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| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats显示文摘 | R Maiti D Jana U.K Das D Ghosh | 2004 | Journal of Ethnopharmacology2004，，1： | 2 |
| 3 | Decomposition and/or hydrogenation of hydrogen peroxide over Pd/Al2O3 catalyst in aqueous medium: Factors affecting the rate of H2O2 destruction in presence of hydrogen显示文摘 | CHOUDARY V R SAMANTA C JANA P | 2007 | Applied Catalysis A: General2007，332，1： | 1 |
| 4 | Wet chemical synthesis of silver nanorods and nanowires of controllable aspect ratios显示文摘 | Jana N R Gearheart L Murphy C | 2001 | J Chem Commun2001，，： | 1 |
| 5 | Characteristics and utilization of copper slag-a review 显示文摘 | Bipra Gorai Jana R K Premchand | 2003 | Resources Conservation and Recycling2003，39，4： | 1 |
| 6 | Thermal stability and molecular interaction of polyurethane nanocomposites prepared by in situ polymerization with functionalized multiwalled carbon nanotubes显示文摘 | Jana R N Cho W | 2008 | J Appl Polym Sci2008，108，： | 1 |
| 7 | A method of non - linear viscoelastic analysis of solid propellant grains for pressure load显示文摘 | JANA M K RENGATHAN K VENKATESWARA R G | 1994 | Computers and Structures1994，52，1： | 1 |
| 8 | Evidence for Seed-Mediated Nucleation in the Chemical Reduction of Gold Salts to Gold Nanoparticles显示文摘 | Jana N R Gearheat L Murphy L | 2001 | J Chem Mater2001，13，： | 1 |
| 9 | Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles显示文摘 | Jana S Maria MS Javier R | 2014 | Eur J Med Chem2014，77，13： | 1 |
| 10 | MAPK p38 regulates transcriptional activity of NF-kappa B in primary human astroeytes via acetylation of p65 显示文摘 | SAHA R N JANA M PAHAN K | 2007 | J Immunol2007，179，10： | 1 |
| 11 | Cr-doped Zr, Si-me- soporous molecular sieves as catalysts of CH2 C12 oxidation 显示文摘 | Janas J Janik R Maehej T | 2000 | Catal Today2000，59，3： | 1 |
| 12 | Effect of herbicides on decomposition of soil organic matter and mineralization of nitrogen in fluventic ustochrept soil显示文摘 | JANA T K DEBNATH N C BASAK R K | 2004 | Journal of Interacademicia2004，8，2： | 1 |
| 13 | The effect of nonlinearities on the strain concentration factors in solid propellant grains显示文摘 | JANA M K RENGATHAN K VENKATESWARA R G | 1996 | Computers and Structures1996，58，2： | 1 |
| 14 | Seed - Mediated Growth Approach for Shape - Controlled Synthesis of Spheroidal and Rod - like Gold Nanoparticles Using a Suffactant Template 显示文摘 | N R Jana L Gearheart C J Murphy | 2001 | Adv Mater2001，13，： | 1 |
| 15 | Inhibition of Rho kina- ses increases directional motility of microvascular endotheli- al cells 显示文摘 | Johannes B Jana S Margot R | 2012 | Biochemical Pharmacology2012，83，5： | 1 |
| 16 | Effect of Cu content on the catalytic activity of CuSiBEA zeolite in the SCR of NO by ethanol: Nature of the copper species 显示文摘 | Janas J Gurgul J Socha R P | 2009 | Applied Catalysis B: Environmental2009，91，12： | 1 |
| 17 | Size and shape-controlled magnetic (Cr, Mn, Fe, Co, Ni) oxide nanocrystals via a simple and general approach 显示文摘 | Jana N R Chen Y F Peng X G | 2004 | Chemistry Materials2004，16，： | 1 |
| 18 | Characteristics and utili- zation of copper slag-a review显示文摘 | Bipra Gorai Jana R K Premchand | 2003 | Conservation Recycling2003，39，： | 1 |
| 19 | Characteristics and utilisation of copper slag- A review 显示文摘 | Gorai B Jana R K | 2003 | Resour Conserv Recycling2003，39，4： | 1 |
| 20 | Fluorescent Carbon Nanoparticles: Synthesis, Characterization,and BioimagingApplication 显示文摘 | RAY S C SAHA A JANA N R | 2009 | Journal of Physical Chemistry C2009，113，18： | 1 |
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