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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | GPU computing显示文摘 | Owens J D Houston M Luebke D | | 0，，05： | 1 |
| 3 | GPU Computing显示文摘 | Owens J D Houston M Luebke D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 4 | The overall gains from large banking mergers显示文摘 | HOUSTON J F RYNGAERT M D | 1994 | Journal of Banking and Finance1994，18，6： | 1 |
| 5 | GPU Computing 显示文摘 | Owens J D Houston M Luebke D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 6 | Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo显示文摘 | Houston A Walsron-Lynch F D Bennett M N et aI | 2003 | Int J Cancer2003，1，10： | 1 |
| 7 | A new look at anchoring effects: Basic anchoring and its antecedents 显示文摘 | Wilson T D Houston C E Eitling K M | 1996 | Journal of Experimental psychology : General1996，125，4： | 1 |
| 8 | Brook for GPUs:Stream computing on graphics hardware显示文摘 | Buck I Foley T Horn D R Sugerman J Fatahalian K Houston M Hanrahan P | | 0，，03： | 1 |
| 9 | Feature Matching,Unique Features,and the Dynamics of the Choice Process:Predecision Conflict and Postdecision Satisfaction显示文摘 | HOUSTON D A SHERMAN S T BAKER S M | 1991 | Journal of Experimental Social Psychology1991，27，5： | 1 |
| 10 | Experiments in autogiro airworthiness for improved handling qualities显示文摘 | THOMSON D G HOUSTON S S SPATHOPOULOS V M | 2005 | Journal of the American Helicopter Society2005，50，4： | 1 |
| 11 | The Overall Gains From Large Bank Mergers显示文摘 | Houston J F Ryngaert M D | 1994 | Journal of Banking and Finance1994，，18： | 1 |
| 12 | GPU computing 显示文摘 | OWENS J D HOUSTON M LUEBKE D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 13 | GPU computing显示文摘 | OWENS J D HOUSTON M LUEBKE D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 14 | A randomized controlled trial of continuous positive airway pressure in mild obstruczive sleep apnea显示文摘 | Houston D Worsnop CJ | 2002 | Am J Respir Crit Care Med2002，165，： | 1 |
| 15 | Homology between ricin and Ricinus communis agglutinin: amino terminal sequence analysis and protein synthesis inhibition studies 显示文摘 | Cawley D B Hedblom M L Houston L L | 1978 | Archives of Biochemistry and Biophysics1978，190，2： | 1 |
| 16 | A multi-agency comparison of aquatic macroinvertebrate-based stream bioassessment methodologies显示文摘 | Houston L Barbour M T Lenat D | 2002 | Ecological Indicators2002，，1： | 1 |
| 17 | Relationship velocity:Toward a theory of relationship dynamics 显示文摘 | Palmatier R W Houston M B Dant R P Grewal D | 2013 | Joumal of Marketing2013，77，1： | 1 |
| 18 | GPU computing显示文摘 | OWENS J D HOUSTON M LUEBKE D | 2008 | Proceedings of the Ieee2008，96，5： | 1 |
| 19 | Loss due to transverse thermoelastic currents in microscale resonators 显示文摘 | Houston B H Photiadis D M Vignola J F | 2004 | Materials Science and Engineering a-Structural Materials Properties Microstructure and Processing2004，370，： | 1 |
| 20 | Homology between ficin and Ricinus communis agglutinin: amino terminal sequence analysis and protein synthesis inhibition studies 显示文摘 | Cawley D B Hedblom M L Houston L L | 1978 | Arch Biochem Biophys1978，190，2： | 1 |
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