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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Partial discharge monitoring for power transformers using UHF sensors, part 1 : sensors and signal interpretation显示文摘 | Judd M D Yang L Hunter B B | 2005 | IEEE Electrical Insulation Magazine2005，21，2： | 1 |
| 3 | PremenstrualSyndrome 显示文摘 | Dickerson L M Mazyck P J Hunter M H | 2003 | American Family Physician2003，67，8： | 1 |
| 4 | Preclinical pharmacology,antitumor activity,and development of pharmacodynamic markers for the novel,potent AKT inhibitor CCT128930显示文摘 | YAP T A WALTON M I HUNTER L J | 2011 | Mol Cancer Ther2011，10，2： | 1 |
| 5 | The growth inhibitory role and potential clinical value of macrophage inflammatory protein 1 alpha in myeloid leukemias显示文摘 | Owen LYNCH P J Czaplewski L G Hunter M G | 1998 | Leuk Lymphoma1998，30，2： | 1 |
| 6 | MicroRNA-126 inhibits invasion in non-small cell lungcarcinoma cell lines显示文摘 | Crawford M Brawner E Batte K Yu L Hunter MG OttersonGA | 2008 | Biochem Biophys Res Commun2008，373，4： | 1 |
| 7 | An intracellular ATP-activated,calciumpermeable conductance on the basolateral membrane of single renal proximal tubule cells isolated from Rana temporaria 显示文摘 | ROBERSON L HUNTER M | 2000 | J Physiol2000，5232，： | 1 |
| 8 | The prognostic significance of CA125 half-life in patients with ovarian cancer who have received primary chemotherapy after surgical cytoredution显示文摘 | Daly L Helms M | 1990 | Am J Obstet Gynecol1990，163，： | 1 |
| 9 | The prognostic significance of CA125 half_life in patients with ovarian cancer who have received primary chemotherapy after surgical cytoreduction 显示文摘 | Hunter V J Daly L Helms M | 1990 | Am J Obstet Gynecol1990，163，： | 1 |
| 10 | Host responses in the bursa of Fabricius of chickens infected with virulent Marek's diseas virus显示文摘 | Abdul-Careem M F Hunter B D Lee L F | 2008 | Virology2008，379，2： | 1 |
| 11 | CART peptides显示文摘 | Kuhar M J Adams L D Hunter R G Vechia S D Smith Y | 2000 | Regul Pept2000，89，13： | 1 |
| 12 | Serologic survey for infectious pathogens in free-ranging American bison 显示文摘 | Taylor S K Lane V M Hunter D L | 1997 | Wildl Dis1997，33，： | 1 |
| 13 | Structural features of oxide coatings on aluminium显示文摘 | Hunter M S Robinson D L | 1953 | Journal of the Eleetrochemi-cal Society1953，100，： | 1 |
| 14 | Variation in concentrations of phloridzin and phloretinin apple foliage显示文摘 | Hunter M D Hull L A | 1993 | Phytochemistry1993，34，5： | 1 |
| 15 | Effect of seed maturation and genotype on seed vigor in maize显示文摘 | TeKrony D M Hunter J L | 1995 | Crop Science1995，35，3： | 1 |
| 16 | Intrauterine growth restriction: identification and management显示文摘 | Peleg D Kennedy C M Hunter S L | 1998 | Am Fam Physician1998，58，2： | 1 |
| 17 | Structural features of anodic oxide films on aluminum显示文摘 | Keller F Hunter M S Obinson D L | 1953 | J Electrochem Soc1953，，100： | 1 |
| 18 | Observations on pigeon circovirus infection in Ontario 显示文摘 | Pare J A Brash M L Hunter D B | 1999 | Can Vet J1999，40，： | 1 |
| 19 | The Dose Uptake Ratio as an Index of Glucose Metabolism: Useful Parameter or Oversimplification显示文摘 | Hambery L M Hunter G J Alpert N M | 1994 | J Nael Med1994，207，： | 1 |
| 20 | CART: fromgeneto function显示文摘 | Adams L D Gong W Vechia S D Hunter R G Kuhar M J | 1999 | BrainRes1999，848，12： | 1 |
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