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| 1 | An experimental investigation on the mechanism of fluid flow through single rough fracture of rock显示文摘The structure of fractures in nature rock appears irregular and induces complicated seepage flow behavior.The mechanism and quantitative description of fluid flow through rock fractures is a difficult subject that has been greatly concerned in the fields of geotechnical,mining,geological,and petroleum engineering.In order to probe the mechanism of fluid flow and the effects of rough structures,we conducted a few laboratory tests of fluid flow through single rough fractures,in which the Weierstrass-Mandelbrot fractal function and PMMA material were employed to produce the fracture models with various fractal roughnesses.A high-speed video camera was employed to record the fluid flow through the entire single rough fracture with a constant hydraulic pressure.The properties of fluid flow varying with the fracture roughness and the influences of the rough structure were analyzed.The components of flow resistance of a single rough fracture were discussed.A fractal model was proposed to relate the fluid resistance to the fracture roughness.A fractal equivalent permeability coefficient of a single rough fracture was formulated.This study aims to provide an experimental basis and reference for better understanding and quantitatively relating the fluid flow properties to the structures of rock fractures. | JU Yang ZHANG QinGang YANG YongMing XIE HePing GAO Feng WANG HuiJie | 2013 | Science China(Technological Sciences)2013，56，8： | 28 |
| 2 | Adoptive cell transfer therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed. The antitumor activities of adoptive cell transfer therapy (ACT), such as strategies based on tumor-infiltrating lymphocytes and cytokine-induced killer cells, are more effective than those of traditional strategies. Currently, chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved numerous breakthroughs in the treatment of hematological malignancies, including relapsed or refractory lymphoblastic leukemia and refractory large B-cell lymphoma? Nevertheless, this approach only provides a modest benefit in the treatment of solid tumors. The clinical results of CAR-T immunotherapy for HCC that could be obtained at present are limited. Some published studies have demonstrated that CAR-T could inhibit tumor growth and cause severe side effects. In this review, we summarized the current application of ACT, the challenges encountered by CAR-T technology in HCC treatment, and some possible strategies for the future direction of immunotherapeutic research. | Renyu Zhang Zhao Zhang Zekun Liu Ding Wei Xiaodong Wu Huijie Bian Zhinan Chen | 2019 | Frontiers of Medicine2019，13，1： | 17 |
| 3 | Analysis of the changes of volatile flavor compounds in a traditional Chinese shrimp paste during fermentation based on electronic nose,SPME-GC-MS and HS-GC-IMS显示文摘Traditionally fermented shrimp paste has a long fermentation period and is susceptible of external factors,which leads to unstable quality and limits its development and application.Therefore,the purpose of this study is to analyze the flavor changes in the shrimp paste fermentation process and screen out the key volatile aroma components in the shrimp paste to control the flavor quality of the shrimp paste products.The overall odor profile was detected by the electronic nose.A total of 106 volatile flavor compounds in the shrimp paste samples at different fermentation stages were identified by solid-phase microextraction-gas chromatography-mass spectrometry(SPME-GC-MS)and headspace-gas chromatography-ion mobility spectrometry(HS-GC-IMS).The main aroma components alcohols,aldehydes,pyrazines and other substances in the fermentation process showed an overall upward trend.A total of 17 key volatile aroma components in shrimp paste at different fermentation stages were identified by the relative aroma activity value(ROAV)method.The combination of electronic nose,SPME-GC-MS and HS-GC-IMS could comprehensively reflect the changes of volatile components in shrimp paste at different fermentation stages,which helps to further understand the mechanism of shrimp paste flavor formation and provides a basis for the regulation of the flavor quality of shrimp paste products. | Ying Li Li Yuan Huijie Liu Hongying Liu Yue Zhou Miaonan Li Ruichang Gao | 2023 | Food Science and Human Wellness2023，12，1： | 16 |
| 4 | Enriching short text representation in microblog for clustering显示文摘社会媒介网站允许用户交换短文章例如在友谊网络经由 microblogs 和用户地位鸣叫。他们的有限长度,弥漫的缩写,和制造缩略词和词加重同义和一词多义的问题,并且引起新挑战到象聚类的文本和分类那样的数据采矿应用程序。处理这些问题,我们把一些潜在的原因并且设计由采用机器翻译从不同语言增加特征的数字充实数据表示的一条有效途径。然后,我们建议通过矩阵因式分解技术同时执行多语言知识集成和特征减小的一个新奇框架。建议途径从 Facebook 和 Twitter 在二社会媒介数据集上以有效性广泛地被评估。与它的重要表演改进,我们进一步调查贡献改进表演的潜在的因素。 | Jiliang TANG Xufei WANG Huiji GAO Xia HU Huan LIU | 2012 | Frontiers of Computer Science2012，6，1： | 14 |
| 5 | Laboratory investigation on mechanisms of stress wave propagations in porous media显示文摘A number of porous models having the similar statistical characteristics of pores and physical properties with natural sandstones have been produced using reactive powder concrete(RPC) and polystyrenes.Spit-Hopkinson-Pressure-Bar tests and CT scans have been carried out on the models with the various porosities to probe the performance of wave propagations and the responses of pores and the matrix during wave propagations.It is shown that porosities significantly influence wave propagations.For an identical impact strain rate,the greater the porosity is,the larger the amplitude of the reflected wave appears,the more the peak in the reflected wave presents,and the smaller the amplitude of the trans-mitted wave turns out.A single peak emerges in the reflected wave when the porosity falls down to 5%.The larger the impact strain rate,the much remarkable the phenomena.The energy-dissipated ratio of porous models,i.e.,WJ /WI,linearly increases with the increment of porosities.The ratio is sensitive to the impact strain rate.Differences in the performance of wave propagations and energy dissipation result from the varied mechanisms that pores response to impacts.For the porosity less than 10%,the mechanism appears to be a process fracturing the matrix to generate new surfaces or pores.Energy has primarily been dissipated in creating new surfaces or pores.No apparent pore deformation takes place.The impact strain rate takes little effect on pore geometry.For the porosity of 15% or more,the mechanism works depending on the impact strain rate.When a low impact strain rate applies,the mechanism still appears to crack the matrix to generate surfaces or pores,but the amount is lower as compared to the case with a low porosity.If a large impact stain rate applies,the mechanism combines both fracturing the matrix and deforming the pores,with the deforming pores predominating.The vast majority of energy has been dissipated to deform pores.Only high porosity and impact strain rate can bring significant deformation to the pores.The proposed eccentricity of pores is capable of character-izing the geometry of pores and its change during wave propagations. | JU Yang YANG YongMing MAO YanZhe LIU HongBin WANG HuiJie | 2009 | Science China(Technological Sciences)2009，52，5： | 13 |
| 6 | Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy显示文摘Lung cancer is the most common incident cancer and the leading cause of cancer death. In recent years, the development of tumor immunotherapy especially chimeric antigen receptor T (CAR-T) cell has shown a promising future. Epidermal growth factor receptor variant III (EGFRvlll) is a tumor-specific mutation expressed in various types of tumors and has been detected in non-small cell lung cancer with a mutation rate of 10%. Thus, EGFRvIII is a potential antigen for targeted lung cancer therapy. In this study, CAR vectors were constructed and transfected into virus-packaging cells. Then, activated T cells were infected with retrovirus harvested from stable virus-producing single clone cell lines. CAR expression on the surfaces of the T cells was detected by flow cytometry and Western blot. The function of CAR-T targeting EGFRvIII was then evaluated. The EGFRvIII-CAR vector was successfully constructed and confirmed by DNA sequencing. A stable virus-producing cell line was produced from a single clone by limited dilution. The culture conditions for the cell line, including cell density, temperature, and culture medium were optimized. After infection with retrovirus, CAR was expressed on more than 90% of the T cells. The proliferation of CAR-T cells were induced by cytokine and specific antigen in vitro. More importantly, EGFRvIII-CART specifically and efficiently recognized and killed A549-EGFRvIII cells with an effector/target ratio of 10:1 by expressing and releasing cytokines, including perforin, granzyme B, IFN-γ, and TNF-α. The in vivo study indicated that the metastasis of A549-EGFRvIII cells in mice were inhibited by EGFRvIII-CART cells, and the survival of the mice was significantly prolonged with no serious side effects. EGFRvIII-CART showed significantly efficient antitumor activity against lung cancer cells expressing EGFRvlll in vivo and in vitro. Therefore, CAR-T targeting EGFRvIII is a potential therapeutic strategy in preventing recurrence and metastasis of lung cancer after surgery. | Zhao Zhang Jun Jiang Xiaodong Wu Mengyao Zhang Dan Luo Renyu Zhang Shiyou Li Youwen He Huijie Bian Zhinan Chen | 2019 | Frontiers of Medicine2019，13，1： | 11 |
| 7 | Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer:A phase II open-label clinical study显示文摘Objective: The aim of this trial was to compare both the efficacy and the safety of a weekly nanoparticle albumin-bound paclitaxel(nab-paclitaxel) plus cisplatin vs. gemcitabine plus cisplatin in patients with advanced non-small-cell lung cancer(NSCLC).Methods: A total of 84 participants received either 100 mg/m^2 nab-paclitaxel each week on d 1, 8 and 15 of a 28 day cycle, as well as cisplatin 75 mg/m^2 on d 1 every three weeks(nab-TP arm); or gemcitabine 1,000 mg/m^2 on d 1 and 8, plus cisplatin 75 mg/m^2 on d 1 every three weeks(GP arm). The primary end point was progression-free survival(PFS). The secondary end points were overall response rate(ORR) and overall survival(OS).Results: According to our analysis, the median PFS was 4.8 months for the nab-TP arm vs. 5.2 months for the GP arm(P=0.55). Analysis showed the median OS was 14.6 months for participants who were in the nab-TP arm vs. 15.1 months for those in the GP arm(P=0.94). Besides, nab-TP showed OS advantages over GP in patients harboring epidermal growth factor receptor(EGFR) mutation(26.7 vs. 15.3 months, P=0.046) and patients with a performance status of 0(23.5 vs. 14.7 months, P=0.020). It was found that incidences of drug-related grade 3 or 4 toxicities were comparable between the two treatment arms.Conclusions: Therefore, it can be seen that weekly nab-TP treatment has a similar efficacy and tolerability to GP treatment for patients who are undergoing their first-line treatment for NSCLC. It could be that survival differences among platinum doublets in the context of both EGFR mutation and performance status have the potential to be the basis for our further clinical trials. | Shanshan Qin Hui Yu Xianghua Wu Zhiguo Luo Huijie Wang Si Sun Mingzhu Huang Jia Jin Zhonghua Tao Jie Qiao Yu Feng Jialei Wang Jianhua Chang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 9 |
| 8 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 9 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 10 | CO_2 permeability of fractured coal subject to confining pressures and elevated temperature: Experiments and modeling显示文摘The CO_2 permeability of fractured coal is of great significance to both coalbed gas extraction and CO_2 storage in coal seams, but the effects of high confining pressure, high injection pressure and elevated temperature on the CO_2 permeability of fractured coal with different fracture extents have not been investigated thoroughly. In this paper, the CO_2 permeability of fractured coals sampled from a Pingdingshan coal mine in China and artificially fractured to a certain extent is investigated through undrained triaxial tests. The CO_2 permeability is measured under the confining pressure with a range of 10–25 MPa, injection pressure with a range of 6–12 MPa and elevated temperature with a range of 25–70°C. A mechanistic model is then proposed to characterize the CO_2 permeability of the fractured coals. The effects of thermal expansion, temperature-induced reduction of adsorption capacity, and thermal micro-cracking on the CO_2 permeability are explored. The test results show that the CO_2 permeability of naturally fractured coal saliently increases with increasing injection pressure. The increase of confining pressure reduces the permeability of both naturally fractured coal and secondarily fractured coal. It is also observed that initial fracturing by external loads can enhance the permeability, but further fracturing reduces the permeability. The CO_2 permeability decreases with the elevation of temperature if the temperature is lower than 44°C, but the permeability increases with temperature once the temperature is beyond 44°C. The mechanistic model well describes these compaction mechanisms induced by confining pressure, injection pressure and the complex effects induced by elevated temperature. | JU Yang WANG JianGuo WANG HuiJie ZHENG JiangTao RANJITH Pathegama G GAO Feng | 2016 | Science China(Technological Sciences)2016，59，12： | 8 |
| 11 | Advances in research of the mid-deep South China Sea circulation显示文摘The South China Sea(SCS)is a large marginal sea connecting the Indian and Pacific oceans.Under the factors of monsoons,strait transport,and varied bathymetry,the SCS presents a three-layer structure and strong diapycnal mixing which is far greater than that in the open ocean.Theoretical analysis and observations reveal that internal tides,internal solitary waves,and strong winds are the sources of the strong mixing in the northern SCS.A major consequence of the strong mixing is an active mid-deep circulation system.This system promotes exchange of water between the SCS and adjacent oceans,and also regulates the upper layer of wind-driven circulation,making the 3 dimensional SCS circulation clearly different from that in other tropical and subtropical marginal seas.The mass transport capacity of the mid-deep circulation has a substantial impact on marine sedimentation,the biogeochemical cycle,and other processes in the SCS.This paper summarizes the recent advances in middeep sea circulation dynamics of the SCS,and discusses the opportunities and challenges in this area. | Dongxiao WANG Qiang WANG Shuqun CAI Xiaodong SHANG Shiqiu PENG Yeqiang SHU Jingen XIAO Xiaohui XIE Zhiwei ZHANG Zhiqiang LIU Jian LAN Dake CHEN Huijie XUE Guihua WANG Jianping GAN Xinong XIE Rui ZHANG Hui CHEN Qingxuan YANG | 2019 | Science China Earth Sciences2019，62，12： | 8 |
| 12 | A natural variation in Ribonuclease H-like gene underlies Rht8 to confer“Green Revolution”trait in wheat显示文摘Dear Editor,Introduction of gibberellin(GA)-insensitive Reduced height(Rht)genes,Rht-B1b and Rht-D1b,has resulted in the“Green Revolution”in modern wheat cultivars(Triticum aestivum)that has skyrocketed wheat grain yields worldwide since the 1960s(Peng et al.,1999;Velde et al.,2021).However,Rht-B1b/D1b also reduce coleoptiles,which is undesired in dryland regions where deep planting is essential for seedling establishment(Rebetzke et al.,1999,Rebetzke et al.,2001;Ellis et al.,2004). | Lingling Chai Mingming Xin Chaoqun Dong Zhaoyan Chen Huijie Zhai Junhong Zhuang Xuejiao Cheng Naijiao Wang Jia Geng Xiaobo Wang Ruolin Bian Yingyin Yao Weilong Guo Zhaorong Hu Huiru Peng Guihua Bai Qixin Sun Zhenqi Su Jie Liu Zhongfu Ni | 2022 | Molecular Plant2022，15，3： | 8 |
| 13 | A drainage-enhancing device for foam fractionation of proteins显示文摘The foam fractionation of nisin from its fermentation broth was studied.Two types of devices consisting of a rubber piston and a foam riser were developed to enhance foam drainage.The separation performance of these two devices was investigated.Experimental results indicated that the second device could significantly reduce the liquid fraction of the foam leaving the column,εout,leading to a higher enrichment of the out-flow stream.As its mounting height increased from 0 to 15 cm,εout declined from 7.07‰ to 6.13 ‰ and the maximum nisin activity in the foamate could reach 39.6 IU/μL.The slight increase in nisin inactivation rate indicated the applicability of this method in the recovery and concentration of proteins.Finally,the mechanism of the process was primarily explained by invoking recent work on pneumatic foams.This research provides a basis for the design of multistage draining foam fractionator which could potentially be an effective separation equipment. | WU ZhaoLiang QIAN ShaoYu ZHENG HuiJie ZHAO YanLi | 2010 | Chinese Science Bulletin2010，55，12： | 7 |
| 14 | Co-seismic displacements of 2011 Japan Mw9.0 earthquake recorded by far-field GPS stations显示文摘Co-seismic displacements of the 2011 Mw9.0 Japan earthquake recorded by GPS stations in China and surrounding areas showed a movement toward the epicenter. The horizontal displacements were up to 1-3 cm in northeastern China, 3-8 mm in the North China, and 2 cm in the Korean peninsula. The vertical movements in China were small uplifts. | Yang Shaomin Nie Zhaosheng Jia Zhige Chen Huijie Peng Maolei | 2011 | Geodesy and Geodynamics2011，2，3： | 7 |
| 15 | A Positive Mutual Impact between Inclusive Finance and Poverty Alleviation显示文摘The contradiction between profitability requirement of commercial finance and non-profitability nature of inclusive finance inhibits bankers' motivation in providing financial services to farmers,further restricting the already narrow financing channels for low-income rural households and preventing them from jumping out of the poverty trap.There is a mutual promotion relationship between inclusive finance and poverty reduction.On one hand,providing affordable and subsidized financial services to farmers can help them increase income steadily; On the other hand,the institutions reap a good payoff by business expansion,a thick base of loyal clients,as well as public recognition,which in turn stimulates the institutes to provide more financial products,improve their service quality and scale up the investment amount for lowincome farmers.Nevertheless,to set off this positive feedback loop process,a forcible intervention by government is needed.On the base of theoretical analysis and practical research,this article brought related advice for financial institutions in order to promote the development of inclusive finance and alleviate the financing difficulties of farmers households to realize poverty alleviation. | Huijie ZHAO Luochuan CHEN | 2019 | Asian Agricultural Research2019，11，1： | 7 |
| 16 | miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells显示文摘在这研究,我们鉴别五 miRNAs 高度在小房间的肺癌症(SCLC ) 表示了房间线 NCI-H209。在他们之中, miR-375 的表示层次戏剧性地在检验的所有 SCLC 房间线被提高,与抄写因素 achaete 鳞甲建筑群相当或相同的事物的表示重合 1 (ASCL1 ) 。而且, miR-375 是 upregulated 并且在也从老鼠象 SCLC 一样肿瘤产生的房间线与 ASCL1 相关。双酶的试金进一步证明 ASCL1 在 miR-375 倡导者由绑定激活 miR-375 的表达式到三个电子盒子元素。这些结果经由 miR-375 的 upregulation 在 SCLC 暗示 ASCL1 的一个角色。 | Huijie Zhao Lei Zhu Yujuan Jin Hongbin Ji Xiumin Yan Xueliang Zhu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 6 |
| 17 | High efficiency all-dielectric pixelated metasurface for near-infrared full-Stokes polarization detection显示文摘Pixelated metasurfaces integrating both the functions of linear polarization and circular polarization filters on a single platform can achieve full-Stokes polarization detection.At present,the pixelated full-Stokes metasurfaces mainly face the following problems:low transmission,low circular dichroism(CD)of circular polarization filters,and high requirements in fabrication and integration.Herein,we propose high performance ultracompact all-dielectric pixelated full-Stokes metasurfaces in the near-infrared band based on silicon-on-insulator,which is compatible with the available semiconductor industry technologies.Circular polarization filters with high CD are achieved by using simple two-dimensional chiral structures,which can be easily integrated with the linear polarization filters on a single chip.In addition,the dielectric materials have higher transmission than metal materials with intrinsic absorption.We experimentally demonstrated the circular polarization filter with maximum CD up to 70%at a wavelength of 1.6μm and average transmission efficiency above 80%from 1.48μm to 1.6μm.Therefore,our design is highly desirable for many applications,such as target detection,clinical diagnosis,and polarimetric imaging and sensing. | Chong Zhang Jingpei Hu Yangeng Dong Aijun Zeng Huijie Huang Chinhua Wang | 2021 | Photonics Research2021，9，4： | 6 |
| 18 | Comparison of the very high cycle fatigue behaviors of INCONEL 718 with different loading frequencies显示文摘In order to clarify the differences of very high cycle fatigue(VHCF) behavior of nickel based superalloy IN718 with different loading frequencies,stress-controlled fatigue tests were carried out by using ultrasonic testing method(20 KHz) and rotary bending testing method(52.5 Hz),both at room temperatures,to establish stress versus cycles to failure(S-N) relationships.Results disclosed that cycles to failure at a given stress level increased with an increase of the applied frequency,i.e.,the higher frequency produced an upper shift of the S-N curves.Fractographic analysis suggested that crack initiation and propagation behaviors had large differences:cracks in low-frequency tests preferentially initiated from multiple sources on the specimen surface,while in high-frequency tests,cracks mostly originated from a unique source of subsurface inclusions.Subsequently,frequency-involved modeling was proposed,based on the damage accumulation theory,which could well illustrate qualitatively those comparisons due to different loading frequencies. | ZHANG YangYang DUAN Zheng SHI HuiJi | 2013 | Science China Chemistry2013，56，3： | 6 |
| 19 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 20 | Variations of sea ice in the Antarctic and Arctic from 1997-2006显示文摘在极的区域的海冰是全球气候系统的重要部分。以便为南极和北极在海冰程度获得变化,这份报纸分析了特殊传感器微波 / 成像器(SSM/I ) 从 1997 年 3 月 1 日标明日期到 2006 年 12 月 31 日的海冰数据产品。在这个时期期间,海冰程度与趋势在南极增加了(0.5467 | Huijie DONG Xiaolei ZOU | 2014 | Frontiers of Earth Science2014，8，3： | 6 |
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