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| 1 | 内蒙古乌奴格吐山斑岩铜钼矿床的成岩、成矿时代显示文摘内蒙古满洲里地区乌奴格吐山斑岩铜钼矿床系80年代探明的特大型斑岩铜钼矿床,关于其成岩成矿时代,一直是本区研究的薄弱环节。以前据二长花岗斑岩体的一件K-Ar年龄(138Ma),认为其系晚燕山期成矿。这一认识与中、蒙邻区同类矿床时代相悖。本文进行了多种方法同位素年龄系统测定,获得三组年龄:二长花岗斑岩单颗粒锆石U-Pb年龄183.3±0.6Ma;全岩Rb-Sr等时线年龄183.9±1.0Ma;蚀变岩绢云母K-Ar年龄183.5±1.7Ma。其分别代表岩浆侵位后开始结晶年龄、岩浆冷却年龄和热液蚀变年龄。这充分证明,乌奴格吐山铜钼矿床的成岩成矿时代为早燕山期(早侏罗世)。原测K-Ar年龄可能代表成矿后晚期火山—侵入热事件。 | 秦克章 李惠民 李伟实 Shunso Ishihara | 1999 | 地质论评1999，45，2： | 98 |
| 2 | 伊藤法“单开门”颈椎椎管扩大椎板成形术的并发症及其原因分析显示文摘目的:探讨伊藤法“单开门”颈椎椎管扩大椎板成形术并发症的发生率及其原因。方法:对1983年2月~1992年3月行伊藤法“单开门”颈椎椎管扩大椎板成形术的87例患者的临床资料进行回顾性分析,通过查阅病历及门诊随访,确定其手术并发症。采用临床观察、影像学评价及统计学方法分析其原因。结果:随访2~14年,平均5.3年。39例(45%)患者出现轴性症状,4例(4.6%)出现神经根麻痹,颈部旋转受限48例(55.2%),过伸受限33例(37.9%),屈曲受限17例(18.3%),侧屈受限17例(18.3%)。颈椎曲度:术前平均14.8°,术后平均4.9°,平均减少9.9°。结论:伊藤法“单开门”颈椎椎管扩大椎板成形术后轴性症状较多见,术后颈椎前凸减小,尤其是颈椎后凸可能是产生轴性症状的原因之一。 | 刘洪 Hirokazu Ishihara 张腾云 | 2006 | 中国脊柱脊髓杂志2006，16，5： | 23 |
| 3 | 伊藤法“单开门”颈椎椎管扩大椎板成形术及其临床应用显示文摘目的:总结伊藤法“单开门”颈椎椎管扩大椎板成形术的临床应用效果。方法:对123例发育性颈椎管狭窄症、连续性颈椎后纵韧带骨化(OPLL)及多节段脊髓型颈椎病患者行伊藤法“单开门”颈椎椎管扩大椎板成形术,于开门侧将植骨块通过钢丝或尼龙线固定于掀起的椎板和小关节间。87例患者随访2~14年,平均5.3年。结果:术前JOA评分平均9.1分,随访时JOA评分平均14.4分,改善率平均为67.0%,其中优44例(50.6%),良26例(29.9%),可11例(12.6%),差6例(6.9%)。术后侧位X线片示椎管直径扩大1.5~7.0mm,平均4.1mm,椎管扩大率为15%~100%,平均40%。术后CT示植骨愈合良好,无再关门现象,MRI示脊髓受压解除。并发症包括轴性症状(颈部疼痛或僵硬57例次)、神经根麻痹(4例次)及颈部活动受限(旋转、过伸、屈曲或侧屈受限115例次)等。结论:伊藤法“单开门”颈椎椎管扩大椎板成形术是治疗发育性颈椎管狭窄症、连续性颈椎后纵韧带骨化(OPLL)及多节段脊髓型颈椎病安全有效的手术方法,椎管扩大稳定持久,但其并发症有待于进一步解决。 | 刘洪 Hirokazu Ishihara 智慧明 | 2005 | 中国脊柱脊髓杂志2005，15，9： | 19 |
| 4 | 伴有侧凸的退变性腰椎管狭窄症中神经根病的特点显示文摘目的研究伴有侧凸的退变性腰椎管狭窄症(degenerativelumbarstenosiswithscoliosis,DLSS)中,受累神经根及其致压因素与脊柱侧凸之间的关系。方法回顾性分析22例伴有神经根病的DLSS患者的病例资料,男10例,女12例;;平均年龄71岁。通过疼痛分布区、神经学检查及神经根造影确定受累神经根,并通过术中所见及术后症状的改善证实。致压因素通过脊髓造影、椎间盘造影、CT造影或CT椎间盘造影、MR检查以及神经根造影确定。在正位X线片上确定上、下端椎,Cobb角及椎体的侧方移位。将椎体的侧方移位分为两组:移位组(≥10mm)和无移位组(<10mm)。结果受累神经根为L3神经根5个(14%)、L4神经根15个(42%)、L5神经根12个(33%)、S1神经根4个(11%),其中L3和L4神经根以及L5和S1神经根同时受累者分别为5例(23%)和4例(18%)。L3和L4神经根压迫多由椎间孔或其外侧狭窄引起,而L5和S1神经根多由侧隐窝狭窄引起(χ2=10.08,P<0.01)。L3和L4神经根多在侧凸凹侧受压,而L5和S1神经根多在凸侧受压(χ2=8.92,P<0.01)。L3和L4神经根受压者的Cobb角和侧方移位大于L5和S1受压者(t=8.843,P<0.01;;χ2=8.23,P<0.01)。结论DLSS中神经根的压迫不仅可以发生在脊柱侧凸的凹侧,也可以发生在凸侧。不同受累神经根的致压因素不同。 | 刘洪 Hirokazu Ishihara 李淳德 马忠泰 | 2004 | 中华骨科杂志2004，24，5： | 15 |
| 5 | Feasibility of cold snare polypectomy in Japan: A pilot study显示文摘AIM: To investigate the feasibility of cold snare polypectomy(CSP) in Japan.METHODS: The outcomes of 234 non-pedunculated polyps smaller than 10 mm in 61 patients who underwent CSP in a Japanese referral center were retrospectively analyzed. The cold snare polypectomies were performed by nine endoscopists with no prior experience in CSP using an electrosurgical snare without electrocautery.RESULTS: CSPs were completed for 232 of the 234 polyps. Two(0.9%) polyps could not be removed without electrocautery. Immediate postpolypectomy bleeding requiring endoscopic hemostasis occurred in eight lesions(3.4%; 95%CI: 1.1%-5.8%), but all were easily managed. The incidence of immediate bleeding after CSP for small polyps(6-9 mm) was significantly higher than that of diminutive polyps(≤ 5 mm; 15% vs 1%, respectively). Three(5%) patients complained of minor bleeding after the procedure but required no intervention. The incidence of delayed bleeding requiringendoscopic intervention was 0.0%(95%CI: 0.0%-1.7%). In total, 12% of the resected lesions could not be retrieved for pathological examination. Tumor involvement in the lateral margin could not be histologically assessed in 70(40%) lesions.CONCLUSION: CSP is feasible in Japan. However, immediate bleeding, retrieval failure and uncertain assessment of the lateral tumor margin should not be underestimated. Careful endoscopic diagnosis before and evaluation of the tumor residue after CSP are recommended when implementing CSP in Japan. | Yoji Takeuchi Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Kengo Nagai Fumi Matsui Tomofumi Akasaka Noboru Hanaoka Koji Higashino Hiroyasu Iishi Ryu Ishihara Henrik Thorlacius Noriya Uedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 14 |
| 6 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 7 | 一期前路病灶清除加植骨术治疗化脓性脊椎炎显示文摘 | 刘洪 Hirokazu Ishihara 马忠泰 Yoshiharu Kawaguchi | 2005 | 中华骨科杂志2005，25，11： | 12 |
| 8 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 9 | Cholangiopancreatography troubleshooting:the usefulness of endoscopic retrieval of migrated biliary and pancreatic stents显示文摘BACKGROUND:Stent migration in the hepatopancreatic duct might arise as one of the rare complications associated with biliary or pancreatic stenting.Although there are some procedures to retrieve the migrated stent,including surgical,percutaneous,and endoscopic approaches,endoscopy should be attempted first because it is least invasive.This study set out to evaluate the usefulness of endoscopic retrieval of migrated biliary and pancreatic stents.METHODS:Plastic stents that migrated in the bile duct(35 patients)or pancreatic duct(2)were retrieved with endoscopic retrograde cholangiopancreatography.Devices used were snare forceps,a basket catheter,grasping forceps,biopsy forceps,a balloon catheter,and the Soehendra stent retriever.RESULTS:Endoscopic retrieval of migrated stents was performed successfully in 36(97.0%)of the 37 patients.The devices utilized for successful treatment were basket catheter(13 patients),grasping forceps(10),snare forceps(8),balloon catheter(3),biopsy forceps(1),and the Soehendra stent retriever(1).The unsuccessfully treated patient with chronic pancreatitis underwent surgery since the guide wire did not move forward due to bile duct stenosis,and there was also duodenal stenosis.One patient developed mild pancreatitis after withdrawal of the stent;the pancreatitis was relieved with conservative treatment.CONCLUSIONS:Endoscopic retrieval of migrated biliary and pancreatic stents appears to be useful because of its safety and low invasiveness.However,various forceps should be prepared for the retrieval of a migrated stent. | Yuji Sakai Toshio Tsuyuguchi Takeshi Ishihara Harutoshi Sugiyama Reiko Eto Tatsuya Fujimoto Shin Yasui Ryo Tamura Seiko Togo Motohisa Tada Osamu Yokosuka | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 10 | Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma显示文摘BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often challenging.Recently,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ESCC.Although,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ESCC.And,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.This study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for ESCC.AIM To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.METHODS A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively analyzed.FDG uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or not.The invasion depth of ESCC was classified according to the Japan Esophageal Society.Primary endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial ESCC.Secondary endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.RESULTS A total of 82 lesions in 82 patients were included.FDG-PET showed positive uptake in 29(35.4%)lesions.Univariate analysis showed that uptake of FDG-PET had significant correlations with circumferential extension(P=0.014),pathological depth of tumor invasion(P<0.001),infiltrative growth pattern(P<0.001),histological grade(P=0.002),vascular invasion(P=0.001),and lymphatic invasion(P<0.001).On multivariate analysis,only depth of tumor invasion was independently correlated with FDG-PET/computed tomography visibility(P=0.018).The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of Type B2 in ME-NBI for the invasion depth of T1a muscularis mucosae and T1b upper submucosal layer were 68.4%/79.4%/50.0%/89.3%/76.8%,respectively,and those of Type B3 for the depth of T1b middle and deeper submucosal layers(SM2 and SM3)were 46.7%/100%/100%/89.3%/90.2%,respectively.On the other hand,those of FDGPET for SM2 and SM3 were 93.3%/77.6%/48.2%/98.1%/80.5%,respectively,whereas,if the combination of positive FDG uptake and type B2 and B3 was defined as an indicator for radical esophagectomy or definitive chemoradiotherapy,the sensitivity,specificity,PPV,NPV,and accuracy were 78.3%/91.5%/78.3%/91.5%/87.8%,respectively.CONCLUSION FDG uptake was correlated with the invasion depth of superficial ESCC.Combined use of FDG-PET and ME-NBI,especially with the microvascular findings of Type B2 and B3,is useful to determine whether ER is indicated for the lesion. | Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe Yasushi Yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa | 2019 | World Journal of Gastroenterology2019，25，46： | 7 |
| 11 | 小关节不对称—青少年腰椎间盘突出症的放射学特征显示文摘目的 :成人与青少年腰椎间盘突出症中小关节不对称性的比较。方法 :研究组包括青少年组 2 5名患者 ,2 9个椎间盘和成人组 3 3名患者 ,5 0个椎间盘。使用CT测量每个小关节形态、小关节角、力矩臂角和长度。小关节不对称的诊断标准为 :双侧小关节的形态不同或双侧小关节角相差 10°以上。并比较了两组间小关节不对称的发生率及其与椎间盘突出的位置、类型以及椎间盘退变之间的关系。结果 :青少年组 (12个间盘 ,占 41% )小关节不对称的发生率明显高于成人组 (4个间盘 ,占 8% ) (P <0 .0 1)。小关节不对称与椎间盘突出的位置、类型以及椎间盘退变之间无统计学差异。结论 :小关节不对称性是青少年腰椎间盘突出症的一个放射学特点。 | 刘洪 Hirokazu Ishihara Ryusuke Osada | 2003 | 中国矫形外科杂志2003，11，24： | 7 |
| 12 | 颈椎前路椎间融合术后邻近节段的病变研究显示文摘[目的]研究颈椎前路椎间融合术后症状性邻近节段病变的发生率以及预测其发生的因素。[方法]112例颈椎间盘突出症或颈椎病接受颈椎前路椎体问融合术患者,行术后症状的评价,神经学检查及系列放射学检查,分析症状性邻近节段病变的发生率与临床和影像学参数的关系。症状性邻近节段病变的发生率通过Kaplan-Meier生存分析法进行统计,各参数与症状性邻近节段病变的发生率之间的关系通过u检验和t检验分析。[结果]随访时间2—19a,平均9.4a。112例患者中有19例(17%)出现了症状性邻近节段病变,其中男12例,女7例。Kaplan-Meier生存分析法分析未出现症状邻近节段病变的患者比率,5a时比率为89%,10a时为84%,17a时为67%。出现症状性邻近节段病变的病例中,术前脊髓造影上邻近节段硬膜有明显压迹或MRI上邻近节段椎间盘突出的发生率明显高于未出现症状性邻近节段病变的病例(P分别为0.0087及0.0299,双样本t检验)。而其他参数没有显著性差异。7名患者因保守治疗无效而进行了手术。[结论]当术前脊髓造影或MRI显示该节段存在无症状性椎间盘退变时,颈椎前路椎体间植骨融合术后症状性邻近节段病变的发生率明显高,与融合的节段数、术前颈椎曲度、椎管的直径或融合节段的曲度都无关。 | 刘洪 Hirokazu Ishihara 智慧明 | 2006 | 中国矫形外科杂志2006，14，9： | 7 |
| 13 | Efficacy of multiple biliary stenting for refractory benign biliary strictures due to chronic calcifying pancreatitis显示文摘AIM To investigate endoscopic therapy efficacy for refractory benign biliary strictures(BBS) with multiple biliary stenting and clarify predictors.METHODS Ten consecutive patients with stones in the pancreatic head and BBS due to chronic pancreatitis who underwent endoscopic therapy were evaluated. Endoscopic insertion of a single stent failed in all patients. We used plastic stents(7F, 8.5F, and 10F) and increased stents at intervals of 2 or 3 mo. Stents were removed approximately 1 year after initial stenting. BBS and common bile duct(CBD) diameter were evaluated using cholangiography. Patients were followed for ≥ 6 mo after therapy, interviewed for cholestasis symptoms, and underwent liver function testing every visit. Patients with complete and incomplete stricture dilations were compared.RESULTS Endoscopic therapy was completed in 8(80%) patients, whereas 2(20%) patients could not continue therapy because of severe acute cholangitis and abdominal abscess, respectively. The mean number of stents was 4.1 ± 1.2. In two(20%) patients, BBS did not improve; thus, a biliary stent was inserted. BBS improved in six(60%) patients. CBD diameter improved more significantly in the complete group than in the incomplete group(6.1 ± 1.8 mm vs 13.7 ± 2.2 mm, respectively, P = 0.010). Stricture length was significantly associated with complete stricture dilation(complete group; 20.5 ± 3.0 mm, incomplete group; 29.0 ± 5.1 mm, P = 0.011). Acute cholangitis did not recur during the mean follow-up period of 20.6 ± 7.3 mo.CONCLUSION Sequential endoscopic insertion of multiple stents is effective for refractory BBS caused by chronic calcifying pancreatitis. BBS length calculation can improve patient selection procedure for therapy. | Hiroshi Ohyama Rintaro Mikata Takeshi Ishihara Yuji Sakai Harutoshi Sugiyama Shin Yasui Toshio Tsuyuguchi | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，1： | 6 |
| 14 | Is ERCP really necessary in case of suspected spontaneous passage of bile duct stones?显示文摘AIM:To investigate the usefulness of magnetic resonance cholangiopancreatography (MRCP) and the need for endoscopic retrograde cholangiopancreatography (ERCP) in cases of suspected spontaneous passage of stones into the common bile duct.METHODS:Thirty-six patients with gallbladder stones were clinically suspected of spontaneous passage of stones into the common bile duct because they presented with clinical symptoms such as abdominal pain and fever,and showed signs of inflammatory reaction and marked rise of hepatobiliary enzymes.These symptoms resolved and they showed normalized values of blood biochemical parameters after conservative treatment without evidence of stones in the common bile duct on MRCP.All these patients were subjected to ERCP within 3 d of MRCP to check for the presence of stones.RESULTS:No stones were detected by ERCP in any patient,confi rming the results of MRCP.CONCLUSION:When clinical symptoms improve,blood biochemical parameters have normalized,and MRCP shows there are no stones in the common bile duct,it can be considered the stone has spontaneously passed and thus ERCP is not necessary. | Yuji Sakai Toshio Tsuyuguchi Takeshi Ishihara Seigo Yukisawa Tadashi Ohara Masaru Tsuboi Yoshihiko Ooka Kazuki Kato Kiyotake Katsuura Michio Kimura Makoto Takahashi Kazuhisa Nemoto Masaru Miyazaki Osamu Yokosuka | 2009 | World Journal of Gastroenterology2009，15，26： | 6 |
| 15 | Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity显示文摘Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and polycarbonate.BPA,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum worldwide.The pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 responses.The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th response.In the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in DCs.In addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 deviation.BPA exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 polarization.These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions. | Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling | 2010 | Cellular & Molecular Immunology2010，7，3： | 6 |
| 16 | Nomograms for colorectal cancer:A systematic review显示文摘AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily clinicalpractice.METHODS: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was developed.RESULTS: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed nomograms.CONCLUSION: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice. | Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro Tanaka Toshiaki Tanaka Takeshi Nishikawa Joji Kitayama Toshiaki Watanabe | 2015 | World Journal of Gastroenterology2015，21，41： | 5 |
| 17 | Molecular Functions of Oxygen-Evolving Complex Family Proteins in Photosynthetic Electron Flow显示文摘Oxygen-evolving complex (OEC) protein is the original name for membrane-peripheral subunits of photosystem (PS) II. Recently, multiple isoforms and homologs for OEC proteins have been iden- tified in the chloroplast thylakoid lumen, indicating that functional diversification has occurred in the OEC family. Gene expression profiles suggest that the Arabidopsis OEC proteins are roughly categorized into three groups: the authentic OEC group, the stressresponsive group, and the group including proteins related to the chloroplast NAD(P)H dehydrogenase (NDH) complex involved in cyclic electron transport around PSI. Based on the above gene expression profiles, molecular functions of the OEC family proteins are discussed together with our current knowledge about their functions. | Kentaro Ifuku Seiko Ishihara Fumihiko Sato | 2010 | Journal of Integrative Plant Biology2010，52，8： | 5 |
| 18 | Dysbiotic infection in the stomach显示文摘Microbiota in human alimentary tract plays important roles for homeostatic maintenance of the body. Compositional difference of gut microbiota is tightly associated with susceptibility of many diseases,including inflammatory diseases,obesity,diabetes mellitus,cancer,and atherosclerosis. 'Dysbiosis' refers to a state of imbalance among the colonies of microorganisms within the body,which brings abnormal increase of specific minor components and decrease in the normally dominant species. Since stomach secrets strong acid for its digestive role,this organ has long been thought a sterile organ. However,the discovery of Helicobacter pylori(H. pylori) has changed the concept. This bacterium has proven to cause gastritis,peptic ulcer,and gastric cancer. However,recent cross-sectional studies revealed that H. pylori carriers had a decreased risk of developing immunological diseases,such as asthma. H. pylori coinfection also suppresses inflammatory bowel diseases. This review describes human gastric microbiota by discussing its mutual interaction and pathogenic enrollment. Gastric 'dysbiosis' may affect host inflammatory response and play important role for gastric pathogenesis. We will topically discuss enrollment of dysbiosis for genesis of gastric cancer as well as for disruption of immunological homeostasis affecting oncogenic resistance. | Hisashi Iizasa Shyunji Ishihara Timmy Richardo Yuichi Kanehiro Hironori Yoshiyama | 2015 | World Journal of Gastroenterology2015，21，40： | 5 |
| 19 | 应力比对WC-Co硬质合金疲劳寿命及裂纹生长行为的影响(英文)显示文摘通过两种疲劳试验:旋转弯曲疲劳试验和3-或4-点弯曲疲劳试验测试细晶WC-Co硬质合金的裂纹生长行为和疲劳寿命。疲劳试验结果表明:所测试的大部分WC-Co硬质合金的疲劳寿命取决于裂纹生长周期。利用断裂力学基本方程推导出疲劳裂纹生长速率(da/dN)和最大应力强度因子(Kmax)的关系。根据此关系,获得材料的强度因子阈值(Kth)和疲劳断裂韧性值(Kfc)。基于修正的线性弹性断裂力学方程,对WC-Co硬质合金材料的疲劳寿命进行计算,疲劳寿命的计算结果与实验结果吻合较好。 | Hiroko MIKADO Sotomi ISHIHARA Noriyasu OGUMA Kenichi MASUDA Syo KITAGAWA Shingo KAWAMURA | 2014 | Transactions of Nonferrous Metals Society of China2014，24，S1： | 4 |
| 20 | 利用钐掺杂氧化铈提高燃料电池阳极活性显示文摘用浸渍法制备并采用交流阻抗、极化等技术考察了不同组成的Ni-Sm^(3+)掺杂的CeO_2(SDC)复合镍阳极的电化学性能及相应电池的功率输出性能.结果表明,SDC掺入镍阳极后,阳极极化过电位及电池的欧姆电阻显著减小.其中阳极过电位的减小与SDC掺入镍电极引起的三相界扩展有关,但SDC的掺入同时引起了电极反应活化能的增加,造成低温下Ni-SDC的极化过电位大于纯Ni电极.高温下,Ni-SDC阳极的阻抗谱由两个半圆组成,其中高频半圆随着SDC掺入量的增加而减小,而低频环与SDC的掺入量基本无关.低温下只观察到一个高频环.高频环可能对应三相界反应,而低频环可能对应氢的解离吸附及扩散.75%(w)Ni-25%(w)SDC/La_(0.9)Sr_(0.1)Ga_(0.8)Mg_(0.2)O_3(LSGM)/Sm_(0.5)Sr_(0.5)CoO_3(SSC)在所研究的电池中具有最大功率输出密度,其值在1073、973、873 K下分别达到1.1、0.43、0.14 W·cm^(-2). | 王世忠 Ishihara Tatsumi | 2003 | 物理化学学报2003，19，9： | 4 |
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