome 的 dichloromethylene diphosphate (CL2MDP ) 的 intravenouslyinjected 有选择地从 theliver 消除 Kupffer 房间。老鼠肝然后在 situ 被酒,并且 mHSCs 与一种优化密度坡度 centrifugation 技术被孤立。在磷酸盐缓冲区答案(PBS )-liposome 组, mHSCs 的收益是(1. | Wenj u Chang Mengxuan Yang Lujun Song Kuntang Shen Hongshan Wang Xiaodong Gao Min Li Weixin Niu Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 6 |
| 17 | Optimization of dosage ratio of chlorogenic acid and gardenia glycosides in the treatment of rats with fatty liver disease induced by high-fat feed显示文摘OBJECTIVE: To investigate the optimal dosage ratio of chlorogenic acid and gardenia glycosides in treating the rates with fatty liver disease induced by high-fat feed.METHODS: A rat model of non-alcoholic fatty liver disease(NAFLD) was established by using a high-fat diet. According to mathematical model 'uniform design', varying doses of chlorogenic acid and gardenia glycosides have been combined to form 6 medications for the treatment of NAFLD.Samples were then taken to observe pathological changes of the liver tissue(HE staining); changes in the fat metabolism pathway e.g. triglyceride(TG)and free fatty acid(FFA) content; alterations in liver function, i.e. serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST) activity; and differences in Malondialdehyde(MDA) and superoxide dismutase(SOD) content in the liver tissue. Multiple regression analysis was conducted to test the optimal dosage ratio of chlorogenic acid and gardenia glycosides.RESULTS: Fatty degeneration and vacuole-like changes of different degrees occurred in hepatic cells of the model group. Markers for fat metabolism, serum ALT and AST activities, and expression of MDA in liver tissue significantly increased, while SOD decreased. Combination of 90 mg chlorogenic acid and 90 mg Gardenia glycosides was the optimal dosage ratio of chlorogenic acid and gardenia glycosides in the treatment of rats with fatty liver induced by high-fat diet.CONCLUSION: Chlorogenic acid of 90 mg plus gardenia glycosides of 90 mg was the best combination in the treatment of fatty liver disease in rats induced by high-fat feed. | Liang Huiqing Yang Jiaen Tang Jinmo Wu Chuncheng Li Hongshan Chen Shaodong | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 6 |
| 18 | Instability characteristics of the East Asian Monsoon recorded by high-resolution loess sections from the last interglacial (MIS5)显示文摘The selection of high-resolution loess sections is needed in order to determine the climatic variability of the East Asian Monsoon during the last interglacial. Two sequences of S1 on the eastern and west-ern sides of the Liupan Mountain were both composed of five paleosol layers and four loess layers,indicating that there were five strong summer monsoon events and four strong winter monsoon events in MIS5. This corresponds with other records of the East Asian Monsoon,along with NGRIP and the North Atlantic records,implying that the climate of the Northern Hemisphere was very instable during the last interglacial. Two layers of paleosols and one layer of loess had developed during MIS5a and MIS5c. Compared with MIS5e,the climate in MIS5a and MIS5c fluctuated more intensively on a millen-nial scale,whereas the climate was relatively stable in MIS5e. | GUAN QingYu PAN BaoTian GAO HongShan LI BingYuan WANG JunPing SU Huai | 2007 | Science China Earth Sciences2007，50，7： | 5 |
| 19 | Biological applications of copper-containing materials显示文摘Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the bile.Copper is an important component and catalytic agent of many enzymes and proteins in the body,so it can influence human health through multiple mechanisms.Based on the biological functions and benefits of copper,an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials,which exhibit unique properties in protecting the cardiovascular system,promoting bone fracture healing,and exerting antibacterial effects.Copper can also be used in promoting incisional wounds healing,killing cancer cells,Positron Emission Tomography(PET)imaging,radioimmunological tracing and radiotherapy of cancer.In the present review,the biological functions of copper in the human body are presented,along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials.Furthermore,this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications. | Peng Wang Yonghui Yuan Ke Xu Hongshan Zhong Yinghui Yang Shiyu Jin Ke Yang Xun Qi | 2021 | Bioactive Materials2021，6，4： | 5 |
| 20 | Retroperitoneal hematoma after implantation of double inferior vena cava filters显示文摘A 55-year-old man developed deep venous thrombosis and inferior vena cava(IVC) thrombosis 7 years earlier and was treated by placement of a permanent IVC filter. One week ago, he was admitted with bilateral lower limb swelling and pain. Digital subtraction angiography showed a filling defect above the original filter. A retrievable Tulip filter was placed and catheter-directed thrombolysis was performed. Six days later, the patient experienced sudden, persistent upper right abdominal pain, and a computed tomography scan revealed the formation of retroperitoneal hematoma. Symptomatic treatments were administered, and the hematoma gradually resolved during follow-up. | Yulong Tian Hongshan Zhong Wei Zhang | 2018 | Journal of Interventional Medicine2018，1，4： | 5 |
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