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| 1 | Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma显示文摘AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P < 0.0001,respectively). In contrast,the serum levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay. | Mansour S Al-Moundhri A Al-Shukaili M Al-Nabhani B Al-Bahrani IA Burney A Rizivi SS Ganguly | 2008 | World Journal of Gastroenterology2008，14，24： | 32 |
| 2 | 异烟肼预防性治疗对机体抗结核分枝杆菌免疫反应的影响:随机、对照和探索性研究显示文摘背景:异烟肼的预防性治疗(isoniazid preventive therapy,IPT)已被证明在高危人群中的有效性,如HIV病毒感染者和新近感染结核者,IPT可以减少70%以上的患者发展成为活动性结核的风险,并降低了25%死亡率。已有的研究证实异烟肼对活动性肺结核患者具有将Th2通路的免疫反应逆转为具有保护作用的Th1免疫反应的作用,本研究观察IPT对结核潜伏感染的患者是否具有类似的效果并对宿主起到长期的免疫保护作用。 | Biraro IA Egesa M, Kimuda S 何亦凡 沙巍 | 2015 | 中国防痨杂志2015，37，12： | 8 |
| 3 | Identification of mesen-chymal stem/progenitor cells in human first-trimester fetal blood,liver,and bone arrow显示文摘 | Campagnoli C hoberts IA Kumar S | 2001 | Blood2001，98，8： | 1 |
| 4 | Neonatal intracranial ischemia and hemorrhage: role of cranial sonography and CT scanning 显示文摘 | Khan IA Wahab S Khan RA | 2010 | J Korean Neurosurg Soc2010，47，2： | 1 |
| 5 | Idiopathic lymphocytic cerebellitis显示文摘 | Omeis IA Khoshyomn S Braff SP | | 0，，： | 1 |
| 6 | Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase - 9 me- diated pathway显示文摘 | McNeish IA Bell S McKay T | 2003 | Exp Cell Res2003，286，： | 1 |
| 7 | Differential diagnosis of breast lesions using ultrasound elastography显示文摘 | Gheonea IA Stoica Z Bondari S | 2011 | Indian Radiol Imaging2011，21，4： | 1 |
| 8 | Increased matenal plasma leptin in early pregnancy and risk of gestational diabetes mellitus 显示文摘 | Qiu c Will iams M A Vadachkor ia S | 2004 | Obstet Gynecol2004，103，3： | 1 |
| 9 | Inhibition of mononuclear cell recruitment in aortic intima by treatment with anti-ICAM- 1 and anti-LFA- 1 monoclonal antibodies in hypercholesterolemic rats: implications of the ICAM- 1 and LFA- 1 pathway in athergenesis 显示文摘 | Nie Qing-hua Fan J ia Haraoka S | 1997 | Lab Invest1997，77，： | 1 |
| 10 | Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians显示文摘 | MACPHEE IA FREDERICKS S MOHAMED M | 2005 | Transplantation2005，79，： | 1 |
| 11 | Symbiotic interaction of endophytic bacteria with arbuscular mycorrhizal fungi and its antagonistic effect on Ganoderma boninense显示文摘 | Sundram S Meon S Seman IA | 2011 | The Journal of Microbiology2011，49，4： | 1 |
| 12 | Mefformin reduces abortion in pregnant women with polyeystie ovary syndrome 显示文摘 | Khattab S Mohsen IA Foutouh IA | 2006 | Gynecol Endocrinol2006，22，12： | 1 |
| 13 | Nonoperative versus operative treatment for thoracolumbar burst fractures without neurologic deficit:a meta-analysis显示文摘 | Gnanenthiran SR Adie S Harris IA | | 0，，02： | 1 |
| 14 | Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation显示文摘 | Mercer TR Qureshi IA Gokhan S | 2010 | BMC Neurosci2010，11，： | 1 |
| 15 | Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian canc er stem cells that portend poor patient survival显示文摘 | Silva IA Bai S Yang K | 2011 | Cancer Res2011，71，11： | 1 |
| 16 | Clinical and radiographic outcomes of the treatment of adolescent idiopathic scoliosis with segmental pedicle screws and combined local autograft and allograft bone for spinal fusion: a retrospective case series显示文摘 | Yang X Xu H IA M Gu S Fang X Wang J | 2010 | BMC Musculoskelet Disord2010，11，： | 1 |
| 17 | Transforming growth factor-betas in a rat model of neonatal posthaemorrhagic hydrocephalus显示文摘 | Cherian S Thoresen M Silver IA | 2004 | Neuropathol Appl Neurobiol2004，30，6： | 1 |
| 18 | HM G2COA reductase inhi-bitons reduce MM P29 secretion by macrophages显示文摘 | Bellosta S V ia D CanavesiM | 1998 | ArteriosclerThromb Vasc biol1998，18，： | 1 |
| 19 | Energy metabolism in mammalian brain during development显示文摘 | Erecinska M Cherian S Silver IA | | 0，，06： | 1 |
| 20 | Nonoperative versus operative treatment for thoracolumbar burst fractures without neurologic deficit:a meta-analysis显示文摘 | Gnanenthiran SR Adie S Harris IA | | 0，，02： | 1 |
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