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| 1 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 2 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 3 | An improved small antenna radiation-efficiency measurement method显示文摘 | JOHNSTON R H MCRORY J G | 1998 | IEEE Antennas and Propagation Magazine1998，40，5： | 2 |
| 4 | Effects of Reduced Nocturnal Temperature on Performance and Behavior of Nursery Pigs显示文摘Previous studies suggested that pigs prefer lower environmental temperatures during nighttime compared to daytime. So reducing nocturnal temperature in nursery barns may not jeopardize performance or welfare of pigs, but can save energy for heating the barn. A study was conducted to investigate growth performance and behavioral response of nursery pigs to reduced nocturnal temperature. This study was conducted in four replicates, each utilizing 270 newly weaned pigs and lasting for 5 wk. Temperature setpoint in the control room (CON) was started at 30°C and decreased by 2°C per week. In the treatment room (RNT), temperature setpoint was maintained same as in CON between 7:00 h and 19:00 h, and reduced by 8°C between 19:00 h and 7:00 h starting from d 5. Growth performance (15 pens/room, 9 pigs/pen, BW=(6.3±0.61) kg) was monitored for 5 wk, and behaviors in 6 pens in each room were video-recorded for 24 h 3 d after being exposed to the experimental temperature. Instantaneous scan sampling was performed to determine time budgets for standing, sitting, eating, drinking, belly nosing, three postures of lying, and huddling. Two focal pigs were continuously viewed to record duration and occurrence of eating and drinking. Reduced nocturnal temperature did not affect the growth performance of the pigs, time spent standing, sitting, total lying and eating or duration and frequencies of eating and drinking (all P>0.10). However, RNT increased time spent lying sternal (83 vs. 72%, P<0.001) and number of pigs that were huddling (70 vs. 50% of lying pigs, P<0.001), and decreased time spent lying laterally (0.8 vs. 4.6%, P<0.001), lying half laterally (5.3 vs. 11.0%, P<0.001), and belly nosing (0.9 vs. 1.7%, P=0.01) during nighttime. These results indicate that nursery pigs adopted the posture of lying sternal and huddled together to reduce heat loss from their body surface to maintain thermal balance and growth performance in RNT. Such mild reduction in nocturnal temperature in the nursery barn can save energy for heating the barn without negative effects on performance and behavior of nursery pigs. | Lee J Johnston | 2012 | Journal of Integrative Agriculture2012，11，9： | 2 |
| 5 | Anticipatory Activation in the Amygdala and Anterior Cingulate in Generalized Anxiety Disorder and Prediction of Treatment Response显示文摘 | Nitschke Jack B Sarinopoulos Issidoros Oathes Desmond J Johnstone Tom Whalen Paul J Davidson Richard J Kalin Ned H | 2009 | The American Journal of Psychiatry2009，，3： | 2 |
| 6 | Genetic and environmental control of fruit maturation,dry matter and firmness in apple(Malus×domestica Borkh.)显示文摘For any given genotype,the environment in which an apple is grown can influence the properties of the fruit considerably.While there has been extensive research on the mechanism of the genetic control of fruit quality traits,less effort has been made to investigate the way that these genetic mechanisms interact with the environment.To address this issue,we employed a large‘Royal Gala’בBraeburn’population of 572 seedlings replicated over sites in three climatically diverse apple-growing regions in New Zealand.Phenotyping for traits including fruit maturation timing,firmness and dry matter content was performed at each of these three sites for a single growing season(2011),and at two sites(Motueka and Hawke’s Bay)for two seasons(2009 and 2010).The phenotype data collected over 2 years at two sites enabled the detection of 190 quantitative trait loci(QTL)that controlled these traits regardless of year or growing location,as well as some chromosomal loci that influenced the traits in a single given environment or year.For those loci that were environmentally stable over three sites,there was an interdependency of fruit maturation date,dry matter content and storage potential within this population,with two regions on Linkage Groups(LGs)10 and 16 strongly contributing.If these loci were used in a marker-assisted selection programme to select for progeny bearing firmer fruit,this would have the unintentional consequence of selecting,high dry matter content,later maturing apples.In addition,a further 113 new QTLs with a smaller effect were identified,some of which were exhibited only in a single growing environment,demonstrating the underlying complexity of control of traits determining fruit quality,in addition to the need for being aware of environmental effects when developing new apple varieties. | David Chagne Daya Dayatilake Robert Diack Murray Oliver Hilary Ireland Amy Watson Susan E Gardiner Jason W Johnston Robert J Schaffer Stuart Tustin | 2014 | Horticulture Research2014，1，1： | 2 |
| 7 | Urban Geography: City structure 显示文摘 | Johnston R J | 1997 | Progress in Human Geography1997，2，1： | 1 |
| 8 | Phospholipid - stabilized nanoparticles of cyclosporine A by rapid expansion from supercritical to aqueous solution显示文摘 | YOUNG T J JOHNSTON K P PACE G W | 2004 | AAPS Pharm Sci Tech2004，5，1： | 1 |
| 9 | Multiple physiological functions for multidrug transporter P glycoprotein显示文摘 | Johnstone R W Ruefli A A Smyth M J | 2000 | Trends Biochem Sci2000，25，1： | 1 |
| 10 | Pritonitis influences mortality in peritoneal dialysis显示文摘 | Fried LF Bernardinni J Johnston JR | 1996 | J Am Soc Nephrol1996，7，： | 1 |
| 11 | A framework for assessing direct economic impacts of tourist events: distinguishing ori- gins,destinations, and causes of expenditures显示文摘 | TYRRELL T J JOHNSTON R J | 2001 | J Travel Res2001，40，： | 1 |
| 12 | A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma显示文摘 | Johnston P B Inwards D J Colgan J P | 2010 | Am JHematol2010，85，5： | 1 |
| 13 | A firm's ability to managing in complex business networks : A review of concepts 显示文摘 | Ritter T Wilkinson I F Johnston W J | 2004 | Industrial Marketing Management2004，33，3： | 1 |
| 14 | J Anita Sci显示文摘 | Johnston L J Fogwell R L Weldon N K | 1989 | 67: 9431989，67，： | 1 |
| 15 | Compucations of surgery for arteriovenous maiformation of the brain显示文摘 | Morgan M K Johnston I H Haulan J M | 1993 | J Neurosurg1993，78，： | 1 |
| 16 | Efficacy of sucrose and milk chocolate product or dried porcine solubles to increase feed intake and impmve performance of lactating sows显示文摘 | Johnston L J Pettigrew J E Bmdoo SK | 2003 | Anim Sci2003，81，： | 1 |
| 17 | The measurement and study of very thin lubricant films in concentrated contact显示文摘 | G J Johnston R Wayte H A Spikes | 1991 | Trib Trans1991，34，： | 1 |
| 18 | Effect of room temperature and dietary amino acid concentration on performance of lactating sows 显示文摘 | Johnston L J Ellis M Libal G W | 1999 | Journal of Animal Science1999，77，： | 1 |
| 19 | Thermally induced dynamics of satellite solar panels 显示文摘 | Johnston J D Thornton E A | 2000 | Journal of Spacecraft and Rockets2000，37，5： | 1 |
| 20 | PCR as a Confirmatory Technique for Laboratory Diagnosis of Ma- laria显示文摘 | Stephanie P Johnston Norman J Pieniazek Maniphet V Xayavong | 2006 | J Clin Microbiol2006，44，3： | 1 |
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