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| 1 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 2 | Fractionation of Heavy Metals in Sediments from Dianchi Lake,China显示文摘FVactionation of heavy metals in sediments can help in understanding potential hazards of heavy metals. The present study analyzed total concentrations and fractions of selected heavy metals (Cd, Cr, Cu, Pb, and Zn) in surface sediments from Dianchi Lake, Yunnan Province, China, as well as factors that may affect distributions of the various heavy metal fractions. Total concentrations of the heavy metals decreased in the order Zn > Cu > Pb > Cr > Cd. These heavy metals, except Cr, were much higher than their background levels, indicating that Dianchi Lake was polluted by Cd, Zn, Pb, and Cu. Cadmium occurred mainly as the non-residual fraction (sum of the HOAc-soluble, reducible, and oxidizable fractions) (97.6%), and Zn (55.7%) was also predominantly found in the non-residual fraction. In contrast, most of the Cr (88.5%), Pb (81.8%), and Cu (59.2%) occurred in the residual fraction. Correlation analysis showed that total heavy metal concentrations, organic matter and reducible Fe were the main factors affecting the distributions of the various heavy metal fractions. In the Waihai section of Dianchi Lake (comprising 97% of the lake area), the concentrations of Cd, Zn, Pb, and Cu in the non-residual fraction were significantly lower (P < 0.01 or 0.05) than those of the Caohai section (3% of the lake area). This indicated that potential heavy metal hazards in the Caohai section were greater than the Waihai section. | LI Ren-Ying YANG Hao ZHOU Zhi-Gao Lü Jun-Jie SHAO Xiao-Hua JIN Feng | 2007 | Pedosphere2007，17，2： | 29 |
| 3 | Hepatic venous outflow reconstruction in adult right lobe living donor liver transplantation without middle hepatic vein显示文摘背景重建困难、挑战性在没有中间的肝的静脉(MHV ) 的成年正确脑叶生活施主肝移植(LDLT ) 的肝的静脉的流出。门静脉和静脉的流出阻塞的过多的灌注将导致接枝的尖锐拥挤,最终导致主要 nonfunction。尽管各种各样的重建模式在许多国家被探索了,当前没有清楚的一致。在这研究,我们描述一种技术没有 MHV.Methods A ,用正确脑叶接枝在 LDLT 与劣等的静脉 cava ( IVC )在流出吻合阻止接枝的“ chocking ”回顾的分析从没有 MHV ,用正确脑叶接枝经历 LDLT 的 55 个接受者在临床的数据上被进行或肝的静脉的流出的重建。施主的恰好肝的静脉(RHV ) 与接受者 IVC 的三角形的开始被吻合;劣等的恰好肝的静脉(IRHV ) 足够大,直接被吻合到 IVC。大 saphenous 静脉(GSV ) 被用于重要 MHV tributaries.Results 的重建没有死亡发生在任何施主。55 个接受者,复杂并发症发生在 6,包括 hepaticvein 苛评(1 个盒子) , small-for-size 症候群(1 ) ,肝的动脉血栓(1 ) ,肠的流血(1 ) ,胆汁漏(1 )(1 ) ,左 subphrenic 脓肿和肺的感染。三个病人的一个总数死了,从 small-for-size 症候群的并且二从多重系统机关 failure.Conclusions,多重洞的垂直吻合与肝的静脉流出被重建。这种技术减轻生活施主的外科的风险,保证优秀静脉的排水,并且阻止脉管的 thromboses 和主要 nonfunction。 | WU Hong YANG Jia-yin YAN Lü-nan LI Bo ZENG Yong WEN Tian-fu ZHAO Ji-chun WANG Wen-tao XU Ming-qing LU Qiang CHEN Zhe-yu MA Yu-kui LI Jin | 2007 | Chinese Medical Journal2007，，11： | 27 |
| 4 | Multi-level decollement zones and detachment deformation of Longmenshan thrust belt,Sichuan Basin,southwest China显示文摘As is well known that many decollement layers were developed in the Longmenshan thrust belt,Si-chuan Basin,China. Through field investigation,explanation of seismic profiles and analysis of the balanced sections,we can divide the decollement zones into 3 categories: (1) the deep level decolle-ment zones,including the crust-mantle decollement layer,intracrustal decollement layer,and presinian basal decollement layer. The main structural styles of their deformation are the crust-mantle decoup-ling detachment deformation,the basal ductile shear deformation,etc.; (2) the middle level decollement zones,including the Cambrian-Ordovician decollement layer,the Silurian decollement layer,etc.,the main structural styles of their deformation are the isopachous fold,the angular fold,the saddle struc-ture,and the combination styles of them; and (3) the shallow level decollement zones,including the Xujiahe Formation decollement layer of Upper Triassic and the Jurassic decollement layers,the main structural styles of their deformation are the thrust-nappe tectonic,the pop-up,the triangle zone ,the duplex,etc. Multi-level decollement zones not only made the Longmenshan thrust belt develop many different deformation styles from deep place to shallow place,but also made some local areas have the superimposition of the tectonic deformation apparently. This study indicates that the multi-level de-collement zones have a very important effect on the shaping and evolution of the Longmenshan thrust belt. | TANG LiangJie1,2,3,YANG KeMing4,JIN WenZheng1,2,3,L ZhiZhou4 & YU YiXin1,2,3 1 State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China 2 Key Laboratory for Hydrocarbon Accumulation Mechanism,China University of Petroleum,Ministry of Education,Beijing 102249,China 3 Basin and Reservoir Research Center,China University of Petroleum,Beijing 102249,China 4 Southwest Division Company,SINOPEC,Chengdu 610081,China | 2008 | Science China Earth Sciences2008，51，S2： | 18 |
| 5 | A prospective randomized antiplatelet trial of cilostazol versus clopidogrel in patients with bare metal stent显示文摘Background Cilostazol is a newly developed antiplatelet drug that has been widely applied for clinical use. Its antiplatelet action appears to be mainly related to inhibition of intracellular phosphodiesterase activity. Recently, cilostazol has been used for antiplatelet therapy after coronary bare metal stent implantation for thrombosis and restenosis prevention. This prospective randomized and double blind trial was designed to investigate the safety and efficacy of cilostazol for the prevention of late restenosis and acute or subacute stent thrombosis. Methods One hundred and twenty patients who underwent elective stent were randomly assigned to treatment group with cilostazol 200 mg/d (n = 60), clopidogrel 75 mg/d and aspirin 100 mg/d or to control group with clopidogrel treatment 75 mg/d (n = 60) and aspirin 100 mg/d. Follow-up coronary angiography was performed 6-9 months later. Results Nine months major adverse cardio-cerebral event (MACCE) were lower in treatment groups (P<0.05). The quantitative coronary angiography (QCA) at 6 months follow-up showed that minimum lumen diameter (MLD) was higher in treatment group than that of control group [(2.14±0.52)mm vs (1.82±0.36)mm, P<0.05]. Late lumen loss (LL) [(0.82±0.42)mm vs (1.31±0.58)mm; P<0.01], restenosis rate (RR) (14% vs 32%; P<0.05) and target lesion revascularizaion (TLR) rate (5% vs 17%; P<0.05) were lower in treatment group than in control group. Conclusion Cilostazol therapy is an effective regimen for prevention not only stent thrombosis but also RR and TLR through reducing MLD without the risk of increasing bleeding. | CHEN Yun-dai, LU Yan-ling, JIN Ze-ning, YUAN Fei and Lü Shu-zhengDepartment of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences Beijing Institute of Heart, Lung and Blood Vessel, Beijing 100029, China | 2006 | Chinese Medical Journal2006，，5： | 15 |
| 6 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 7 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 8 | Management of borderline and locally advanced pancreatic cancer:Where do we stand?显示文摘Many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic laparoscopy.The definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of LAPC.For the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal vein.When feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 resection.For initially unresectable LAPC,neoadjuvant should be strongly considered.Specifically,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual resection.The efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with radiation.This review focuses on patients with LAPC and addresses recent advances and controversies in the field. | Jin He Andrew J Page Matthew Weiss Christopher L Wolfgang Joseph M Herman Timothy M Pawlik | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 9 | Updates in the management of cranial dural arteriovenous fistula显示文摘Dural arteriovenous fistula(dAVF)accounts for approximately 10%of all intracranial vascular malformations.While they can be benign lesions,the presence of retrograde venous drainage and cortical venous reflux makes the natural course of these lesions aggressive high risk of haemorrhage,neurological injury and mortality.Endovascular treatment is often the first line of treatment for dAVF.Both transarterial and transvenous approaches are used to cure dAVF.The selection of treatment approach depends on the angioarchitecture of the dAVF,the location,the direction of venous flow.Surgery and,to a lesser extent,stereotactic radiosurgery are used when endovascular approaches are impossible or unsuccessful. | Humain Baharvahdat Yinn Cher Ooi Wi Jin Kim Ashkan Mowla Alexander L Coon Geoffrey P Colby | 2020 | Stroke & Vascular Neurology2020，5，1： | 10 |
| 10 | Tectonic Evolution of the Middle Frontal Area of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘由分析平衡的生气的节和 Longmen 山戳带的沉淀历史,中国,我们断定它经历了五个构造阶段:(1 ) 形成阶段(T 3 x ) Longmen 的缩影,山,早 Indosinian 运动,和 Anxian 构造运动创造了 Longmen 山;(2 ) 稳定的构造阶段(更弱的构造运动导致了 Longmen 山戳带的 J 1) 稍微正在被高举并且稍微减退低岬盆;(3 ) 强烈构造阶段(J2.3 ) ,也就是早 Yanshan 运动;(4 ) 连续构造运动(K-E ) ,也就是迟了的 Yanshan 运动和早喜玛拉雅的运动;并且(5 ) Longmen 山(N-Q ) 的形成,也就是晚喜玛拉雅的运动。在那些构造变丑阶段期间, Anxian 运动和喜玛拉雅的运动在 Longmen 山的形成起了重要作用。喜玛拉雅的运动影响了 Longmen 山大多数;阶层强烈地推进了并且严重地被侵蚀。因为一些越过水坝落下的水被推,在 Longmen 山戳带的中间的部分有某 klippes 在以后向东南构造变丑。 | JIN Wenzheng TANG Liangjie YANG Keming WAN Guimei Lü Zhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 10 |
| 11 | Clinical application of repetitive transcranial magnetic stimulation in stroke rehabilitation显示文摘Proper stimulation to affected cerebral hemisphere would promote the functional recovery of patients with stroke. Effects of repetitive transcranial magnetic stimulation on cortical excitability can be can be altered by the stimulation frequency, intensity and duration. There has been no consistent recognition regarding the best stimulation frequency and intensity. This study reviews the intervention effects of repetitive transcranial stimulation on motor impairment, dysphagia, visuospatial neglect and aphasia, and summarizes the stimulation frequency, intensity and area for repetitive transcranial magnetic stimulation to yield the best therapeutic effects. | Joonho Shin EunJoo Yang KyeHee Cho Carmelo L Barcenas Woo Jin Kim Nam-Jong Paik | 2012 | Neural Regeneration Research2012，7，8： | 9 |
| 12 | Differential Tectonic Deformation of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘地调查和地震的节解释证明 Longmen 山戳带有明显的微分变丑:带状配列,分割和层化。带状配列意味着那,从 NW 到 NE, Longmen 山戳带能被划分成 Songpan-Garz ê构造的带,可锻的变丑带,基础深奥的戳带,正面的褶层戳带,和低岬消沉。它能向南向北被划分成五个片断从到的分割工具:北片断, Anxian 转移地区,中心片断, Guanxian 转移地区和南部的片断。层化意味着分开层在侧面划分结构的式样。在 Longmen 山戳带的分开层能被分类进三个范畴:深水平的分开层包括外壳披风系统分开层, intracrustal 分开层,和 Presinian 系统基础分开层;中间级的分开层包括寒武纪奥陶纪的分开层,志留纪分开层,等等;并且浅水平的分开层,包括的上面的三叠纪的 Xujiahe 形成分开层和侏罗记分开层。多水平分开层在塑造和 Longmen 山戳带的进化上有很重要的效果。 | TANG Liangjie YANG Keming JIN Wenzheng WAN Guimei LüZhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 6 |
| 13 | Predictive factors of recurrent angina after acute coronary syndrome: the global registry acute coronary events from China (Sino-GRACE)显示文摘背景:有急性冠的症候群(交流) 的许多病人在住院期间开发周期性的咽峡炎(RA ) 。非使随机化的、未来的学习是与交流在 unselected 病人调查 RA 的预兆的因素的这的目的在中国在住院期间在全球登记注册了尖锐冠的事件(优雅) 。方法:在 2001 年 3 月和 2004 年 10 月之间,注册了是有交流的 1433 个病人,包括圣片断举起心肌的梗塞(662, 46.2%) ,非圣片断举起心肌的梗塞(239, 16.7%) 并且不稳定的咽峡炎(532, 37.1%) 。人口统计的分发,病历和临床的数据被收集由逻辑回归调查 RA 的预兆的因素。结果:(19.2%) 在住院 275 期间,病人们包括不稳定的咽峡炎(53.2%) 与 RA 被记录,非圣片断举起心肌的梗塞(27.5%) ,圣片断举起心肌的梗塞(19.3%) 。dyslipidemia 的 comorbidity,优先的咽峡炎,在 6 个月以内的经皮的冠的干预(一种总线标准) 在有 RA 的病人是更普通的, P <
0.05。在有 RA 的病人,有尖锐肺水肿的病人的一个显著地更高的比例被观察, 23 (8.4%) 对 43 (3.7%) , P = 0.001。尖锐肾衰竭在 8 是在场的(2.9%) 有 RA 的病人对 19 (1.6%) 没有 RA 的病人, P = 0.165。出血性的事件在 6 是在场的(2.2%)有 RA 的病人对 8 (0.7%)没有 RA ,在 12 个病人(4.3%)的室的 tachycardia/ventricular 纤维性颤动事件对 22 个病人(1.9%)的病人,在 69 个病人(25.0%)的充血心力衰竭对 94 个病人(8.1%),在 28 个病人(10.1%)对 15 个病人(1.3%)的心肌的重新梗塞, P <
0.05 分别地。有 RA 的病人的一个更低的比例经历了在里面医院一种总线标准, 687 (59.3%) 对 114 (41.5%) , P = 0.000。有 RA 的病人的一个更高的比例收到了肝磷脂, 260 (94.5%) 对 1035 (89.4%) , P = 0.006;并且 beta-blockers 176 (64.0%) 对 864 (74.5%) , P = 0.000。 Multivarible 回归分析证明 RA 与优先的咽峡炎被联系(或 2.086 ,95% CI 1.466 - 2.967 ),在里面医院一种总线标准(或 0.579 ,95% CI 0.431 - 0.778 ),在里面医院充血心力衰竭(或 2.410 ,95% CI 1.634 - 3.555 ),心肌的重新梗塞(或 7.695 ,95% CI 3.701 - 15.999 ),贝它块(或 0.626 ,95% CI 0.458 - 0.855 ),并且肝磷脂(或 3.411 ,95% CI 1.604 - 7.382 )。结论:在里面医院充血心力衰竭,心肌的重新梗塞,优先的咽峡炎历史和肝磷脂的使用是 RA 的更强壮的独立预言者;beta-blockers 和一种总线标准也是为 RA 的重要预兆的因素。 | ZHAO Fu-hai CHEN Yun-dai SONG Xian-tao PAN Wei-qi JIN Ze-ning YUAN Fei LI Yong-bin Ren Fang Lü Shu-zheng | 2008 | Chinese Medical Journal2008，，1： | 6 |
| 14 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 15 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 16 | Numerical surface characterization of wear debris from artificial joints using atomic force microscopy显示文摘Study on surface features of wear particles generated in wear process provides an insight into the progress of material failure of artificial joints. It is very important to quantify the surface features of wear particles in three dimensions. In this study, a new approach using atomic force microscopy was proposed to carry out 3D numerical surface characterization of wear debris generated from artificial joints. Atomic force microscopy combined with image processing techniques was used to acquire appropriate 3D images of wear debris. Computerized image analysis techniques were then used to quantify surface texture features of wear debris such as surface roughness parameters and surface texture index. The method developed from the present study was found to be feasible to quantity the surface characterization of nanoand micro-sized wear debris generated from artificial joints. | YUAN ChengQing JIN ZhongMin TIPPER J L YAN XinPing | 2009 | Chinese Science Bulletin2009，54，24： | 5 |
| 17 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 18 | A New Species of Huaxiapterus (Pterosauria: Pterodactyloidea) from the Lower Cretaceous of Western Liaoning, China with Comments on the Systematics of Tapejarid Pterosaurs显示文摘tapejarid 翼龙的新种, Huaxiapterus corollatus sp。nov。根据一个将近完全的颅骨被树立并且从辽宁省的更低的 CretaceousJiufotang 形成张贴头部的骨骼,中国。Huaxiapterus corollatus sp。nov。被一个塑造和斧的矩形的过程在切牙骨上描绘,其短轴对 premaxillae 的前面的边缘垂直。除了这个过程,颅骨的另外的人物如此的著名计算机生产厂商他在 nasoantorbital 窗的前面的边缘和切牙骨的前面的边缘之间的猪嘴的宽度类似于 Huaxiapterus jii 的。Huaxiapterus 和第二 Chinesetapejarid, Sinopterus,和 Tapejara 一样的份额几独特头部的人物和这三个类看起来比到另外的 azhdarchoids 与对方有关仔细是更多。Chinesetapejarids (Sinopterus 和 Huaxiapterus ) 相对伸长颅骨和微弱地发达的头部的冠并且似乎少些比 Tapejara 被发源,与它的更短的、更深的颅骨和大头部的冠。Tupuxuarids (Tupuxuara 和 Thalassodromeus ) 经常是在家庭 Tapejaridae 的联系 withtapejarids,但是因为一些种系发生的分析支持了与 Azhdarchidae 配对 tupuxuarids,这种关系是争论的。我们建议 thatTapejaridae 被限制为 Tapejara, Sinopterus 和 Huaxiapterus。 | Lü Junchang JIN Xingsheng David M. UNWIN ZHAO Lijun AZUMA Yoichi JI Qiang | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 5 |
| 19 | Nanosecond photoelectric effects in all-oxide p-n junction of La_(0.9)Sr_(0.1)MnO_(3)/SrNb_(0.01)Ti_(0.99)O_(3)显示文摘Nanosecond (ns) photoelectric effects have been observed in all-oxide p-n junctions of La0.9Sr0.1MnO3/SrNb0.01Ti0.99O3 for the first time. The rise time was about 23 ns and the full width at half maximum was about 125 ns for the open-circuit photovoltaic pulse when the La0.9Sr0.1MnO3 thin film in the p-n junction was irradiated by a laser of ~20 ns pulse duration and 308 nm wavelength. The photovoltaic sensitivity was 80 mV/mJ for a 308 nm laser pulse. | HUANG Yanhong L(U) Huibin HE Meng ZHAO Kun CHEN Zhenghao CHENG Bolin ZHOU Yueliang JIN Kuijuan DAI Shouyu YANG Guozhen | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 4 |
| 20 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
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