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| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system显示文摘MicroRNAs (miRNAs ) 是内长的 noncoding RNA (~ 22 nt ) 在细胞质在 post-transcriptional 水平调整目标基因表示。在房间原子核的要求功能的 argonaute 家庭蛋白质提示了我们假设那 miRNAs 的 miRNAs 和 miRNA 的存在的最近的发现可以也在房间原子核有规章的功能。在这研究,我们证明老鼠 miR-709 主要位于各种各样的房间类型的原子核并且它的原子本地化模式很快在 apoptotic 刺激之上变化。在房间原子核, miR-709 直接在 pri-miR-15a/16-1 上绑在一个 19-nt miR-709 识别元素并且阻止它处理成 pre-miR-15a/16-1,导致 miR-15a/16-1 成熟的抑制。而且,原子 miR-709 通过 miR-15a/16-1 小径参予房间 apoptosis 的规定。在摘要,现在的学习提供一 miRNA 能由直接在原子核指向他们的主要抄本控制另外的 miRNAs 的生物的续生说的第一条证据。 | Rui Tang Limin Li Dihan Zhu Dongxia Hou Ting Cao Hongwei Gu Jing Zhang Junyuan Chen Chen-Yu Zhang Ke Zen | 2012 | Cell Research2012，22，3： | 23 |
| 3 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 4 | The impact of the new cooperative medical scheme on financial burden of tuberculosis patients: evidence from six counties in China显示文摘Background:Tuberculosis(TB)patients in China encounter heavy financial burdens throughout the course of their treatment and it is unclear how China’s health insurance systems affect the alleviation of this burden under the integrated approach.This study aimed to measure reimbursement for TB services under the New Cooperative Medical Scheme(NCMS)in rural China and to evaluate changes in catastrophic health expenditure(CHE)caused by the reimbursement policies.Methods:Reimbursement data were obtained from routine data systems for the NCMS in Yichang(YC)and Hanzhong(HZ).1884 TB inpatients reimbursed by NCMS from 2010 to 2012 were included.Household surveys were conducted.A total of 494 TB patients under the NCMS were selected in this paper.12 Focus Group Discussions(FGDs)were held.We measured the impact of the NCMS by counterfactual analysis,which analyzed the financial burden alleviation.Equity was assessed by Concentration Index(CI),and disaggregated by project sites.Results:TB inpatients were reimbursed with an effective reimbursement rate of 57.3%.Average out-of-pocket(OOP)payments for outpatient and inpatient services after diagnosis were 1413 yuan and 430 yuan,and 3572 yuan and 3013 yuan in YC and HZ,respectively.The reimbursement level for TB outpatient care after diagnosis was very low due to a limited outpatient quota.TB patients in HZ incurred higher effective reimbursement rates,but the incidence of CHE remained higher.The reduction of CHE incidence after the NCMS showed no difference statistically(P>0.05).The severity of CHE was alleviated slightly.CIs after reimbursement were all below zero and their absolute values were higher than those before reimbursement.Conclusions:Low reimbursement for TB patients could lead to heavy financial burden.Poor TB patients incurred high rates of CHE.The NCMS was found to be a protective factor for CHE,but the impact was modest and the equity of CHE did not improve.The NCMS reimbursement policies should be improved in the future to include a more comprehensive coverage of care.Supplemental programs may be necessary to expand coverage for TB care. | Li Xiang Yao Pan Shuangyi Hou Hongwei Zhang Kaori DSato Qiang Li Jing Wang Shenglan Tang | 2016 | Infectious Diseases of Poverty2016，5，1： | 9 |
| 5 | Achieving the nitrite pathway using FA inhibition and process control in UASB-SBR system removing nitrogen from landfill leachate显示文摘An up-flow sludge blanket(UASB) and sequencing batch reactor(SBR) system was introduced to remove organics and nitrogen from landfill leachate.The synergetic effect of free ammonia(FA) inhibition and process control was used to achieve the nitrite pathway in the SBR.In previous research,inhibition of FA on nitrite oxidizing bacteria(NOB) activity has been revealed and the process control parameters(DO,ORP and pH) exactly indicate the end-point of nitritation.The method was implemented in the SBR achieving stable nitrogen removal via the nitrite pathway from landfill leachate.The degree of nitrite accumulation during the nitritation was monitored along with the simultaneous and advanced removal of organics and nitrogen in the UASB-SBR system.The nitrifying bacteria community was quantitatively analyzed by fluorescence in situ hybridization(FISH) techniques.Batch tests were carried out to investigate the denitritation kinetics of microbial bacteria in the SBR.Experimental results showed that the nitrite pathway could be repeatedly and reliably achieved by synergetic effect of FA inhibition and process control.FISH analysis showed the dominant nitrifying bacteria were ammonia-oxidizing β-Proteobacteria. Relationship between nitrite concentration and nitrite reduction rate followed the Monod-type equation.The maximum specific nitrite utilization rate(k) and half-velocity constant(Ks) were calculated as 0.44 gN gVSS-1d-1and 15.8 mg L-1,respectively. | Sun, HongWei Yang, Qing Dong, GuoRi Hou, HongXun Zhang, ShuJun Yang, YingYing Peng, YongZhen | 2010 | Science China Chemistry2010，53，5： | 8 |
| 6 | Oxygen adsorption/desorption behavior of YBaCo4O7+δ and its application to oxygen removal from nitrogen显示文摘A new medium-temperature (200-400℃) adsorbent material for oxygen removal and air separation, YBaCo4O7+β, was prepared by the solid-state reaction method. This new adsorbent could adsorb a large quantity of oxygen in the temperature range of 200-370 ℃. Ad-sorbed oxygen could be released by raising temperature over 400 ℃ or by switching the atmosphere from oxygen to nitrogen. This oxygen adsorption and desorption process had good reproducibility. Taking advantage of this unique oxygen intake/release behavior, a nitrogen puri-fication process was investigated. The results showed that YBaCo4O7+δ material was a promising candidate for the oxygen sorption process and could be used to produce high-purity nitrogen or to remove trace oxygen from other gases. | HAO Haoshan ZHAO Limin FIU Jie HU Xing HOU Hongwei | 2009 | Journal of Rare Earths2009，27，5： | 8 |
| 7 | The three-dimensional structure and seasonal variation of the North Pacific meridional overturning circulation显示文摘The three-dimensional structure and the seasonal variation of the North Pacific meridional overturning circulation (NPMOC) are analyzed based on the Simple Ocean Data Assimilation data and Argo profiling float data.The NPMOC displays a multi-cell structure with four cells in the North Pacific altogether.The TC and the STC are a strong clockwise meridional cell in the low latitude ocean and a weaker clockwise meridional cell between 7°N and 18°N,respectively, while the DTC and the subpolar cell are a weaker anticlockwise meridional cell between 3°N and 15°N and a weakest anticlockwise meridional cell between 35°N and 50°N,respectively. The DTC,the TC and the STC are all of very strong seasonal variations.As to the DTC, the southward transport is strongest in fall and weakest in spring.For the TC,the northward transport is strongest in winter and weakest in spring,while the southward transport is strongest in fall and weakest in spring, which is associated with the strong southward flow of the DTC in fall.As the STC,the northward transport is strongest in winter and weakest in summer,while the southward transport is strongest in summer and weakest in spring. This seasonal difference may be associated with the DTC.The zonal wind stress and the east-west slope of sea level play important roles in the seasonal variations of the TC,the STC and the DTC. | LIU Hongwei ZHANG Qilong DUAN Yongliang HOU Yijun | 2011 | Acta Oceanologica Sinica2011，30，3： | 7 |
| 8 | Eddy properties in the Pacific sector of the Southern Ocean from satellite altimetry data显示文摘Mesoscale eddies play a key role in the ocean dynamics of the Southern Ocean, and eddy response to the climate changes has also been widely noted. Both eddy kinetic energy(EKE) and eddy detection algorithm are used to study the eddy properties in the Pacific sector of the Southern Ocean. Consistent with previous works,the maps of the EKE illustrate that higher energy confines to the Antarctic Polar Frontal Zone(APFZ) and decreases progressively from west to east. It also shows that the most significant increase in the EKE occurs in the western and central parts of the Pacific sector, where the baroclinicity of the Antarctic Circumpolar Current(ACC) is much stronger. Statistical eddy properties reveal that both of the spatial pattern and interannual variation of the EKE are primarily due to the eddy amplitude and the eddy rotational speed, rather than the eddy number or the eddy radius. In general, these results furtherly confirm that anomalous westerly wind forcing associated with the positive Southern Annular Mode(SAM) index enhances the Southern Ocean eddy activity by strengthening the eddy properties. | DUAN Yongliang LIU Hongwei YU Weidong HOU Yijun | 2016 | Acta Oceanologica Sinica2016，35，11： | 5 |
| 9 | Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma显示文摘Background:We previously showed that the expression of follistatin-like protein 1(FSTL1)was significantly down-regulated in metastatic clear-cell renal cell carcinoma(ccRCC).In this study,we aimed to characterize the role of FSTL1 in the development of ccRCC.Methods:The effects of FSTL1 on cell activity and cell cycle were investigated in ccRCC cell lines with altered FSTL1 expression.Gene expression microarray assays were performed to identify the major signaling pathways affected by FSTL1 knockdown.The expression of FSTL1 in ccRCC and its effect on postoperative prognosis were estimated in a cohort with 89 patients.Results:FSTL1 knockdown promoted anchorage-independent growth,migration,invasion,and cell cycle of ccRCC cell lines,whereas FSTL1 overexpression attenuated cell migration.FSTL1 knockdown up-regulated nuclear factor-κB(NF-κB)and hypoxia-inducible factor(HIF)signaling pathways,increased epithelial-to-mesenchymal transition,up-regulated interleukin-6 expression,and promoted tumor necrosis factor-α-induced degradation of NF-κB inhibitor(IκBα)in ccRCC cell lines.FSTL1 immunostaining was selectively positive in epithelial cytoplasm in the loop of Henle,and positive rate of FSTL1 was significantly lower in ccRCC tissues than in adjacent renal tissues(P<0.001).The mul-tivariate Cox regression analysis showed that the intratumoral FSTL1 expression conferred a favorable independent prognosis with a hazard ratio of 0.325(95%confidence interval 0.118-0.894).HIF-2αexpression was negatively cor-related with FSTL1 expression in ccRCC specimens(r=−0.229,P=0.044).Intratumoral expression of HIF-2α,rather than HIF-1α,significantly predicted an unfavorable prognosis in ccRCC(log-rank,P=0.038).Conclusions:FSTL1 plays a tumor suppression role possibly via repressing the NF-κB and HIF-2αsignaling pathways.To increase FSTL1 expression might be a candidate therapeutic strategy for metastatic ccRCC. | Yan Liu Xiaojie Tan Wenbin Liu Xi Chen Xiaomei Hou Dan Shen Yibo Ding Jianhua Yin Ling Wang Hongwei Zhang Yongwei Yu Jianguo Hou Timothy C.Thompson Guangwen Cao | 2018 | Cancer Communications2018，38，1： | 5 |
| 10 | Cellulose-hydrogen production from corn stalk biomass by anaerobic fermentation显示文摘Cellulose-hydrogen production from corn stalk by lesser panda manure was carried out in batch tests and a 5 L scale-up continuously stirred anaerobic bioreactor(CSABR),respectively.The bio-pretreatment of corn stalk was found most effective at 25℃ using microbe additive of 7.5 g/kg,in which the yields of soluble saccharides(SS) and lactic acid were 212 mg/g-TS and 21 mg/g-TS,respectively.The maximum cumulative H2 yield(176 ml/g-TS) and H2 production rate(14.5 ml/g-TS h-1) were obtained at pH 5.5,36℃ by treating a substrate of 15 g/L.The hydrogen content in biogas was 57.2% and there was no significant methane gas observed.During the optimal period of H2 production,the ORP values stayed in the lower level ranging from -445 mV to -455 mV.The results show that the bio-pretreatment of the raw materials played a vital role in the effective conversion of corn stalk into cellulose-hydrogen by mixed culture. | XING Yan MA HongCui FAN YaoTing HOU HongWei CHEN JingRun | 2009 | Chinese Science Bulletin2009，54，8： | 3 |
| 11 | Myeloma cells resistance to NK cell lysis mainly involves an HLA class I-dependent mechanism显示文摘房间具有升起的生来的杀手(NK ) 的反多重的骨髓瘤(公里) 潜力对最近的年的兴趣。然而,到骨髓瘤房间的 NK 房间 cytotoxicity 的分子的机制仍然保持不清楚。在现在的学习,我们调查了人的白血球的 theexpressions 在耐心的骨髓瘤房间的抗原(HLA ) 一级和 HLA-G,并且决定了他们的关联住院病人肿瘤房间危险性到 NK 房间 cytotoxicity。我们的结果给那个病人看了骨髓瘤房间(n = 12 ) 对 NK-92 房间细胞溶解相对抵抗,与骨髓瘤房间线相比(n = 7, P < 0.01 ) 。基因表示介绍和流动 cytometry 分析证明 HLA 一级的 mRNA 和蛋白质是在 12 个耐心的骨髓瘤房间的 highlyexpressed。有趣地,没有或低 HLA-G 表面表示被检测,尽管多重 HLA-Gtranscripts 在这些骨髓瘤房间被检测。NK 房间功能试金证明由酸治疗的下面调整的 HLA 一级 expressionon 病人房间显著地增加了公里房间的危险性到调停 NK 的细胞溶解。而且,我们发现在骨髓瘤上用抗体堵住膜界限 HLA 一级而非 HLA-G 显著地取样 increasedtheir 危险性到调停 NK 的杀死。这些结果证明到 NK 的耐心的公里房间的抵抗 lysismainly 包含一个 HLA 班我依赖的机制,建议那 HLA 一级可以涉及保护公里房间调停 fromNK 在 vivo 攻击并且贡献他们的有免疫力的逃跑。 | Minjie Gao Lu Gao Guang Yang Yi Tao Jun Hou Hongwei Xu Xiaojing Hu Ying Han Qianqiao Zhang Xiaosong Wu Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 3 |
| 12 | Cytosolic delivery of the immunological adjuvant PolyⅠ:C and cytotoxic drug crystals via a carrier-free strategy significantly amplifies immune response显示文摘Co-delivery of chemotherapeutics and immunostimulant or chemoimmunotherapy is an emerging strategy in cancer therapy.The precise control of the targeting and release of agents is critical in this methodology.This article proposes the asynchronous release of the chemotherapeutic agents and immunostimulants to realize the synergistic effect between chemotherapy and immunotherapy.To obtain a proof-of-concept,a co-delivery system was prepared via a drug-delivering-drug(DDD)strategy for cytosolic co-delivery of Poly I:C,a synthetic ds RNA analog to activate RIG-I signaling,and PTX,a commonly used chemotherapeutics,in which pure PTX nanorods were sequentially coated with Poly I:C and mannuronic acid via stimulating the RIG-I signaling axis.The co-delivery system with a diameter of 200 nm enables profound immunogenicity of cancer cells,exhibiting increased secretion of cytokines and chemokines,pronounced immune response in vivo,and significant inhibition of tumor growth.Also,we found that intracellularly sustained release of cytotoxic agents could elicit the immunogenicity of cancer cells.Overall,the intracellular asynchronous release of chemotherapeutics and immunomodulators is a promising strategy to promote the immunogenicity of cancer cells and augment the antitumor immune response. | Xiaoqing Du Yuqi Hou Jia Huang Yan Pang Chenlu Ruan Wei Wu Chenjie Xu Hongwei Zhang Lifang Yin Wei He | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 13 | Proteasome inhibitor carfilzomib interacts synergistically with histone deacetylase inhibitor vorinostat in Jurkat T-leukemia cells显示文摘在现在的学习,我们在 Jurkat T 白血病房间调查了在 proteasome 禁止者 carfilzomib (CFZ ) 和 histone deacetylaseinhibitor vorinostat 之间的相互作用。到 CFZ 与的最低限度地致命的集中的细胞的 Coexposure 很, vorinostat 的 lowconcentration 导致了 synergistic antiproliferative 效果并且在 Jurkat T-leukemiacells 提高了 apoptosis ,与严厉地增加的反应的氧种( ROS )伴随了,在 mitochondrial membranepotential ( MMP )的惹人注目的减少,细胞色素 c 的增加的版本, caspase-9 和-3,和 PARP.The 的劈开的提高的激活联合了 Jurkat 细胞的处理与 ROS 预先对待而且, NAC 也在 apoptotic 房间导致了显著减小,显示为由联合处理的 increasedROS 产生的一个关键角色。另外,联合了逮捕的处理在 G 2-M 的房间周期阶段。这些结果暗示 CFZ 在 Jurkat T 白血病房间与 vorinostat synergistically 交往了,哪个有 vorinostat 的 carfilzomib 的联合可以在对待 T 房间代表新奇策略的 raisedthe 可能性白血病。 | Minjie Gao Lu Gao Yi Tao Jun Hou Guang Yang Xiaosong Wu Hongwei Xu Van S. Tompkins Ying Han Huiqun Wu Fenghuang Zhan Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 3 |
| 14 | Fronts,baroclinic transport,and mesoscale variability of the Antarctic Circumpolar Current in the southeast Indian Ocean显示文摘Fronts,baroclinic transport,and mesoscale variability of the Antarctic Circumpolar Current(ACC) along 115°E are examined on the basis of CTD data from two hydrographic cruises occupied in 1995 as a part of the World Ocean Circulation Experiment(WOCE cruise I9S) and in 2004 as a part of CLIVAR/CO2 repeat hydrography program.The integrated baroclinic transport across I9S section is(97.2×106±2.2×106) m3/s relative to the deepest common level(DCL).The net transport at the north end of I9S,determined by the south Australian circulation system,is about 16.5×106m3/s westward.Relying on a consistent set of water mass criteria and transport maxima,the ACC baroclinic transport,(117×106 ±6.7×10 6)m3/s to the east,is carried along three fronts:the Subantarctic Front(SAF) at a mean latitude of 44°-49°S carries(50.6×10 6 ±13.4×106)m3/s;the Polar Front(PF),with the northern branch(PF-N) at 50.5°S and the southern branch(PFS) at 58°S,carries(51.3×106 ±8.7×106)m3/s;finally,the southern ACC front(SACCF) and the southern boundary of the ACC(SB) consist of three cores between 59°S and 65°S that combined carry(15.2×106 ±1.8×106)m3/s.Mesoscale eddy features are identifiable in the CTD sections and tracked in concurrent maps of altimetric sea level anomalies(SLA) between 44°-48°S and 53°-57°S.Because of the remarkable mesoscale eddy features within the SAF observed in both the tracks of the cruises,the eastward transport of the SAF occurs at two latitude bands separating by 1°.Both the CTD and the altimetric data suggest that the mesoscale variability is concentrated around the Antarctic Polar Frontal Zone(APFZ) and causes the ACC fronts to merge,diverge,and to fluctuate in intensity and position along their paths. | DUAN Yongliang HOU Yijun LIU Hongwei HU Po | 2012 | Acta Oceanologica Sinica2012，31，6： | 2 |
| 15 | Highly [010]-oriented self-assembled LiCoPO4/C nanoflakes as high-performance cathode for lithium ion batteries显示文摘 | Yan Hou Kun Chang Bao Li Hongwei Tang Zhenyu Wang Jianli Zou Huimin Yuan Zhouguang Lu Zhaorong Chang | 2018 | Nano Research2018，11，5： | 2 |
| 16 | Multidimensional and quantitative interlinking approach for Linked Geospatial Data显示文摘Linked Data is known as one of the best solutions for multisource and heterogeneous web data integration and discovery in this era of Big Data.However,data interlinking,which is the most valuable contribution of Linked Data,remains incomplete and inaccurate.This study proposes a multidimensional and quantitative interlinking approach for Linked Data in the geospatial domain.According to the characteristics and roles of geospatial data in data discovery,eight elementary data characteristics are adopted as data interlinking types.These elementary characteristics are further combined to form compound and overall data interlinking types.Each data interlinking type possesses one specific predicate to indicate the actual relationship of Linked Data and uses data similarity to represent the correlation degree quantitatively.Therefore,geospatial data interlinking can be expressed by a directed edge associated with a relation predicate and a similarity value.The approach transforms existing simple and qualitative geospatial data interlinking into complete and quantitative interlinking and promotes the establishment of high-quality and trusted Linked Geospatial Data.The approach is applied to build data intra-links in the Chinese National Earth System Scientific Data Sharing Network(NSTI-GEO)and data-links in NSTI-GEO with the Chinese Meteorological Data Network and National Population and Health Scientific Data Sharing Platform. | Yunqiang Zhu A-Xing Zhu Jia Song Jie Yang Min Feng Kai Sun Jingqu Zhang Zhiwei Hou Hongwei Zhao | 2017 | International Journal of Digital Earth2017，10，9： | 2 |
| 17 | New statistical model for radar HRRP target recognition显示文摘The mixture of factor analyzers(MFA) can accurately describe high resolution range profile(HRRP) statistical characteristics.But how to determine the proper number of the models is a problem.This paper develops a variational Bayesian mixture of factor analyzers(VBMFA) model.This procedure can obtain a lower bound on the Bayesian integral using the Jensen's inequality. An analytical solution of the Bayesian integral could be obtained by a hypothesis that latent variables in the model are independent.During computing the parameters of the model,birth-death moves are utilized to determine the optimal number of model automatically.Experimental results for measured data show that the VBMFA method has better recognition performance than FA and MFA method. | Qingyu Hou Feng Chen Hongwei Liu Zheng Bao | 2010 | Journal of Systems Engineering and Electronics2010，21，2： | 2 |
| 18 | The water mass variability and southward shift of the Southern Hemisphere mid-depth supergyre显示文摘The Southern Hemisphere subtropical supergyre at intermediate depths connects all three ocean basins and plays a significant role in responding and conveying the climate-change-related variations in the global ocean.On the basis of the Simple Ocean Data Assimilation(SODA)ocean reanalysis,the thermohaline variability and southward shift of the mid-depth supergyre are demonstrated.The steric height of the subsurface relative to 1 500 m(400–1 500 m)from the SODA depicts exactly the flow patterns and variability of the oceanic supergyre.During 1958–2007 the water masses in the gyre interiors become cooler/fresher,with the significant exceptions of the Agulhas Current system and Agulhas leakage.The results also exhibit a pronounced strengthening of the inter-basin connection of the supergyre,and the strongest southward shift,by about 2.5 over the whole period,occurs in the central-south Pacific,which is associated with the changes in the basin-scale wind forcing. | DUAN Yongliang HOU Yijun LIU Hongwei LIU Yahao | 2013 | Acta Oceanologica Sinica2013，32，11： | 2 |
| 19 | Structure and magnetism of a porous three-dimensional metal-organic framework based on planar tetranuclear copper(Ⅱ) cluster units显示文摘A porous three-dimensional copper(Ⅱ) metal-organic framework (MOF) {[Cu2(tci)(OH)(pip)0.5(H2O)]·6H2O}n (1) [tci = tris (2-carboxyethyl)isocyanurate, pip = piperazine] has been generated under hydrothermal conditions at 120 °C. Single crystal X-ray diffraction reveals that the polymer exhibits a novel three-dimensional framework based on planar tetranuclear copper(Ⅱ) cluster units. The variable temperature magnetic susceptibility data in the range 2-280 K show antiferromagnetic spin-spin coupling in the tetranuclear unit in complex 1. A theoretical fitting of the magnetic data gives J values of -31.3 cm-1, -30.8 cm-1, and 13.5 cm-1. | LI HuiJun, ZHANG ErPeng, GUO QianQian, HOU HongWei & FAN YaoTing Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China | 2010 | Science China Chemistry2010，53，10： | 2 |
| 20 | Classification of facial wrinkles among Chinese women显示文摘It is generally recognized that Caucasians and Asians have different skin aging features.The aim of this study was to develop a facial wrinkle grading scale for Chinese women.Standard photographs were taken of 242 Chinese women.Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected,including grading scales for resting and hyperkinetic crow's feet,frontalis lines,glabellar frown lines,and nasolabial folds.To identify the scale by objective quantitative measurement,skin surface measurements from the Visioscan~ VC98 were used.To test the reliability and validity of our wrinkle scale,a multi-rater consensus method was used.A double-blind,randomized,vehicle-controlled 12-week study was conducted to use this clinical photo-score to evaluate the efficacy and safety of Centella triterpenes cream~ in treating crow's feet.A newly developed 10-point photographic and descriptive scale emerged from this study.The final atlas of these photographs contained a total of 6 sets with 10 pictures each.From 0 to 9,surface evaluation of smoothness(SEsm) parametric measurements decreased progressively,indicating that the scale increased inversely.Weighted kappa coefficients for intra-assessor were between 0.75-0.87.The overall Kendall's coefficient is 0.86 on the first rating and 0.87 on the second rating.Thirtysix volunteers were recruited and 35 subjects completed a 12-week trial.Clinical photo-score by investigator showed a significant difference(P < 0.05) between the treatment side and control side after 4 weeks.Use of these scales in clinical settings to evaluate facial wrinkles in Asians individuals is recommended. | Jiechen Zhang Wei Hou Suying Feng Xiangsheng Chen Hongwei Wang | 2017 | The Journal of Biomedical Research2017，31，2： | 2 |
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