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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Formation of PVP - protected metal nanopartical in DMF 显示文摘 | Isabel P S Luis M L | 2002 | Langmuir2002，，18： | 1 |
| 3 | Formation and stabilization of silver nanopartieles through reduction by N, N - dimethylformamide 显示文摘 | Isabel P S Luis M L | 1999 | Langmuir1999，15，4： | 1 |
| 4 | Formation and Stabilization of Silver Nanoparticles through Reduction by N, N-Dimethylformamide显示文摘 | P S Isabel M L Luis | 1999 | Langmuir1999，15，： | 1 |
| 5 | The effect of anchor voices and visible speech in training in the GRABS scale of perceptual evaluation of dysphonia显示文摘 | FAUSTINO N B JUAN P D M ISABEL G L | 2012 | Acta Otorrinolaringológica Espa1ola2012，63，： | 1 |
| 6 | Formation of PVP-Protected Metal Nanoparticles in DMF显示文摘 | P S Isabel M L Luis | 2002 | Langmuir2002，18，： | 1 |
| 7 | Effects of the combination of hydrophobic polypeptides,iso-αacids,and malto-oligosaccharides on beer foam stability显示文摘 | Isabel M P L V O F Erreira Kaa Tia Jorge Luciana C Nogueira | 2005 | J Agric Food Chem2005，53，12： | 1 |
| 8 | The Cys-loop pentameric ligand-gated ion channel receptors: 50 years on显示文摘 | JANNA L K ISABELLE M P | 2012 | Can J Physiol Pharmacol2012，90，6： | 1 |
| 9 | Synthesis of silver nanoprisms in DMF显示文摘 | ISABEL P S LUIS M L M | 2002 | Nano Letters2002，2，8： | 1 |
| 10 | Reduction of silver nanoparticles in DMP-Pormation of monolayers and stable coHids显示文摘 | ISABEL P S LUIS M L M | 2000 | Pure and Applied Chemistry2000，72，12： | 1 |
| 11 | Simultaneous determination of benzoic and sorbic acids in quince jam by HPLC 显示文摘 | Isabel M P L V O Ferreira Eullia Mendes Paula Brito | 2000 | Food Research International2000，33，： | 1 |
| 12 | Formation and Stabilization of Silver Nanoparticies through Reduction by N,N-Dimethylformamide显示文摘 | Isabel P S Luis M L | 1998 | Langmuir1998，15，4： | 1 |
| 13 | Extension of the Job Demands-Resources Model in the Prediction of Burnout and Engagement among Teachers over Time显示文摘 | LAURA L P MARISA S S ISABEL M M | 2008 | Psicothema2008，20，3： | 1 |
| 14 | Contribution of Circulating Leuoeytes to Cytoine Production in Pancreatic Duct Obstruction-induced Acute Pancreatitis in Rats 显示文摘 | Isabel D D Martin P Ana D L M | 2002 | Cytoine2002，20，6： | 1 |
| 15 | Antioxidant strategies inthe treatment of stroke显示文摘 | Isabelle M Michel P Dominique L | 2005 | Free Radical Biology&Medicine2005，39，： | 1 |
| 16 | The Determination and Distribution of Nucleotides in Dairy Products Using HPLC and Diode Array Detection 显示文摘 | ISABEl M P L V O | 2001 | Food Chemistry2001，74，： | 1 |
| 17 | Antioxidant strategies in the treatment of stroke 显示文摘 | Isabelle M Michel P Dominique L | 2005 | Free Radical Biology and Medicine2005，39，4： | 1 |
| 18 | Formation of PVP-protected metal nanoparticals in DMF显示文摘 | Isabel P S Luis M L | 2002 | Langmuir2002，8，： | 1 |
| 19 | Formation and stabilization of silver nanopartieles through reduction by N, N-dimethylformamide 显示文摘 | Isabel P S Luis M L | 1999 | Langmuir1999，15，4： | 1 |
| 20 | Formation and stabilization of silver nanoparticles through Reduction by N,N-Dimethylformamide显示文摘 | Isabel P S Luis M L M | | 0，，04： | 1 |
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